Clinical trials: Early Phase 1, completed
Vaccine Reaction
Intradermal Influenza Vaccination- Healthy Cohort
The goal of this study is to characterize the immune response, both innate and adaptive, as well as locally and systemic, to intradermal (ID) vaccination in healthy individuals compared to intramuscular vaccination and placebo.
- Trial name
- NCT06067555
- Testing
- MicronJet, Fluzone® Quadrivalent, Bacteriostatic Saline
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Yale University
Chronic Pain
Mechanisms of CBD for Chronic Pain
This is a study designed to examine the neurochemical mechanisms associated with Cannabidiol (CBD) versus placebo for chronic non-cancer pain.
- Trial name
- NCT04044729
- Testing
- Cannabidiol
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Utah
Salt; Excess, Blood Pressure Disorders
Uric Acid, Klotho and Salt Sensitivity in Young Adults Born Preterm
The purpose of this research is to learn about how salt in the diet influences blood pressure in young adults who were born prematurely.
- Trial name
- PEPC3 (NCT04026776)
- Testing
- Allopurinol, Dietary Intervention
- Where
- United States
- Volunteers
- 154 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Lymphomas Non-Hodgkin's B-Cell
Feasibility Study of Induction and Maintenance Avelumab Plus R-CHOP in Patients With Diffuse DLBCL: The AvR-CHOP Study
To evaluate the feasibility of adding induction and maintenance Avelumab to the standard combination of R-CHOP in patients with stage II, III and IV diffuse large B cell lymphoma (DLBCL)
- Trial name
- AvR-CHOP (NCT03244176)
- Testing
- Avelumab
- Where
- 3 sites in Australia
- Volunteers
- 28 people
- Sponsor
- Austin Health
Infertility, Female, Infertility
Vitamin D and Polycystic Ovarian Syndrome (PCOS)
Primary Objectives: To evaluate the efficacy of metformin and Vitamin D supplementation on serum insulin and serum androgen levels (Total testosterone, Steroid Hormone Binding Globulin, Free Androgen Index) levels compared…
- Conditions
- Infertility, Female, Infertility, Vitamin D Deficiency
- Trial name
- NCT03989778
- Testing
- Vitamin D
- Where
- 2 sites in Pakistan
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
Brain Mapping
Human Brain Mapping of the Apparent Diffusion Coefficient (ADC) During Sleep and Wakefulness
Background: The glymphatic system helps keep harmful waste from building up in the brain. Researchers think it is more active in people during sleep than while awake.
- Trial name
- NCT02311374
- Testing
- Brain connectivity and physiology, Brain Wave
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- National Institute on Alcohol Abuse and Alcoholism (NIAAA)
HIV Infections, Opioid Use
Evaluation of Neuroinflammation FNOS PET/CT in HIV (+) and (-) Subjects With OUD and Healthy Controls
The purpose of this research is to measure the extent of inflammation in the brain between different groups of participants using a radioactive tracer called [18F]NOS.
- Trial name
- NCT04401917
- Testing
- [18F]NOS
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Post Operative Cognitive Dysfunction
Pre-operative Intra-nasal Dexmedetomidine or Insulin for Prevention of Early Post-operative Cognitive Dysfunction in Patients Undergoing Elective Coronary Artery Bypass Graft.
On pump coronary revascularization is a very common leading cause for post-operative cognitive dysfunction regarding patient age grouping and diffuse systemic inflammatory response induced by bypass machine .
- Trial name
- NCT06741566
- Testing
- intranasal saline group, intranasal insulin, Intranasal dexmedetomidine
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Minia University
Fatigue Related to Cancer Treatment
Evaluation of the Feasibility and Safety of ENCER for Cancer Treatment-Related Fatigue in Patients Receiving Chemotherapy or Radiotherapy
This is a feasibility, double blind, placebo-controlled clinical study designed to evaluate the effect of 'Encer' on Cancer treatment Related Fatigue. 'Encer' is a combination of 5 Homeopathic Medical Product (HMP).
- Trial name
- CTRF (NCT07707648)
- Testing
- encer
- Where
- Israel
- Volunteers
- 62 people
- Sponsor
- Beaura for Para Pharmaceutical Products Trading LLC
Motor Function of Healthy Physiology
Modulation of Motor Function by Stimulation of the Central and Peripheral Nervous System
Objectives When a stroke damages the part of the brain that controls movement, people have weakness and difficulty using their hand.
- Trial name
- NCT00453505
- Testing
- TMS, tDCS, tACS
- Where
- United States
- Volunteers
- 976 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Healthy Adult Participants
Effects of Different Doses of Ayahuasca on Personality in Healthy Volunteers
Randomized, double-blind, placebo-controlled clinical trial that included 28 healthy volunteers allocated to four experimental single dose groups (n = 7 per group) (ayahuasca 0.5 mL/kg, 1.0 mL/kg, 1.5 mL/kg, or placebo)
- Trial name
- NCT07893769
- Testing
- Ayahuasca
- Where
- Brazil
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Obesity, Diabetes Mellitus, Type 2
Postprandial Profiles of Metabolites and Appetite-regulating Hormones in Plasma and Cerebrospinal Fluid
Overweight and obesity are rising in prevalence and becoming a growing threat to public health. Obesity is associated with an increased all-cause mortality, impaired quality of life, and numerous of disorders.
- Trial name
- NCT06115304
- Testing
- Large liquid meal, spinal catheter and venous line
- Where
- Denmark
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mikkel Bring Christensen
Metabolism
Effects of Casein Protein on Metabolism When Taken Prior to Sleep and in the Morning
The purpose of this study is to investigate the effect of casein protein consumption both prior to sleep as well first thing in the morning on metabolism (increase satiety and appetite, lower resting metabolic rate, and lower…
- Trial name
- NCT06250270
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Ohio University
Depression, Anxiety
Integrating Inuit Knowledge Principles in Multi-Level Mental Health Clinical Trials
This study is looking at how eating more country foods affects mental health among Inuit men and women in Arviat, NU. The goal is to evaluate if eating more of these foods helps people feel less depressed or anxious, and whether…
- Trial name
- NCT07014852
- Testing
- Traditional Country Foods, Cultural Workshops
- Where
- 2 sites in Canada
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Alberta
Osteopenia
Melatonin and Osteogenic Loading on Osteopenia
This study will be assessing the efficacy of melatonin and/or osteogenic loading on modulating bone health in an osteopenic population.
- Trial name
- MelaOstrong (NCT04233112)
- Testing
- Melatonin 5 mg, Osteogenic loading, Mock for Osteogenic Loading
- Where
- 2 sites in United States
- Volunteers
- 27 people
- Sponsor
- Duquesne University
Platelet Function and Reactivity Tests
Comparison of Antiplatelet Effects of Sotagliflozin to FDA-approved Antiplatelet Drugs
This study will identify the potential benefits of regulating platelet activation with sotagliflozin compared to other FDA-approved drugs known to limit platelet activation.
- Trial name
- NCT06933056
- Testing
- Sotagliflozin (SOTA) followed by 3 drugs in a random order, Aspirin followed by 3 drugs in a random order, Clopidogrel followed by 3 drugs in a random order
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Obesity &Amp; Overweight
Studying the Influence of LEAP2 on Integrated Endocrine Control of Eating During Semaglutide Treatment
This clinical study investigates how blocking the hunger-related ghrelin receptor affects appetite and metabolism in individuals with obesity who are treated with semaglutide (a GLP-1 receptor agonist).
- Trial name
- SILENCED (NCT07171723)
- Testing
- Liver-Expressed Antimicrobial Peptide 2 (LEAP2)
- Where
- Denmark
- Volunteers
- 24 people
- Sponsor
- University Hospital, Gentofte, Copenhagen
Cannabis Use Disorder
Cannabinoids and Biological Reactivity to Stress
The goal of this study is to test the impact of two drugs that produce temporary stress-like symptoms, both in isolation and together, on cannabis use motivation in individuals with Cannabis Use Disorder.
- Trial name
- COBRAS (NCT06430580)
- Testing
- Hydrocortisone Oral, Yohimbine Hydrochloride
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Florida State University
Malignant Tumour
Dosimetry and Preliminary Clinical Application Study of a Novel Probe Targeting CD73
As a new CD73-targeted PET radiotracer, 68Ga-dPNE, is promising as an excellent imaging agent applicable to various cancers. In this study, we observed the safety, biodistribution and radiation dosimetry of 68Ga-dPNE in human…
- Trial name
- NCT06995976
- Testing
- 68Ga-dPNE, 18F-FDG
- Where
- China
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Interaction Drug Food
Assessing the Pharmacokinetics and Drug Interaction Liability of Kratom, an Opioid-like Natural Product
Kratom is a botanical natural product that has opioid-like effects. Kratom is commonly used to self-treat withdrawal symptoms associated with opioid addiction, as well as pain.
- Trial name
- NCT04392011
- Testing
- Midazolam HCl, Dextromethorphan HBr, Kratom
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Washington State University
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