Clinical trials: not yet recruiting
Post-mastectomy Pain Syndrome
Regenerative Peripheral Nerve Interface for Prophylaxis Against Post-Breast Surgery Pain Syndrome
Regenerative peripheral nerve interface (RPNI) was first developed in 2012 by Dr. Paul Cederna at the University of Michigan as a means for amputees to control their prothesis with their minds.
- Trial name
- NCT06580951
- Testing
- Regenerative Peripheral Nerve Interface
- Volunteers
- 200 people
- Sponsor
- George Kokosis
Hemophilia B
Lentiviral FIX Gene Therapy
This study is a Phase I trial using an advanced lentiviral vector to deliver a functional gene for human clotting factor IX into patients with hemophilia B, to evaluate the safety and efficacy of infusion of lentiviral gene…
- Trial name
- NCT03961243
- Testing
- YUVA-GT-F901
- Where
- China
- Volunteers
- 10 people
- Sponsor
- Shenzhen Geno-Immune Medical Institute
Alcohol Use Disorder (AUD)
Connecting Online Military Personnel to Alcohol Harm-reducing Smartphone Support Study
The purpose of this research is to test the effectiveness of a free mobile phone app designed to help veterans improve their relationship with alcohol and reduce alcohol-related harms.
- Trial name
- COMPASS (NCT07911345)
- Testing
- VetChange (Explorer/Research version) Mobile App, Sober Time
- Volunteers
- 150 people
- Sponsor
- University of New Mexico
B Cell Lymphoma (BCL)
Multi-CAR-T Cells Targeting B Cell Lymphomas
This study aims to evaluate safety and efficacy of a combination of 4th generation chimeric antigen receptor gene-modified T cells targeting B cell surface molecules including CD19 and alternative CARTs as booster and…
- Trial name
- NCT04429438
- Testing
- 4SCAR19 and 4SCAR20/22/70/PSMA/13/79b/GD2
- Where
- China
- Volunteers
- 11 people
- Sponsor
- Shenzhen Geno-Immune Medical Institute
Dementia
Inpatient Hospice Transitions Checklist
This is an NIH Stage IB single-arm feasibility study will adapt and test the Inpatient Hospice Transitions Checklist (I-HTC), an Epic-embedded intervention supporting hospice eligibility assessment and clinician-surrogate…
- Trial name
- I-HTC (NCT07889830)
- Testing
- I-HTC
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- New York University
Plaque-Induced Gingivitis
Efficacy of Thymus Vulgaris Mouthwash in the Management of Biofilm-Induced Gingivitis
The goal of this clinical trial is to determine whether a mouthwash made from thyme (Thymus vulgaris) helps improve gum health in people with plaque-induced gingivitis.
- Trial name
- NCT07905456
- Testing
- 0.2% Thymus vulgaris mouthwash, Chlorhexidine 0,12%
- Where
- Iraq
- Volunteers
- 60 people
- Sponsor
- University of Sulaimani
Depression - Major Depressive Disorder, Generalised Anxiety Disorder
Effectiveness of Internet-based Unified Protocol (iUP) for Emotional Problems: A Randomized Controlled Trial
The goal of this clinical trial is to learn if an internet-based Unified Protocol (iUP) intervention is effective for treating depression and anxiety disorders in Hong Kong young adults aged 18-29 years.
- Conditions
- Depression - Major Depressive Disorder, Generalised Anxiety Disorder, Anxiety Disorder (Panic Disorder or GAD), Depressive and Anxiety Disorders
- Trial name
- NCT07908628
- Testing
- Internet-based Unified Protocol (iUP), Waitlist Control Group
- Where
- Hong Kong
- Volunteers
- 78 people
- Sponsor
- New Life Psychiatric Rehabilitation Association
Oral Hygiene in Patients With Fixed Orthodontic Appliances
Effectiveness of Personalized Digital Oral Health Intervention in Patients With Fixed Orthodontic Appliances: a Randomized Controlled Trial
This study will evaluate whether personalized digital oral-health education delivered through WhatsApp messages can improve oral hygiene in patients aged 16-25 years who wear fixed orthodontic appliances (braces).
- Trial name
- PDHOI (NCT07910851)
- Testing
- Personalized Digital Oral Health Education via WhatsApp, Standard Oral-Hygiene Instructions
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Kurdistan Higher Council of Medical Specialties
Cervical Neuroendocrine Carcinoma
Immunotherapy in Neuroendocrine Carcinoma of the Cervix
This retrospective study reviews existing medical records. No new treatments or tests are given. The study asks how well immunotherapy worked for people with a rare cancer called neuroendocrine carcinoma of the cervix.
- Trial name
- NCT07911423
- Testing
- No study intervention; observational study.
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Peking Union Medical College Hospital
Strength Training Adaptations
Effects of Traditional and Cluster Set Resistance Training on Muscle Strength, Hypertrophy, and Power
This study aims to compare the effects of traditional resistance training and two different cluster set configurations on muscle strength, muscle hypertrophy, and explosive performance.
- Trial name
- NCT07910188
- Testing
- Traditional Set Resistance Training, Three-Repetition Cluster Set Training, Six-Repetition Cluster Set Training
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- GÜRKAN DİKER
Renal Impairment, Digestive Cancers
DESIR. Evaluation of the Pre-therapeutic Activity of Dihydropyrimidine dEShydrogenase (DPD) in Patients With Cancer and/or Renal Failure
Fluoropyrimidine drugs (5-Fluorouracil or 5-FU and its prodrug capecitabine) are a widely used in the treatment of numerous solid tumors in adults.
- Conditions
- Renal Impairment, Digestive Cancers, Breast Cancer
- Trial name
- DESIR (NCT07124403)
- Testing
- blood sampling
- Volunteers
- 742 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Glioblastoma of Cerebellum
DLL3 CAR-T Therapy Targeting Brain Tumors
The purpose of this study is to assess the feasibility, safety and efficacy of Delta-like ligand 3 (DLL3)-specific CAR-T cell therapy in patients with DLL3 positive brain tumors including glioblastomas and diffused intrinsic…
- Trial name
- NCT07180927
- Testing
- 4SCAR DLL3 T cells
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shenzhen Geno-Immune Medical Institute
Hematopoietic and Lymphatic System Neoplasm, Malignant Solid Neoplasm
Implementation Development for Distress Screening in Pediatric Oncology (ID-DISTRESSS)
This study is being done to understand how digital strategies (e.g., electronic health record [EHR]-technology, third-party platforms, and institution-developed solutions) can be used to deliver and respond to evidence-based…
- Trial name
- NCT07908485
- Testing
- Non-Interventional Study
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Children's Oncology Group
Multiple Myeloma (MM)
Study of CM336+CM313 Combination Therapy in Patients With Relapsed or Refractory Multiple Myeloma
This study consists of two parts. The purpose of Part 1 is to evaluate the safety and tolerability of CM336+CM313 combination therapy in participants with relapsed or refractory multiple myeloma (RRMM).
- Trial name
- NCT07910903
- Testing
- CM336, CM313, Daratumumab
- Where
- China
- Volunteers
- 320 people
- Sponsor
- Keymed Biosciences Co.Ltd
Gait Balance
EVS With Exercise for Balance With Older Adults
This study will test whether electrical stimulation of the balance system adds benefit to an exercise program for adults aged 60 years and older. The treatment is called noisy electrical vestibular stimulation (nEVS).
- Trial name
- NCT07890623
- Testing
- Noisy electrical vestibular stimulation
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Calgary
B Cell Malignancies
CD19/70 Bi-specific CAR-T Cell Therapy
The purpose of this study is to assess the feasibility, safety and efficacy of CD19/70 bi-specific CAR-T cell therapy in patients with CD19 and/or CD70 positive B cell malignancies.
- Trial name
- NCT05436496
- Testing
- bi-4SCAR CD19/70 T cells
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Shenzhen Geno-Immune Medical Institute
Pediatric Sepsis
Personalized Metabolic Nutrition Sepsis Study
Children with sepsis, a condition in which infection causes organ dysfunction will be enrolled with parental permission in this study.
- Trial name
- PMNS (NCT07910591)
- Testing
- For group Peds Sep A: Standard nutrition will be given, For Group Peds SepB: Low leucine, isoleucine formula, For Group Peds Sep C: Medium chain triglyceride oil enriched formula.
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- University of Pittsburgh
Crowding of Teeth, Malocclusion; Displaced Teeth
Timing, Trajectories and Prediction in Severe Dental Crowding: The Create SPACE (cSPACE)
Dental crowding is the most common malocclusion affecting up to 45% of the population and represents one of the leading reasons for seeking orthodontic treatment.
- Conditions
- Crowding of Teeth, Malocclusion; Displaced Teeth, Malocclusion in Children
- Trial name
- cSPACE (NCT07911176)
- Testing
- Early first premolar extraction with observation, Early first premolar extraction with planned fixed orthodontic treatment
- Volunteers
- 300 people
- Sponsor
- Vastra Gotaland Region
Opioid Use Disorder
Behavioral Optimization for Overcoming Suboptimal Treatment Retention (BUP-BOOSTeR)
Buprenorphine, a medication for opioid use disorder (MOUD), is associated with decreased opioid overdose and all-cause mortality.
- Trial name
- BUP-BOOSTeR (NCT07607743)
- Testing
- Behavioral Activation (BA), Attendance Reinforcement (AR), Peer-Delivered Motivational Interviewing (PDMI)
- Volunteers
- 240 people
- Sponsor
- Boston University
Cyberaggression
Effects of Transcranial Direct Current Stimulation on Cyberaggressive Behaviour in Adults
This study examines whether transcranial direct current stimulation (tDCS), a non-invasive form of brain stimulation, influences cyberaggressive behaviour in adults.
- Trial name
- NCT07908862
- Testing
- Anodal transcranial direct current stimulation, Cathodal transcranial direct current stimulation
- Where
- Singapore
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Nanyang Technological University
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