Clinical trials: sponsored by Shirley Ryan AbilityLab
Opioid Use, Opioid Dependence
Project 1 Aim 2, Adaptations of the Brain in Chronic Pain With Opioid Exposure
This study is designed to track brain functional changes in individuals with i) chronic back pain + opioid use (CBP+O) and individuals with ii) chronic back pain + opioid misuse disorder (CBP+mOUD) following a brief drug delay…
- Conditions
- Opioid Use, Opioid Dependence, Opioid-use Disorder, Narcotic Use
- Trial name
- NCT05463367
- Testing
- Carbidopa-Levodopa 25 Mg-100 Mg Oral Tablet, Naproxen 500 Mg, Opioids
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Northwestern University
Stroke, Cerebral Vascular Accident (CVA)/Stroke
Error-enhanced Learning & Recovery in 2 & 3 Dimensions
This study is being done to see how errors lead to improvement. Specifically, we are evaluating the errors stroke participants make during an upper extremity exercise program when reaching for a target using their affected arm.
- Trial name
- NCT05180786
- Testing
- Error Fields, No Error Fields
- Where
- 3 sites in United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Stroke, Stroke, Acute
Looking Glass: Bimanual Balanced Reaching With Visual Biofeedback
The goal of this research study is to increase understanding of error augmentation by applying it to visual feedback during motion tracking with a Leap Motion device - a recently developed optical hand tracking tool - and the…
- Conditions
- Stroke, Stroke, Acute, Healthy
- Trial name
- NCT03300141
- Testing
- Veridical Visual Feedback, Augmented Visual Feedback, Healthy Comparative Reaching Task
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Spinal Cord Injuries
Enhanced Medical Rehabilitation for Spinal Cord Injury
Background: Patient engagement is a cornerstone of patient-centered care. Studies show that an increased level of patient engagement in medical rehabilitation is associated with greater functional recovery.
- Trial name
- EMRSCI (NCT03952416)
- Testing
- Enhanced Medical Rehabilitation (EMR)
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Shirley Ryan AbilityLab
Stroke, Spasticity, Muscle
Robotic Interventions for Spasticity Treatment
The researchers have developed games controlled by electromyographic (EMG) and inertial measurement unit (IMU) activity recorded by a sensor.
- Trial name
- NCT05006248
- Testing
- Conventional robotic continuous passive movement training, Visual Feedback, Haptic and Visual Feedback
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Multiple Sclerosis, Multiple Sclerosis, Secondary Progressive
Development of Camera Based Gait Quality Measure for Persons With Multiple Sclerosis
The purpose of this study is to develop a measurement of walking quality, called Gait Deviation Index (GDI) for people with Multiple Sclerosis (MS).
- Conditions
- Multiple Sclerosis, Multiple Sclerosis, Secondary Progressive, Multiple Sclerosis Relapse, Multiple Sclerosis, Relapsing-Remitting
- Trial name
- MS-GDI (NCT06516458)
- Testing
- Camera Based Kinematic Analysis
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Shirley Ryan AbilityLab
Acquired Brain Injury
Rewards Sensitivity After Brain Injury
A study measuring rewards sensitivity in individuals with acquired brain injury at an acute rehabilitation level.
- Trial name
- NCT06510023
- Testing
- Type of reward presented
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Amputation, Amputation, Traumatic
Understanding How Powered Componentry Impacts K2-Level Transfemoral Amputee Gait
The goal of this study is to understand how providing power at the knee or ankle individually, or providing power at both the knee and ankle, impacts ambulation for K2 level transfemoral amputees.
- Conditions
- Amputation, Amputation, Traumatic, Amputation of Knee, Amputation; Traumatic, Limb
- Trial name
- NCT06433648
- Testing
- Ottobock CLeg4 + Ottobock foot, SRALAB Hybrid Knee + Polycentric Ankle, SRALAB Hybrid Knee + Passive Ankle
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Shirley Ryan AbilityLab
Amputation
Intuitive Control of a Hybrid Prosthetic Leg During Ambulation
The objective of this research is to determine the clinical benefits of an innovative and lightweight powered leg controlled using our intent recognition framework in laboratory and community environments.
- Trial name
- NCT04038151
- Testing
- Hybrid Leg, Prescribed Passive Prosthesis
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Shirley Ryan AbilityLab
Chronic Back Pain, Opioid Use
Adaptations of the Brain in Chronic Pain With Opioid Exposure I
This study investigates brain reorganization and behavioral responses in chronic pain with opioid exposure in Chronic Back Pain (CBP).
- Trial name
- NCT05203770
- Where
- 2 sites in United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Stroke
Comparison of Two High-intensity Gait Training Interventions on Contraversive Pushing Behaviors in Individuals Poststroke
The purpose of this study is to investigate the effect of two high-intensity gait training interventions on contraversive pushing behaviors in individuals poststroke in the acute inpatient rehabilitation setting.
- Trial name
- NCT04550039
- Testing
- Body-weight-supported treadmill, Ekso Bionics EksoNR exoskeleton
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Shirley Ryan AbilityLab
Stroke, Acute, Gait Disorders, Neurologic
The Effect of Powered-Knee Exoskeleton Assist on Stair Climbing in Acute CVA
Hypothesis/Specific Aims: The purpose of this research study is to determine if using an exoskeleton during stair climbing training will result in an improved ability to walk and climb stairs in individuals affected by recent…
- Trial name
- NCT03264235
- Testing
- Keeogo, Traditional Stair Training
- Where
- 2 sites in United States
- Volunteers
- 15 people
- Sponsor
- Shirley Ryan AbilityLab
Breast Cancer Treatment, Cognitive Deficits
Treating Verbal Memory Deficits Following Chemotherapy for Breast Cancer
The primary purpose of this study is to test the effects of a targeted, computerized cognitive training program on verbal memory in older women who have undergone chemotherapy treatment for early-stage breast cancer.
- Trial name
- NCT03017560
- Testing
- Computerized cognitive treatment
- Volunteers
- 45 people
- Sponsor
- Northwestern University
Spinal Cord Injuries
Measuring the Neurological Benefits of Intermittent Hypoxia Therapy With MRI
This study uses Magnetic Resonance Imaging to image the brain and spinal cord before and after an Intermittent Hypoxia intervention.
- Trial name
- NCT05183113
- Testing
- Acute Intermittent Hypoxia
- Where
- United States
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Acute Spinal Cord Injury, Spinal Cord Injuries
Spasticity and Functional Recovery After SCI
Spasticity is one of the most common symptoms manifested in humans with spinal cord injury (SCI). However, the neural mechanisms underlying the development of spasticity over time after an acute SCI are not yet understood.
- Trial name
- NCT06030531
- Testing
- Measures of spasticity, connectivity and analysis of single nucleotide polymorphisms and biomarkers of inflammation, Analysis of biomarkers
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Stroke
Safety and Usability of the Honda Walking Assist Device (HWA) in the Home Environment
The purpose of this study is to verify the safety and validate the usability of the Honda Walk Assist (HWA) device in the home setting versus an exercise program without the device in a gym setting for individuals diagnosed with…
- Trial name
- NCT04380363
- Testing
- Honda Walk Assist (HWA) device, SRALab fitness center membership
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Shirley Ryan AbilityLab
Stroke
Safety and Feasibility of eGlove
The purpose of this study is to measure how cortical signals improve in stroke participants after passive hand stretching therapy from a robotic glove.
- Trial name
- NCT05345301
- Testing
- Event related desynchronization measurement
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Shirley Ryan AbilityLab
Amyotrophic Lateral Sclerosis, Stroke
Telehealth Implementation of Brain-Computer Interface
Determine if Telehealth intervention can allow/empower a caregiver (who is untrained) to effectively implement and utilize a Brain-Computer Interface for communication with a participant who is "Locked in" following progression…
- Trial name
- NCT05951556
- Testing
- Use of BCI
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Shirley Ryan AbilityLab
Phantom Limb Pain
Phantom Motor Execution Via MPR, VR/AR, and SG, as a Treatment of PLP
This international, multi-center, double-blind, randomized, controlled clinical trial aims to evaluate the efficacy of Phantom Motor Execution (PME) and Phantom Motor Imagery (PMI) as treatments of Phantom Limb Pain (PLP).
- Trial name
- NCT03112928
- Testing
- Phantom Motor Execution, Phantom Motor Imagery
- Where
- 9 sites in United States, Canada and 5 more
- Volunteers
- 77 people
- Sponsor
- Integrum
Age-associated Memory Impairment
TMS for Investigating Memory Facilitation
The aim of this study is to investigate the effects of Transcranial Magnetic Stimulation (TMS) following a Paired Associative Stimulation (PAS) protocol on the memorization capacity of elderly individuals.
- Trial name
- NCT05462782
- Testing
- Transcranial Magnetic Stimulation (TMS) Cone Coil
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab