Clinical trials: sponsored by Georgetown University
Breast Cancer
Diarrhea Prevention and Prophylaxis With Crofelemer in HER2 Positive Breast Cancer Patients
Chemotherapy induced diarrhea is seen in up to 40-80% of patients receiving this treatment for HER2 positive locally advanced or metastatic breast cancer.
- Trial name
- HALT-D (NCT02910219)
- Testing
- Crofelemer
- Where
- 4 sites in United States
- Volunteers
- 53 people
- Sponsor
- Sandra Swain
Breast Cancer, Ovarian Cancer
Decision Support Following Genetic Testing for Breast-Ovarian Cancer Susceptibility
This non-therapeutic trial is for women who have received results of genetic testing for BRCA1/2 mutations. The trial compares decision support tools designed to facilitate informed decision making regarding risk management…
- Trial name
- NCT02133703
- Testing
- Enhanced Internet DA, Internet DA, Enhanced Print DA
- Where
- United States
- Volunteers
- 369 people
- Sponsor
- Georgetown University
Nonalcoholic Steatohepatitis
Safety and Tolerability of Oral Proglumide for NASH
This study is an open labelled Phase I/II clinical trial, designed to evaluate the safety and efficacy of an oral cholecystokinin (CCK) receptor antagonist, proglumide, at escalating doses in subjects with NASH.
- Trial name
- STOPNASH (NCT04152473)
- Testing
- Proglumide
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- Georgetown University
Lung Cancer
Educating Providers About Lung Screening
We are conducting a randomized trial to compare the Health Disparities module to an existing provider module on lung cancer screening to evaluate the impact on primary care providers' knowledge, attitudes, and lung cancer…
- Trial name
- NCT05064046
- Testing
- LuCa + Health Disparity module
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Indoor Tanning
A Mobile Text Messaging Intervention for Indoor Tanning Addiction
The purpose of this study is to test the effects of messages communicating the risks (i.e., health harms, addictiveness) of indoor tanning delivered via mobile text messaging among young adult women ages 18 to 30 years who meet…
- Trial name
- NCT04055272
- Testing
- Mobile text messaging intervention
- Where
- United States
- Volunteers
- 265 people
- Sponsor
- Georgetown University
Stress Disorders, Post-Traumatic
A Cognitive Behavioral Therapy and Yoga Program for Trauma Symptoms
The purpose of the proposed study is to evaluate the effectiveness of a cognitive behavioral therapy (CBT) and yoga program for improving posttraumatic stress disorder (PTSD) symptoms and sleep quality in people who have…
- Trial name
- NCT02368444
- Testing
- Cognitive Behavioral Therapy and Yoga
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Wound Infection
Investigation of a Novel Wound Gel to Improve Wound Healing in Chronic Wounds
This is a prospective, randomized, double-blinded, single site study examining the impact of a biofilm-based treatment of chronic wounds of the lower extremity. 200 subjects will be enrolled in this study.
- Trial name
- NCT03686904
- Testing
- Benzalkonium Gel, standard of care topical gel, Debridement
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Georgetown University
Hereditary Breast and Ovarian Cancer Syndrome
Enhance the Use of Genetic Counseling and Testing in Latinas
The investigators will conduct a two-arm RCT to evaluate the preliminary effectiveness of a culturally-adapted video developed by the team vs.
- Trial name
- NCT04544501
- Testing
- Culturally-Targeted Video, FORCE Fact Sheet
- Where
- 4 sites in United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Hereditary Breast and Ovarian Cancer
Testing an Intelligent Tutoring System to Enhance Genetic Risk Assessment
Participating in genetic cancer risk assessments (GCRA) for hereditary breast and ovarian cancer can inform treatment and risk management decisions and improve breast cancer outcomes.
- Trial name
- NCT03511690
- Testing
- BRCA-Gist
- Where
- 4 sites in United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Cirrhosis, Liver
Single-dose PK Assessment of Oral Proglumide in Those With Hepatic Impairment
Proglumide is an oral cholecystokinin (CCK) receptor antagonist that has been shown in non-clinical studies to reverse hepatic fibrosis and decrease the incidence of hepatocellular carcinoma (HCC).
- Trial name
- HIPK (NCT04814602)
- Testing
- Proglumide
- Where
- United States
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Advanced Cholangiocarcinoma
Evaluating Combination Immunotherapy for Advanced Cholangiocarcinoma With Pembrolizumab and PEG-Intron
This is an open-label, single-arm, multicenter Phase II safety and efficacy study of combination therapy with pembrolizumab and Sylatron (Peginterferon alpha-2b) in patients with advanced cholangiocarcinoma who have progressed on…
- Trial name
- NCT02982720
- Testing
- Pembrolizumab, Sylatron
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Aiwu Ruth He, MD
Anxiety Disorders, Generalized Anxiety Disorder
Treatments for Anxiety: Meditation and Escitalopram
We propose the first randomized, controlled study to assess the comparative effectiveness of Mindfulness-Based Stress Reduction (MBSR) with a medication for anxiety disorders.
- Conditions
- Anxiety Disorders, Generalized Anxiety Disorder, Panic Disorder, Social Anxiety Disorder
- Trial name
- TAME (NCT03522844)
- Testing
- Mindfulness-Based Stress Reduction, Escitalopram
- Where
- 3 sites in United States
- Volunteers
- 276 people
- Sponsor
- Georgetown University
Tobacco Use
Effect of Cigarette Pack Warnings and Packaging Among Young Adult Smokers
The objective of this study is to examine whether cigarette packaging regulations including graphic health warning labels on cigarette packs and requiring plain, unbranded packaging reduce the appeal of cigarettes and prompt…
- Trial name
- NCT03446170
- Testing
- Graphic cigarette warning labels, plain packaging
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Georgetown University
Malaria, Diarrhea
Liberia National Community Health Assistant (NCHA) Program and Under-five Mortality
Last Mile Health (LMH) has partnered with the Liberian Ministry of Health (MOH) to support the design and implementation of the National Community Health Assistant Program (NCHAP).
- Conditions
- Malaria, Diarrhea, Acute Respiratory Infection, Malnutrition, Child
- Trial name
- NCT05123378
- Testing
- Liberia National Community Health Assistant Program
- Where
- Liberia
- Volunteers
- 23,702 people, healthy volunteers welcome
- Sponsor
- Last Mile Health
Hookah Smoking
Optimizing Risk Messages for Waterpipe Tobacco Cessation in Young Adults
The objective of this study is to examine whether messages conveying the harms and addictiveness of waterpipe (i.e., hookah) tobacco delivered by mobile phone multimedia messaging (MMS) are effective for promoting hookah tobacco…
- Trial name
- NCT03595280
- Testing
- Hookah tobacco risk messages
- Where
- 2 sites in United States
- Volunteers
- 349 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Type 1 Diabetes, Children, Only
Pediatric Boot Camp Program
An intensive 13 weeks program that aims to improve glucose control in children with type 1 diabetes.
- Trial name
- NCT05066893
- Testing
- telehealth visits
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Georgetown University
Hormone Receptor Positive HER-2 Negative Breast Cancer
Palbociclib / Letrozole or Fulvestrant in African American Women With HR+ HER2- Breast Cancer
This study aims to evaluate the hematological safety of palbociclib with letrozole and fulvestrant in African American women with hormone receptor positive HER2 negative advanced breast cancer.
- Trial name
- PALINA (NCT02692755)
- Testing
- Palbociclib + Letrozole or Fulvestrant
- Where
- 6 sites in United States
- Volunteers
- 35 people
- Sponsor
- Georgetown University
Breast Cancer, Hereditary Breast Cancer
Testing a Culturally Adapted Telephone Genetic Counseling Intervention
Participating in genetic cancer risk assessments (GCRA) for hereditary breast and ovarian cancer (HBOC) can inform treatment and risk management decisions and improve breast cancer outcomes.
- Trial name
- NCT03959267
- Testing
- Telephone Genetic Counseling
- Where
- 4 sites in United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Georgetown University
Smoking, E-cigarette Use
Impact of New Product Standards for JUUL Among Dual JUUL/Combusted Cigarette Users
To date the majority of experimental tobacco regulatory science has focused specifically on the impact of possible tobacco product standards (e.g.
- Conditions
- Smoking, E-cigarette Use, Cigarette Smoking
- Trial name
- NCT04179617
- Testing
- 5% nicotine content JUUL pod, 3% nicotine content JUUL pod
- Sponsor
- Duke University
Chronic Diseases, Multiple
Healthy Eating for Successful Living in Older Adults Program (HE) Study
The Healthy Eating for Successful Living in Older Adults™ (HESL) is a six-week community nutrition and lifestyle education program designed specifically for the elderly (>60 years), to promote dietary and behavioral changes…
- Trial name
- HES (NCT04991844)
- Testing
- Intervention Group
- Where
- United States
- Volunteers
- 292 people, healthy volunteers welcome
- Sponsor
- Health and Healing Research Education and Service, Inc.