Clinical trials: sponsored by Unity Health Toronto
Cancer Gi
Prophylactic EUS-guided Gastroenterostomy in Advanced Periampullary Cancers
The goal of this randomized controlled trial is to investigate the effectiveness and safety of Prophylactic EUS-gastroenterostomy (ProEUS-GE) as a preventative approach for malignant gastric outlet obstruction (MGOO) in men and…
- Trial name
- INTERCEPT (NCT05994521)
- Testing
- ERCP alone, ERCP +ProEUS-GE
- Where
- 5 sites in Canada, France and 1 more
- Volunteers
- 110 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Patient Navigation
Empowering Families of Migrant Children and Youth with Special Healthcare Needs
The goal of this randomized controlled trial is to test if a patient navigator program improves healthcare experiences and outcomes for migrant families caring for a child or youth with special healthcare needs (i.e.
- Trial name
- MiNav (NCT06373588)
- Testing
- Patient Navigator
- Where
- 3 sites in Canada
- Volunteers
- 324 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Older Adults, Social Isolation
Adaptation and Implementation of an Intensive Geriatric Service Worker (IGSW) Model of Care for Socially Isolated Older Adults
In this study, participants will be randomly assigned to receive either the intervention or control treatment for up to 6 months.
- Trial name
- NCT06603610
- Testing
- Intensive geriatric service worker model of care, Information brochure and telephone follow-up support
- Volunteers
- 60 people
- Sponsor
- Unity Health Toronto
Infectious Disease
Antibiotics for Delirium in Older Adults With No Clear Urinary Tract Infection
Delirium is an acute confusional state that is experienced by many older adults who are admitted to hospital. To treat delirium the underlying cause needs to be identified promptly, but this is challenging.
- Trial name
- A-DONUT (NCT06004739)
- Testing
- Start Antibiotics / Continue Antibiotics for treatment of bacteriuria, No Antibiotics for treatment of bacteriuria
- Where
- 7 sites in United States, Canada
- Volunteers
- 550 people
- Sponsor
- Mount Sinai Hospital, Canada
Subarachnoid Hemorrhage
Ketamine Infusion in Neurologic Deficit
Subarachnoid hemorrhage (SAH) or bleeding in the brain as a result of ruptured aneurysm is a devastating type of stroke. Many patients who undergo emergent neurosurgery to repair the aneurysm and remove the bleeding suffer from…
- Trial name
- KIND (NCT02636218)
- Testing
- Ketamine, 0.9% NaCl
- Where
- Canada
- Volunteers
- 9 people
- Sponsor
- Unity Health Toronto
HIV Testing, HIV Infections
Near Patient Study of the OraQuick ADVANCE® HIV-1/2 Rapid Antibody Test in Oral Fluid and Fingerstick Whole Blood
Point-of-care (POC) tests for HIV are easy to use, rapid and provide accurate results while the patient is still in-front of a healthcare provider (HCP).
- Trial name
- NCT04810559
- Testing
- OraQuick ADVANCE® HIV-1/2 Rapid Antibody Test
- Where
- 4 sites in Canada
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
HIV, HIV Self-testing
Our Healthbox - Evaluating Interactive Dispensing Systems for Low-Barrier Access to HIV Testing and Harm Reduction.
When REACH Nexus at MAP Centre for Urban Solutions out of St. Michael's Hospital launched its signature program, I'm Ready in 2021, our goal was to democratize access to free HIV self-testing to reach the undiagnosed in Canada.
- Conditions
- HIV, HIV Self-testing, Harm Reduction, Sexually Transmitted Diseases
- Trial name
- NCT05516069
- Testing
- Our Healthbox (smart vending machine or interactive dispensing system)
- Where
- Canada
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Cystic Fibrosis
Modulation by Sex Hormones of Inflammation and Susceptibility to Pseudomonas Aeruginosa in Cystic Fibrosis Airways
The general objective is to elucidate the mechanisms whereby sex hormones may modulate the severity of respiratory disease. An important component of this proposal is a systematic and intensive approach to characterize how the…
- Trial name
- NCT00700050
- Testing
- Hypertonic saline
- Where
- Canada
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- The Hospital for Sick Children
Poverty
Screening for Poverty And Related Social Determinants to Improve Knowledge of and Links to Resources (SPARK)
The SPARK RCT will test the impact of engagement with a Community Health Worker who is embedded in interprofessional primary care teams on change in estimated annual income at 6 months for people living in poverty.
- Trial name
- SPARK (NCT04461080)
- Testing
- Community Health Worker
- Volunteers
- 110 people
- Sponsor
- Unity Health Toronto
Violence, Assault
Evaluation of Thriving, Substance Use, Mental Health, and Repeat Injury Among Participants in the THRIVE Program
The goal of this observational study is to determine the impact of a hospital-based violence intervention program on a person's capacity to thrive and recurrent intentional injury. The aims of this study are: 1.
- Trial name
- NCT06455943
- Volunteers
- 90 people
- Sponsor
- Unity Health Toronto
Surgery-Complications, Postoperative Complications
FUNCTIONAL ASSESSMENT FOR SURGERY BY A TIMED WALK
The FAST Walk study aims to determine whether a walking test called the 6-minute walk test (6MWT) can help identify people who are more likely to experience complications after surgery. This test will be completed before surgery.
- Trial name
- FAST Walk (NCT06412367)
- Where
- Canada
- Volunteers
- 1,672 people
- Sponsor
- Unity Health Toronto
Reverse Triggering, Patient Ventilator Dyssynchrony
Intrinsic Respiratory Rate Assessment During Mechanical Ventilation to Accelerate Spontaneous Breathing and Extubation
The goal of this study is to identify patients with reverse triggering who's the potential to breath spontaneously is hidden because of the ventilator management strategy by performing a simple 30sec-test with includes reducing…
- Trial name
- INTRINSIC (NCT06445049)
- Testing
- brief test
- Volunteers
- 70 people
- Sponsor
- Unity Health Toronto
Cancer
Genetics Adviser: Evaluating a Digital Decision Support Tool for Genetic Results
Oncologists are increasingly using genomic sequencing to diagnose and optimize care for their patients. A consequence of this technology is its capacity to detect a patient's risk for thousands of current and future conditions or…
- Trial name
- NCT04725565
- Testing
- Genetics ADvISER Decision Aid Plus Standard Genetic Counselling, Standard Genetic Counseling
- Where
- 3 sites in Canada
- Volunteers
- 133 people
- Sponsor
- Unity Health Toronto
Acute Hypoxemic Respiratory Failure
Airway Closure During Extracorporeal Membrane Oxygenation: The AiCLOSE Study
About 65,000 Canadians develop acute respiratory failure requiring breathing machines (ventilators) to give oxygen to their lungs. Unfortunately, up to 50% of these individuals will not survive their illness.
- Trial name
- AiCLOSE (NCT05196074)
- Testing
- Acute hypoxemic respiratory failure patients on VV-ECMO
- Where
- Canada
- Volunteers
- 299 people
- Sponsor
- Lorenzo delSorbo
Suicide, Major Depressive Disorder
Effect of Suicidality on Social Cognition
Major Depressive Disorder (MDD) is a very common illness that is usually treated with antidepressant medication. Depression can be caused by many things such as childhood experiences, genetics, and changes in the way the body and…
- Trial name
- NCT06163612
- Testing
- Clinical Interview, Clinical Questionnaires, Brain Scan
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- Unity Health Toronto
Treatment Resistant Depression, Major Depressive Disorder
Sustained Mood Improvement With Laughing Gas Exposure: A Randomized Controlled Pilot Trial
The purpose of the study is to investigate a short-term treatment option for major depressive disorders by administering nitrous oxide gas.
- Trial name
- SMILE (NCT04957368)
- Testing
- Nitrous Oxide 99 %, Oxygen + Midazolam
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Unity Health Toronto
Alzheimer's Disease, Mild Cognitive Impairment
BEAM: Brain-Eye Amyloid Memory Study
The main objectives for this study are: 1. To investigate novel, non-invasive ocular measurements including optical coherence tomography and eye tracking in a cross-sectional study of participants with various neurodegenerative…
- Conditions
- Alzheimer's Disease, Mild Cognitive Impairment, Vascular Cognitive Impairment, Parkinson's Disease
- Trial name
- BEAM (NCT02524405)
- Testing
- Pittsburgh Compound B [11C]-PIB
- Where
- 5 sites in Canada
- Volunteers
- 345 people, healthy volunteers welcome
- Sponsor
- Sunnybrook Health Sciences Centre
HIV Infections
Virtual PrEP: Rendering PrEP Delivery More Efficient
Gay, bisexual and other men who have sex with men (GBM) account for over half of new HIV infections in Canada each year, and have a 131-fold higher risk of HIV than other Canadian men.
- Trial name
- VPrEP (NCT05159531)
- Testing
- PrEP, mHealth Model of Care, Standard of Care
- Where
- 5 sites in Canada
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Mpox (Monkeypox)
Looking for Asymptomatic Mpox in a Population at High Risk
Mpox is caused by a virus that can be spread through touching the affected skin of someone who has the infection, touching sheets or clothes that has been used by someone with the infection, or breathing in particles of virus…
- Trial name
- LAMP (NCT06353737)
- Where
- Canada
- Volunteers
- 450 people
- Sponsor
- Unity Health Toronto
Cerebrovascular Disease
On-Premise and Remote Robotic Neurointervention
This study is a prospective, single arm, single-center study to evaluate the safety and feasibility of the Remedy Robot for on premise and remote robotic Neurointervention.
- Trial name
- NCT06365554
- Testing
- Remedy Robot
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Remedy Robotics, Inc.