Clinical trials: sponsored by Baylor College of Medicine
Major Depressive Disorder
XEN1101 for Major Depressive Disorder
This project is designed to examine the neuronal KCNQ2/3 potassium (K+) channel subtype as a novel treatment target for mood disorders through the administration of the KCNQ-selective channel opener XEN1101 (Xenon…
- Trial name
- NCT04827901
- Testing
- XEN1101
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- James Murrough
Gastroschisis
Fetal Repair of Complex Gastroschisis: A Safety and Feasibility Trial
The goal of this clinical trial is to evaluate the safety and feasibility of fetal repair of complex gastroschisis (GS) via a fetoscopic surgical approach by assessing maternal, fetal, neonatal, and infant outcomes in a cohort of…
- Trial name
- NCT05704257
- Testing
- fetoscopy
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Baylor College of Medicine
Premature Infants, Bronchopulmonary Dysplasia
Optimization of Saturation Targets And Resuscitation Trial (OptiSTART)
This study is designed to answer one of the fundamental gaps in knowledge in the resuscitation of preterm infants at birth: What is the optimal target oxygen saturation (SpO2) range that increases survival without long-term…
- Conditions
- Premature Infants, Bronchopulmonary Dysplasia, Intraventricular Hemorrhage, Neurodevelopmental Outcomes
- Trial name
- OptiSTART (NCT05849077)
- Testing
- Sat75, Sat50
- Where
- United States
- Volunteers
- 700 people
- Sponsor
- University of Texas Southwestern Medical Center
Dystonic Cerebral Palsy
Intrathecal Baclofen and Pediatric Dystonia
The goal of this study is to better understand outcomes in children with dystonic cerebral palsy (CP) receiving intrathecal baclofen (ITB), ventral dorsal rhizotomy (VDR), or deep brain stimulation (DBS) as part of standard…
- Trial name
- PREDICT-ITB (NCT06606574)
- Testing
- ITB Titration Protocol, Ventral Dorsal Rhizotomy, Deep Brain Stimulation
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Baylor College of Medicine
Pancreatic Ductal Adenocarcinoma
Neoadjuvant Folfirinox Combined With Pembrolizumab Followed by Surgery for Patients With Resectable Pancreatic Cancer
Abbreviated Title: Neoadjuvant FOLFIRINOX combined with Pembrolizumab followed by surgery for patients with resectable pancreatic cancer Trial Phase: Phase II Clinical Indication: Pancreatic ductal adenocarcinoma; Adenocarcinoma…
- Trial name
- NCT05132504
- Testing
- Pembrolizumab, Folfirinox
- Where
- 3 sites in United States
- Volunteers
- 39 people
- Sponsor
- Baylor College of Medicine
Viral Infection
TETRAVI Multivirus CTL for Treatment of EBV, CMV, Adenovirus, and BK Infections Post Allogeneic SCT.
The purpose of this study is to use VSTs (virus-specific T cells) from a donor that is a partial HLA (human leukocyte antigen) match with the patient to treat viral infections after an allogeneic hematopoietic stem cell…
- Trial name
- TETRAVI (NCT04013802)
- Testing
- HLA-matched VSTs
- Where
- 2 sites in United States
- Volunteers
- 47 people
- Sponsor
- Baylor College of Medicine
Neuroblastoma
GD2 Specific CAR and Interleukin-15 Expressing Autologous NKT Cells to Treat Children With Neuroblastoma
This research study combines two different ways of fighting cancer: antibodies and Natural Killer T cells (NKT). Antibodies are types of proteins that protect the body from infectious diseases and possibly cancer.
- Trial name
- GINAKIT2 (NCT03294954)
- Testing
- GINAKIT Cells, GINAKIT cells + Etanercept
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Baylor College of Medicine
Tuberculosis, HIV Coinfection
Closing -TB GAPs - for People Living With HIV: TB Guidance for Adaptable Patient-Centered Service
Tuberculosis (TB) is the world's leading infectious cause of mortality and responsible for 1/3 of deaths in people living with human immunodeficiency virus (PLHIV).
- Conditions
- Tuberculosis, HIV Coinfection, Tuberculosis Infection
- Trial name
- TB_GAPS (NCT05342064)
- Testing
- patient-centered TB preventive therapy, TB preventive therapy adherence support
- Where
- 5 sites in Eswatini, Lesotho and 3 more
- Volunteers
- 5,733 people
- Sponsor
- Baylor College of Medicine
Esophageal Neoplasm, Esophageal Polyp
Novel Bipolar Radiofrequency Ablation Knife in Esophageal Lesions
Both Baylor St Luke's Medical Center and Mayo Scottsdale are considered endoscopic submucosal dissection (ESD) centers of excellence.
- Conditions
- Esophageal Neoplasm, Esophageal Polyp, Endoscopic Submucosal Dissection, Bipolar Electrocautery
- Trial name
- NCT06476678
- Testing
- Speedboat™ Ultraslim
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Baylor College of Medicine
Opioid Use, Substance Use Disorders
Evaluation of the Safety and Effects of Psychoactive Substances in People With Past Opioid Use
The purpose of this study is to understand how kratom affects people. In this study, kratom will be compared with another substance and a placebo (an inactive substance).
- Conditions
- Opioid Use, Substance Use Disorders, Opioid Analgesia
- Trial name
- NCT07218549
- Testing
- Oxycodone HCl, Kratom 8g, Kratom 12g
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Christopher D. Verrico
T-cell Acute Lymphoblastic Lymphoma, T-non-Hodgkin Lymphoma
Autologous T-Cells Expressing a Second Generation CAR for Treatment of T-Cell Malignancies Expressing CD5 Antigen
Patients eligible for this study have a type of blood cancer called T-cell leukemia or lymphoma (lymph gland cancer). The body has different ways of fighting infection and disease. No one way seems perfect for fighting cancers.
- Conditions
- T-cell Acute Lymphoblastic Lymphoma, T-non-Hodgkin Lymphoma, T-cell Acute Lymphoblastic Leukemia
- Trial name
- MAGENTA (NCT03081910)
- Testing
- Autologous CD5.CAR/28zeta CAR T cells, Allogeneic CD5.CAR/28zeta CAR T cells
- Where
- 2 sites in United States
- Volunteers
- 104 people
- Sponsor
- Baylor College of Medicine
Osteogenesis Imperfecta
Cardiopulmonary Outcomes in Osteogenesis Imperfecta: BBD7708
Osteogenesis imperfecta (OI) is a group of congenital and heritable bone disorders that currently affects at least 50,000 people in the United States. OI varies in severity from perinatally lethal to mild forms.
- Trial name
- NCT05317637
- Where
- 3 sites in United States
- Volunteers
- 18 people
- Sponsor
- Baylor College of Medicine
Ascites
High Dose Albumin in Refractory Ascites
Advanced cirrhosis with complications is a serious problem imposing a heavy financial burden on health care system. Moreover, ascites is associated with increase in mortality rates among cirrhotic patients.
- Trial name
- NCT05867602
- Testing
- Albumin
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Baylor College of Medicine
End Stage Kidney Disease (ESKD)
Comparative Feasibility and Effectiveness of Medically Tailored Meals Approaches for Pediatric End-Stage Kidney Disease
End-Stage Kidney Disease (ESKD) in children is a severe and irreversible condition that significantly impacts their growth, development, and overall quality of life.
- Trial name
- NCT07911969
- Testing
- Culinary Medicine Intervention, Pre-prepared MTMs
- Volunteers
- 30 people
- Sponsor
- Baylor College of Medicine
Lipid Disorder, Dyslipidemias
Causal Mechanisms in Adolescent Arterial Stiffness
Hardening of the blood vessels, called arterial stiffness, is a risk factor for future heart disease and its causes are unclear.
- Conditions
- Lipid Disorder, Dyslipidemias, Aortic Stiffness, Insulin Resistance Syndrome
- Trial name
- NCT04128969
- Testing
- CS+, CS-
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Baylor College of Medicine
Traumatic Brain Injury
Predict Severe Traumatic Brain Injury
Severe traumatic brain injury (TBI) is associated with a 20-30% mortality rate and significant disability among most survivors. The Centers for Disease Control and Prevention (CDC) estimate that 2% of the U.S.
- Trial name
- NCT06966713
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- University of Chicago
GATA2 Deficiency
Natural History Study of GATA2 Deficiency and Related Disorders
Background: GATA2 deficiency is a genetic disorder that can cause problems with a person s immune system and other body systems. Some people who have this disorder develop few problems from it.
- Trial name
- NCT01905826
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Langerhan's Cell Histiocytosis, Juvenile Xanthogranuloma
Cobimetinib in Refractory Langerhans Cell Histiocytosis (LCH), and Other Histiocytic Disorders
This is a research study of a drug called cobimetinib in children and adults diagnosed with Langerhans cell histiocytosis (LCH), and other histiocytic disorders that has returned or does not respond to treatment.
- Conditions
- Langerhan's Cell Histiocytosis, Juvenile Xanthogranuloma, Erdheim-Chester Disease, Rosai Dorfman Disease
- Trial name
- NACHO-COBI (NCT04079179)
- Testing
- Cobimetinib
- Where
- 12 sites in United States
- Volunteers
- 90 people
- Sponsor
- Carl Allen
Lymphoma, Hodgkin's Disease
Autologous/Allogeneic TGFbeta-resistant LMP-specific CTL, Lymphoma (TGF-beta)
Patients have a type of lymph gland cancer called HD, NHL or lymphoepithelioma (these 3 diseases will be referred to as "Lymphoma"). The lymphoma has come back or has not gone away after treatment.
- Conditions
- Lymphoma, Hodgkin's Disease, Relapse, Lymphoma, Non-Hodgkin
- Trial name
- TGF-beta (NCT00368082)
- Testing
- TGFbeta resistant LMP-specific CTLs
- Where
- 2 sites in United States
- Volunteers
- 8 people
- Sponsor
- Baylor College of Medicine
Intellectual Disability
Future Planning and Well-Being for Individuals With Intellectual Disabilities and Family Caregivers
This study will compare the effectiveness of a web-based long-term care planning tool (Map Our Life) partnered with traditional case management services to traditional case management services partnered with an attention-control…
- Trial name
- NCT06065527
- Testing
- Map Our Life, Attention Control
- Where
- United States
- Volunteers
- 1,050 people
- Sponsor
- Northwell Health
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