Clinical trials: sponsored by Georgetown University
Persistent Atrial Fibrillation
Left Atrial Posterior Wall and PV Isolation Using Cryoballoon for Treatment of Persistent AF
The purpose of this study it to learn whether pulmonary vein isolation (PVI) along with isolation of the posterior left atrial wall (PWI) in the region of the pulmonary venous component will reduce the likelihood of atrial…
- Trial name
- PIVoTAL-IDE (NCT04505163)
- Testing
- Standard Cryoballoon Pulmonary Vein Isolation (PVI), Cryoballoon PVI + Posterior Wall Isolation
- Where
- 11 sites in United States
- Volunteers
- 153 people
- Sponsor
- Dignity Health Medical Foundation
Gulf War Veterans' Illness
CAM in Veterans With Gulf War Illnesses
The purpose of this study is to explore the effectiveness Gulf War Health Education (GWHE) and iRest Yoga Nidra (mindfulness meditation)/auricular (ear) acupuncture for Veterans with Gulf War Veterans' Illnesses (GWVI).
- Trial name
- GW-CAM (NCT02180243)
- Testing
- Mindfulness meditation/Acupuncture, Gulf War Health Education
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- VA Office of Research and Development
Breast Cancer, Metastatic Breast Cancer
Oral SM-88 in Patients With Metastatic HR+/HER2- Breast Cancer
This is a phase II single arm, open-label study of SM-88 used with methoxsalen, phenytoin, and sirolimus (MPS) in metastatic HR+/HER2- breast cancer.
- Conditions
- Breast Cancer, Metastatic Breast Cancer, Hormone Receptor Positive Breast Carcinoma
- Trial name
- OASIS (NCT04720664)
- Testing
- SM-88
- Where
- 5 sites in United States
- Volunteers
- 11 people
- Sponsor
- Georgetown University
Post-Traumatic Stress Disorder
Implementation of an Evidence Based Post-Traumatic Stress Disorder (PTSD) Treatment in Public Sector Settings
Researchers hope to learn whether a flexibly applied cognitive behavioral treatment for Post-Traumatic Stress Disorder (PTSD) is more effective than the psychotherapy usually provided in the clinic (called Treatment as Usual or…
- Trial name
- NCT01488539
- Testing
- STAIR/NT treatment, Treatment as Usual (TAU)
- Where
- 5 sites in United States
- Volunteers
- 210 people
- Sponsor
- Palo Alto Veterans Institute for Research
Multi-morbidity, Non-communicable Diseases
Estonia's Enhanced Care Management Impact Evaluation
Estonia's aging population faces an increasing burden of non-communicable diseases (NCDs) and a growing population suffers with multiple chronic conditions.
- Trial name
- ECM (NCT05829642)
- Testing
- Enhanced Care Management
- Where
- Estonia
- Volunteers
- 2,389 people
- Sponsor
- Harvard School of Public Health (HSPH)
Coronavirus Infection
Study of the Treatment and Outcomes in Critically Ill Patients With COVID-19
Multicenter observational/registry study of the clinical features and outcomes of critically ill patients with COVID-19.
- Trial name
- STOP-COVID (NCT04343898)
- Testing
- No intervention
- Where
- United States
- Volunteers
- 5,154 people
- Sponsor
- Brigham and Women's Hospital
Exercise, Health Behavior
Physical Activity Smartphone App for African American Men (FitBros) Phase I
Low physical activity levels contribute to African American men experiencing health disparities across a number of chronic diseases.
- Conditions
- Exercise, Health Behavior, Technology
- Trial name
- FitBros (NCT05509712)
- Testing
- Focus Groups to Refine MobileMen App Content, Beta testing of MobileMen App Prototype
- Where
- 3 sites in United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Klein Buendel, Inc.
Posttraumatic Stress Disorder
Suvorexant and Sleep's Benefits to Therapeutic Exposure for Posttraumatic Stress Disorder
The purpose of this study is to examine effects of blocking the orexin system with suvorexant after exposure-based intervention for posttraumatic stress disorder (PTSD) on sleep, PTSD symptoms, and intersession habituation.
- Trial name
- NCT02849548
- Testing
- suvorexant
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Howard University
Obesity
Weight Management Counseling in Medical Schools
Eight U.S. medical schools will be participating in the study: Weight Management Counseling in Medical Schools, also known as MSWEIGHT.
- Trial name
- MSWEIGHT (NCT02725905)
- Testing
- Multi-Modal Education (MME), Traditional Education (TE)
- Where
- 8 sites in United States
- Volunteers
- 3,199 people
- Sponsor
- University of Massachusetts, Worcester
Prematurity, Premature Birth
Vibroacoustic Study of Lung Development in Newborn Infants
Investigators hypothesize that premature newborns with poor cardiopulmonary performance have higher morbidities and poorer physical and cognitive developmental outcomes.
- Conditions
- Prematurity, Premature Birth, Premature Lungs, Prematurity; Extreme
- Trial name
- NCT05827250
- Testing
- imPulse Tor
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Level 42 AI, Inc.
Population at Risk
Educating QUitline Callers About Lung Cancer Screening
The specific aims are: 1. To evaluate the potential barriers of providing educational lung screening interventions to quitline users, the investigators will seek input from 10-20 stakeholders on the newly adapted print version of…
- Trial name
- EQUAL (NCT05046951)
- Testing
- Should I Screen website, Should I Screen print booklet
- Where
- United States
- Volunteers
- 298 people
- Sponsor
- Georgetown University
Prostate Cancer
Metabolomic Study for Localized Prostate Cancer
Prostate cancer is a common disease in men treated using surgery, radiation therapy and/or hormonal therapy. Clinical prognosis relates to stage and grade of disease.
- Trial name
- NCT01968538
- Testing
- Radiation Therapy
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Prostate Cancer, Localized Malignant Neoplasm
Quality of Life in Patients With Clinically Localized Prostate Cancer Treated With Radiosurgery
Quality of life data following SBRT for prostate cancer has been obtained in only a small numbers of patients. A prospective study using validated quality of life questionnaires is needed to determine outcomes after treatment…
- Trial name
- PR-PROS (NCT01766492)
- Testing
- Stereotactic Body Radiation Therapy (SBRT)
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Georgetown University
Prostate Cancer
Phase II Study to Evaluate Conventional Radiation Therapy Followed by Radiosurgical Boost in Clinically Localized Prostate Cancer
This phase II study designed to prospectively evaluate the efficacy and morbidity of IMRT with CyberKnife radiosurgical boosts for clinically localized prostate cancer.
- Trial name
- NCT01618851
- Testing
- Radiotherapy with IMRT and CyberKnife Boost
- Volunteers
- 70 people
- Sponsor
- Georgetown University
Antibiotic-associated Diarrhea
Mechanisms of Preventing Antibiotic-Associated Diarrhea and the Role for Probiotics
The focus of the study is to better understand the mechanisms causing antibiotic-associated diarrhea (AAD) and how probiotics may prevent some of the iatrogenic effects of antibiotic medications.
- Trial name
- YOBIOTIC (NCT03755765)
- Testing
- Amoxicillin-Clavulanate 875 Mg-125 Mg Oral Tablet, BB-12, Control
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Thymoma, Advanced Thymic Epithelial Tumor
Selinexor in Patients With Advanced Thymic Epithelial Tumor Progressing After Primary Chemotherapy
The purpose of this study is to evaluate the safety, tolerability and effectiveness of selinexor in patients with advanced thymic epithelial tumor progressing after primary chemotherapy.
- Trial name
- SELECT (NCT03193437)
- Testing
- Open Label Selinexor
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Georgetown University
Hookah Tobacco Smoking
Optimizing Hookah Tobacco Public Education Messages to Reduce Young Adult Use
This is a 2-arm randomized controlled trial to test the effects of hookah tobacco public education messages among young adults who are susceptible non-users of hookah tobacco and those who are current hookah tobacco users.
- Trial name
- NCT04252014
- Testing
- Hookah tobacco messages
- Where
- United States
- Volunteers
- 830 people
- Sponsor
- Georgetown University
Non-Small Cell Lung Cancer
Trial of Brigatinib After Treatment With Next-Generation ALK Inhibitors
The purpose of this study is to evaluate the safety and effectiveness of this investigational drug, brigatinib (AP261136) in patients with advanced non-small cell lung cancer Non-small cell lung cancer (NSCLC) who have had…
- Trial name
- NCT02706626
- Testing
- brigatinib
- Where
- 4 sites in United States
- Volunteers
- 32 people
- Sponsor
- Criterium, Inc.
Gender Relations, Reproductive Health
Global Early Adolescent Study - Kinshasa
The Global Early Adolescent Study (GEAS) is the first international study exploring how gender norms evolve over time and inform a spectrum of adolescent health outcomes, including sexual and mental health, through the adolescent…
- Trial name
- GEAS_KI (NCT03610568)
- Testing
- Growing up GREAT! Intervention
- Where
- Democratic Republic of the Congo
- Volunteers
- 2,862 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Anxiety Disorders, Generalized Anxiety Disorder
Effect of Mindfulness Meditation on Physiological Response to Unpredictable Stimuli
This study will evaluate the effects of Mindfulness-Based Stress Reduction (MBSR) on physiological reactivity. This study will focus on individuals with anxiety who will participate in an 8-week MBSR class.
- Conditions
- Anxiety Disorders, Generalized Anxiety Disorder, Social Anxiety Disorder, Panic Disorder
- Trial name
- NCT03206437
- Testing
- Mindfulness-Based Stress Reduction, Waitlist
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Georgetown University