Clinical trials: sponsored by Nova Scotia Health Authority
Ascending Aortic Aneurysm Enlargement, Ascending Aorta Aneurysm
Treatment in Thoracic Aortic Aneurysm: Surgery vs Surveillance
The ascending aorta conducts blood from the heart to the rest of the body. The ascending aorta can become enlarged, and the risk of tearing and rupturing becomes higher with larger aorta.
- Trial name
- TITAN:SvS (NCT03536312)
- Testing
- Thoracic Aortic Surgery
- Where
- 31 sites in United States, Canada and 1 more
- Volunteers
- 610 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Sedative Adverse Reaction, Anticholinergic Adverse Reaction
Pharmacist Led Intervention to Improve Medication Use in Older In-patients Living With Frailty: the Drug Burden Index
Older people in Canada commonly take multiple medicines for their health conditions. Certain medicines, especially when taken together can lead to serious harms, such as falls.
- Trial name
- NCT03698487
- Testing
- Intervention
- Where
- Canada
- Volunteers
- 198 people
- Sponsor
- Emily
Post-operative Pain, Acute, Opioid Use, Unspecified
Patient Centered Post-Op Pain Management Software Tool Interventional Study Verses Standard of Care
The goal of this clinical trial is to learn if the Pain Coach App will result in less opioids being prescribed to and used by patients undergoing Shoulder/Hip/Knee Arthroplasty surgery while maintaining the same or better pain…
- Conditions
- Post-operative Pain, Acute, Opioid Use, Unspecified, Arthroplasty Complications, Knee Osteoarthritis
- Trial name
- NCT06469177
- Testing
- Pain Coach App
- Where
- Canada
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Eating Disorders
Impact of Peer Mentors on Individuals Transitioning to Adult Eating Disorder Treatment
Participants will be males and females aged 16-24 with an eating disorder (ED) diagnosis who are transitioning to adult-oriented ED treatment in Nova Scotia, New Brunswick, or Prince Edward Island.
- Trial name
- TAY-Mentors (NCT05543044)
- Testing
- Peer mentor intervention
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- Nova Scotia Health Authority
Bariatric Surgery Patients, Disordered Eating Behaviors
Implementing an Interdisciplinary Eating Disorder Screening and Treatment Program for Post-Bariatric Surgery Patients in Nova Scotia
The goal of this interventional study is to evaluate the Treatment and Evaluation for After Metabolic Surgery with Eating Disorders (TEAM-ED) program, which combines streamlined access to screening, diagnostic assessment, and…
- Trial name
- TEAM-ED (NCT06914219)
- Testing
- Treatment and Evaluation for After Metabolic Surgery with Eating Disorders (TEAM-ED) Program
- Where
- Canada
- Volunteers
- 250 people
- Sponsor
- Aaron Keshen
Atrial Fibrillation (AF), Heart Failure With Mildly Reduced Ejection Fraction
Treating Atrial Fibrillation in Heart Failure With Preserved Ejection Fraction: Ablation or Medication
This study is testing two different ways of treating atrial fibrillation (AF) in people who also have heart failure with mildly reduced or preserved heart function.
- Conditions
- Atrial Fibrillation (AF), Heart Failure With Mildly Reduced Ejection Fraction, Heart Failure With Preserved Ejection Fraction (HFPEF), Rate Control
- Trial name
- NCT07272902
- Testing
- Catheter Ablation for Atrial Fibrillation, Rate Control Medications (beta-blockers, calcium channel blockers, digoxin)
- Where
- 4 sites in Canada
- Volunteers
- 84 people
- Sponsor
- Nova Scotia Health Authority
Mechanical Ventilation, Cardiac Surgery
Planned Operating-Room Extubation After Cardiac Surgery
The goal of this clinical trial is to learn whether removing the breathing tube in the operating room after cardiac surgery helps adults recover faster than removing the breathing tube later in the intensive care unit (ICU)…
- Conditions
- Mechanical Ventilation, Cardiac Surgery, Fast Track Program,(Enhanced Recovery After Surgery (ERAS))
- Trial name
- NCT07874607
- Testing
- Planned Operating-Room Extubation, Standard Early ICU Extubation
- Where
- 2 sites in Canada
- Volunteers
- 336 people
- Sponsor
- Nova Scotia Health Authority
Traumatic Brain Injury, Mild Traumatic Brain Injury
Memantine Targeting Neurovascular Dysfunction After Mild and Moderate Traumatic Brain Injury (MEND)
The goal of this pilot clinical trial is to learn whether memantine can be given safely and successfully to adults in hospital with a mild or moderate traumatic brain injury (TBI).
- Conditions
- Traumatic Brain Injury, Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury (TBI), TBI
- Trial name
- MEND (NCT07867210)
- Testing
- Memantine
- Where
- Canada
- Volunteers
- 45 people
- Sponsor
- Nova Scotia Health Authority
Gender Affirming Surgery, Mastectomy
Gender Affirming Mastectomy Analgesia Rial
Introduction: Optimizing pain management after gender-affirming mastectomy (removal of breast tissue, aka top surgery) surgery is important for recovery and minimizing opioid use.
- Conditions
- Gender Affirming Surgery, Mastectomy, Acute Pain
- Trial name
- GAMA (NCT07861165)
- Testing
- Paravertebral (single injection), Wide local infiltration
- Where
- Canada
- Volunteers
- 64 people
- Sponsor
- Nova Scotia Health Authority
Stroke
Using Omnidirectional Virtual Reality and Treadmill Training for Chronic Stroke
The primary objective of this pilot randomized controlled trial (RCT) is to test the feasibility (consent rate, retention rate, participant burden, adherence, technical issues, safety) and usability (system usability scale, SUS)…
- Trial name
- PROVE (NCT06495450)
- Testing
- Omnidirectional Virtual Reality and Treadmill Training, Traditional Exercise
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Nova Scotia Health Authority
Hiv, Syphilis
Validation of Self Testing Using the INSTI Multiplex HIV1/2 Syphilis Antibody Test
This study aims to validate the percent agreement of the INSTI Multiplex Human Immunodeficiency (HIV) 1/2 syphilis antibody (Ab) test (INSTI POCT) when used as a self-test by patients compared to conventional serologic testing.
- Trial name
- NCT06953024
- Testing
- INSTI HIV/syphilis Point of Care Self-Test Administration
- Where
- Canada
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Nerve Block, Regional Anesthesia
Training Non-Anesthesia Personnel to Perform Nerve Blocks in Microgravity
Space exploration is rapidly progressing with multiple upcoming missions planned to the moon and International Space Station, and projected missions to Mars in the early 2030s.
- Conditions
- Nerve Block, Regional Anesthesia, Microgravity, Space Analogue
- Trial name
- Block-aid (NCT07849049)
- Testing
- Simulated microgravity, Normal earth gravity
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- Nova Scotia Health Authority
Regional Anesthesia, Regional Anesthesia Morbidity
Impact of Communication Delays on Anesthesia Response to Medical Emergencies and Ultrasound-Guided Regional Anesthesia
Hypotheses The investigators hypothesize that a communication delay of 80 seconds compared to no delay will be associated with longer procedural times and decreased quality during brachial plexus block scanning.
- Conditions
- Regional Anesthesia, Regional Anesthesia Morbidity, Regional Anesthesia Success, Remote Consultation, Teleconsultation
- Trial name
- ICARUS (NCT07675863)
- Testing
- Real-time communication, Delayed communication
- Where
- Canada
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
First Episode Psychosis (FEP), Psychosis
Mobile Application-Based Interventions for Cannabis Use in Young Adults With First Episode Psychosis
Psychotic disorders affect approximately 4% of Canadians and have a significant impact on individuals' well-being, their families and social networks, and healthcare systems.
- Conditions
- First Episode Psychosis (FEP), Psychosis, Schizophreni-form Disorder, Dependence Addictive
- Trial name
- Mobile Health (NCT07811466)
- Testing
- CHAMPS, I Can Change
- Volunteers
- 550 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Inflammatory Bowel Diseases, Ulcerative Colitis
IBD Strong Peer2Peer for Self-Management of Psychological Distress
Psychological distress (PD) as a result of inflammatory bowel disease (IBD) is prevalent and associated with worse disease-related outcomes.
- Conditions
- Inflammatory Bowel Diseases, Ulcerative Colitis, Crohn Disease
- Trial name
- NCT05722236
- Testing
- IBD Strong Peer2Peer, Waitlist control
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Jennifer Jones
IBS - Irritable Bowel Syndrome
Evaluating the Impact of Including Virtual Dietary Education Within an Electronic Irritable Bowel Syndrome Pathway
Irritable bowel syndrome is a functional bowel disorder that affects many Canadians. The syndrome involves abdominal pain and change in frequency or form of bowel movements, and these symptoms can lead to a decreased quality of…
- Trial name
- NCT05721742
- Testing
- virtually administered dietitian consults for IBS patients., IBS Group Online Session
- Where
- Canada
- Volunteers
- 71 people
- Sponsor
- Nova Scotia Health Authority
Inflammatory Bowel Disease (Crohn&Amp;#39;s Disease and Ulcerative Colitis)
A Mindfulness-based Stress Reduction Program for IBD
The gut-brain connection is important for good health and when it is disrupted it can worsen existing chronic disease. Studies have shown that chronic stress has negative effects on the gastrointestinal tract such as inflammation…
- Trial name
- MBSRforIBD (NCT07266883)
- Testing
- Mindfulness based stress reduction, Active Control
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Nova Scotia Health Authority
Pacemaker
Virtual E-health System for Pacemakers
While remote monitoring (RM) technology is currently available and has permitted surveillance and device assessment from any patient location, the use has been inconsistent in Canada, where only 8500 out of a potential 120 000…
- Trial name
- VIRTUES PM (NCT03636230)
- Testing
- Remote Monitoring, Standard of care
- Where
- 11 sites in Canada
- Volunteers
- 848 people
- Sponsor
- Ratika Parkash
Stroke
YOGA-FIT: Protocol for a Crossover Trial Investigating the Feasibility and Impact of Yoga for People With Stroke
The primary objective of this mixed-methods pilot crossover study is to determine the feasibility (participant satisfaction, recruitment rate, retention, participant and assessor burden, adherence, equipment and technology…
- Trial name
- YOGA-FIT (NCT07143162)
- Testing
- LoveYourBrain Yoga
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Nova Scotia Health Authority
Cardiac Arrhythmia
Virtual E-health System for Implantable Cardioverter Defibrillators
This is a Canadian multicenter randomized controlled trial to assess remote patient management. Patients will be randomized to remote patient management with VIRTUES versus usual care, and will be stratified by RemoteView vs no…
- Trial name
- VIRTUES ICD (NCT03405740)
- Testing
- Remote Patient Management, Standard of Care
- Where
- 12 sites in Canada
- Volunteers
- 1,115 people
- Sponsor
- Ratika Parkash