Clinical trials: sponsored by University Hospital, Clermont-Ferrand
Heart Failure
Evaluation of a French Hospital Discharge Therapeutic Education Program by Nurses for Heart Failure Patient (EduSor)
Heart failure affects 2.3% of the adult French population. Readmission within 30 days doubles the risk of early death within the following 30 to 60 days, as well as the risk of rehospitalization over the subsequent two years.
- Trial name
- EDUSOR (NCT07706543)
- Testing
- Nurse-led discharge education
- Where
- 3 sites in France
- Volunteers
- 412 people
- Sponsor
- University Hospital, Clermont-Ferrand
Metabolic Syndrome, Vascular Compliance
Orange Juice, Hesperidin and Their Role in Vascular Health Benefit
Although epidemiological studies have associated the consumption of sugary beverages with adverse health effects, experimental studies have demonstrated that the metabolic response of the human body to fruit juice as compared to…
- Conditions
- Metabolic Syndrome, Vascular Compliance, Predisposition to Cardiovascular Disease
- Trial name
- HESPER-HEALTH (NCT04731987)
- Testing
- Beverage consumption
- Where
- France
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
PARKINSON DISEASE (Disorder), Bipolar 1 Disorder
Compulsive Eating and Brain's Reward System in Different Pathologies
Compulsive eating behaviors represent a significant issue across various disorders such as Parkinson's disease, bipolar disorders, and obesity.
- Conditions
- PARKINSON DISEASE (Disorder), Bipolar 1 Disorder, Obesity (BMI>30)
- Trial name
- BI-POTATOS (NCT07923513)
- Testing
- MRI/ MRS (Magnetic Resonance Imaging /Magnetic Resonance Spectroscopy)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Clermont-Ferrand
PCOS (Polycystic Ovary Syndrome)
Efficacy of Ovarian Drilling Via vNOTES Laparoscopy in Patients With PCOS
Polycystic Ovary Syndrome (PCOS) is a common condition among young women (the leading endocrine disorder) and is responsible for 70% of anovulatory infertility cases.
- Trial name
- DRINOTES (NCT07923552)
- Testing
- ovarian drilling by abdominal Laparoscopy, Ovarian drilling by vaginal laparoscopy VNotes
- Where
- France
- Volunteers
- 48 people
- Sponsor
- University Hospital, Clermont-Ferrand
Joint Osteoarthritis, Atherosclerosis of the Distal Arteries, Without Gangrene
Evaluation of Impaired Mobility in Chronic Illness Constitution of a Cohort
Chronic illness is a public health issue and mobility loss is frequent in this population. Among its' multiple physical and psychological consequences, increased mortality and cardiovascular morbidity seem the main concern.
- Conditions
- Joint Osteoarthritis, Atherosclerosis of the Distal Arteries, Without Gangrene, Parkinson Disease, Chronic Obstructive Pulmonary Disease, Unspecified
- Trial name
- EVALMOB (NCT04375280)
- Testing
- Development of a screening algorithm designed to determine a "dysmobility" profile in patients with chronic illness.
- Where
- France
- Volunteers
- 5,000 people
- Sponsor
- University Hospital, Clermont-Ferrand
Congenital Malformations
Contribution of Optical Genome Mapping (OGM) in the Diagnosis of Multiple Congenital Malformations With or Without Intellectual Disability Without Genetic Abnormality
Congenital malformations result from an embryonic or foetal developmental disorder (DD) affecting one or more systems (cardiac, skeletal, nervous, etc.). These are referred to as multiple congenital anomalies (MCAs).
- Trial name
- CARTOGEN-N (NCT07370792)
- Testing
- blood sample
- Where
- France
- Volunteers
- 55 people
- Sponsor
- Céline PEBREL-RICHARD
Aging
Plant-based Diet in Older People: What Consequences for Muscle Health?
This randomized, controlled, two-arm clinical study aims to determine how increasing the proportion of plant-based foods in the diet affects skeletal muscle strength, mass and function, protein metabolism, microbiota and key…
- Trial name
- MYOVEG (NCT07681986)
- Testing
- Plant-enriched dietary intervention, Control diet
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Clermont-Ferrand
Periodontitis, Periodontal Diseases
Evaluation of the Impact of Periodontitis and Its Treatment on Swallowing Functions and Oral Quality of Life
The objective of this single-center prospective study is to evaluate the impact of periodontal treatment on masticatory performance in patients with periodontitis.
- Conditions
- Periodontitis, Periodontal Diseases, Quality of Life
- Trial name
- FI-PAROCROC (NCT07651579)
- Testing
- Functionnal test
- Where
- France
- Volunteers
- 44 people
- Sponsor
- University Hospital, Clermont-Ferrand
TAVI(Transcatheter Aortic Valve Implantation), Left Bundle Branch Block
LBBAP Versus ILR in Patients With New-Onset LBBB and Moderately Reduced LVEF After TAVI
Patients with new-onset complete LBBB (QRS > 120 ms, persisting > 24 h after TAVI) and moderately reduced LVEF (35-50%) will be screened in participating centers.
- Conditions
- TAVI(Transcatheter Aortic Valve Implantation), Left Bundle Branch Block, Reduced Left Ventricular Ejection Fraction
- Trial name
- LBB(AP)TAVI (NCT07909239)
- Testing
- Left bundle branch area pacing with pacemaker, Implantation loop recorder
- Where
- France
- Volunteers
- 700 people
- Sponsor
- University Hospital, Clermont-Ferrand
Intravascular Lithotripsy; Rotational Atherectomy; OFDI
Intravascular Lithotripsy in Comparison to Rotational Atherectomy: An Evaluation by OFDI
The ICARE trial will aim to assess the efficacy of rotational atherectomy by Rotablator and Intravascular Lithotripsy by C2 Shockwave Medical® (IVL) in a randomized fashion in highly calcified lesions measured by final minimal…
- Trial name
- ICARE (NCT05394649)
- Testing
- Intravascular Lithotripsy, Rotational Atherectomy
- Where
- 17 sites in France
- Volunteers
- 178 people
- Sponsor
- University Hospital, Clermont-Ferrand
Chronic Pain
Cohort of Chronic Pain Patients
Chronic pain affects approximately 20% of adults, 50% of the elderly population and over 1.5 billion people worldwide. Societal and economic issues are also crucial, as 60% of people with pain are less able or unable to work and…
- Trial name
- e-DOL cohort (NCT04880096)
- Testing
- eDOL
- Where
- 22 sites in France
- Volunteers
- 5,000 people
- Sponsor
- University Hospital, Clermont-Ferrand
Myocardial Infarction (MI), Sudden Cardiac Death Due to Cardiac Arrhythmia
ODSSEY-SCD_Identification Of Markers to preDict the rISk of Sudden Cardiac Death in Moderated LVEF in ischEmic cardiomyopathY
Although advances in treatment and patient management have considerably improved post-infarction prognosis, the risk of sudden cardiac death remains a major concern.
- Trial name
- ODISSEY (NCT07545512)
- Testing
- This study involved an auxillary CE-marked medical device (implantable holter for cardiac rhythm monitoring)
- Where
- 15 sites in France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Clermont-Ferrand
Sepsis - to Reduce Mortality in the Intensive Care Unit, Septic Shock
Veno-arterial Carbon Dioxide Partial Pressure Difference (CO2gap) for Early Resuscitation of Septic Shock
Sepsis is a dysregulated host response to infection that leads to life-threatening organ dysfunction and represents a major healthcare problem.
- Trial name
- CARBON (NCT07179276)
- Testing
- CO2gap-guided resuscitation strategy
- Where
- 29 sites in France
- Volunteers
- 750 people
- Sponsor
- University Hospital, Clermont-Ferrand
Breast Cancer, Breast Surgery
Evaluation of the Effect of Antibiotic Prophylaxis During Lumpectomy for Breast Cancer: Prospective Randomised Double-blind Noninferiority Study of Placebo vs Cefazolin
The goal of this clinical trial is to determine whether preoperative antibiotic prophylaxis with cefazolin is necessary to prevent surgical site infections in adult women undergoing breast-conserving surgery (lumpectomy or…
- Conditions
- Breast Cancer, Breast Surgery, Surgical Site Infection (SSI), Surgical Site Infection Prevention
- Trial name
- PROPHY-SEIN (NCT07898943)
- Testing
- Cefazolin 2 g Infusion
- Where
- 33 sites in France
- Volunteers
- 1,600 people
- Sponsor
- University Hospital, Clermont-Ferrand
Nausea and Vomiting
Prevalence of Hyperemesis Gravidarum
Nausea and vomiting during pregnancy represent one of the most common symptoms of pregnancy, affecting 35 to 91% of women. Most often, the symptoms are mild, without impairment of quality of life and disappear at the end of the…
- Trial name
- PHyperEG1 (NCT06415084)
- Where
- France
- Volunteers
- 619 people, healthy volunteers welcome
- Sponsor
- University Hospital, Clermont-Ferrand
Fallers Aged 60 Years and Older, Biomarkers / Blood
Contribution of GFAP and UCH-L1 Assays in Whole Blood to Optimizing Personalized Care for "Repeated Fallers" Hospitalized in Geriatric Wards
The BACHUS study focuses on a population of patients aged 75 years and older who are hospitalized after recurrent falls. The objective is to evaluate the performance of an innovative, personalized biological screening strategy to…
- Conditions
- Fallers Aged 60 Years and Older, Biomarkers / Blood, Intracranial Bleeding
- Trial name
- BACHUS (NCT07342023)
- Testing
- blood sampling
- Where
- France
- Volunteers
- 770 people
- Sponsor
- University Hospital, Clermont-Ferrand
Ulcerative Colitis (UC)
FirST Lines of Biologics in pAtients With ulceRaTivE Colitis: a Randomised Controlled Trial
Ulcerative colitis (UC) is a chronic bowel disease. It causes inflammation of the rectum and sometimes the colon. This disease can also affect other parts of the body. It can be very difficult to live with on a daily basis.
- Trial name
- STARTER (NCT07576452)
- Testing
- 1: infliximab 2: filgotinib 3: ustekinumab 4: vedolizumab, 1: ustekinumab 2: vedolizumab 3: infliximab 4: filgotinib, 1: vedolizumab 2: infliximab 3: filgotinib 4: ustekinumab
- Where
- 13 sites in France
- Volunteers
- 240 people
- Sponsor
- University Hospital, Clermont-Ferrand
Severe Chest Trauma
EffecT of eARly analGesia With Erector Spinae Plane Block to Reduce Ventilation After Severe Chest Trauma
Blunt chest trauma is commonly associated with rib fractures and early pain management is a key goal after chest trauma. In spontaneous breathing patients, pain limits coughing efficiency and secretion clearance, thereby…
- Trial name
- TARGET (NCT05920109)
- Testing
- ESP block
- Where
- 14 sites in France
- Volunteers
- 400 people
- Sponsor
- University Hospital, Grenoble
Parkinson s Disease
Primary Parkinsonian Pain: Clinical Association and Phenotype
Among the different types of pain observed in Parkinson's disease, primary parkinsonian pain (PPP) is the most severe, the most difficult to treat, but also the least well characterized and the hardest to describe, not only by…
- Trial name
- PHENOPAIN (NCT07702266)
- Testing
- Online self-administered questionnaire
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Clermont-Ferrand
Periodontitis, Adult, Periodontitis
Evaluation of Masticatory Performance in Patients With Periodontitis
The objective of this observational study is to assess the correlation between the severity of periodontal involvement and masticatory performance in patients with periodontitis.
- Conditions
- Periodontitis, Adult, Periodontitis, Oral Disease
- Trial name
- PAROCHEW (NCT07665489)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Clermont-Ferrand