Clinical trials: sponsored by NYU Langone Health
Metastatic Clear Cell Renal Cell Carcinoma
Effects of Belzutifan on 89Zr-DFO-girentuximab PET Uptake in Patients With Renal Cell Carcinoma (RCC)
The purpose of this study is to identify changes in Carbonic Anhydrase IX (CAIX) expression induced by hypoxia-inducible factor 2 alpha (HIF-2α) inhibition by initiating belzutifan single agent therapy and imaging CAIX expression…
- Trial name
- NCT07179770
- Testing
- Belzutifan, 89Zr-DFO-girentuximab, 89Zr-DFO-girentuximab PET
- Where
- United States
- Sponsor
- NYU Langone Health
Acute Kidney Injury (AKI), Postnatal AKI
NIRS Monitoring in the NICU and AKI
The primary objective of this study is to describe the pattern of renal tissue oxygen saturation (SrSO2) using near-infrared spectroscopy (NIRS) in premature infants <30 weeks gestational age.
- Trial name
- NCT07222722
- Testing
- NIRS Monitoring
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Prostate Adenocarcinoma
SURPASS: Stereotactic Ultra-hypofractionated Radiotherapy for Post-prostatectomy Patients: Adaptive Salvage SBRT
The purpose of the study is to evaluate the safety and feasibility of daily-adaptive post-prostatectomy stereotactic body radiotherapy (SBRT) to the prostate fossa in men undergoing salvage radiotherapy after radical…
- Trial name
- NCT07888283
- Testing
- Adaptive stereotactic body radiotherapy (SBRT)
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- NYU Langone Health
Dementia
Inpatient Hospice Transitions Checklist
This is an NIH Stage IB single-arm feasibility study will adapt and test the Inpatient Hospice Transitions Checklist (I-HTC), an Epic-embedded intervention supporting hospice eligibility assessment and clinician-surrogate…
- Trial name
- I-HTC (NCT07889830)
- Testing
- I-HTC
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- New York University
Hearing Loss
Nucleus Hybrid L24 Extended Duration Post Approval Study
This post approval study evaluates the long term safety and efficacy of the Nucleus Hybrid L24 Implant System in a group of already implanted recipients.
- Trial name
- HED (NCT02379273)
- Testing
- Nucleus Hybrid L24 Implant
- Volunteers
- 35 people
- Sponsor
- Cochlear
Tracheomalacia
Dynamic Airway CT is Diagnostic for Tracheomalacia in Children
The purpose of this pilot interventional study is to evaluate the use of Dynamic Airway Computed Tomography (DA-CT) for diagnosis of tracheomalacia in children 0-18 years for whom flexible bronchoscopy has been performed.
- Trial name
- NCT06028646
- Testing
- Dynamic Airway CT scan (DA-CT)
- Where
- 2 sites in United States
- Volunteers
- 14 people
- Sponsor
- NYU Langone Health
Biliary Track Cancer
Histotripsy in Biliary Tract Cancer
The purpose of this pilot study is to examine the safety and feasibility of histotripsy in two cohorts of 12 patients each with Biliary Track Cancer (BTC), with a plan to expand to a larger multi-center study if both safety and…
- Trial name
- NCT07853690
- Testing
- Gemcitabine, Cisplatin, Durvalumab
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- NYU Langone Health
Pulmonary Embolism
Pulmonary Embolism - Thrombus Removal With Catheter-Directed Therapy
PE-TRACT is an open-label, assessor-blinded, randomized trial, aiming to compare catheter-directed therapy (CDT) and anticoagulation (CDT group) with anticoagulation alone (No-CDT) in 500 patients with submassive PE, proximal…
- Trial name
- PE-TRACT (NCT05591118)
- Testing
- Anticoagulant Therapy, Catheter-Directed Therapy
- Where
- 40 sites in United States
- Volunteers
- 500 people
- Sponsor
- NYU Langone Health
Vascular Anomalies, Vascular Anomaly
24VA022; VATCH Alpelisib for TIE2/PIK3CA Pathway VAs
The study will enroll participants 2 months of age up to 30 years of age. The purpose of this study is to assess the effectiveness and safety of Alpelisib (the "Study Drug") in patients with PIK3CA/TIE-2/TEK pathway driven…
- Conditions
- Vascular Anomalies, Vascular Anomaly, TIE2/PIK3CA Pathway Driven Vascular Anomalies
- Trial name
- VATCH (NCT07543822)
- Testing
- alpelisib (BYL719)
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Children's Hospital of Philadelphia
Ras/MAPK Pathway Vascular Anomalies, Vascular Anomalies
24VA021; VATCH Trametinib for Ras/MAPK Pathway VAs
The purpose of this study is to assess the effectiveness and safety of Trametinib (the "Study Drug") in patients with Ras/MAPK pathway driven vascular anomalies (VA). Trametinib has been approved by the U.S.
- Conditions
- Ras/MAPK Pathway Vascular Anomalies, Vascular Anomalies, Vascular Anomaly
- Trial name
- VATCH (NCT07549646)
- Testing
- Trametinib
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Children's Hospital of Philadelphia
Heart Failure, Heart Failure New York Heart Association Class III
Inspiratory Muscle Training in Hospitalized Patients With Heart Failure Awaiting Advanced Therapies
The primary objective of this study is to evaluate the feasibility and safety of inspiratory muscle training (IMT) when implemented as part of routine inpatient physical therapy care in patients undergoing evaluation for advanced…
- Conditions
- Heart Failure, Heart Failure New York Heart Association Class III, Heart Failure New York Heart Association Class IV
- Trial name
- NCT07862738
- Testing
- POWERbreathe KH2, Usual Care
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- NYU Langone Health
Squamous Cell Carcinoma of Head and Neck
Candida Therapeutic Vaccine in Head and Neck Cancer Patients to Reduce Recurrence
This is a Phase II randomized, double-blind, placebo controlled, multi-site study of Candin. It is designed to show the efficacy and safety of a 7-dose regimen of Candin over a two-year period in terms of reducing cancer…
- Trial name
- NCT05952934
- Testing
- 0.5 mL Candin®/injection
- Where
- 6 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Arkansas
Non-Small Cell Lung Cancer With Mutation in Epidermal Growth Factor Receptor
Osimertinib and Cyclosporine A to Enhance Antitumor Efficacy in NSCLC
This single-site, biomarker-enriched, randomized Phase II study will evaluate osimertinib with or without cyclosporine A (CsA) in metastatic epidermal growth factor receptor (EGFR )-mutant non-small cell lung cancer (NSCLC) [exon…
- Trial name
- OCEAN (NCT07874490)
- Testing
- Osimertinib, Cyclosporine A (CsA), ctDNA Biopsy Panel
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- NYU Langone Health
Advanced Cancer
Psilocybin Therapy in Advanced Cancer
The purpose of this research is to study the safety and effects of single-dose psilocybin 25mg versus an active placebo (single dose niacin 100mg) in the treatment of anxiety, depression, and existential distress (i.e., loss of…
- Trial name
- NCT05398484
- Testing
- Psilocybin 25 mgs, Niacin 100mg, Psychotherapy
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- NYU Langone Health
Hepatitis b Virus, Hepatitis B
HepB mAb19 in Individuals With Chronic Hepatitis B Infection
This is a first-in-human, placebo-controlled, single dose, dose-escalation phase 1 study to evaluate the safety, pharmacokinetics and antiviral activity of a highly potent neutralizing anti-HBV monoclonal antibody (mAb), HepB…
- Trial name
- NCT05856890
- Testing
- HepB mAb19, Sterile Saline
- Where
- 2 sites in United States
- Volunteers
- 37 people
- Sponsor
- Rockefeller University
Metabolic Testing
The Metabolic Response of Unweighted Treadmill Walking
This study will use an experimental quantitative research design. Participants will serve as their own control with a metabolic assessment by open circuit spirometry when walking on the Alter G treadmill for less than ten minutes…
- Trial name
- NCT07870434
- Testing
- AlterG Treadmill, Metabolic Assessment
- Where
- 2 sites in United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- NYU Langone Health
Adenotonsillectomy, Postoperative Pain
Preoperative Celecoxib and Acetaminophen Versus Acetaminophen Alone for Pain Control After Pediatric Adenotonsillectomy
This is an open-label randomized study of approximately 500 pediatric patients (2-18 years of age, weighing more than 10 kg) undergoing adenotonsillectomy.
- Trial name
- NCT07870447
- Testing
- Celecoxib, Acetaminophen, Dexamethasone
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- NYU Langone Health
Pre Diabetes, Weight Loss
Integrated Community-Clinical Linkage Model to Promote Weight Loss Among South Asians With Pre-Diabetes
The study "Integrated Community-Clinical Linkage Model to Promote Weight Loss among South Asians with Pre-Diabetes" is a two-arm randomized control trial that analyzes the implementation and effectiveness of a multi-component…
- Trial name
- NCT03188094
- Testing
- CHW-Led Health Coaching, EHR Alerts
- Where
- United States
- Volunteers
- 974 people
- Sponsor
- NYU Langone Health
Glaucoma, Glaucoma, Open-Angle
Electrical Stimulation for the Treatment of Glaucoma
The overall aim of this study is to see whether long-term electrical stimulation with a home-stimulation device works well and is safe for the treatment of open-angle glaucoma.
- Trial name
- rtACS (NCT05626491)
- Testing
- Repetitive, Transorbital Alternating Current Stimulation (rtACS)
- Where
- 4 sites in United States, Germany
- Volunteers
- 45 people
- Sponsor
- Stanford University
Migraine
RELAXaHEAD for Headache Patients (Phase III)
This study is a fully powered, remote randomized control trial to evaluate RELAXaHEAD in people with migraine.
- Trial name
- NCT06077838
- Testing
- RELAXaHEAD Smartphone App Version 1, RELAXaHEAD Smartphone App Version 2
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- NYU Langone Health