Clinical trials: sponsored by Unity Health Toronto
Chronic Kidney Diseases, COVID-19
COVID-19 Vaccine Boosters in Patients With CKD
This study is a 12-month, four-arm parallel-group randomized control trial of Pfizer-BioNTech versus MODERNA COVID-19 (Corona Virus disease 2019)vaccine boosters in chronic kidney disease and dialysis patients with poor humoral…
- Trial name
- BOOST KIDNEY (NCT05022329)
- Testing
- Pfizer-BioNTech COVID-19 Vaccine, MODERNA SARS-CoV-2 Vaccine
- Where
- 3 sites in Canada
- Volunteers
- 273 people
- Sponsor
- Sunnybrook Health Sciences Centre
Proliferative Vitreoretinopathy in Rhegmatogenous Retinal Detachment
Intravitreal Topotecan in the Repair of Rhegmatogenous Retinal Detachment with Proliferative Vitreoretinopathy
Intravitreal topotecan has anti-inflammatory, anti-proliferative and anti-fibrotic activity that we hypothesize may exhibit high efficacy for the treatment of proliferative vitreoretinopathy (PVR) in patients with rhegmatogenous…
- Trial name
- TOPO-RD (NCT05523869)
- Testing
- Intravitreal topotecan, Pars plana vitrectomy with or without scleral buckle
- Where
- 2 sites in Canada
- Volunteers
- 50 people
- Sponsor
- Unity Health Toronto
Anemia, Iron Deficiency Anemia
Daily vs. Every Other Day Oral Iron Supplementation in Patients With Absolute Iron Deficiency Anemia
Iron deficiency anemia is a global health problem and the most common cause of anemia worldwide. Patients with iron deficiency (ID) and IDA can present with a multitude of symptoms including fatigue, restless legs syndrome and…
- Trial name
- DEODO (NCT03725384)
- Testing
- Ferrous Sulfate 300Mg Tablet, Vitamin C 500Mg tablet
- Where
- 2 sites in Canada
- Volunteers
- 51 people
- Sponsor
- Sunnybrook Health Sciences Centre
Primary Care
Screening for Poverty and Related Social Determinants to Improve Knowledge of and Links to Resources (SPARK) Pilot Study
Research question and objectives This pilot study will help us answer the following research question: Is it feasible to conduct a large cluster randomized controlled trial (RCT) of an intervention that consists of routine…
- Trial name
- SPARK Pilot (NCT04211025)
- Testing
- Modest, Intensive
- Where
- 6 sites in Canada
- Volunteers
- 75 people
- Sponsor
- Unity Health Toronto
COVID-19
Coagulopathy of COVID-19: A Pragmatic Randomized Controlled Trial of Therapeutic Anticoagulation Versus Standard Care
Coagulopathy of COVID-19 afflicts approximately 20% of patients with severe COVID-19 and is associated with need for critical care and death.
- Trial name
- NCT04362085
- Testing
- Therapeutic Anticoagulation
- Where
- Canada
- Volunteers
- 465 people
- Sponsor
- Unity Health Toronto
SARS CoV-2 Post-Acute Sequelae
Antiviral Strategies in the Prevention of Long-term Cardiovascular Outcomes Following COVID-19: The paxloviD/Remdesivir Effectiveness For the prEvention of loNg coviD Clinical Trial
The DEFEND trial will be the world's first clinical trial to study the effectiveness of Paxlovid or Veklury in the prevention of cardiovascular post-acute sequelae of SARS-CoV-2 among hospitalized adults.
- Trial name
- DEFEND (NCT06792214)
- Testing
- Nirmatrelvir/ritonavir, Remdesivir
- Where
- 4 sites in Canada
- Volunteers
- 118 people
- Sponsor
- Mount Sinai Hospital, Canada
Homeless Persons
Effect of a Rent Subsidy and Mentoring on Youth Transitioning Out of Homelessness
Compared to the vast amount of literature about the risk factors associated with young people entering and becoming entrenched in homelessness, much less is known about how to facilitate and sustain transitions off the streets.
- Trial name
- NCT03779204
- Testing
- Mentorship, Rent Subsidies
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Mental Health Wellness, Emotional Problem
Behaviours and Emotions in Preschoolers
In this TARGet Kids! Study, we want to find out whether a short questionnaire can be used to help find out about mental health problems in preschool age children.
- Conditions
- Mental Health Wellness, Emotional Problem, Behavioural Problem, Post Partum Depression
- Trial name
- BeEPS (NCT03856931)
- Where
- Canada
- Volunteers
- 183 people, healthy volunteers welcome
- Sponsor
- TARGetKids!
Housing
Housing Conditions: Evaluation, Advocacy and Research in Toronto Community Housing
This project will examine whether a health promotion campaign using community organizing and joint advocacy by a coalition of tenants, health providers, social service agencies and advocates can lead to improvements in building…
- Trial name
- HEARTH (NCT04131101)
- Testing
- Community Organizing
- Where
- Canada
- Volunteers
- 53 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Quality of Health Care, HIV/AIDS
Using Electronic Medical Record Data to Improve HIV Primary Care
This cluster randomized control trial examines whether an audit and feedback study improves care of patients living with HIV/AIDS in a family health team setting.
- Conditions
- Quality of Health Care, HIV/AIDS, Electronic Health Records
- Trial name
- NCT04107233
- Testing
- Audit and Feedback
- Where
- Canada
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Major Depressive Disorder, Treatment Resistant Depression
The Impact of Working Memory and Reward Markers on DLPFC Activity in Treatment-resistant Depression
Major Depressive Disorder (MDD) is a very common illness that is usually treated with antidepressant medication. Depression can be caused by many things such as childhood experiences, genetics, and changes in the way the body and…
- Trial name
- NCT06163625
- Testing
- Repetitive Transcranial Magnetic Stimulation, Research Interview, Questionnaires, Brain Scan
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Coronavirus, COVID-19
TARGet Kids! COVID-19 Study of Children and Families
The novel coronavirus (COVID-19) was declared a global pandemic in March 2020. Early research suggests that children are no more susceptible to COVID-19 infection than adults and that children with confirmed COVID-19 have…
- Conditions
- Coronavirus, COVID-19, Virus, Family and Household
- Trial name
- NCT04449978
- Where
- 2 sites in Canada
- Volunteers
- 1,145 people
- Sponsor
- The Hospital for Sick Children
Major Depressive Disorder (MDD), Major Depressive Episode
Digital Interventions for Adults with Treatment-Resistant Depression: a Pilot Study
The goal of this observational study is to learn about remote mental health monitoring technology for adults with treatment-resistant depression.
- Conditions
- Major Depressive Disorder (MDD), Major Depressive Episode, Treatment-Resistant Major Depressive Disorder
- Trial name
- NCT06732089
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- Unity Health Toronto
Respiratory Insufficiency, Diaphragm Injury
Feasibility of Reducing Respiratory Drive Using the Through-flow System
Mechanical ventilation can lead to diaphragm and lung injury. During mechanical ventilation, the diaphragm could be completely rested or it could be overworked, either of which may cause diaphragm injury.
- Conditions
- Respiratory Insufficiency, Diaphragm Injury, Lung Injury
- Trial name
- Throughflow (NCT05642832)
- Testing
- Throughflow titration phase
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- University Health Network, Toronto
Multiple Sclerosis
Implementation of Online Mindfulness-Based Stress Reduction Tailored for People with Multiple Sclerosis
This project aims to implement and investigate a mindfulness-based stress reduction (MBSR) in people with multiple sclerosis (PwMS).
- Trial name
- NCT06415552
- Testing
- Mindfulness-Based Stress Reduction
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Robert Simpson
Multiple Sclerosis, Self-Compassion
Self-compassion for People with Multiple Sclerosis: an Exploratory Feasibility Study
The goal of this clinical trial is to develop and investigate a compassion-based intervention (Mindful Self-Compassion course) in people with multiple sclerosis. The main objectives are: 1.
- Trial name
- NCT06337903
- Testing
- Self-compassion intervention (the Mindful Self-Compassion course)
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- Robert Simpson
Pre-Exposure Prophylaxis (PrEP), Counseling
Filling Gaps in the HIV Pre-exposure Prophylaxis Cascade Through Counseling
This study s objective is to test the acceptability and feasibility of a guide to facilitate counseling about HIV prevention, focusing on HIV pre-exposure prophylaxis (PrEP).
- Conditions
- Pre-Exposure Prophylaxis (PrEP), Counseling, Sexual and Gender Minorities
- Trial name
- NCT06710171
- Testing
- Counseling, List of resources
- Where
- Canada
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Disorder, Heart
Transfusion Requirements in Younger Patients Undergoing Cardiac Surgery
TRICS-IV is an international, multi-centre, open-label randomized controlled trial of two commonly used transfusion strategies in moderate to high risk patients who are 65 years of age or younger undergoing cardiac surgery on…
- Conditions
- Disorder, Heart, Postoperative, Cardiac Surgery
- Trial name
- TRICS-IV (NCT04754022)
- Testing
- Restrictive Transfusion Strategy, Liberal transfusion strategy
- Where
- 54 sites in United States, Australia and 14 more
- Volunteers
- 1,440 people
- Sponsor
- Unity Health Toronto
Colorectal Cancer, Cancer Screening
Social Media for Colorectal Cancer Screening
Using social media for health promotion is an innovative and emerging approach but remains relatively unexplored in cancer screening.
- Trial name
- NCT04296630
- Testing
- Social media message #1, Social media message #2, Social media message #3
- Where
- Canada
- Volunteers
- 56,000 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Acute Kidney Injury
Standard vs. Accelerated Initiation of RRT in Acute Kidney Injury (STARRT-AKI: Principal Trial)
The objectives of this trial are to determine whether, in critically ill patients with severe acute kidney injury (AKI), randomization to accelerated initiation of renal replacement therapy (RRT), compared to standard initiation…
- Trial name
- NCT02568722
- Testing
- Standard RRT initiation, Accelerated RRT initiation
- Where
- 105 sites in United States, Australia and 13 more
- Volunteers
- 3,019 people
- Sponsor
- Unity Health Toronto