Clinical trials: sponsored by Yonsei University
Head and Neck Squamous Cell Carcinoma
Trial of Neoadjuvant Therapy With Paclitaxel and Carboplatin in Operable Locally Advanced Head and Neck Cancer Patients
Objective: Primary objective: To evaluate the major pathologic response (mPR) of locally advanced head and neck cancer after paclitaxel and carboplatin-induction chemotherapy followed by surgery.
- Trial name
- NEOS (NCT05294900)
- Testing
- paclitaxel/carboplatin
- Where
- South Korea
- Volunteers
- 79 people
- Sponsor
- Yonsei University
Depression
Demonstration Study of the Effect of the Transcranial Direct Current Stimulation (tDCS) on Depressed Patients
Purpose of research: It aims to demonstrate the effectiveness of transcranial direct current stimulation (tDCS) in the clinical domain for patients with depression and to optimize home-based e-medication technology.
- Trial name
- NCT05539131
- Testing
- transcranial direct current stimulation (tDCS)
- Where
- 5 sites in South Korea
- Volunteers
- 198 people
- Sponsor
- Yonsei University
Esophageal Squamous Cell Carcinoma
Preoperative Chemoradiotherapy and MK-3475 for Esophageal Squamous Cell Carcinoma (ACTS-29)
In this study, participants with esophageal squamous cell carcinoma will receive preoperative chemoradiotherapy with paclitaxel,carboplatin and pembrolizumab then undergo surgery.
- Trial name
- NCT02844075
- Testing
- MK-3475(pembrolizumab)
- Where
- South Korea
- Volunteers
- 28 people
- Sponsor
- Yonsei University
Rheumatoid Arthritis
Rheumatoid Arthritis Satisfaction Outcome Research
RA satisfaction OR: This study aim to compare treatment satisfaction and quality of life between patients who have been using tofacitinib citrate and patients who have been using adalimumab for 6 months or more and less than 2…
- Trial name
- NCT03703817
- Where
- 23 sites in South Korea
- Volunteers
- 421 people
- Sponsor
- Pfizer
Hypertension
Clinical Study to Evaluate the Antihypertensive Efficacy and Safety of Fimasartan in Hypertension Patients
The purpose of this study is to evaluate the antihypertensive efficacy and safety of Fimasartan (BR-A-657•K) 60 mg~120 mg in patients with mild to moderate essential hypertension.
- Trial name
- NCT00922480
- Testing
- Fimasartan, Losartan (Control)
- Volunteers
- 506 people
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Chronic Otitis Media, Anesthesia
Optimal Dose of Combination of Rocuronium and Cisatracurium
BACKGROUND: The combinations of rocuronium and cisatracurium have a synergic effect. The investigators studied whether the prediction is possible to have a sufficient effect of reducing the dose when combining the two…
- Trial name
- CRC (NCT02495038)
- Testing
- 10% reduction of combination of Esmeron® and Nimbex®, 20% reduction of combination of Esmeron® and Nimbex®
- Volunteers
- 81 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Type 2 Diabetes
Effect of Pentoxifylline on Proteinuria in Korean Type 2 Diabetic Patients
This multi-center, randomized controlled study aims to evaluate the effects of pentoxifylline on proteinuria in Korean type 2 diabetic patients.
- Trial name
- NCT01382303
- Testing
- Pentoxifylline
- Where
- South Korea
- Volunteers
- 174 people
- Sponsor
- Ajou University School of Medicine
Epilepsy
The Efficacy and Safety of Low Dose Combination of LTG and VPA Compared to CBZ Monotherapy
To evaluate the efficacy of usual monotherapy and low dose combination of Lamotrigine and Valproate. Low dose combination may be more effective and tolerable because they are low dose and VPA reduce Lamotrigine metabolism.
- Trial name
- NCT00807989
- Testing
- Carbamazepine, Lamotrigine/Valproate
- Where
- South Korea
- Volunteers
- 207 people
- Sponsor
- Yonsei University
Robot-Assisted Laparoscopic Radical Prostatectomy
The Impacts of Surgical Visibility Through Deep Neuromuscular Blockade on Intraocular Pressure in Patients Undergoing Robot-Assisted Laparoscopic Radical Prostatectomy
Intraocular pressure is significantly increase during robot-assisted laparoscopic radical prostatectomy which is performed in a steep trendelenburg position at prolonged times of pneumoperitoneum.
- Trial name
- NCT02109133
- Testing
- deep neuromuscular blockade, moderate neuromuscular blockade, Rocuronium
- Where
- South Korea
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Yonsei University
Myocardial Infarction
Efficacy of Everolimus-Eluting Versus Zotarolimus-Eluting Sten for Coronary Lesions in Acute Myocardial Infarction
Most of the previous data regarding the efficacy of the everolimus-eluting stent (EES) was derived from studies comparing EES with bare metal stent (BMS) or EES with paclitaxel-eluting (PES).
- Trial name
- EVERZOTA (NCT01347554)
- Testing
- Everolimus eluting stent, Zotarolimus eluting stent
- Where
- South Korea
- Volunteers
- 461 people
- Sponsor
- Yonsei University
Thyroid Cancer, Neck Pain
The Effect of Transcutaneous Electrical Nerve Stimulation on Posterior Neck Pain After Thyroidectomy
The purpose of tihs study is to determine whether transcutaneous electric nerve stimulation (TENS) during thyroidectomy is effective in the reduction of posterior neck pain after thyroidectomy.
- Trial name
- NCT02012686
- Testing
- TENS
- Where
- South Korea
- Volunteers
- 100 people
- Sponsor
- Yonsei University
Stomach Neoplasms
Docetaxel and Epirubicin in Advanced Gastric Cancer
1.Study rationale:There is no standard regimen for the advanced and/or metastatic gastric cancer patients who relapsed after adjuvant chemotherapy or failed to first systemic chemotherapy.
- Trial name
- NCT00375999
- Testing
- Docetaxel and epirubicin
- Where
- South Korea
- Volunteers
- 34 people
- Sponsor
- Yonsei University
Coughing
Effect of Single-dose Dexmedetomidine on Airway Reflex in Adult With Oral Intubation After Thyroidectomy
Coughing during emergence from general anaesthesia may lead to dangerous effects including laryngospasm, detrimental haemodynamic changes.
- Trial name
- NCT01774305
- Testing
- Dexmedetomidine, Saline
- Where
- South Korea
- Volunteers
- 141 people
- Sponsor
- Yonsei University
Dissection of Thoracic Aorta
Prevention of Acute Kidney Injury by Erythropoietin in Thoracic Aorta Surgery With Hypothermic Cardiac Arrest
During thoracic aortic surgery, hypothermic cardiac arrest causes aortic ischemia and reperfusion (IR) periods, respectively. Aortic ischemia results in an ischemic insult to the lower extremities and successive reperfusion…
- Trial name
- NCT01369732
- Testing
- recombinant human erythropoietin, saline
- Where
- South Korea
- Volunteers
- 66 people
- Sponsor
- Yonsei University
Sustained Virologic Response, IL28B Polymorphism
100% VS 80% Of Pegasys In Koreans With Chronic Hepatitis C (CHC)
1. Randomized controlled multicenter study 2. The response of reducing dose of peginterferon alfa-2a in Koreans with chronic hepatitis C genotype 1 3. IL28B polymorphism in Koreans with CHC
- Trial name
- NCT01378104
- Testing
- peginterferon alfa 2a (pegasys), peginterferon alfa-2a (pegasys)
- Where
- 14 sites in South Korea
- Volunteers
- 178 people
- Sponsor
- The Catholic University of Korea