Clinical trials: sponsored by University Hospital, Montpellier
Systemic Sclerosis (SSc)
Tissue Modeling in Systemic Sclerosis Using Induced Pluripotent Stem Cells (iPSCs)
The objective of the study is to establish an in vitro model using iPSCs to test the hypotheses developed. The primary objective is to generate, via the SAFE-IPS platform, 8 iPSC lines derived from blood samples taken from: Two…
- Trial name
- hiPSSS (NCT07650565)
- Testing
- Blood Sample Collection
- Where
- France
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Infertility Assisted Reproductive Technology
Artificial Shrinkage of Fresh Blastocysts
The aim of the study is to determine if collapsing an embryo (or making it fold compactly by taking away its fluid) before the transfer in the uterine cavity improves pregnancy rates in assisted reproductive technology (ART).
- Trial name
- BlastoCollapse (NCT02988544)
- Testing
- Artificial shrinkage
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Montpellier
Hand Fractures
Repair of Extra-articular Fractures of the Metacarpals and First Phalanges of the Long Fingers
The goal of this randomized controlled trial is to compare the effectiveness, complications, and cost-effectiveness of three surgical techniques (intramedullary screw fixation, locked plating, and percutaneous pinning) for…
- Trial name
- FinXger (NCT07186829)
- Testing
- Percutaneous pinning, Locked plate, Intramedullary screw
- Where
- France
- Volunteers
- 111 people
- Sponsor
- University Hospital, Montpellier
Rheumatoid Arthritis
Microbiota Analysis to Predict Outcomes of Rheumatoid Arthritis Patients Treated With JAK-inhibitor
Personalized medicine in which each patient would receive the ideal personalized treatment and regimen, holds great promise to improve patient's care.
- Trial name
- MARAJA (NCT04530305)
- Testing
- Upadacitinib <15 MG [Rinvoq]
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Montpellier
Health Communication, Patient Discharge
AI-Assisted Discharge Documents for Children and Families in a Pediatric Emergency Department
This study compared two ways of preparing discharge documents for children and families leaving a pediatric emergency department.
- Trial name
- EA (NCT07874659)
- Testing
- Conventional Discharge Documentation Workflow, LLM-Assisted Discharge Documentation Workflow
- Where
- 2 sites in France
- Volunteers
- 153 people
- Sponsor
- University Hospital, Montpellier
Acid Sphingomyelinase Deficiency (ASMD), Niemann Pick Disease
National Multicentre Study of the Natural History of Acid Sphingo-myelinase Deficiency in Adults and Children
The goal of this study is to describe the natural history of ASMD in adult and paediatric patients with or without specific treatment in order to assess the impact of the disease on their daily lives and quality of life.
- Trial name
- FASMD (NCT06985212)
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Wladimir MAUHIN, Dr
Scleroderma, Systemic
Phase IIa Trial of Anti-CD19 CAR T-Cells in Systemic Sclerosis Resistant to Immunosuppressive Therapy
The goal of this clinical trial is to evaluate whether anti-CD19 CAR T-cell therapy can improve disease activity in adults with severe, treatment-resistant systemic sclerosis (SSc).
- Trial name
- SCLEROCAR (NCT07493395)
- Testing
- CD19 CAR T Arm
- Where
- 4 sites in France
- Volunteers
- 6 people
- Sponsor
- University Hospital, Montpellier
Anesthesia, Pediatric Surgery
Intravenous Dexmedetomidine as an Adjuvant to Locoregional Anesthesia in Pediatric Surgery
The main objective of this study is to study the impact of intravenous dexmedetomidine combined with locoregional anesthesia on postoperative pain in children undergoing surgery.
- Trial name
- DEXPED (NCT06736483)
- Testing
- Dexmedetomidine, Face Legs Activity Cry Consolability scale, Post-Hospitalization Behavior Questionnaire
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Montpellier
Pneumocystis Pneumonia, Pneumocystis Jirovecii Infection
CaspoNEB: Efficacy and Safety of Caspofungin Aerosols for the Curative Treatment of Pneumocystis Pneumonia
To assess the efficacy of administrating daily caspofungin aerosols versus placebo for seven days, in adjunction of conventional systemic antifungal therapy during curative treatment of Pneumocystis pneumonia, on the clinical…
- Conditions
- Pneumocystis Pneumonia, Pneumocystis Jirovecii Infection, Pneumocystis Infections
- Trial name
- CaspoNEB (NCT06892951)
- Testing
- Caspofungin Acetate 50 MG, Physiologic saline
- Where
- 3 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Tours
Chronic Stroke, Non-use of the Paretic Upper Limb
Actimetry Monitoring of the Paretic Upper Limb in Chronic Post Stroke.
After a stroke, 80% of patients continue to have difficulty using their paretic upper limb in activities of daily living (ADL) despite post-stroke rehabilitation practices that aim to promote the use of the paretic upper limb.
- Trial name
- ParUse (NCT05581602)
- Testing
- Wearing bracelets (3-Axis Logging Accelerometer)
- Where
- 2 sites in France
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Amyloidosis
Impact of a Cardiac Rehabilitation Program on Patients With Cardiac Amyloidosis
The goal of this clinical trial is to learn if a structured cardiac rehabilitation program can help people with cardiac amyloidosis improve their ability to exercise and their quality of life.
- Trial name
- RECARDA (NCT07494942)
- Testing
- Cardiac Rehabilitation Program
- Where
- France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Montpellier
Human Papillomavirus Infection, Anal HPV Infection
Epidemiology of Anal Human Papillomavirus Carriage in Female Solid Organ Transplant Recipients With More Than 10 Years of Immunosuppression
Anal canal cancer is primarily associated with persistent infection by high-risk human papillomavirus (HR-HPV), particularly HPV-16.
- Conditions
- Human Papillomavirus Infection, Anal HPV Infection, Human Papillomavirus 16 Infection
- Trial name
- EPAHTOS (NCT07858201)
- Testing
- Anal Self-Sampling for High-Risk HPV Detection
- Volunteers
- 190 people
- Sponsor
- University Hospital, Montpellier
Severe Asthma, Allergic Bronchopulmonary Aspergillosis (ABPA)
Modeling Bronchial Epithelium in Severe Asthma With Human Induced Pluripotent Stem Cells (iPSC)
Asthma is severe when it cannot be controlled with maximum-dose inhaled therapies while management of comorbidities and other precipitating or aggravating factors has been optimized.
- Trial name
- MOSAIC (NCT05616338)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 4 people
- Sponsor
- University Hospital, Montpellier
Rheumatoid Arthritis (RA)
National Cohort of Subjects at Risk of Developing Rheumatoid Arthritis
PROMESS 1 is a multicenter cohort interventional study aiming at analyzing the factors associated with the risk of developing clinical arthritis among exposures or combinations of exposures in patients at risk of rheumatoid…
- Trial name
- PROMESS_1 (NCT06876064)
- Testing
- Blood test, Urine test, stool collection
- Where
- France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Chronic Obstructive Pulmonary Disease
Chronic Airway Disease, Mucus Rheology and Exacerbations
The main objective of this trial is to compare the exacerbation number over 12 months of follow-up between a group of patients with COPD treated according to standardized management (azithromycin prescribed in the event of severe…
- Trial name
- COPD-CARhE (NCT04339270)
- Testing
- Azithropycin according to symptoms, Azithromycin according to rheology or symptoms
- Where
- 3 sites in France
- Volunteers
- 72 people
- Sponsor
- University Hospital, Montpellier
Adverse Cardiac Event, Major Adverse Cardiac Events
Impact of Assessment and Management of Comorbidities in Internal Medicine on Cardiovascular Risk
The aim of assessing and managing cardiovascular risk is to avoid, limit or delay cardiovascular morbidity and mortality. Planned internal medicine hospitalization is developed around the management of cardiovascular risk in…
- Trial name
- COMMEDCARDIO (NCT06204549)
- Testing
- Screening and management of cormobidities
- Where
- France
- Volunteers
- 70 people
- Sponsor
- University Hospital, Montpellier
Heart Failure
Medico-economic Evaluation of Therapeutic Adaptation Guided by the Soluble Suppression of Tumorigenicity 2 (sST-2) Biomarker in the Management of Patients With Acute Heart Failure
Management of patients with heart Failure remains a major health concern because of the high rate of rehospitalization, mortality and induced-cost.
- Trial name
- ICAME (NCT04554277)
- Testing
- Biomarker guided therapy
- Where
- 12 sites in France
- Volunteers
- 154 people
- Sponsor
- University Hospital, Montpellier
Patellar Tendinitis, Jumper's Knee
Identification of Kinematic Variables Specific of Patellar Tendinopathy in Athletes at Risk
This research aims to identify and monitor specific kinematic markers associated with patellar tendinopathy in athletes at risk.
- Conditions
- Patellar Tendinitis, Jumper's Knee, Musculoskeletal Injuries, Knee Injuries
- Trial name
- TENVOL (NCT07406516)
- Testing
- The intervention consists of a series of vertical jump tests captured using high-resolution cameras with markerless motion capture technology., The intervention consists of a series of vertical jump tests captured using high-resolution cameras with markerless motion capture technology at 6 months and 12 months
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Restless Legs Syndrome (RLS)
Intravenous Iron in the Management of Drug-resistant Restless Legs syndromeI
The pathophysiology of restless legs syndrome (RLS) is not well understood: it is thought to involve intracerebral iron deficiency and dopaminergic dysregulation.
- Trial name
- IRON-RLS (NCT07822607)
- Testing
- Ferric Carboxymaltose Injection [Ferinject], Randomization, Questionnaire and Physical Exam
- Where
- France
- Volunteers
- 66 people
- Sponsor
- University Hospital, Montpellier
Asthma in Children
Forced Oscillations Technique During a Metacholine Test in Children
Asthma is the most common chronic lung disease in children. It affects more than 1 in 10 children in France. The methacholine bronchial challenge test (MBT) is indicated to assess the probability of asthma suggested by clinical…
- Trial name
- TPM AOS (NCT05734261)
- Testing
- Airway Oscillation System
- Where
- France
- Volunteers
- 112 people
- Sponsor
- University Hospital, Montpellier
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