Clinical trials: sponsored by University Hospital, Limoges
Drug Resistance, Microbial, Biomarkers
INterest of the Negative Predictive Value of Integrons in the reduCtion of Large Broad-spectrum anTibiotics Consumption for Urinary Tract infectionS
Urinary tract infections (UTI), mainly driven by Gram-negative bacteria (GNB) are a frequent cause of hospitalization and the second cause of antibiotic prescription after lower respiratory tract infections.
- Conditions
- Drug Resistance, Microbial, Biomarkers, Urinary Tract Infections (UTI's), Antibacterial Agents
- Trial name
- INVICTUS (NCT07675018)
- Testing
- Detection of integrons, Gold standard
- Where
- 7 sites in France
- Volunteers
- 204 people
- Sponsor
- University Hospital, Limoges
Mentally Ill Old Subjects
Assessment of an Automated Telesurveillance System on Serious Falls Prevention in an Elderly Suffering From Dementia Specialized Care Unit: the URCC
2 URCC in the Limousin region will be equipped with the automated telesurveillance system. Patient will be selected by ward's geriatrician and randomized into two groups after informed consent.
- Trial name
- GET-BETTER (NCT01561872)
- Where
- France
- Volunteers
- 350 people
- Sponsor
- University Hospital, Limoges
Lung Cancer, Exosomes
Molecular Profiling of Exosomes in Tumor-draining Vein of Early-staged Lung Cancer
This is an observational prospective single-center study of 30 patients operated for early-staged non-small cell lung cancer. The main aim is the analysis of molecular profiling of exosome with a sample in tumor-draining vein in…
- Conditions
- Lung Cancer, Exosomes, Non Small Cell Lung Cancer
- Trial name
- ExOnSite-Pro (NCT04939324)
- Testing
- Blood samples at 2 sites: peripheral vein and tumor-draining vein
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Limoges
Thoracic Ultrasound, Pleural Drain Removal
Evaluation of Thoracic Ultrasound in Monitoring Pleural Drainage in Postoperative Thoracic Surgery
The investigator would like to conduct a study in patients undergoing thoracic surgery to evaluate the effectiveness of thoracic ultrasound in the decision to discharge the patient after pleural drain removal.
- Trial name
- EchTHor (NCT05545566)
- Testing
- Thoracic ultrasound versus chest X-ray
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Limoges
Pneumocystis Pneumonia, Pneumocystis Jirovecii Infection
CaspoNEB: Efficacy and Safety of Caspofungin Aerosols for the Curative Treatment of Pneumocystis Pneumonia
To assess the efficacy of administrating daily caspofungin aerosols versus placebo for seven days, in adjunction of conventional systemic antifungal therapy during curative treatment of Pneumocystis pneumonia, on the clinical…
- Conditions
- Pneumocystis Pneumonia, Pneumocystis Jirovecii Infection, Pneumocystis Infections
- Trial name
- CaspoNEB (NCT06892951)
- Testing
- Caspofungin Acetate 50 MG, Physiologic saline
- Where
- 3 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Tours
Geriatrics, Oral Health Care
Evaluation of Efficacy of Coconut Oil Mouth Care for Non-autonomous Hospitalised Elderly People.
This is a prospective, longitudinal, randomised, open-label, multicentric, interventional, comparative superiority study. The main objective is to demonstrate the superiority of oral care with coconut oil on the oral status of…
- Trial name
- COCO-CARE (NCT07406425)
- Testing
- Coconut oil mouth care, Glycerin mouthwashes
- Where
- 2 sites in France
- Volunteers
- 94 people
- Sponsor
- University Hospital, Limoges
Ventilator-associated Pneumonia
B Lymphocyte Populations in the Pulmonary Microenvironment of Patients Under Mechanical Ventilation With or Without VAP (Ventilator-Associated Pneumonia)
Diagnosis of VAP relies on a set of non-specific clinical, biological, and imaging criteria. Understanding host-pathogen interactions and the mechanisms of deregulations leading to infection of pulmonary tissue appears essential.
- Trial name
- OLYMPE (NCT07436780)
- Where
- France
- Volunteers
- 75 people
- Sponsor
- University Hospital, Limoges
Non Small Cell Lung Cancer
Erlotinib and Docetaxel in Second Line of Treatment in Patients With Non Small Cell Lung Cancer
This 2 arms study will compare the efficacy and safety of treatment with sequential erlotinib plus docetaxel therapy versus docetaxel alone as second line treatment in patients with recurrent non-small cell lung cancer.
- Trial name
- TARSEQ (NCT01350817)
- Testing
- Erlotinib + docetaxel, Docetaxel
- Where
- 30 sites in France
- Volunteers
- 156 people
- Sponsor
- University Hospital, Limoges
Cannabis Intoxication in Children
Contamination of Young Children Hair During Acute Cannabis Intoxication
Hair analysis in pediatric cannabis intoxication is limited by possible sudoral self-contamination, especially in young children due to hair porosity. However, adult studies show no THC-COOH in sweat, challenging this hypothesis.
- Trial name
- INTERACTION (NCT07524088)
- Testing
- sudoral and hairing sampling
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Toulouse
Systemic Sclerosis, Dermatomyositis
Subcutaneous Injection of Sodium Thiosulfate for Ectopic Calcifications or Ossifications. A Pilot Study
Ectopic soft tissue calcifications or ossifications can complicate the course of numerous diseases; most of them are rare or very rare.
- Conditions
- Systemic Sclerosis, Dermatomyositis, iPPSD2
- Trial name
- ITS-PILOT (NCT03582800)
- Testing
- STS
- Where
- 11 sites in France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Limoges
Ventilator Associated Pneumonia
Perpetual Observational Study - Ventilator Associated Pneumonia
Ventilator-Associated Pneumonia (VAP) is a bacterial respiratory infection that patients in the Intensive Care Unit (ICU) often get when they cannot breathe for themselves and require mechanical ventilation.
- Trial name
- POS-VAP (NCT05719259)
- Where
- 35 sites in Albania, Belgium and 11 more
- Volunteers
- 20,000 people
- Sponsor
- European Clinical Research Alliance for Infectious Diseases (ECRAID)
Endometriosis, Pain
ENDometriosis: Evaluation of Detection and Need for ALGOlogic Care Before Surgery
Endometriosis surgery is required when medical treatment fails to release women from pain. However, complete surgery does not work every time to improve patients' symptoms.
- Trial name
- ENDALGO (NCT06997809)
- Testing
- pathway care
- Where
- 9 sites in France
- Volunteers
- 187 people
- Sponsor
- University Hospital, Limoges
POEMS Syndrome
POEMS Syndrome Treatment With Lenalidomide
POEMS syndrome is a rare form of B cell dyscrasia combining a proliferation usually of plasma cells, a polyneuropathy, osteocondensing bone lesions and multiple other clinical signs.
- Trial name
- POEMS (NCT01639898)
- Testing
- Lenalidomide and dexamethasone
- Where
- 11 sites in France
- Volunteers
- 51 people
- Sponsor
- University Hospital, Limoges
Colorectal Cancer
Identification of the Most Suitable Questionnaire to Assess the Sexual Function of Women Living in France After Colorectal Cancer Surgery
Sexual quality of life is rarely mentioned by physicians during follow-up consultations, even though it is the source of a significant deterioration in quality of life (QOL).
- Trial name
- EVAS-CCR (NCT05391321)
- Testing
- administration of the 4 quality of sexual life questionnaires
- Where
- France
- Volunteers
- 23 people
- Sponsor
- University Hospital, Limoges
Apnea of Prematurity
MICropsampling for CAffeine in PREMature Newborns
Caffeine is one of the top five most prescribed drugs in neonatology. Caffeine has many beneficial impacts on preterm infants (cardiac, neurologic and pulmonary). One of these beneficial impacts is to prevent apnea.
- Trial name
- MICCAPREM (NCT07779915)
- Testing
- collection of an extra drop of capillary blood
- Where
- 2 sites in France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Limoges
Amyotrophic Lateral Sclerosis
French-German Cohort Study to Determine Factors Associated With Weight Loss in Amyotrophic Lateral Sclerosis
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease. Studies have shown the importance of weight loss at the time of diagnosis and during the progression of the disease.
- Trial name
- FG-CoALS (NCT06147843)
- Testing
- Blood sample
- Where
- 9 sites in France, Germany
- Volunteers
- 1,000 people
- Sponsor
- University Hospital, Limoges
Giant Cell Arteritis (GCA)
Kinetics of C-Reactive Protein in Giant Cell Arteritis Following Glucocorticoid Initiation: A Pilot Study (GIDEON)
We propose to analyze the kinetics of the main marker of inflammation in GCA in order to understand its links with initial clinical manifestations and the possible appearance of complications and/or relapses.
- Trial name
- GIDEON (NCT07720804)
- Testing
- Blood tests to measure CRP
- Volunteers
- 40 people
- Sponsor
- University Hospital, Limoges
Lymphoma, B-cell, Aggressive Non-Hodgkin (B-NHL)
Exosomes and Immunotherapy in Non-Hodgkin B-cell Lymphomas
Diffuse large B-cell lymphomas (DLBCL) are highly aggressive and heterogeneous B-cell lymphoma that would imminently be fatal without treatment.
- Trial name
- ExoReBLy (NCT03985696)
- Testing
- blood sample
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital, Limoges
Ventilator Acquired Pneumonia, Mechanical Ventilation Complication
ClusterVAP: Multicentre Proteomic Endotyping of Ventilator-associated Pneumonia
Ventilator-associated pneumonia (VAP) is a common and serious infection in patients receiving mechanical ventilation in intensive care units.
- Trial name
- ClusterVAP (NCT07245888)
- Where
- 4 sites in France, Portugal and 1 more
- Volunteers
- 400 people
- Sponsor
- Region Skane
Hematologic Cancer
The Point of View of Hematological Cancer Patients and Their Loved Ones Regarding Spirituality
The management of patients with malignant hemopathy is based on comprehensive management. In this context and faced with the various difficulties encountered by cancer patients, the question of spirituality and its experience is…
- Trial name
- SPIRIHEMATO (NCT04412135)
- Testing
- spirituality
- Sponsor
- University Hospital, Limoges