Clinical trials: sponsored by Menoufia University
Parkinson Disease
Clinical Study to Evaluate the Possible Efficacy of Metformin in Patients With Parkinson's Disease
Parkinson's disease (PD) is one of the most common neurodegenerative diseases characterized by the progressive loss of dopaminergic (DA) neurons in the substantia nigra compacta (SNc) and aggregation of Lewy bodies in neurons.
- Trial name
- NCT05781711
- Testing
- levodopa-carbidopa, Metformin
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Depressive Disorder
Clinical Study to Evaluate the Possible Efficacy of Dapagliflozin and Atorvastatin in Patients With Major Depressive Disorders
Major depressive disorder (MDD) is a significant cause of disability that affects approximately 16% of the world's population and is associated with chronic inflammation.
- Trial name
- NCT05792540
- Testing
- Fluoxetine 20 mg, Dapagliflozin 10mg Tab, Atorvastatin 80mg
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Tanta University
Post Operative Analgesia
Intravenous Ibuprofen Postoperative Analgesia After Abdominal Hysterectomy
The current research is designed to investigate the analgesic efficacy of intravenous ibuprofen on the postoperative analgesic requirements, pain intensity and other recovery parameters.
- Trial name
- NCT05750264
- Testing
- Ibuprofen
- Where
- Egypt
- Volunteers
- 152 people
- Sponsor
- Menoufia University
Analgesia
Comparing Different Regional Blocks for Analgesia After Off-pump Cardiac Surgery
This study aims to compare the analgesic effects of erector spinae plane block versus Superficial Parasternal Intercostal Plane Block block along with rectus sheath block after off-pump cardiac surgery
- Trial name
- NCT05763810
- Testing
- Erector Spinae Plane Block, Superficial Parasternal Intercostal Plane Block combined with Rectus Sheath Block
- Where
- Egypt
- Volunteers
- 22 people
- Sponsor
- Amal Gouda Elsayed Safan
Induced Menopause
Nurse-Led Self-Compassion Intervention for Women With Induced Menopause
This study evaluated the effectiveness of a nurse-led self-compassion intervention on self-compassion, menopausal symptom severity, and self-esteem among women with medically induced menopause.
- Trial name
- NCT07884357
- Testing
- Nurse-Led Self-Compassion Intervention
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Aya Ibrahim
Inflammatory Bowel Diseases
Repurposing Fenofibrate in Modulating AMPK/NLRP3 Inflammasome in Patients With Ulcerative Colitis
Fibrates, specific pharmacological agonists of PPARα, have been widely used to treat hypercholesterolemia and hypertriglyceridemia.
- Trial name
- NCT05781698
- Testing
- Mesalamine, Fenofibrate
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Tanta University
Anatomical Distal Fibular Plate, Conservative Treatment
Anatomical Distal Fibular Plate and Conservative Treatment in Management of Infrasyndesmotic Fibular Fracture
The aim of this study is to evaluate the functional and radiological outcome of treatment of infrasyndesmotic distal fibula fracture by operative management by anatomical distal fibular plate vs conservative treatment and to…
- Conditions
- Anatomical Distal Fibular Plate, Conservative Treatment, Infrasyndesmotic Fibular Fracture
- Trial name
- NCT07872540
- Testing
- Anatomical distal fibular plate., Conservative treatment
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Menoufia University
Edentulism Complete
Accuracy of Complete-Arch Implant Scans Using Non Calibrated Splinting Scanbodies
This randomized crossover clinical study will evaluate and compare the accuracy and chairside time of two non-calibrated splinting systems, IoConnect and Scan Pro, for obtaining complete-arch implant digital scans.
- Trial name
- NCT07862218
- Testing
- Scan Pro, IoConnect
- Where
- Egypt
- Volunteers
- 24 people
- Sponsor
- Menoufia University
Breast Cancer, Radiotherapy Induced Fatigue
Efficacy of High-Dose Melatonin in Alleviating Radiotherapy-Induced Fatigue in Breast Cancer Patients
To assess the role of High-Dose Melatonin in Alleviating Radiotherapy-Induced Fatigue in Breast Cancer Patients. The primary end point is assessment of fatigue severity .
- Trial name
- NCT07865988
- Testing
- Melatonin
- Where
- Egypt
- Volunteers
- 51 people
- Sponsor
- Menoufia University
Edentulism in Lower Jaw
Accuracy of Immediate Implant Placement
This randomized clinical study will compare the accuracy of immediate implant placement performed using three different surgical approaches: freehand surgery, conventional tooth-supported static computer-guided surgery, and a…
- Trial name
- NCT07863700
- Testing
- Freehand Immediate Implant Placement, Tooth-Supported Static Computer-Guided Implant Placement, Tooth- and Socket-Supported Static Guided Implant Placement
- Where
- Egypt
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Menoufia University
Bilateral Inguinal Hernia Repair, Open Upper Abdominal Surgeries
Ultrasound-guided Quadratus Lumborum Block Versus Erector Spinae Plane Block for Postoperative Analgesia in Children Undergoing Elective Open Lower Abdominal Surgeries
To compare the postoperative analgesic efficacy of ultrasound-guided Quadratus Lumborum Block (anterior approach) versus Erector Spinae Plane Block (T10-T12 level), both performed bilaterally with 0.25% bupivacaine (0.5 mL/kg per…
- Trial name
- NCT07853586
- Testing
- ultrasound guided anterior oudratus lumborum block, Ultrasound guided erector spinae plane block
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Menoufia University
Cesarean Section, Spinal Anesthesia
Low Dose Hyperbaric Bupivacaine and Dexmedetomidine as an Adjuvant, Caesarean Section
The aim of this study is to evaluate the effectiveness of low dose scheme with dexmedetomidine as an adjuvant. Taking in consideration optimum intraoperative surgical conditions, best post-operative pain free experience, and more…
- Conditions
- Cesarean Section, Spinal Anesthesia, Dexmedetomidine
- Trial name
- NCT03775655
- Testing
- Dexmedetomidine
- Where
- Egypt
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Menoufia University
Autoimmune Encephalitis (AE)
Plasma Exchange in Pediatric Autoimmune Encephalitis
The aim of the study will be to compare the efficacy of daily plasma exchange (PLEX) versus alternate-day PLEX in achieving a favorable functional outcome in children with autoimmune encephalitis.
- Trial name
- PE/AIE (NCT07707739)
- Testing
- Plasma exchange (PE)
- Where
- Egypt
- Volunteers
- 22 people
- Sponsor
- Menoufia University
Severe Sepsis
Plasma Exchange in Children With Severe Sepsis and Septic Shock
The aim of the study will be to to evaluate whether therapeutic plasma exchange (TPE) reduces mortality in critically ill children with severe sepsis or septic shock compared to the standard care of sepsis alone.
- Trial name
- PE/Sepsis (NCT07706413)
- Testing
- Plasma exchange (PE)
- Where
- Egypt
- Volunteers
- 22 people
- Sponsor
- Menoufia University
Treatment of Non-monosymptomatic Nocturnal Enuresis
Efficacy of Mirabegron for Treatment of Non-monosymptomatic Nocturnal Enuresis in Children
This phase 3 clinical trial will compare use of individual treatment with mirabegron or desmopressin and their combination for treatment of non-monosymptomatic nocturnal enuresis in children
- Trial name
- NCT07398261
- Testing
- Mirabegron 25 MG
- Where
- Egypt
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- Menoufia University
Urethral Stricture, Anterior, Urethral Stricture Disease
Outcomes of Double-face Augmentation Urethroplasty
Combined dorsal and ventral onlay augmentation for bul¬bar urethral reconstruction. Nontraumatic near-obliterative bulbar urethral strictures (BUS) of <2 cm in length can be managed with non-transecting anastomotic bulbar…
- Trial name
- BMG (NCT07436819)
- Testing
- Double-face augmentation urethroplasty
- Where
- 2 sites in Egypt
- Volunteers
- 30 people
- Sponsor
- Menoufia University
Prophylactic, Anticoagulation
Prophylactic Anticoagulation for Central Venous Line Insertion in Critically Ill Children
This will be a Prospective, randomized, open- label, parallel-group, center trial, which will include 80 of Children which will be admitted at Pediatric Intensive Care Unit (PICU) of Menoufia university Hospital from August 2026…
- Trial name
- NCT07710482
- Testing
- Enoxaparin
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Menoufia University
Sepsis and Septic Shock
Dynamic SvO2 in Predicting Fluid Responsiveness in Septic Shock
This prospective observational diagnostic accuracy study investigates the efficacy of dynamic central venous oxygen saturation in predicting fluid responsiveness in septic shock, compared to measurements obtained using…
- Trial name
- NCT07516236
- Testing
- Measuring dynamic central venous oxygen saturation (ScvO2) at baseline and after fluid challenge. Measuring Cardiac output by echocardiography or cardiometry at baseline and after fluid challenge.
- Where
- Egypt
- Volunteers
- 115 people
- Sponsor
- Menoufia University
Liver Resection, Upper Abdominal Surgeries
Comparative Effects of ESP Block and EOIP Block on Postoperative Respiratory Recovery Following Liver Resection
This study evaluates respiratory recovery as a multidimensional construct using clinically relevant and measurable parameters, including LUS, diaphragmatic excursion, oxygen requirement, and PPCs.
- Trial name
- NCT07740382
- Testing
- Ultrasound-guided bilateral external oblique intercostal plane (EOIP) block, Ultrasound-guided bilateral erector spinae plane (ESP) block
- Where
- Egypt
- Volunteers
- 116 people
- Sponsor
- Menoufia University
Quadratus Lumborum Block, Transversus Abdominis Plane Block
Quadratus Lumborum Block, Transversus Abdominis Plane Block, and Erector Spinae Block in Pediatric Abdominal Surgery
The aim of this study is to compare the analgesic efficacy and safety of Quadratus Lumborum (QL), Transversus Abdominis Plane (TAP), and Erector Spinae Plane (ESP) blocks in pediatric abdominal surgery.
- Conditions
- Quadratus Lumborum Block, Transversus Abdominis Plane Block, Erector Spinae Plane Block, Pediatric
- Trial name
- NCT07850596
- Testing
- Quadratus lumborum (QL) block, Transversus abdominis plane (TAP) block, Erector spinae plane (ESP) block
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Menoufia University