Clinical trials: sponsored by Hospices Civils de Lyon
Pediatric Liver Transplantation
Hypothermic Oxygenated Machine PErfusion During Ex-vivo SPLITting in Liver Pediatric Transplantation (HOPESPLIT)
Ex-vivo split liver transplantation (SLT) has been developed to increase organ availability and offer a rapid access to transplantation for pediatric recipients.
- Trial name
- HOPE SPLIT (NCT07918183)
- Testing
- End-ischemic Hypothermic Oxygenated Machine Perfusion (HOPE), Classic static cold storage
- Where
- 7 sites in France
- Volunteers
- 200 people
- Sponsor
- Hospices Civils de Lyon
MItochondrial Myopathies
Role of AMPKalpha2 in Myonuclear Accretion in Mitochondrial Myopathies
Mitochondrial cytopathies are a heterogeneous group of rare inherited diseases characterized by primary mitochondrial dysfunction caused by a pathogenic mutation located either in nuclear DNA or mitochondrial DNA.
- Trial name
- MITOMYO (NCT07920562)
- Testing
- Analysis of signaling pathway : AMPK
- Where
- France
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Liver Transplantation
Study of Sleep Quality and Its Specific Determinants During the Care Pathway of a Liver Transplant Patient
In the LIVERSLEEP study, investigators provide an overview of sleep disorders among patients in a liver transplantation (LT) pathway and a description of the criteria that can influence their sleep.
- Trial name
- LIVERSLEEP (NCT07674355)
- Where
- France
- Volunteers
- 108 people
- Sponsor
- Hospices Civils de Lyon
Cerebral Palsy Infantile, Upper Limb Spasticity
Peripheral Neurotomies of the Upper Limb in Children With Cerebral Palsy.
Cerebral palsy (CP) is the leading cause of neurological disability in children, with a prevalence of 2-2.5 per 1,000 live births in Europe.
- Trial name
- PN-ULCP (NCT07915466)
- Testing
- Peripheral neurotomy of the upper limb (musculocutaneous and/or median and/or ulnar).
- Where
- France
- Volunteers
- 21 people
- Sponsor
- Hospices Civils de Lyon
Acute Kidney Injury, Fluid Overload
Early Deresuscitation Strategy Driven by Tissue Perfusion in Renal Replacement Therapy in Patients With Acute Renal Failure
In Intensive Care Unit (ICU) patients with acute kidney injury (AKI) and treated with renal replacement therapy (RRT) often present a fluid overload which is associated with morbidity (mechanical ventilation duration increase…
- Trial name
- EarlyDry (NCT05817539)
- Testing
- Fluid balance negativation, Body weight Stabilization
- Where
- 14 sites in France
- Volunteers
- 250 people
- Sponsor
- Hospices Civils de Lyon
Hormone Therapy-induced Arthralgia, Phytotherapy
Evaluation of the Efficacy and Acceptability of a Phytotherapy Combining Devil's Claw, Blackcurrant and Meadowsweet for the Management of Aromatase Inhibitor-induced Arthralgia in Patients Treated for Localized Breast Cancer in the Adjuvant Setting
Adjuvant hormonotherapy is a cornerstone of treatment for localized hormone receptor-positive (HR+) breast cancer, accounting for approximately 80% of patients.
- Conditions
- Hormone Therapy-induced Arthralgia, Phytotherapy, Symptom Management, Adjuvant Treatment
- Trial name
- ERABLE (NCT07859319)
- Testing
- Phytotherapy Dietary Supplement (Harpagophytum, Meadowsweet, and Blackcurrant), Patient Experience Questionnaire
- Where
- 3 sites in France
- Volunteers
- 105 people
- Sponsor
- Hospices Civils de Lyon
Alcohol Use, Alcohol Consumption
FLOW: Influence of the Menstrual Cycle on Alcohol Use in Women
The FLOW study aims to assess the association between menstrual cycle phases and alcohol consumption in women from the general population.
- Conditions
- Alcohol Use, Alcohol Consumption, Menstrual Cycle, Women's Health
- Trial name
- FLOW (NCT07910643)
- Where
- France
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Intracranial Sacciform Aneurysm
Evaluation of Intestinal Microbiota Implication in Ruptured Intracranial Aneurysm
The physiopathology of intracranial aneurysm from initiation to ruptured is incompletely understood but included inflammation. The microbiota is known to interact with brain and can promote inflammation.
- Trial name
- AneBiote (NCT05914636)
- Testing
- analysis of foecal microbiota
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Hospices Civils de Lyon
Critically Ill Patients, Circulatory Shock
Capillary Refill Time Variation to Predict Oxygen Comsumption Variation After FLuid Challenge (CARTOFL)
Circulatory shock is characterized by tissue hypoxia. Although fluid resuscitation is an essential treatment in many forms of circulatory shock, its benefits are variable, and its administration carries a risk of potentially…
- Conditions
- Critically Ill Patients, Circulatory Shock, Ventilated Patients
- Trial name
- CARTOFL (NCT07837843)
- Testing
- Indirect calorimetry measurement
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Hospices Civils de Lyon
Bulkamid® for Urinary Incontinence, Urinary Incontinence
Quantity of Bulkamid® After Injection for Urinary Incontinence
Bulkamid filler is a gel that we use very regularly to treat female urinary leakage during exercise. It is a minimally invasive technique which is increasingly used around the world because it has almost no adverse effects…
- Conditions
- Bulkamid® for Urinary Incontinence, Urinary Incontinence, Ultrasound
- Trial name
- BULKA3D (NCT07900880)
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Hospices Civils de Lyon
Bulkamid® for Urinary Incontinence, Urinary Incontinence
Perineal Ultrasound After Bulkamid® Injection for Urinary Incontinence
There are currently different treatment options in the management of stress urinary incontinence (SUI). Given a risk of complications inherent to prosthetic reinforcement and numerous current controversies over the use of a…
- Conditions
- Bulkamid® for Urinary Incontinence, Urinary Incontinence, Ultrasound
- Trial name
- BULKPOS (NCT07900906)
- Testing
- Improvement in patients' symptoms
- Where
- France
- Volunteers
- 70 people
- Sponsor
- Hospices Civils de Lyon
Neurostimulation, TENS
Transcutaneous Electrical Neurostimulation After Ablation of Essure®
The ESSURE® device is an implantable medical device for definitive and irreversible sterilization indicated for adult women of childbearing age. These implants are inserted into the fallopian tubes by hysteroscopy.
- Conditions
- Neurostimulation, TENS, Vagus Nerve, Neurostimulation After Ablation of Essure
- Trial name
- TENSES (NCT07900971)
- Testing
- Improvement in patients' symptoms
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Hospices Civils de Lyon
Hyperthermic Intraperitoneal Chemotherap, Colorectal Cancer Metastatic
Cost-utility Evaluation of Cytoreductive Surgery With or Without Mitomycin-C Hyperthermic Intraperitoneal Chemotherapy (HIPEC) for Resectable Colorectal Peritoneal Metastases
Colorectal cancer is the second leading cause of cancer death in France, with close to 50,000 new cases each year. About half of the patients develop liver, lung and/or peritoneal metastases during the course of the…
- Conditions
- Hyperthermic Intraperitoneal Chemotherap, Colorectal Cancer Metastatic, Peritoneal Metastases, Cytoreductive Surgery
- Trial name
- ECO-CHIP (NCT07901075)
- Volunteers
- 398 people
- Sponsor
- Hospices Civils de Lyon
Bronchiolitis, Clinical Phenotype
Short-Term Enteral Nutrition for Infants With Bronchiolitis in Pediatric Emergency Departments
Bronchiolitis is a common viral infection of the small airways that affects infants, particularly during respiratory syncytial virus epidemics.
- Conditions
- Bronchiolitis, Clinical Phenotype, Nutritionnal Impairment, Short-Term Enteral Nutrition
- Trial name
- STENP-PER (NCT07901400)
- Testing
- Usual inpatient bronchiolitis care, STENP-PER care pathway
- Where
- 8 sites in France
- Volunteers
- 448 people
- Sponsor
- Hospices Civils de Lyon
Puberty, Precocious
First Observatory of Precocious Puberty.
The age of puberty has fluctuated throughout history. Recent data shows an increase in the age of onset of puberty signs, in the United States but also in Europe.
- Trial name
- PAPPEL (NCT06263868)
- Where
- 23 sites in France
- Volunteers
- 3,360 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Osteomyelitis Chronic
Evaluation of the Efficiency of the Bone Substitute Cerament-G Locally Delivering Gentamicin in the Treatment of Chronic Osteomyelitis of Long Bones
Chronic osteomyelitis is a serious osteoarticular infection that most often occurs in the long bones (tibia, femur, humerus), responsible for significant morbidity with risk of fracture and amputation.
- Trial name
- CONVICTION (NCT04805164)
- Testing
- Corticotomy and use of the bone substitute : Cerament-G device., Corticotomy
- Where
- 15 sites in France
- Volunteers
- 220 people
- Sponsor
- Hospices Civils de Lyon
Smith-Magenis Syndrome, Autism Spectrum Disorder
Smith Magenis Syndrome and Autism Spectrum Disorders
Autism Spectrum Disorders (ASD) are a neurodevelopmental disorder. Their prevalence is estimated at around 0.4% of the general population worldwide.
- Trial name
- SMS/TSA (NCT05116904)
- Testing
- Assessment
- Where
- 2 sites in France
- Volunteers
- 40 people
- Sponsor
- Hospices Civils de Lyon
Bladder Calculi, Continent Catheterizable Urinary Reservoir
Comparison of Trans-Stomial Bladder Lithotripsy Using Mini-Percutaneous Equipment Versus Trans-stomial Bladder Lithotripsy Using Flexible Fibroscope, Percutaneous Approach and Open Cystolithotomy in Patients With Continent Catheterizable Urinary Reservoir
The urological management of neurological patients is crucial to ensure patient survival and improve their quality of life. The natural progression of disease in central neurological bladders typically involves a major decrease…
- Conditions
- Bladder Calculi, Continent Catheterizable Urinary Reservoir, Trans-Stomal Bladder Lithotripsy, Open Cystolithotomy
- Trial name
- Mini-DUCC (NCT07643454)
- Testing
- QoL-DUCC questionnaire, Qualiveen Questionnaire
- Where
- 2 sites in France
- Volunteers
- 80 people
- Sponsor
- Hospices Civils de Lyon
Craniostenosis
Multimodal Mechanical, Tissue, Architectural, and Histological Evaluation of the Bone and Sutures of the Parietal Bone in an Infant With Craniosynostosis.
The human skull is a complex structure that protects the underlying tissues, including the brain. Certain rare conditions and diseases, such as craniosynostosis-which affects 1 in 2,000 to 2,500 children-impair these functions…
- Trial name
- CRANIOMECA (NCT07650981)
- Testing
- Biological sample, bones sample and questionaires.
- Where
- France
- Volunteers
- 80 people
- Sponsor
- Hospices Civils de Lyon
Anaesthetic Induction, Respiratory Complications of Care
Two Modalities of Ventilation on the Occurrence of Respiratory Complications During Inhalational Anaesthetic Induction in Children
Induction of anesthesia by inhalation is the most common method of induction (70% in France) for young children admitted for non-emergency surgery. It has the advantage of not requiring an intravenous line.
- Conditions
- Anaesthetic Induction, Respiratory Complications of Care, Pediatrics, Ventilation
- Trial name
- PEDIAMOVE (NCT07767851)
- Testing
- Induction with PEEP (5 cmH2O) and PSV (2-12 cmH2O), Induction in spontaneous breathing
- Where
- 9 sites in France
- Volunteers
- 2,032 people
- Sponsor
- Hospices Civils de Lyon