Clinical trials: sponsored by Unity Health Toronto
Acute Respiratory Distress Syndrome (ARDS)
RecruitmEnt Assessed by eleCtRical Impedance Tomography
The RECRUIT study is a multinational, multicenter physiological observational study conducted by the PLUG working group. It is a single-day study (1.5-2 hours) associated with specific lung (de)recruitment maneuvers to verify the…
- Trial name
- RECRUIT (NCT04460859)
- Testing
- Specific lung recruitment maneuvers
- Where
- 4 sites in Brazil, Canada and 2 more
- Volunteers
- 171 people
- Sponsor
- Unity Health Toronto
Acute Hypoxemic Respiratory Failure
Pressure Muscle Index and Threshold of Over-assistance During Pressure Support Ventilation
Pressure support ventilation (PSV) is used to assist the breathing of the intubated patient with some pressure from the ventilator.
- Trial name
- PUMA (NCT06494085)
- Testing
- Measuring Respiratory Mechanics, Randomized Pressure Support
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- Unity Health Toronto
Exacerbation Copd, Acute Respiratory Distress
High Flow Nasal Cannula Versus Non-Invasive Ventilation in Exacerbations of Chronic Obstructive Pulmonary Disease
Chronic obstructive lung disease is a disabling disease that affects people usually after several years of smoke tobacco exposure and affects millions of patients worldwide.
- Conditions
- Exacerbation Copd, Acute Respiratory Distress, Acute Hypercapnic Respiratory Failure
- Trial name
- HiFOLD (NCT03033251)
- Testing
- Non Invasive Ventilation, High Flow Oxygen Cannula 50, High Flow Oxygen Cannula 30
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Unity Health Toronto
COVID-19
Canadian Adaptive Platform Trial of Treatments for COVID-19 in Community Settings
CanTreatCOVID is an open-label, individually randomized, multi-centre, national trial. CanTreatCOVID aims to establish an adaptive platform trial aimed at evaluating the clinical- and cost-effectiveness, practical challenges, and…
- Trial name
- CanTreatCOVID (NCT05614349)
- Testing
- Paxlovid, Antioxidant
- Where
- 6 sites in Canada
- Volunteers
- 797 people
- Sponsor
- Unity Health Toronto
Breastmilk Collection, Childhood Obesity
Breastmilk Composition and Microbial Profile in the Growth and Development of Healthy Term-born Infants
An increasing number of children are developing non-communicable diseases that carry immediate and long-term significant societal and economic impacts.
- Conditions
- Breastmilk Collection, Childhood Obesity, Childhood Asthma, Allergy
- Trial name
- NCT06970535
- Where
- 2 sites in Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
HIV Testing, HIV Infections
OraQuick® HIV Self-Test Study in Canada
Oral fluid based HIV Self-testing (HIVST) provides another innovative and simple option to increase opportunities for HIV testing.
- Trial name
- OQHIVST (NCT05020353)
- Testing
- OraQuick® HIV Self-Test
- Where
- 7 sites in Canada
- Volunteers
- 951 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Interphalangeal Joint Injury
Management of Proximal Interphalangeal (PIP) Joint Injuries
This project seeks to compare the treatment efficacy of two different approaches to treating interphalangeal joint (PIP) joint injuries.
- Trial name
- NCT06951607
- Testing
- Coban wrap, Neoprene sleeve
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Unity Health Toronto
Treatment-resistant Depression, Major Depressive Disorder
Physical Activity Program for TRD
This is a pilot study examining the delivery of a remotely delivered, one-on-one, individualized physical activity (PA) program in adult participants with treatment-resistant depression (TRD).
- Trial name
- NCT06404320
- Testing
- PA program - MoveU.HappyU
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Unity Health Toronto
Stress, Trauma
STEP: Building Trauma Resilience Among Nurses and Personal Support Workers During and Beyond COVID-19
The COVID-19 pandemic has amplified the need for skills training and mental health support for healthcare workers who are exposed to the numerous stressors and potential trauma of a high-risk environment.
- Conditions
- Stress, Trauma, Mental Health Issue, Healthcare Workers
- Trial name
- NCT04682561
- Testing
- Supportive Trauma Exposure Preparation Program
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Major Depressive Disorder
Temporal Interference and Depression
Major Depressive Disorder (MDD) has a high prevalence, is the leading cause of disability, and currently available interventions are associated with side effects and high treatment resistance.
- Trial name
- TI (NCT05295888)
- Testing
- Temporal Interference stimulation
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Unity Health Toronto
Diabetes Mellitus
The REmission of Diabetes Using a PlAnt-based Weight Loss InteRvention (REPAIR) Trial
The goal of this clinical trial is to learn if a plant-based intensive lifestyle intervention can achieve remission of diabetes.
- Trial name
- REPAIR (NCT06906172)
- Testing
- Plant-based intensive lifestyle intervention, Standard of Care
- Where
- Canada
- Volunteers
- 160 people
- Sponsor
- University of Toronto
Hereditary Hemorrhagic Telangiectasia, Epistaxis Nosebleed
Tacrolimus Trial for Hereditary Hemorrhagic Telangiectasia (HHT)
This study will investigate the effectiveness of oral low-dose tacrolimus for the treatment of recurrent nasal hemorrhage in HHT subjects.
- Trial name
- NCT04646356
- Testing
- Tacrolimus capsule (low-dose)
- Where
- Canada
- Volunteers
- 10 people
- Sponsor
- Unity Health Toronto
Hereditary Hemorrhagic Telangiectasia (HHT)
Doxycycline for Hereditary Hemorrhagic Telangiectasia
This study will investigate the effectiveness of oral doxycycline for the treatment of recurrent nasal hemorrhage in Hereditary Hemorrhagic Telangiectasia (HHT) subjects.
- Trial name
- HHT (NCT03397004)
- Testing
- Doxycycline Hyclate
- Where
- Canada
- Volunteers
- 13 people
- Sponsor
- Unity Health Toronto
Chronic Neuropathic Pain, Pain Management
Psilocybin for Enhanced Analgesia in Chronic nEuropathic PAIN
This is a feasibility study to examine the use of use of Psilocybin (magic mushrooms) to alleviate pain in chronic neuropathic pain. While theoretical mechanisms demonstrate promise, there is no clinical evidence.
- Trial name
- PEACE-PAIN (NCT06731335)
- Testing
- Psilocybin
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- Unity Health Toronto
Autism Spectrum Disorder
Exploring the Efficacy and Usability of the My Autism Passport (MAP).
To address developmental service navigation by families of children with autism spectrum disorder (ASD) an innovative paper-based tracking tool called the Pediatric Developmental Passport (Passport) was created by Dr.
- Trial name
- NCT04259671
- Testing
- My Autism Passport (MAP) Application
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- Unity Health Toronto
Cancer, Older Adults
Comprehensive Health Assessment for My Plan: Initial Implementation Study (CHAMP Implementation Study)
The current standard preoperative assessment does not consider the needs of older adults undergoing non-oncological surgery. To enhance the treatment decision-making and planning for older adult surgical patients, the British…
- Trial name
- NCT06464471
- Testing
- Self-reported online geriatric assessment (CHAMP)
- Where
- Canada
- Volunteers
- 210 people
- Sponsor
- University of Toronto
Point-of-Care Testing, HIV
Ayaangwaamiziwin Initiative: Carefulness and Preparedness
The goal of this clinical trial is to implement a test, treat, and connect intervention approach using HIV and syphilis rapid point-of-care (POC) testing in 3 Canadian Prairie provinces (Alberta, Manitoba, and Saskatchewan)…
- Conditions
- Point-of-Care Testing, HIV, Syphilis
- Trial name
- AI (NCT06893159)
- Testing
- INSTI HIV-1/2 Antibody Test, INSTI Multiplex HIV-1/2 Syphilis Antibody Test, Multiplo Complete Syphilis (TP/nTP) Antibody Test
- Where
- 8 sites in Canada
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Retinal Detachment Rhegmatogenous, Proliferative Vitreoretinopathy
Intravitreal Topotecan for Prevention or Treatment of Proliferative Vitreoretinopathy in Retinal Detachment
Intravitreal topotecan exhibits strong anti-inflammatory, anti-proliferative, and anti-fibrotic properties, making it a promising option for preventing and treating proliferative vitreoretinopathy in rhegmatogenous retinal…
- Trial name
- TOPO-PT (NCT06818721)
- Testing
- Intravitreal topotecan, Retinal detachment surgery
- Where
- 2 sites in Canada
- Volunteers
- 394 people
- Sponsor
- Unity Health Toronto
Major Depressive Disorder, Cognitive Dysfunction
Musical Attention Control and Executive Function Training for Adults With MDD
The investigators have developed music-based cognitive training sessions derived from Neurologic Music Therapy (NMT) techniques.
- Conditions
- Major Depressive Disorder, Cognitive Dysfunction, Suicide
- Trial name
- NCT05694156
- Testing
- Music-based cognitive training
- Where
- Canada
- Volunteers
- 18 people
- Sponsor
- Unity Health Toronto
Acute Kidney Injury
Promoting Kidney Recovery After Acute Kidney Injury Receiving Dialysis
The overall goal of this study is to evaluate the feasibility of conducting a randomized controlled trial comparing a standardized dialysis strategy versus usual care (dialysis prescription ordered by each patient's primary…
- Trial name
- Recover-AKI (NCT04948476)
- Testing
- Standardized Dialysis and Structured Discontinuation (S2D2), Usual Care
- Where
- Canada
- Volunteers
- 110 people
- Sponsor
- Samuel Silver