Clinical trials: sponsored by Fondation Ophtalmologique Adolphe de Rothschild
Stroke
Medico-Economic Evaluation of MRI Versus CT as Diagnostic Imaging Strategies in Patients With Suspected Ischemic Stroke: the MAGRITTE Study.
Acute ischemic stroke (AIS) is a leading cause of death and long-term disability worldwide. In patients with suspected large vessel occlusion, rapid diagnosis and reperfusion therapy are critical, as treatment delays are…
- Trial name
- MAGRITTE (NCT07719374)
- Testing
- CT and CT angiography (CTA), MRI and MR angiography (MRA)
- Volunteers
- 600 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Chronic Pain
Behavioural Study in Chronic Pain : Creativity and Motivation, and Circuits Involved in Functional MRI
Being creative means having the ability to produce ideas, actions or works that are original and different from what we have already done.
- Trial name
- AART (NCT06502496)
- Testing
- art-therapy, relaxation
- Where
- France
- Volunteers
- 48 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Amnesia, Alzheimer Disease
OCT-Angiography and Adaptive Optics in Patients With Memory Impairment
Studies suggest an association between retinal abnormalities and NCD (Neuro Cognitive Disorders) whether they are linked to proven or prodromal Alzheimer's disease (aMCI : amnestic mild cognitive impairment), or to other…
- Conditions
- Amnesia, Alzheimer Disease, Lewy Body Disease, Parkinsons Disease With Dementia
- Trial name
- OCTAVO (NCT04389437)
- Testing
- Ophthalmological exam, Blood pressure measurement
- Where
- France
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Subarachnoid Hemorrhage
French Validation of the SAHOT Outcome Scale After Subarachnoid Haemorrhage
Survivors of subarachnoid haemorrhage (SAH) frequently experience cognitive, psychological, physical and social sequelae, but no French-language instrument covers all these dimensions.
- Trial name
- SAHOT-FR (NCT07894666)
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Epilepsy
Identification of Volatile Organic Compounds (VOCs) as Biopredictors of Epileptic Seizures
The unpredictable nature of epileptic seizures places people with epilepsy under permanent psychological stress, which contributes significantly to a restriction in their quality of life.
- Trial name
- ICONE (NCT05865561)
- Testing
- VOC sampling
- Where
- 2 sites in France
- Volunteers
- 45 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Epilepsy
Epilepsy and Driving
Epilepsy can lead to cognitive impairments, particularly in attention, which may affect daily activities such as driving. Driving plays a key role in maintaining autonomy and is essential for the social and professional…
- Trial name
- EPICO (NCT07026591)
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Epilepsy
Impact of Canine Mediation Practice in Psychomotor Therapy on Improving the Quality of Life in Adult Epileptic Patients.
In addition to the search for new pharmaceutical or surgical solutions that could improve the therapeutic management of epileptic individuals, it is interesting to ask whether other complementary approaches, such as canine…
- Trial name
- MCP-Epi (NCT06898749)
- Testing
- canine mediation, standard psychomotor therapy
- Where
- 2 sites in France
- Volunteers
- 76 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Wilson Disease
Oral Health and Wilson's Disease: SOMAWI
Patients with Wilson disease have poorer dental and periodontal health and a have lower oral quality of life than control patients.
- Trial name
- SOMAWI (NCT05444127)
- Testing
- Saliva samples, Questionnaire OHIP-14, Thorough dental examination
- Where
- 2 sites in France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Abdominal Aortic Aneurysm
Screening for Abdominal Aortic Aneurysms in the General Practice by Ultraportable Ultrasound
Abdominal aortic aneurysm (AAA) is a localized dilatation of a segment of the aorta artery in its abdominal portion. It affects 1.7% of men aged 65 years and older.
- Trial name
- DACEP (NCT05617326)
- Testing
- AAA screening by a GP, AAA screening by a radiologist
- Where
- 6 sites in France
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Epilepsy
National Survey on Physical and Sports Activity of Adults With Epilepsy
Epilepsy affects nearly 600,000 people in France and causes neurological seizures that can lead to lasting impairments and stigma.
- Trial name
- ENAPSE (NCT07075380)
- Testing
- online questionnaire
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Focal Epilepsy
Efficacy of Probenecid on Cluster Seizures During Anti Seizure Medication Withdrawal in Presurgical Focal Epilepsy Video-EEG Monitoring
ProbCluster trial aims at making the proof of concept of antiseizure efficacy of the old antigout PBN in SC, in which Panx1 involvement is relevant on SC pathophysiology and in which efficient therapies are still lacking.
- Trial name
- PROBCLUSTER (NCT07318870)
- Testing
- Probenecid
- Where
- 2 sites in France
- Volunteers
- 600 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Homonymous Hemianopia, Stroke
Anatomical and Functional Predictions of Blindsight Capabilities in Patients With Lateral Hemianopsia
Homonymous lateral hemianopia (HLH) is characterized by loss of vision in half the visual field, and is the most common neurovisual disorder following stroke.
- Conditions
- Homonymous Hemianopia, Stroke, Cortical Blindness, Hemianopia
- Trial name
- PRE-SIGHT (NCT06636994)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Wilson's Disease
Description of the Copper Concentration in Breast Milk in Women Treated for Wilson's Disease
Wilson's disease is a rare genetic disease, affecting less than 1,500 people in France. The transmission is autosomal recessive linked to an anomaly of the ATP7B gene on chromosome.This gene codes for an ATPase-type transmembrane…
- Trial name
- WILLACT (NCT05183165)
- Testing
- Patients with Wilson's disease declaring pregnancy,
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Wilson's Disease
Cardiac Involvement in Wilson's Disease
Heart damage by copper accumulation has been reported in Wilson's Disease. However, the disease epidemiology is still poorly understood.
- Trial name
- WIL-HEART (NCT05493605)
- Testing
- Delivery of a long-term Holter 21 days Or placement of an implantable holter from the outset so syncope
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Epilepsy (Treatment Refractory)
CEST-based Biomarkers to Delineate the Epileptogenic Zone
Epilepsy is a common neurological disorder with an incidence of 1%. Although many anti-seizure medications are available, about 30% of patients are resistant to drug treatments.
- Trial name
- CEST-BEST (NCT07316972)
- Testing
- CEST sequence on a 7-Tesla MRI
- Volunteers
- 20 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Wilson Disease
Description of Renal Involvement in Wilson's Disease
Wilson's disease (WD) is a rare genetic disorder that leads to copper accumulation in various tissues, including the liver, nervous system, heart, and kidneys.
- Trial name
- WILKID (NCT07075393)
- Testing
- full renal workup
- Where
- France
- Volunteers
- 150 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Acute Ischemia
REperfusion With P2Y12 Inhibitors in Addition to mEchanical thRombectomy for perFUsion Imaging Selected Acute Stroke patiEnts
The main objective is to evaluate the efficacy of IV administration of the P2Y12 inhibitor (cangrelor) in addition to mecanich thrombectomy and WMD versus mecanich thrombectomy and WMD alone on the functional prognosis at 3…
- Trial name
- REPERFUSE (NCT04667078)
- Testing
- Cangrelor, best medical management
- Where
- 13 sites in France
- Volunteers
- 368 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Acute Ischemic Stroke
Glenzocimab in Anterior Stroke With Large Ischemic Core Eligible for Endovascular Therapy
Until recently, acute ischemic stroke (AIS) patients with a baseline large infarct core have been generally excluded from clinical trials of endovascular therapy (EVT).
- Trial name
- GALICE (NCT06437431)
- Testing
- glenzocimab
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Diplopia
A Predictive Score for the Ischemic Etiology of a Transient Diplopia (VASCO-DIP)
The transient diplopias (TD) is defined by a short diplopia. Their etiology may be ophthalmological, neurological non-ischemic or of ischemic origin.
- Trial name
- VASCO-DIP (NCT02576925)
- Testing
- Clinical, ophthalmological and neurological evaluation
- Where
- 2 sites in France
- Volunteers
- 220 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Myopia
Efficacy of Myopia-control Lenses in a Population of Young Adults : the OPTIMA Study
The goal of this clinical trial is to learn if myopia-control eyeglass lenses (Essilor® Stellest® 2.0) can slow down the progression of short-sightedness (myopia) in young adults, compared with standard single-vision lenses.
- Trial name
- OPTIMA (NCT07804043)
- Testing
- Essilor® Stellest® 2.0 myopia-slowing lenses, Standard lenses
- Where
- France
- Volunteers
- 134 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild