Clinical trials: sponsored by Fondazione Don Carlo Gnocchi ETS
Focal Dystonia, Rehabilitation Exercise
Protocol in Musician's Focal Dystonia (MISA)
Musician's Focal Dystonia (MFD) is a task-specific movement disorder that impairs fine motor control during musical performance and may severely affect professional and amateur musicians.
- Conditions
- Focal Dystonia, Rehabilitation Exercise, Sensorimotor
- Trial name
- MISA (NCT07923799)
- Testing
- Modified Integrated Sensorimotor Approach (MISA)
- Where
- 2 sites in Italy
- Volunteers
- 70 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Amyotrophic Lateral Sclerosis, Chronic Inflammatory Demyelinating Neuropathy
High-Tech Rehabilitation Pathway for Chronic Adult Neuromuscular Diseases - Fit4MedRob-Chronic MND Project
The primary objective is to demonstrate, in a population of chronic neuromuscular disease the non-inferiority of a rehabilitation treatment integrated with robotic and/or technological devices compared to traditional…
- Conditions
- Amyotrophic Lateral Sclerosis, Chronic Inflammatory Demyelinating Neuropathy, Charcot-Marie-Tooth Disease
- Trial name
- Fit4MR-ChrMND (NCT06881979)
- Testing
- High-tech rehabilitative treatment, Rehabilitation
- Where
- 7 sites in Italy
- Volunteers
- 60 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Critical Illness Myopathy, Guillain Barré Syndrome
High-Tech Rehabilitation Pathway for Acute Adult Neuromuscular Diseases - Fit4MedRob-Acute MND Project
The goal of this study is determine if a high-tech rehabilitation circuit is more effective than usual rehabilitation methods in improving functional outcome, particularly balance control, for patients with acute neuromuscolar…
- Conditions
- Critical Illness Myopathy, Guillain Barré Syndrome, Critical Illness Polyneuromyopathy (CIPNM)
- Trial name
- Fit4MR-AcMND (NCT06822231)
- Testing
- High-tech rehabilitative treatment, Rehabilitation
- Where
- 8 sites in Italy
- Volunteers
- 124 people
- Sponsor
- Istituti Clinici Scientifici Maugeri SpA
Caregiver Anxiety, Acquired Brain Injury
Comprehensive Assessment of Rehabilitation Experience Using the SAFE Scale
Patients with severe acquired brain injury (sABI) and disorders of consciousness (DoC) require intensive interdisciplinary rehabilitation involving healthcare professionals, patients, and family caregivers.
- Conditions
- Caregiver Anxiety, Acquired Brain Injury, Caregiver Satisfaction and Connectedness to Clinic, Disorders of Consciousness Due to Severe Brain Injury
- Trial name
- CARE-SAFE (NCT07912372)
- Testing
- Caregiver training and administration of SAFE scale, Standard clinical care
- Where
- Italy
- Volunteers
- 68 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Lower Limb Amputation Above Knee, Lower Limb Amputation Below Knee
TENS for Restoring Somatotopic Sensory Feedback in Lower Limb Amputees and Improving Phantom Limb Perception
The aim of the study is to evaluate the changes induced by a course of Transcutaneous Electrical Nerve Stimulation (TENS) treatment on the perception of phantom limb pain.
- Trial name
- SENSE-P (NCT07448350)
- Testing
- Transcutaneal Electrical Nerve Stimulation
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Campus Bio-Medico University
Cardiac Rehab, Heart Failure
The Italian Alliance for Cardiovascular Rehabilitation and Prevention (ITACARE-P) Registry: An Observational Study on Cardiac Rehabilitation in Patients With Coronary Disease or Heart Failure
The ITACARE-P CardioRehab Registry is a nationwide observational study conducted in Italy and coordinated by the Fondazione Don Carlo Gnocchi in Milan.
- Conditions
- Cardiac Rehab, Heart Failure, Coronary Disease, Heart Conditions
- Trial name
- CardioRehab (NCT07094737)
- Where
- Italy
- Volunteers
- 1,600 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Disorders of Consciousness
Tickle Stimulation in Disorders of Consciousness (DoC)
The aim of this project is to investigate whether tickling stimulations can have a short-term effect on the responsiveness of patients with Disorders of Consciousness due to Severe Acquired Brain Injury and to compare this effect…
- Trial name
- TICKLING-DOC (NCT06922162)
- Testing
- Tickle stimulation, Neurophysiological Monitoring with SedLine
- Where
- 2 sites in Belgium, Italy
- Volunteers
- 16 people
- Sponsor
- Anna Estraneo
Parkinson Desease, Mild Cognitive Impairment (MCI)
Cognitive Rehabilitation With Virtual Reality in Parkinson Disease
The OPERA Clinical Study is an interventional, single-arm, open-label pilot clinical study that aims to evaluate the usability of an innovative bio-cooperative robotic platform (PRoBio) for cognitive rehabilitation in patients…
- Trial name
- OPERA (NCT06920511)
- Testing
- Cognitve rehabilitation with virtual reality and robotic arm
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Disorders of Consciousness
Tactile Stimulation in Disorders of Consciousness (DoC)
The aim of this project is to evaluate the behavioural and neurophysiological responses to pleasant touch in patients with disorders of consciousness (DoC) and to determine whether these responses are related to the level of…
- Trial name
- TACTILE-DOC (NCT06922123)
- Testing
- Tactile stimulation, Neurophysiological Monitoring with SedLine
- Where
- Italy
- Volunteers
- 8 people
- Sponsor
- Anna Estraneo
Acquired Brain Injury, Disorder of Consciousness
Robotic vs. Traditional Verticalization in Patients With Severe Acquired Brain Injury: a Randomized Controlled Trial
In the rehabilitation project for patients with severe Acquired Brain Injury (sABI), it is essential to include exercises that facilitate the recovery of the upright position (or verticalization).
- Trial name
- VEM-sABI (NCT06469983)
- Testing
- ErigoBasic or ErigoPro®, Traditional Verticalization
- Where
- 6 sites in Italy
- Volunteers
- 118 people
- Sponsor
- Anna Estraneo
Multiple Sclerosis
Effect of High Intensity Training on Motor and Cognitive Functions
Fatigability is one of the most prevalent disorder in MS followed by walking, balance and cognitive disorders. However, there are few experimental studies on the effects of fatigability on balance and gait hampering the knowledge…
- Trial name
- FAST (NCT06219304)
- Testing
- Multimodal functional training, Usual care
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Stroke
Study on the Effects of an EMG-controlled Functional Electrical Stimulator for Upper Limb for Post-stroke Patients
Upper limb disabilities are among the most debilitating issues after a cerebral stroke. One promising approach in motor rehabilitation is the use of functional electrical stimulation (FES).
- Trial name
- NCT06928857
- Testing
- EMG-based FES rehabilitation, Traditional rehabilitation
- Where
- 3 sites in Italy
- Volunteers
- 50 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Cardiovascular Diseases, Diabete Type 2
EffectiVenEss of a Rehabilitation Treatment With Nordic Walking in obEse or oveRweight Patients
Nordic Walking (NW) is a biomechanically correct walking technique that originated in Finland in the 1930s as an off-season training method for cross-country skiers.
- Conditions
- Cardiovascular Diseases, Diabete Type 2, Overweight and Obesity
- Trial name
- VENERE (NCT05987410)
- Testing
- Nordic Walking (NW), Standard Rehabilitation (SR), Cardiological Counselling (CC)
- Where
- Italy
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Heart Transplant
Exercise aNd hEArt Transplant
Registry-based randomized clinical trial (RRCT) to assess the safety and efficacy of two different schemes of exercise training in patients who have recently undergone heart transplantation
- Trial name
- ENEA (NCT05824364)
- Testing
- telerehabilitation, rehabilomic
- Where
- Italy
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Cardiogenic Shock
Cardiac Rehabilitation in Patients Acutely Managed for Cardiogenic Shock (ENIGMA)
This is a prospective and retrospective multicentre study conducted under the scientific coordination of the IRCCS Fondazione Don Gnocchi and funded by the Italian Ministry of Health (PNRR-MCNT2-2023-12377767).
- Trial name
- ENIGMA (NCT06572826)
- Testing
- Cardiac Rehabilitation intervention
- Where
- Italy
- Volunteers
- 2,000 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Multiple Sclerosis
Home Rehabilitation as Continuity of Care in MS
RCT pilot study to evaluate adherence, satisfaction and feasibility in the use of a telemedicine station for balance rehabilitation in patients with multiple sclerosis.
- Trial name
- HoReConCareMS (NCT06699095)
- Testing
- Telerehabilitation
- Where
- 3 sites in Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Stroke
Biodiversity and Human Functioning Following Acquired Cerebrovascular Lesions - Phase 1
The study aims to investigate the impact that the set of factors to which a post-stroke person is exposed during daily life can have on their health.
- Trial name
- EspertaMente (NCT07504692)
- Where
- 3 sites in Italy
- Volunteers
- 150 people
- Sponsor
- Dr. Franco Molteni
Traumatic Brain Injury
Home-Based Exergame Motor-Cognitive Rehabilitation for Traumatic Brain Injury
The goal of this clinical trial is to evaluate the effectiveness of a home-based cognitive-motor telerehabilitation program in individuals with traumatic brain injury (TBI) following discharge from intensive inpatient…
- Trial name
- HOME-TBI (NCT07733336)
- Testing
- HOME-EXER telerehabilitation protocol, OUT-REHAB rehabilitation protocol
- Where
- 2 sites in Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Dystrophinopathy, Muscular Dystrophies
VirtualPark_Pediatric
The goal of this clinical trial is to assess the effects of a dual-task, multimodal training program on slowing functional motor decline in children and adolescents with neuromuscular disorders.
- Conditions
- Dystrophinopathy, Muscular Dystrophies, Congenital Myopathies
- Trial name
- NCT07580365
- Testing
- Dual-task cycling, Standard therapy
- Where
- 4 sites in Italy
- Volunteers
- 22 people
- Sponsor
- Istituto di Sistemi e Tecnologie Industriali Intelligenti per il Manifatturiero Avanzato
MCI, Mild Cognitive Impairment (MCI)
Prevalence of Mild Cognitive Impairment and Dementia in Patients Admitted to Non-neurological Rehabilitation Wards
Cognitive impairment is common among older adults hospitalized for non-neurological conditions but often goes unrecognized, particularly in rehabilitation settings where clinical attention is mainly focused on physical recovery.
- Conditions
- MCI, Mild Cognitive Impairment (MCI), Mild Cognitive Impairment, Cognitive Deficit
- Trial name
- COGinREHAB (NCT07731334)
- Testing
- Cognitive and clinical screening, Extended neuropsychological assessment, Blood biomarker sampling and APOE genotyping
- Where
- 3 sites in Italy
- Volunteers
- 384 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS