Clinical trials: sponsored by Institut du Cancer de Montpellier - Val d'Aurelle
Rectal Cancer, Chemoradiotherapy
Multidimensional Study Designed to Develop a Methodological Framework Based on MRI Data to Predict Pathological Complete Response (pCR) in Patients With Locally Advanced Rectal Cancer After Neoadjuvant Treatment
Rectal cancer presents a significant global health challenge. Despite improvements in clinical outcomes, significant disparities persist across Europe.
- Conditions
- Rectal Cancer, Chemoradiotherapy, Mri
- Trial name
- RESTAGE (NCT07404228)
- Testing
- questionnaire completion
- Where
- France
- Volunteers
- 115 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Cancer, Lung Cancer, Non-Small Cell
Analysis of Circulating Tumor Markers in Blood - ALCINA 5
The circulating tumoral biomarkers in the blood are the object of numerous researches for several decades. The potential clinical interests of these circulating biomarkers are diagnostic, prognostic, predictive of the efficiency…
- Trial name
- ALCINA 5 (NCT07060950)
- Testing
- Blood sampling C1
- Where
- France
- Volunteers
- 620 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Breast Cancer
Clinical Database of Safe Personalized Adjuvant Breast Radiotherapy Based on Individual Radiosensitivity
Severe but also moderate toxicities after curative-intent radiotherapy (RT), such as a poor cosmetic outcome following breast cancer can have a negative impact on quality of life and a marked effect on subsequent psychological…
- Trial name
- SAHARA-01 (NCT04282122)
- Testing
- Radiotherapy
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Lung Cancer, Bronchial Cancer
Development of Clinical and Biological Database on Bronchial Cancer
A Clinical and Biological Database will provide to the scientific community a collection of blood and tissues with clinical data to improve knowledge about cancer and help to develope new cancer treatments.
- Trial name
- BCBPoumon (NCT07085429)
- Testing
- Blood and tissue sampling
- Where
- France
- Volunteers
- 750 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
High Grade Serous Ovarian Cancer
Unravelling Tumour Biology In Ovarian Cancer With Precision Imaging
The objective of this study is to explore the integration of in vivo and ex vivo of MRI with histology and molecular assessments to advance non-invasive characterization of tumor heterogeneity in high-grade serous ovarian cance
- Trial name
- MR-O-MICS (NCT06084195)
- Testing
- Blood sample and tissue sample
- Where
- France
- Volunteers
- 120 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Metastatic Colorectal Cancer
Sorafenib With Irinotecan in Metastatic Colorectal Cancer (mCRC) and K-RAS Mutation
A multicentre two-part phase I/II study evaluating response and safety of SORAFENIB in combination with irinotecan in the second line treatment or more of metastatic colorectal cancer with K-RAS mutation.
- Trial name
- NEXIRI (NCT00989469)
- Testing
- Nexavar (Sorafenib) and irinotecan (Campto)
- Where
- 5 sites in France
- Volunteers
- 64 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Breast Cancer, Physiotherapy
Evaluation of the Impact of Pre-habilitation Using Physiotherapy and Mechanical Stimulation on Shoulder Pain and Mobility in Patients Undergoing Breast Reconstruction Using a Latissimus Dorsi Flap
Each year in France, nearly 59,000 new cases of breast cancer are diagnosed, and approximately 22,000 mastectomies are performed. Among these patients, 30% choose to undergo breast reconstruction.
- Conditions
- Breast Cancer, Physiotherapy, Breast Reconstruction, Latissimus Dorsi Flap
- Trial name
- PREHAB KINELGD (NCT07418060)
- Testing
- Prehabilitation with physiotherapy including mechanostimulation, No Prehabilitation with physiotherapy including mechanostimulation
- Where
- 2 sites in France
- Volunteers
- 96 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Thyroid Cancer, Prostate Cancer
Clinico-biological Database in Patients Treated With Metabolic Radiotherapy in the Nuclear Medicine Department
Development of a clinico-biological database allowing the provision of clinical data and corresponding biological materials to the medical and scientific community.
- Conditions
- Thyroid Cancer, Prostate Cancer, Neuroendocrine Tumors, SSTR Positive Tumors
- Trial name
- BCB RIV (NCT04104529)
- Testing
- Biological collection, tumor collection
- Where
- 4 sites in France
- Volunteers
- 350 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Cervical Cancer, Brachytherapy
Impact of an Educational Physiotherapy-Yoga Intervention on Perceived Stress in Women Treated With Brachytherapy for Cervical Cancer
Every year in France, nearly 3,000 women develop a cervical cancer. The average age of women diagnosed is 51. Uterovaginal brachytherapy is one of the reference treatments.
- Trial name
- KYOCOL (NCT06263283)
- Testing
- session of Kine-Yoga
- Where
- 3 sites in France
- Volunteers
- 98 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Rectal Cancer, Colon Cancer
Contribution of Preserving the Superior Left Colic Artery to the Vascularization of the Descending Colon Prior to Colorectal Anastomosis During Left-Sided or Rectal Resections for Colorectal or Ovarian Cancer. (Revascularisation Colique)
Colorectal cancers and ovarian cancers are respectively the 2nd and 5th cause of cancer mortality in France. Surgical resection is a crucial step in the therapeutic management of colorectal cancers.
- Conditions
- Rectal Cancer, Colon Cancer, Ovarian Cancer
- Trial name
- NCT07098182
- Testing
- Clamping and restauration of arterial blood of the inferior mesenteric artery
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Thyroid Cancer
Predictive Value of microRNA in Thyroid Cytologies of Undetermined Type
The aim is to validate a signature of microRNA (micro Ribonucleic acid) based in a first exploratory study allowing the stratification of the cytologies of indeterminate type and to study and select others.
- Trial name
- PREDICYTHY (NCT04285476)
- Testing
- Signature of microRNA for patients with bethesda classification 3, 4 or 5
- Where
- 3 sites in France
- Volunteers
- 71 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Anal Cancer, Sexuality
Assessment of Patients' Quality of Sexual Life After Anal Cancer Treatment
The purpose of this this study, to evaluate the quality of sexual life of patients treated for anal cancer treated by radiotherapy, during their treatment, then 3 months after treatment and, finally, 2 years after treatment.
- Conditions
- Anal Cancer, Sexuality, Psychologic Stress, HPV
- Trial name
- SEQUOIA (NCT05109468)
- Testing
- Quality of life questionnaire
- Where
- France
- Volunteers
- 46 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Locally Advanced Malignant Neoplasm, Rectal Carcinoma
Study Evaluating the Tailored Management of Locally-advanced Rectal Carcinoma
Locally advanced rectal carcinoma raise the issue of both the oncological control, local and general, and the therapeutic morbidity.
- Trial name
- GRECCAR14 (NCT04749108)
- Testing
- Induction chemotherapy - modified FOLFIRINOX regimen, Early tumor response evaluation by MRI volumetry, Radiochemotherapy Cap 50
- Where
- 30 sites in France
- Volunteers
- 1,075 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Cancer Survivors, Peripheral Neuropathic Pain
Evaluating Laser Photobiomodulation for the Treatment of Neuropathic Pain in Chemotherapy-induced Peripheral Neuropathy in Cancer Patients
Chemotherapy-induced peripheral neuropathy (CIPN) (including taxanes, platinum, al pervenche from Madagascar alkaloids...), is a frequent secondary effect of treatments: 68% at 1-month post-chemotherapy, 60% at 3 months and 30%…
- Trial name
- NEUROdoux (NCT06834685)
- Testing
- Photobiomodulation sessions
- Where
- 2 sites in France
- Volunteers
- 70 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Metastatic Invasive Breast Cancer
Rising ctDNA to Tailor Endocrine Therapy Switch in Patients With ER+/HER2- Metastatic Breast Cancer.
Rationale: In patients with metastatic breast cancer, fragments of tumor DNA called "circulating tumor DNA" or "ctDNA" can be detected in the blood.
- Trial name
- TAILORswitch (NCT07717450)
- Testing
- Tumor assessment, Completion of Quality-of-life questionnaires, ECG
- Volunteers
- 370 people
- Sponsor
- UNICANCER
Invasive Breast Cancer, Breast-conserving Surgery
Observational Study of Intra-operative Partial Irradiation of Invasive Ductal Breast Carcinomas With a Good Prognosis
Due to screening, T1N0 early-stage breast cancer now accounts for more than 50% of the tumors diagnosed in France. The prognosis of these tumors is good, even excellent in women ≥ 65 years of age, with specific survival of 98% at…
- Trial name
- INTRA-OBS (NCT04414202)
- Testing
- tumorectomy with axillary dissection (sentinel lymph node), per-operative partial irradiation
- Where
- France
- Volunteers
- 519 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Prostate Cancer
Evaluation of Late Toxicity Following Intensity-Modulated Radiotherapy and Two Image-Guided Strategies With Corresponding Treatment Margins.
The Calypso® System (Varian Medical Systems, Inc., Palo Alto, CA) is a recent technology using electromagnetic transponders implanted within the prostate.
- Trial name
- RCMIGI (NCT03254420)
- Testing
- Calypso beacon implant, moderate hypofractionation Radiotherapy
- Where
- France
- Volunteers
- 74 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Breast Cancer, Biopsy Wound
Pain Monitoring After Breast Biopsy: Benefit of E-health
Each year, approximately 1500 breast biopsies (1000 microbiopsies and 500 macrobiopsies) are performed in the radiologic department of the Montpellier Cancer Institute (ICM).
- Trial name
- BIO-PSY (NCT04456920)
- Testing
- phone consultation, e-PRO self-completed via connected objects (tablet/phone), visit
- Where
- France
- Volunteers
- 193 people
- Sponsor
- Institut du Cancer de Montpellier - Val d'Aurelle
Cancer, Immunotherapy
Retrospective Study of COVID-19 Vaccines in Patients Undergoing Immunotherapy for Cancer.
The investigators wish to set up a pharmaco-epidemiological cohort within the Hospital Territorial Groups of the Cévennes-Gard Camargue, East-Hérault and Haute-Garonne and West Tarn on a specific population, patients undergoing…
- Trial name
- IVACOV (NCT05025514)
- Where
- 5 sites in France
- Volunteers
- 125 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Cervical Cancer Stage IA1, Cervical Cancer Stage IB1
Research of Circulating Tumor Cells Released During Cervical Cancer Surgery
Cervical cancer is a rare pathology. Recent studies showed that the risk of recurrence is higher for patients treated by coelioscopy in comparison with laparotomy.
- Conditions
- Cervical Cancer Stage IA1, Cervical Cancer Stage IB1, Cervical Cancer Stage IA2, Cervical Cancer Stage IB2
- Trial name
- CTC-COL (NCT04770090)
- Testing
- Blood samples
- Where
- 3 sites in France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Montpellier