Clinical trials: sponsored by The Cleveland Clinic
Migraine, Depressive Symptoms
Treatment for Migraine and Mood
The researchers propose a three-arm pilot study of Mindfulness-Based Cognitive Therapy (MBCT) delivered via telephone (MBCT-T), video (MBCT-V) or Enhanced Usual Care (EUC).
- Trial name
- TEAM-M (NCT05576467)
- Testing
- MBCT-Telephone, MBCT-Video, Enhanced Usual Care (EUC)
- Where
- 3 sites in United States
- Volunteers
- 145 people
- Sponsor
- Amanda Shallcross
Stool Spore Colony Forming Units, Microbiome Composition
Aimmune Longitudinal Collaboration Study
This study will include healthy households around the Irvine, CA area (based local to employees) and Tempe, AZ and Philadelphia, PA sites that will be instructed to take a daily fiber supplement (2.5 tablespoons of chia seeds…
- Conditions
- Stool Spore Colony Forming Units, Microbiome Composition, Dietary Fiber, Stress
- Trial name
- FIBER-IMPACT (NCT07218640)
- Testing
- Chia seeds
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aimmune Therapeutics, Inc.
Dermatomyositis
Topical Ruxolitinib Cream for Refractory Cutaneous Dermatomyositis
This study will assess the safety and efficacy of topical ruxolitinib for treating the refractory cutaneous manifestations in patients with dermatomyositis.
- Trial name
- NCT06857240
- Testing
- Ruxolitinib Topical Cream
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- The Cleveland Clinic
Cardiac Disease
Hemodynamic Effect of Norepinephrine Versus Vasopressin on the Pulmonary Circulation in Cardiac Surgery Patients:
The relative increase in the mPAP with the same unit increase in MAP adjusted for baseline, and RV function assessed by GLS, between VP and NE in patients with normal and increased pulmonary artery pressure, who require…
- Trial name
- NCT04501861
- Testing
- Vasopressin, Norepinephrine
- Where
- United States
- Volunteers
- 153 people
- Sponsor
- The Cleveland Clinic
Atrial Fibrillation, Postoperative Atrial Fibrillation
SGB for Prevention of Postop A-Fib After Cardiac SurgeryTrial
This research study is being conducted to determine whether a stellate ganglion block, a small injection in the neck that temporarily reduces sympathetic nervous system activity, can help reduce the risk of developing…
- Trial name
- NCT07893275
- Testing
- Stellate Ganglion Block Injection with 10 mL 0.5% Bupivacaine, Stellate Ganglion Block Injection with 10 mL Normal Saline
- Volunteers
- 60 people
- Sponsor
- The Cleveland Clinic
Cardiac Surgery
Low Tidal Volume Ventilation With Hyperoxia Avoidance During Cardiopulmonary Bypass (The FOCUS Trial)
This is a multi-institutional study (CCF, UPMC, OSU) evaluating different ventilation strategies during cardiopulmonary bypass on mortality and postoperative pulmonary complications, with sub-study investigating…
- Trial name
- NCT04978636
- Testing
- Continuous low-tidal volume ventilation with using FiO2 of 0.21, Continuous low tidal volume ventilation with using FiO2 of 1.0, Apnea During CPB
- Where
- United States
- Volunteers
- 5,502 people
- Sponsor
- The Cleveland Clinic
Hernia Abdominal Wall, Botox Injection
Preoperative BOTOX® Injection for Large Ventral Hernia Repair
This study is for adults who need open surgery to repair a very large abdominal (ventral) hernia. This study tests whether a one-time, image-guided injection of a medicine commonly known as "BOTOX®" (onabotulinumtoxinA) into the…
- Conditions
- Hernia Abdominal Wall, Botox Injection, Hernia Incisional Ventral, Hernia Repair With Compartment Syndrome
- Trial name
- PRETOX (NCT07220382)
- Testing
- OnabotulinumtoxinA Injection, OnabotulinumtoxinA, 0.9 % Normal Saline
- Where
- United States
- Volunteers
- 188 people
- Sponsor
- The Cleveland Clinic
Parkinson Disease, Freezing of Gait
Decoding the Neural Mechanisms Underlying Postural Instability and Gait Dysfunction in Parkinson's Disease
The purpose of this study is to learn how brain signals are related to freezing of gait (FOG) and balance problems in Parkinson's disease (PD) and to study how different deep brain stimulation (DBS) settings may affect these…
- Trial name
- NCT07748962
- Testing
- Multiple Deep Brain Stimulation (DBS) Conditions, Moving Overground in a Virtual Environment (MOVE), Cleveland Clinic Stair Ambulation and Functional Evaluation of Gait (SAFE-Gait)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- The Cleveland Clinic
Paraesophageal Hernia, GERD
Mesh Vs Pledgets for Repair of Paraesophageal Hernia
The goal of this clinical trial is to compare whether the use of Ovitex mesh provides superior reduction in 2-year recurrence compared to pledgeted suture closure (no mesh) for patients undergoing paraesophageal hernia repair at…
- Trial name
- NCT05974722
- Testing
- OviTex Mesh, Pledgeted sutures
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- David Krpata
Kidney Stone
Randomized Controlled Trial of Miniaturized Percutaneous Nephrolithotomy With Vacuum-Assisted Access Sheaths Versus Conventional Sheaths for Treatment of Nephrolithiasis
The purpose of this study is to compare two variations of the mini-PCNL procedure using either a vacuum-assisted sheath or standard sheath which are both used for the surgical treatment of kidney stones.
- Trial name
- NCT05993546
- Testing
- vacuum assisted sheath, passive suction via conventional sheath
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- The Cleveland Clinic
Parkinson's Disease, Deep Brain Stimulation
Neural Mechanisms of Aerobic Exercise Benefits in PD With DBS
This study is focused on people with Parkinson's disease who already have deep brain stimulation devices. The goal is to understand how aerobic exercise, specifically forced vs voluntary cycling, affects movement, thinking, and…
- Trial name
- NCT07442747
- Testing
- Exercise
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- The Cleveland Clinic
Parkinson Disease
Genetics and Aerobic Exercise to Slow Parkinson's Disease Trial
The proposed multi-site, Genetics and Aerobic Exercise to Slow PD (GEARS) Trial will, for the first time, determine the interplay between genetics and exercise in altering PD progression.
- Trial name
- GEARS (NCT06442033)
- Testing
- High intensity stationary cycling
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Jay Alberts
Patient Engagement
Virtual and Video Counseling Versus In-Office Counseling for Laparoscopic Hysterectomy
Compare preparedness for total laparoscopic hysterectomies between patients who undergo virtual visits and those who undergo in-office visits for pre-operative counseling.
- Trial name
- NCT05086406
- Testing
- Combination of Video and Virtual Pre-operative Counseling
- Where
- United States
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Postoperative Pain
Perioperative Lidocaine and Ketamine in Abdominal Surgery
The investigators propose to test the hypothesis that perioperative infusions of lidocaine and/or ketamine reduce opioid consumption and pain scores in adults recovering from elective inpatient abdominal surgery.
- Trial name
- NCT04084548
- Testing
- Lidocaine and ketamine, Lidocaine, Ketamine
- Where
- United States
- Volunteers
- 420 people, healthy volunteers welcome
- Sponsor
- The Cleveland Clinic
Liver Cirrhoses, Portal Hypertension Related to Cirrhosis
Optimizing Portal Hypertension With TIPS and Interval Metabolic Surgery for Advanced Liver Disease
Cirrhosis is a form of advanced liver disease that can lead to serious complications, especially when combined with severe obesity.
- Conditions
- Liver Cirrhoses, Portal Hypertension Related to Cirrhosis, Severe Obesity, TIPS
- Trial name
- OPTIMAL (NCT07058155)
- Testing
- Transjugular Intrahepatic Portosystemic Shunt (TIPS), Sleeve Gastrectomy, Anti-Obesity Pharmacotherapy (Class Effect)
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- The Cleveland Clinic
Post-Operative Ileus (POI)
At-Home Bowel Stimulation
Postoperative ileus (POI) is a common complication after ileostomy closure and is associated with patient discomfort, delayed return of bowel function, prolonged hospital stay, and increased healthcare costs.
- Trial name
- NCT07574437
- Testing
- At-home bowel stimulation
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- The Cleveland Clinic
Physical Therapy Evaluation
Analysis of a Stepped-Wedge Implementation of the PT-PENCIL Tool
Despite the need to evolve, the fact that physical therapists are a constrained resource prompts the need for care prioritization that is optimally targeted.
- Trial name
- PT-PENCIL Tool (NCT05964205)
- Testing
- Electronic clinical decision support tool
- Where
- United States
- Volunteers
- 9,704 people
- Sponsor
- Brittany Lapin
Dementia (Diagnosis), Mild Cognitive Impairment
Choose Myself (Before) Losing Myself
The purpose of this study is to see if an educational interactive booklet about how dementia progresses throughout a person's life can be a helpful tool for patients to think about future decisions that might need to be made…
- Conditions
- Dementia (Diagnosis), Mild Cognitive Impairment, Alzheimer's Disease Dementia, Alzheimer's Disease
- Trial name
- CYOA (NCT07846566)
- Testing
- CYOA booklet
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- The Cleveland Clinic
Necrotizing Fascitis, Necrotizing Soft Tissue Infection
The Management of Necrotizing Soft Tissue Infection Wounds With Cytal® Wound Matrix and MicroMatrix®
This is a prospective, pilot, parallel group, randomized controlled trial with 1:1 allocation. This will be a single center study coordinated at the Cleveland Clinic Foundation (CCF) Main Campus in Cleveland, Ohio.
- Trial name
- NCT06857708
- Testing
- Cytal® Wound Matrix, MicroMatrix®
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Benjamin T. Miller
Parkinson's Disease
Utilization of Aerobic Exercise to Maintain Neurologic Health
A promising approach to combat the protein aggregation, oxidative stress, and neuroinflammation occurring with PD is consistent aerobic exercise. Dr.
- Trial name
- NCT07882446
- Testing
- Aerobic Exercise
- Volunteers
- 100 people
- Sponsor
- The Cleveland Clinic
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