Clinical trials: sponsored by McMaster University
Orthopaedic Fractures, Socioeconomic Factors
Trial of Social Work Services in Fracture Clinic Setting
Every year, many Canadians sustain a fracture that requires surgical treatment and results in a long recovery period. During this recovery period, patients may experience new or worsening mental health issues including…
- Trial name
- SWRCT (NCT06973655)
- Testing
- Social Work support
- Where
- 2 sites in United States, Canada
- Volunteers
- 2,000 people
- Sponsor
- Sheila Sprague
Knee Arthroplasty, Total, Partial Knee Arthroplasty
Opioid Reduction and Enhanced Recovery in Orthopaedic Surgery (OREOS)-Knee
Knee replacements are the second most common surgery in Canada. Most patients recover very well but research consistently shows that 1 in 5 patients still have pain many months after surgery.
- Conditions
- Knee Arthroplasty, Total, Partial Knee Arthroplasty, Chronic Pain, Postoperative, Osteoarthritis (OA) of the Knee
- Trial name
- OREOS-K (NCT07895472)
- Testing
- Standard care, Multicomponent opioid reduction and pain management pathway
- Volunteers
- 170 people
- Sponsor
- McMaster University
Open tíbia Fracture
Antibiotic Cement Bead Pouch Versus Negative Pressure Wound Therapy
The Beads vs Vac trial is a multi-centre randomized controlled trial of 312 participants with a severe open tibia fracture requiring multiple irrigation and debridement surgeries.
- Trial name
- BeadsvsVac (NCT05615844)
- Testing
- Antibiotic Cement Bead Pouch, Negative Pressure Wound Therapy
- Where
- 35 sites in United States, Canada
- Volunteers
- 312 people
- Sponsor
- University of Maryland, Baltimore
Cancer
Partner4Exercise Study
Background: As Canada's population ages, the number of older adults facing cancer is on the rise. By 2030, 23% of Canadians will be over 65, and two in five will be diagnosed with cancer in their lifetime.
- Trial name
- P4E RCT (NCT07408128)
- Testing
- Peer matching, Quailfied Exercise Professional (QEP) Support
- Where
- Canada
- Volunteers
- 183 people
- Sponsor
- McMaster University
Obesity (Disorder)
Mechanisms of Weight Loss: Tirzepatide vs Semaglutide
The goal of this clinical trial is to determine if there are differences in the effect of 12 weeks of tirzepatide versus semaglutide on energy balance in adults with obesity and without known diabetes.
- Trial name
- JOULE3 (NCT07900074)
- Testing
- Tirzepatide, Semaglutide
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- McMaster University
Healthy Nutrition
Sex Differences in Metabolism Following a High-fat Meal
Long-term consumption (i.e., several weeks to months) of a diet that is high in fat (>35% daily calories from fat) is associated with the development of insulin resistance, a condition that can lead to a diagnosis of type 2…
- Trial name
- HFM (NCT05332301)
- Testing
- High-fat test meal
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Kirsten Bell
Glucose Homeostasis
Postprandial Glucose Handing in Contraceptive and IUD Users
Goals: The long-term use of hormonal birth control has been shown to effect glucose handling, or blood sugar regulation, and potentially lead to insulin resistance which increases a person's risk for metabolic diseases such as…
- Trial name
- HCPG (NCT07169591)
- Testing
- Oral Glucose Tolerance test (75g 2-hour)
- Where
- Canada
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- McMaster University
Labour Dystocia
Oral Sodium Bicarbonate for the Prevention of Labour Dystocia
Sodium bicarbonate is often used by athletes to improve their muscle's ability to contract and power their activity. It works by decreasing the risk of lactic acid build-up, which causes cramping and fatigue.
- Trial name
- Labour-Aide (NCT06249061)
- Testing
- oral sodium bicarbonate
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Liz Darling
Mechanical Ventilation, Critically Ill Intensive Care Unit Patients
Ketamine Sedation in the ICU (KANINE) RCT
Sedation is given to intensive care unit (ICU) patients to treat discomfort, anxiety, agitation, and to help facilitate care, particularly when they require a breathing tube.
- Trial name
- KANINE (NCT06767358)
- Testing
- ketamine hydrochloride
- Where
- 3 sites in Canada
- Volunteers
- 54 people
- Sponsor
- McMaster University
Knee Osteoarthritis
Cannabinoids vs. Placebo on Persistent Post-surgical Pain Following TKA: A Pilot RCT
Each year, approximately 75,000 Canadians undergo knee replacement surgery, and up to 25% develop persistent post-surgical pain.
- Trial name
- NCT03825965
- Testing
- MPL-001 (CBD: THC 25:1)
- Where
- 2 sites in Canada
- Volunteers
- 39 people
- Sponsor
- McMaster University
Atrial Fibrillation, Atrial Flutter
Pericardiotomy in Cardiac Surgery
PRINCE is an international, multicentre, randomized controlled trial of posterior pericardiotomy in patients without a history of atrial fibrillation (AF) or flutter undergoing cardiac surgery.
- Conditions
- Atrial Fibrillation, Atrial Flutter, Cardiac Events
- Trial name
- PRINCE (NCT06486636)
- Testing
- Left Posterior Pericardiotomy
- Where
- 19 sites in United States, Austria and 3 more
- Volunteers
- 1,400 people
- Sponsor
- Population Health Research Institute
Diabetic Macular Edema
Mean Visual Acuity Changes Following Five Injections of Aflibercept
Diabetic Macular Edema is a serious ocular consequence of poorly controlled diabetes. Even though significant research has been done to clarify the pathogenesis of DME, a clear causal pathway of the complication is of yet…
- Trial name
- NCT02645266
- Testing
- Aflibercept Injection [Eylea]
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- McMaster University
Cough, Refractory Chronic Cough
A 2x2 Factorial, Randomized, Open-label Trial to Evaluate Neuromodulators and Cough Control Therapy in Patients With Refractory or Unexplained Chronic Cough
The FORTITUDE trial will provide head-to-head evidence on the benefits and harms of two commonly prescribed neuromodulators (low-dose morphine and pregabalin), the effectiveness of a virtual cough control therapy, exploratory…
- Conditions
- Cough, Refractory Chronic Cough, Unexplained Chronic Cough, Cough Hypersensitivity Syndrome
- Trial name
- FORTITUDE (NCT07288528)
- Testing
- Morphine Sulphate, Morphine Sulphate + Cough Control Therapy, Pregabalin
- Where
- 5 sites in Canada
- Volunteers
- 124 people
- Sponsor
- McMaster University
Cancer
The IMPACT Implementation-Effectiveness Trial
More Canadians are surviving cancer, however, individuals with cancer live with side effects for years after treatments have ended.
- Trial name
- IMPACT (NCT06323707)
- Testing
- Exercise, Self-management e-module
- Where
- 3 sites in Canada
- Volunteers
- 129 people
- Sponsor
- McMaster University
Late-Onset Neonatal Sepsis, Extreme Prematurity
Dopamine vs. Norepinephrine for Hypotension in Very Preterm Infants With Late-onset Sepsis
Fluid-unresponsive hypotension needing cardiotropic drug treatment is a serious complication in very preterm neonates with suspected late-onset sepsis (LOS; defined as culture positive or negative bloodstream infection or…
- Conditions
- Late-Onset Neonatal Sepsis, Extreme Prematurity, Neonatal Hypotension
- Trial name
- NCT05347238
- Testing
- Dopamine, Norepinephrine
- Where
- 22 sites in United States, Canada and 3 more
- Volunteers
- 550 people
- Sponsor
- Mount Sinai Hospital, Canada
Community-acquired Pneumonia
Optimizing Care for Children Hospitalized With Community-acquired Pneumonia: Novel Diagnostics
Children are commonly hospitalized because of community-acquired pneumonia. Despite the fact that many of these children have viral disease, a majority is treated with antibiotics.
- Trial name
- PRESTO-1 (NCT06114888)
- Testing
- MeMed BV + Usual Care, Usual Care Alone
- Where
- Canada
- Volunteers
- 75 people
- Sponsor
- Jeffrey Pernica
Type 2 Diabetes, Mental Health
Technology-Enabled Collaborative Care for Diabetes and Mental Health
Managing both type 2 diabetes and mental health challenges can be difficult, and many people do not receive care that supports both.
- Conditions
- Type 2 Diabetes, Mental Health, Diabetes Distress
- Trial name
- TECC-DM (NCT07181863)
- Testing
- Health coaching, Educational emails
- Where
- 2 sites in Canada
- Volunteers
- 160 people
- Sponsor
- McMaster University
Female, Premenopausal
The Influence of Plan B® on Cardiovascular Health.
The goal of this double-blind randomized controlled trial is to learn about the impacts of a single dose of Plan B® on the cardiovascular system in young, health, premenopausal females.
- Trial name
- LEVOH (NCT07759635)
- Testing
- Plan B (Levonorgestrel)
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- McMaster University
Chronic Disease, Aging
Compassionate Communities Neighbourhood Program
This study will evaluate a Compassionate Communities-based intervention aimed at reducing social isolation by mobilizing individuals to act on their health and social needs individually, and in collaboration with fellow members…
- Trial name
- WECCC-NHB (NCT03634163)
- Testing
- Neighbourhood exchange, Quality of Life Assessment
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- McMaster University
Back Pain
The Effect of Chiropractic Care on Opioid Use for Chronic Spinal Pain: A Feasibility Study
The investigators will conduct a pilot cluster randomized controlled trial (RCT) of chiropractic care added to usual medical care, versus usual medical care alone, for adult patients prescribed opioid therapy for chronic…
- Trial name
- ACCESS-DC (NCT06160947)
- Testing
- Usual Medical Care, Usual Medical Care + Chiropractic Care
- Where
- Canada
- Volunteers
- 24 people
- Sponsor
- McMaster University
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