Clinical trials: sponsored by Boston University
Tuberous Sclerosis Complex
Tuberous Sclerosis Complex Natural History Study: Renal Manifestations
Eighty percent of patients with tuberous sclerosis complex (TSC) have renal angiomyolipomata. These lesions grow and can lead to significant morbidity by hemorrhage or renal failure.
- Trial name
- NCT00598455
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Colorectal Neoplasms
Initiation of Colon Cancer Screening in Veterans or "Start Screening Now"
Initiation of colon cancer screening in veterans is a theory-based stepped intervention to increase first time colorectal cancer screening (CRCS) among male and female veterans age 50 and over.
- Trial name
- SSN (NCT01079533)
- Testing
- Stepped CRCS Interventions, Control
- Where
- United States
- Volunteers
- 1,892 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Smokers
D-Cycloserine Enhancement of Exposure-Based CBT for Smoking Cessation (DCSSmoking)
This study examines whether isolated doses of D-cycloserine enhance the efficacy of CBT for smoking cessation.
- Trial name
- NCT00827281
- Testing
- D-cycloserine
- Where
- United States
- Sponsor
- Boston University Charles River Campus
Vascular Disease, Endothelial Dysfunction
Effects of Almonds on Vascular Reactivity in Patients With Coronary Artery Disease
This is a study of the effects of 3 oz almonds added daily to a National Cholesterol Education Program Therapeutic Lifestyle Changes (TLC) diet in improving endothelial function in patients with Coronary Artery Disease.
- Conditions
- Vascular Disease, Endothelial Dysfunction, Heart Disease, Cardiovascular Diseases
- Trial name
- NCT00782015
- Testing
- Almonds
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Tufts University
Propionic Acidemia, Methylmalonic Acidemia
Long-term Outcome of N-Carbamylglutamate Treatment in Propionic Acidemia and Methylmalonic Acidemia
Background: Very few drugs exist that treat hyperammonemia, specifically PA and MMA. Diet restrictions and alternate pathway agents are the current primary treatments, but they frequently fail to prohibit brain damage.
- Trial name
- NCT01597440
- Testing
- N-carbamylglutamate, Standard of Care
- Where
- 7 sites in United States
- Volunteers
- 1 people
- Sponsor
- Mendel Tuchman
Coronary Artery Disease, Ischemic Heart Disease
Everolimus-eluting SYNERGY Stent Versus Biolimus-eluting Biomatrix NeoFlex Stent - SORT-OUT VIII
The purpose of this study is to perform a randomised comparison between the SYNERGY and the Biomatrix NeoFlex stents in treatment of unselected patients with ischemic heart disease.
- Trial name
- SORT-OUT VIII (NCT02093845)
- Testing
- Biomatrix NeoFlex coronary stent, SYNERGY stent
- Where
- 3 sites in Denmark
- Volunteers
- 2,800 people
- Sponsor
- Aarhus University Hospital Skejby
Medication Adherence
China Adherence Through Technology Study
The CATS project is designed to increase understanding of interventions that are feasible and effective in helping injection drug users (IDU) or other patients at high risk of poor medication adherence who are HIV-positive to…
- Trial name
- CATS (NCT01722552)
- Testing
- adherence feedback, standard of care
- Where
- 2 sites in United States, China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Boston University
Depression
Transcranial Magnetic Stimulation in Major Depression With EEG and Near Infrared Spectroscopy (NIRS) Monitoring
This a 12- week study (1-4 week screening, 6 weeks treatment, 2 weeks follow-up) outpatient open label clinical trial. Twenty-five subjects diagnosed with depression with a Montgomery Asberg Depression Rating Scale (MADRAS) score…
- Trial name
- NCT01192685
- Testing
- Transcranial Magnetic Stimulation (TMS), near infrared spectroscopy (NIRS)
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Boston University
Cardiovascular Disease, Periodontal Disease
Impact of Gum Infection on Heart Disease
The purpose of this study is to determine the effect of gum infection on parameters of cardio-vascular disease.
- Trial name
- NCT00093236
- Testing
- Early Periodontal Treatment, Usual Dental Hygiene
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Boston University
Cocaine Dependence, Depression
Efficacy of Mirtazapine in Depressed Cocaine Dependent Subjects
This research study is being done to look at the safety of the medication Mirtazapine (Remeron) in people who have cocaine dependence and depression. Hypotheses I.
- Trial name
- NCT00322309
- Testing
- Mirtazapine
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Boston University
HIV
Linkage and Retention: A Randomized Trial to Optimize HIV/TB Care in South Africa
The purpose of this study is to test the effects of a health system navigator intervention on rates of linkage to human immunodeficiency virus (HIV) and tuberculosis (TB) care among newly diagnosed HIV-infected outpatients in…
- Trial name
- Sizanani (NCT01188941)
- Testing
- Health System Navigator
- Where
- 4 sites in South Africa
- Volunteers
- 1,899 people
- Sponsor
- Massachusetts General Hospital
Breast Cancer
Healthy Families to Change Obesity in Public Housing Residents
This is a cluster randomized study of an environmental level intervention to improve nutrition and physical activity, among public housing residents. Followup was one year post baseline
- Trial name
- NCT03111680
- Testing
- environmental intervention
- Where
- United States
- Volunteers
- 211 people, healthy volunteers welcome
- Sponsor
- University of Washington
Claustrophobia, Complication of Diagnostic Procedure
Reduction of Claustrophobia and Patient Motion After Training of MRI Personnel in Comfort TalkTM
Annually, an estimated 700,000 patients do not complete their scheduled MRI scans because of claustrophobia or inability to hold still.
- Trial name
- NCT01563198
- Testing
- Comfort Talk®
- Where
- 4 sites in United States
- Volunteers
- 97,712 people
- Sponsor
- Hypnalgesics, LLC
Pancreatic Solid Lesions, Pancreatic Mass
Comparison of Two Needle Aspiration Techniques for Endoscopic Ultrasound-guided Fine Needle Aspiration (EUS-FNA) in Solid Pancreatic Lesions
The aim of this study is to compare Endoscopic Ultrasound and Fine Needle Aspirate with a standard 22-gauge needle using either "standard-suction" or "capillary suction" methods for solid pancreatic lesions.
- Trial name
- NCT01936467
- Testing
- Standard technique EUS-FNA, Capillary suction technique for EUS FNA
- Where
- 2 sites in United States
- Volunteers
- 121 people
- Sponsor
- Johns Hopkins University
Pancreatic Neoplasm
EUS-FNA of Solid Pancreatic Mass: Comparison Between Negative Pressure and Slow-pull Technique
50 patients with pancreatic mass will undergo endoscopic ultrasound-guided fine needle aspiration using two techniques: negative pressure and slow-pull. Cytological results will be compared.
- Trial name
- EUS-FNA (NCT03111368)
- Testing
- Endoscopic ultrasound-guided fine needle aspiration
- Where
- Brazil
- Volunteers
- 1 people
- Sponsor
- University of Sao Paulo General Hospital
Insulin Resistance, Cardiovascular Disease
Processing Responses of Grains (PRO-Grains) Study
The primary objective of this pilot study will be to examine the effects of consuming whole grains, differing in the degree of processing, on insulin sensitivity and other cardiometabolic risk factors.
- Conditions
- Insulin Resistance, Cardiovascular Disease, Diabetes
- Trial name
- NCT02186353
- Testing
- Partial feeding study
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Abortion; Induced
Same-day Long-acting Reversible Contraception for Medication Abortion
Contraception after abortion is an important public health issue, as women who have an abortion are at high risk for additional unintended pregnancy.
- Trial name
- SaLMA (NCT01356927)
- Testing
- DMPA, Etonogestrel implant
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Boston University
Vitamin D Deficiency
The Effect Of Vitamin D On Measures Of Bone Health And Gene Expression
Vitamin D deficiency is now recognized as one of the most common vitamin deficiencies in adults in the United States. Vitamin D deficiency has been connected to many chronic health diseases.
- Trial name
- NCT01696409
- Testing
- 400 IU vitamin D3, 2000 IU vitamin D3
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Boston University
Aphasia
Intensive Interdisciplinary Treatment Program for Individuals With Stroke-Induced Aphasia
An intensive, interdisciplinary treatment program was administered during the summer as part of regular clinic services in the Aphasia Resource Center (ARC) at Sargent College.
- Trial name
- NCT03096015
- Testing
- Intensive Comprehensive Aphasia Program
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Vitamin D Deficiency
Availability of Vitamin D in Orange Juice
The purpose of this study was to determine whether vitamin D2 and vitamin D3 in orange juice are effective at raising vitamin D levels in the blood and if vitamin D2 and vitamin D3 in orange juice raised blood levels of 25(OH)D…
- Trial name
- NCT01778114
- Testing
- Vitamin D2 in orange juice, Vitamin D3 in orange juice, Vitamin D2
- Where
- United States
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Boston University
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