Clinical trials: sponsored by Rush University Medical Center
Chronic Low-back Pain
Efficacy of Spinal Manipulation Therapy or Mindfulness-based Reduction Therapy on Patients With Chronic Low Back Pain
Chronic Pain Management (CPM) has increasingly utilized long-term opioid analgesic therapy, a change associated with increased opioid abuse (a greater exposure in vulnerable individuals), non-pain health consequences (hormone…
- Trial name
- NCT04744883
- Testing
- Spinal Manipulation Therapy (SMT), Naloxone, Mindfulness Based Stress Reduction Therapy (MT)
- Where
- 2 sites in United States
- Volunteers
- 140 people
- Sponsor
- Rush University Medical Center
Candida Auris Infection, Colonization, Asymptomatic
Nasal Antisepsis for C. Auris Prevention
This is a randomized, controlled, open-label trial of effect of 10% povidone iodine intranasal antisepsis on the detection of Candida auris.
- Trial name
- NCT06282510
- Testing
- Povidone Iodine Topical
- Where
- 3 sites in United States
- Volunteers
- 120 people
- Sponsor
- Mary K Hayden
PTSD - Post Traumatic Stress Disorder
Evaluating Evidenced Based Options for PTSD Treatment
This study will look at: How practical it is to offer another round of proven therapy. How effective different therapy options are for people who didn't respond to the first treatment.
- Trial name
- NCT06733376
- Testing
- Cognitive Processing Therapy, Prolonged Exposure, Skills Training for Affective and Interpersonal Regulation
- Where
- United States
- Volunteers
- 400 people
- Sponsor
- Rush University Medical Center
Inflammatory Bowel Disease
A Randomized Crossover Trial of Bright Light Therapy in Crohn's Disease on Intestinal Barrier Homeostasis
Crohn's Disease (CD) and Ulcerative Colitis (UC), collectively known as inflammatory bowel disease (IBD), are two of the most significant chronic conditions of the gastrointestinal tract (GIT) and affects over 1.5 million…
- Trial name
- NCT05579392
- Testing
- Bright Light Therapy
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Rush University Medical Center
Spontaneous Breathing Trial in ICU
Automatic Tube Compensation vs. Pressure Support Ventilation During Spontaneous Breathing Trials in Adults
For patients requiring mechanical ventilation, spontaneous breathing trials (SBTs) are conducted to determine if it is safe to remove the breathing tube. There are multiple methods for conducting SBTs.
- Trial name
- NCT07005505
- Testing
- Pressure Support Ventilation (PSV), Automatic tube compensation (ATC)
- Where
- United States
- Volunteers
- 880 people
- Sponsor
- Rush University Medical Center
Total Knee Arthroplasty
Oral Tranexamic Acid After Total Knee Arthroplasty
This is a prospective, double-blind, randomized controlled trial evaluating the efficacy of oral tranexamic acid (TXA) in total knee arthroplasty (TKA).
- Trial name
- NCT06894719
- Testing
- tranexamic acid Oral-Short Arm, tranexamic acid Oral-Long Arm
- Volunteers
- 351 people
- Sponsor
- Rush University Medical Center
Type 2 Diabetes
E3 Diabetes - Closing the Gap in Diabetes Control
This study aims to decrease the racial gap in type 2 diabetes control in African American and Latinx patients in Rush University Medical Center clinics.
- Trial name
- E3Diabetes (NCT06643936)
- Testing
- E3 Multidisciplinary Team, E3 Self-Guided Type 2 Diabetes Education
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Rush University Medical Center
Hypertension
E3 Hypertension - A Team-based, Multidisciplinary Model in Addressing Barriers to Hypertension Control
This study aims to compare a multidisciplinary clinical hypertension and social needs intervention to enhanced standard of care for hypertension management in primary care clinics with regards to hypertension control outcomes.
- Trial name
- NCT06899750
- Testing
- E3 Multidisciplinary Team, E3 Self-Guided Hypertension Education Program
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Rush University Medical Center
COPD
COPD Resources, Education, and Activity Designed for You Study
Although COPD self-management treatment programs are effective in reducing COPD-related hospitalizations and increasing quality of life, there is a limited understanding of 'how and why' they work.
- Trial name
- COPD READY (NCT07125053)
- Testing
- Education (self-guided), Education (counselor-led), Physical Activity
- Where
- United States
- Volunteers
- 448 people
- Sponsor
- Rush University Medical Center
Alzheimer Disease, Dementia
Preventing Medication Mismanagement in People Living With Dementia Through Automated Medication Dispensing With Facial Recognition and Video Observation
Globally, >47M individuals live with dementia, with new incidence of 7.7M annually. Medication mismanagement is one of the most common and concerning risk factors in people with dementia (PwD), as it leads to undertreatment…
- Conditions
- Alzheimer Disease, Dementia, Medication Adherence, Type 2 Diabetes Mellitus (T2DM)
- Trial name
- NCT06691256
- Testing
- HiDO-ALZ
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- HiDO Technologies
Cognitive Decline, Dementia, Vascular
Mediterranean-DASH Intervention for Neurodegenerative Delay (MIND) Diet in Stroke Patients Patients
To test the effects of a 2- to 3-year intervention of the MIND diet versus usual post-stroke care on cognitive decline, the characteristic feature of dementia, and on brain biomarkers of Alzheimer's Disease (AD) and vascular…
- Conditions
- Cognitive Decline, Dementia, Vascular, Alzheimer Disease, Dementia
- Trial name
- NCT04337255
- Testing
- Behavioral Dietary intervention ( MIND Diet), Behavioral Usual Care Diet Intervention
- Where
- United States
- Volunteers
- 266 people
- Sponsor
- Rush University Medical Center
Degenerative Disc Disease, Herniated Nucleus Pulposus
The Course of Hip Flexion Weakness Following LLIF or ALIF
The purpose of this study is to assess the course of hip weakness after LLIF or ALIF procedures. These outcomes include measures of hip strength using a dynamometer, which is a device used to measure muscle strength.
- Conditions
- Degenerative Disc Disease, Herniated Nucleus Pulposus, Spondylolisthesis
- Trial name
- NCT04204135
- Testing
- LLIF or ALIF procedures
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Rush University Medical Center
Overweight and Obesity
Circadian Timing, Information Processing and Energy Balance Study
This study design will test biological and behavioral mechanisms in the cross-sectional analyses and determine the prospective effects of circadian alignment and sleep on changes in cardiometabolic risk factors.
- Trial name
- TIME (NCT04759755)
- Where
- United States
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- University of Utah
Heart Diseases
Use of Bedside Imaging and Community Health Workers for Early Screening and Referral of Pre-symptomatic Stage B Heart Failure in the Emergency Department
The goal of this clinical trial is to learn if using point-of-care ultrasound (POCUS) can increase participant engagement and changes in behavior among adults with risk factors for pre-symptomatic heart failure presenting to the…
- Trial name
- NCT06769880
- Testing
- Ultrasound and Educational Intervention, Educational Intervention Alone
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Respiration, Artificial, Weaning
Optimal Timing for Spontaneous Breathing Trials
This study aims to explore how the timing of Spontaneous Breathing Trials (SBTs) affects recovery in adult patients who are on mechanical ventilation in the ICU.
- Trial name
- NCT06561295
- Testing
- Later Morning Timing of Spontaneous Breathing Trials
- Where
- United States
- Volunteers
- 348 people
- Sponsor
- Rush University Medical Center
Ulcerative Colitis
Chronotherapy of 5-Aminosalicylic Acid in Ulcerative Colitis
The hypothesis of this study is that appropriate time of day of administration of oral, once daily 5-ASA therapy in alignment with the host circadian rhythms will improve subclinical inflammation and microbial structure/function…
- Trial name
- NCT05213234
- Testing
- Chronotherapy
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- Rush University Medical Center
Pleural Infection Bacterial, Pleural Infections
Once Daily Intrapleural Enzyme Therapy in Complicated Parapneumonic Effusion or Empyema
The goal of this clinical trial is to find out if giving certain medications once a day works just as well as giving them twice a day to treat infections around the lungs (called pleural infections).
- Conditions
- Pleural Infection Bacterial, Pleural Infections, Pleural Infections and Inflammations, Empyema, Pleural
- Trial name
- ONLY ONCE (NCT07095361)
- Testing
- Fibrinolytic once daily, Fibrinolytic twice daily, DNA degradation once daily
- Where
- 11 sites in United States
- Volunteers
- 270 people
- Sponsor
- University of North Carolina, Chapel Hill
Mechanical Ventilation
Prognostic Estimates Among ICU Clinicians
One challenge with decision making for mechanically ventilated is that their prognosis is often uncertain. The ProVent-14 score incorporates clinical variables measured on the 14th day of mechanical ventilation to predict risk of…
- Trial name
- NCT06452797
- Testing
- ProVent-14 score
- Where
- 3 sites in United States
- Volunteers
- 238 people
- Sponsor
- Rush University Medical Center
Acute Hypoxemic Respiratory Failure, High-Flow Nasal Cannula Therapy
Protocolized Weaning of High-Flow Nasal Cannula in Adult Patients
High-flow nasal cannula (HFNC) is a type of oxygen therapy commonly used in adults with breathing problems. While HFNC can help patients avoid breathing tubes and improve oxygen levels, there is no standard method for deciding…
- Trial name
- PRO-WEAN HFNC (NCT07452406)
- Testing
- Protocolized HFNC Weaning Strategy, Usual Care HFNC Weaning
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- Rush University Medical Center
Parkinson Disease (PD), PARKINSON DISEASE (Disorder)
GBPDC: Gut-Brain in PD Consortium Master Protocol
The purpose of this research study is to identify the role that the gut-brain axis, the group of nerves that connect the brain and gut, plays in Parkinson's disease (PD).
- Conditions
- Parkinson Disease (PD), PARKINSON DISEASE (Disorder), Gut Microbiome, Gut Microbiota
- Trial name
- GBPDC (NCT07567794)
- Where
- 7 sites in United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Duke University