Clinical trials: sponsored by University of Alabama at Birmingham
Gout
Gout in the ED and Improving Research Participation
The prevalence of gout has been steadily increasing over several decades and is correlated with the rising burden of obesity, chronic cardiac and renal disease; all conditions overrepresented in the Southeastern U.S.
- Trial name
- NCT04075903
- Testing
- Storytelling
- Where
- 4 sites in United States
- Volunteers
- 200 people
- Sponsor
- University of Alabama at Birmingham
Language Disorders
Neurophysiological Mechanisms of Language Comprehension
First, in a recording-only self-paced reading experiment, patients with epilepsy undergoing intracranial monitoring for clinical purposes will read or listen to sentences presented to them one word at time while the investigators…
- Trial name
- NCT05283265
- Testing
- Sentence Type, Direct brain stimulation
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- University of Alabama at Birmingham
Type 2 Diabetes
Remotely Delivered Mindfulness-Based Diabetes Education
Diabetes distress is common affecting over one-third of people with type 2 diabetes, negatively impacting self-management and outcomes, and disproportionately affecting low-income individuals.
- Trial name
- NCT06312553
- Testing
- Remotely delivered Mindfulness-Based Diabetes Education, Standard Diabetes Self Management Education
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Alabama at Birmingham
Prematurity
Milk And Growth In Children (MAGIC) Born Very Preterm: A Randomized Trial
The goal of this multi-center randomized, parallel group trial is to determine the effect of human milk diets ranging between 180 and 200 mL/kg/day on the body composition outcomes of moderately preterm infants born between 27…
- Trial name
- MAGIC (NCT06420531)
- Testing
- Human milk
- Where
- 4 sites in United States
- Volunteers
- 486 people
- Sponsor
- University of Alabama at Birmingham
Obesity (Body Mass Index >30 kg/m2)
Effects of a High-protein Diet and Resistance Training on Fat-mass Loss Maintenance
This clinical trial investigates whether a high-protein diet combined with resistance training is more effective than a standard low-calorie diet for maintaining fat mass loss in individuals with obesity.
- Trial name
- PRO-FIT (NCT07113561)
- Testing
- High-protein diet and resistance training, Balanced control diet
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Norwegian University of Science and Technology
Blood Cholesterol, Blood Pressure Monitoring
Empowering Faith-based Communities to Provide Personalized Diabetes Self-management Education and Support (DSMES) in the Magic City
In this study, individuals living with diabetes in the Birmingham area will participate in a free, 3-month DSMES program hosted by MedsPLUS Consulting, a local independent pharmacy and wellness center, at a local faith-based…
- Conditions
- Blood Cholesterol, Blood Pressure Monitoring, Weight Change, BMI
- Trial name
- MCPILOTDSMES (NCT07556354)
- Testing
- Remote Patient Monitoring in a Faith-Based Program, Traditional Cohort Faith-based DSMES program
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Acellular Dermal Matrix, Bone Grafting
Evaluating the Barrier Function, Regenerative Capacity, and Soft Tissue Outcomes of Acellular Dermal Matrix
This investigator-initiated study will compare ADM and resorbable cross-linked collagen membrane barriers for guided bone regeneration at atrophic lateral ridge augmentation sites.
- Conditions
- Acellular Dermal Matrix, Bone Grafting, Soft Tissue Grafting
- Trial name
- NCT07613047
- Testing
- Guided Bone Regeneration with ADM (AlloDerm) as a barrier, Guided Bone Regeneration with Resorbable Crosslinked Collagen Matrix (Mem-Lok) as a barrier
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Head and Neck Cancer
A Motion Exergaming Approach for Symptom Management: HNC
This overall objective of the RCT is to test an intervention to overcome the PA barriers for head and neck cancer (HNC) patients during the first 6 months after their treatment.
- Trial name
- NCT04632654
- Testing
- A personalized Physical Activity intervention with fitness graded Motion Exergames (PAfitME)
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- University of Alabama at Birmingham
Arthritis Knee, Arthritis Hip
Developing an Opioid Taper Intervention Before Total Joint Arthroplasty
The goal of this clinical trial is to develop an pharmacist-led preoperative opioid taper intervention for patients undergoing total knee or hip replacement who are on chronic opioids before their surgery.
- Conditions
- Arthritis Knee, Arthritis Hip, Chronic Pain
- Trial name
- NCT05788016
- Testing
- opioid taper
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of Alabama at Birmingham
Autism Spectrum Disorder, Emotion Regulation
DOD Regulating Together Intervention
Our long-term goal is to validate Regulating Together (emotion regulation intervention) and improve psychosocial outcomes for youth with autism spectrum disorder and emotion dysregulation.
- Trial name
- NCT05803369
- Testing
- Regulating Together (RT), Achieving Independence and Mastery in School (AIMS)
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Rheumatologic Disease, Autoimmune Diseases
Testimonials and Navigation in Rheumatology
The overall goal of this study is to determine whether a novel, multi-modal, patient-directed behavioral intervention initiated in rheumatology clinics is an effective approach to improve uptake of updated COVID-19 vaccine.
- Trial name
- TANGO (NCT06469788)
- Testing
- Video comprised of AIRD patient narratives on COVID-19 vaccination thoughts and experiences, Video on the importance of good oral health for patients with AIRD, Brochure on COVID-19 vaccination in AIRD patients
- Where
- 4 sites in United States
- Volunteers
- 1,170 people
- Sponsor
- University of Alabama at Birmingham
Lung Diseases, Chronic Disease
Housing, Environment, And Living Conditions for Transformed Health
This project will compare the health effects of public housing renovation, neighborhood built and social environment improvements, and indoor air purification, alone and in combination, as well as the cost effectiveness of each…
- Trial name
- HEALTHe (NCT06925373)
- Testing
- Indoor Air Purification, Neighborhood Improvements, Housing Improvements
- Where
- United States
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Subarachnoid Hemorrhage, Aneurysmal
Continuous Assessment of Brain Blood Perfusion in Subarachnoid Hemorrhage Patients Using Near-Infrared Spectroscopy (NIRS)
The goal of this observational study is to continuously assess cerebral autoregulation in patients with subarachnoid hemorrhage (SAH) using cerebral oximetry index (COx) and hemoglobin volume reactivity index (HVx).
- Trial name
- NCT06932640
- Testing
- - Non-Invasive Near-infrared Spectroscopy (NIRS) device (HEM1 with Foresight Elite Sensor)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Alabama at Birmingham
HIV, Hypertension
Assessing Peer Support for Physical Activity in Women With HIV and Hypertension
This clinical trial will assess the acceptability and feasibility of a peer-supported behavioral physical activity intervention for women living with HIV and Hypertension.
- Trial name
- NCT07025109
- Testing
- Peer support, Exercise Prescription, Blood pressure self monitoring
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- University of Alabama at Birmingham
Median Arcuate Ligament
Novel Feasibility Study Demonstrating the Utility of the Intuitive Da Vinci Single Port Robotic System for Treatment of Median Arcuate Ligament Release
This is a prospective, non-randomized, single arm, single center feasibility study to investigate surgical feasibility and technical success of robotic treatment for Median Arcuate Ligament Syndrome using the Intuitive Da Vinci…
- Trial name
- NCT07888764
- Testing
- Single Port Robotic Median Arcuate Ligament Release
- Volunteers
- 5 people
- Sponsor
- University of Alabama at Birmingham
Remote vs. In-Person, Remote Visits
Remote vs. In-Person Study Evaluation (RISE) Trials: RISE Above Smoking (Trial 1 of 3)
The study will employ a randomized, parallel-group design with two-stage randomization. After an initial brief screen for basic eligibility, participants will be randomized (within site) to either Remote (R) or In-Person (IP)…
- Conditions
- Remote vs. In-Person, Remote Visits, In-person Visits
- Trial name
- NCT06822049
- Testing
- Combination Nicotine Replacement Therapy (patch and lozenge)
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Breast Cancer
RAD 1802: Pilot Trial of Five Fraction Stereotactic Body Radiotherapy for Early Stage Breast Cancer Patients Eligible for Post-Operative Accelerated Partial Breast Irradiation (APBI)
This study offers 5 fractions of radiation treatment through partial breast irradiation in patients with early stage breast cancer after having a lumpectomy.
- Trial name
- NCT03643861
- Testing
- 5 Fraction Stereotactic Body Radiation Therapy
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of Alabama at Birmingham
Hiv, Sexually Transmitted Diseases
CAMELLIA Cohort: A Longitudinal Study to Understand Sexual Health and Prevention Among Women in Alabama
Pre-exposure prophylaxis (PrEP) is an important biomedical human immunodeficiency virus (HIV) prevention tool and may particularly benefit black, cis and trans-gender women, who are at an increased risk for HIV and Sexually…
- Trial name
- CAMELLIA (NCT05463692)
- Testing
- Camelia Cohort
- Where
- United States
- Volunteers
- 830 people
- Sponsor
- University of Alabama at Birmingham
Breast Reconstruction
Pulsed Lavage in Implant-Based Breast Reconstruction
To determine if there is any benefit to using pulsed lavage to wash out the mastectomy pocket during breast reconstruction. Primary outcomes will include post-op complications including surgical site infection (SSI), hematoma…
- Trial name
- NCT05585710
- Testing
- Pulsed Lavage Washout, Implant-based breast reconstruction, Bilateral or unilateral mastectomy
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of Alabama at Birmingham
Chronic Lymphocytic Leukemia
Addition of Loncastuximab Tesirine to Acalbrutinib , Chronic Lymphocytic Leukemia
Study is a phase I study to determine the maximum tolerated dose of adding Loncastuximab Tesirine to Aclabrutinib in the treatment of chronic lymphocytic leukemia.
- Trial name
- NCT05971251
- Testing
- Loncastuximab Tesirine and Acalabrutinib
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Alabama at Birmingham