Clinical trials: sponsored by University Hospital, Rouen
Digestive Emergency, New Pathway
Effectiveness of the RAUC Pathway in Reducing Unscheduled Hospitalizations After Emergency Digestive Surgery
The number of emergencies's visits (22 million visits in 2019 in France), the organization of emergencies and the sustainability of the current health system are threatened.
- Conditions
- Digestive Emergency, New Pathway, Connected Health
- Trial name
- RAUCAMIENS (NCT06769438)
- Testing
- ERAS, DEEPSEN, RDS
- Where
- 6 sites in France
- Volunteers
- 3,048 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
HIV Infection
HIV-1 Non-group M in Cameroon : Study of Genotypic and Phylogenetic Diversity (OBSOCAM)
The aim of the study is to study the genotypic characteristics of HIV-1 non-M circulating in the whole Cameroon and their genetic evolution.
- Trial name
- OBSOCAM (NCT06913959)
- Testing
- Prospective
- Volunteers
- 220 people
- Sponsor
- ANRS, Emerging Infectious Diseases
Antiphospholipid Syndrome (APS)
Follow-up Cohort of Patients With Antiphospholipid Syndrome
Antiphospholipid syndrome (APLS) is a rare pathology characterized by the association of thrombotic (arterial, venous) or obstetric clinical manifestations and the persistent presence at least twelve weeks apart of…
- Trial name
- ReLaps (NCT07178925)
- Testing
- Study of Antiphospholipid Syndrome responding to the Sydney classification of 2006
- Where
- France
- Volunteers
- 200 people
- Sponsor
- University Hospital, Rouen
Mycobacterium; Xenopi, Lung Diseases
Amikacin Liposome Inhalation Suspension for Treatment of Mycobacterium Xenopi Pulmonary Infection
Treatment of Mycobacterium xenopi (MX) lung disease is not-well- tolerated and concerned a growing number of patients, especially with chronic pulmonary diseases or immunosuppression.
- Trial name
- AKAPI (NCT06585020)
- Testing
- Arikayce, standard treatment
- Where
- France
- Volunteers
- 190 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Digestive System Neoplasms, Anxiety
Evaluation of Preoperative Anxiety in Digestive Surgery
This prospective observational study aims to evaluate the association between preoperative anxiety and postoperative complications in patients undergoing major oncological digestive surgery.
- Trial name
- EVAPOC (NCT07897942)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Rouen
Depressive Symptoms
Assessment of the Seasonality of Depressive Symptoms in Adolescents
The seasonality of affective disorders-particularly depressive symptoms-is well-documented in adults, yet it remains under-researched in adolescents.
- Trial name
- SPAQ-ADO (NCT07895758)
- Testing
- Measuring the intensity of the seasonality of depressive symptoms in adolescents
- Where
- France
- Volunteers
- 210 people
- Sponsor
- University Hospital, Rouen
Crohn's Diseases
Effect of Intestinal Carriage of *Pilosibacter Rotomagensis* on Intestinal Inflammatory Activity
Crohn's disease is a chronic inflammatory condition that can affect the entire digestive tract. The terminal ileum is the segment most frequently involved, and approximately one-third of patients present with disease limited to…
- Trial name
- ProsPec (NCT07871383)
- Testing
- Microbiota suspension
- Where
- France
- Volunteers
- 116 people
- Sponsor
- University Hospital, Rouen
Anismus, Distal Constipation
Is the Evaluation of Anal Distensibility by Endoflip® Technique Useful for the Diagnosis of Anismus?
Terminal constipation affects 13 to 20% of the french population. Anismus is defined by an absence of relaxation or a paradoxical contraction of the striated anal sphincter muscle during defecation.
- Trial name
- Endo-DC (NCT04155307)
- Testing
- Anal EndoFLIP®, Anal Manometry, Defecography
- Where
- France
- Volunteers
- 61 people
- Sponsor
- University Hospital, Rouen
Anorexia Nervosa
Family Therapy and Anorexia Nervosa : Which is the Best Approach?
The aim of this study is to evaluate whether the implementation of Multiple Family Therapy (MFT) within a multi-disciplinary treatment program for Anorexia Nervosa (AN) in adolescence is at least as effective in terms of clinical…
- Trial name
- THERAFAMBEST (NCT03350594)
- Testing
- Systemic Family Therapy, Multiple Family Therapy
- Where
- 5 sites in France
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- Institut Mutualiste Montsouris
MYT1L Syndrome
MYT1L Syndrome: a Rare Paediatric Genetic Syndrome Responsible for a Neurodevelopmental Disorder
MYT1L syndrome is a rare genetic syndrome, recently described in 2011, with paediatric onset, responsible for a neurodevelopmental disorder combining psychomotor retardation, learning difficulties and/or intellectual development…
- Trial name
- MYT1L (NCT07008612)
- Testing
- Patients with a genetic syndrome linked to the MYT1L gene, Patients with a neurodevelopmental disorder of genetic origin but not linked to MYT1L
- Where
- France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Rouen
Reproductive Disorder
Interest of Morphokinetic Parameters of Early Embryonic Development in the Birth Rates in Vitro Fertilization
In France, nearly 3% of children are conceived by the technique of Assisted Reproductive Medicine, of which nearly 70% by in vitro fertilization (IVF).
- Trial name
- EMCIMO (NCT03806153)
- Testing
- Morphokinetic
- Where
- 2 sites in France
- Volunteers
- 520 people
- Sponsor
- University Hospital, Rouen
Urinary Incontinence,Stress
Evaluation of the Effect of a Postural Reflex Rehabilitation Program on a Foam Surface on Stress Urinary Incontinence in Women
Urinary incontinence is defined by the International Continence Society as "any involuntary loss of urine complained by the patient". UI is a debilating condition affecting 25% to 45% of the female population.
- Trial name
- Protofoam (NCT04390204)
- Testing
- intervenions
- Where
- 5 sites in France
- Volunteers
- 86 people
- Sponsor
- University Hospital, Rouen
Intermittent Fasting, Septic Shock
Evaluation of the Efficiency of Intermittent Enteral Nutrition on Multi-organ Failure From Patients With Mechanical Ventilation in Intensive Care Unit
This study aims to evaluate the efficiency of intermittent enteral nutrition versus continuous enteral nutrition to prevent from organ failures for patients at the acute phase of sepsis shock with mechanical ventilation in ICU.
- Conditions
- Intermittent Fasting, Septic Shock, Organ Failure, Multiple
- Trial name
- ENNUT-CI (NCT06330610)
- Testing
- Intermittent enteral nutrition
- Where
- France
- Volunteers
- 174 people
- Sponsor
- University Hospital, Rouen
Atrial Fibrillation, Persistent
Noninvasive 3D Mapping in Persistent Atrial Fibrillation, to Describe Modifications of the Arrhythmogenic Substrate After Pulmonary Vein Isolation and Identify Potential Predicting Factors of Ablation Success
Atrial fibrillation (AF) is the most common cardiac arrhythmia in adults. It is a major cause of ischemic stroke and heart failure.
- Trial name
- CRYOVEST (NCT04229160)
- Testing
- Noninvasive mapping (Cardioinsight® system), long-term cardiac monitoring (LINQ system), Atrial Fibrillation ablation procedure
- Where
- 4 sites in France
- Volunteers
- 40 people
- Sponsor
- University Hospital, Rouen
Axial or Predominantly Axial SpondyloArthritis With or Without Psoriasis
Evaluation of the Efficacy and Safety of Bimekizumab (BZK) or Adalimumab (ADA) in the Treatment of Anterior Chest Wall Pain Associated With Active Axial Spondyloarthritis Refractory to NSAIDs With Hypothesis of Superiority of Bimekizumab
The primary objective is to demonstrate the superiority of BKZ (dual inhibition of IL-17A and IL-17F) on the ASAS40 response at 6 months compared to a reference treatment (ADA) in patients with active axial or predominantly axial…
- Trial name
- ThoracSPA (NCT07836283)
- Testing
- bimekizumab, adalimumab
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Rouen
Cardiogenic Shock, Extracorporeal Membrane Oxygenation
Individualized or Conventional Transfusion Strategies During Peripheral VA-ECMO
This multicenter randomized controlled trial compare two transfusion strategies of red blood cells transfusion in patients supported by veno-arterial extracorporeal membrane oxygenation for refractory cardiogenic shock.
- Conditions
- Cardiogenic Shock, Extracorporeal Membrane Oxygenation, Transfusion Related Complication, Anemia
- Trial name
- ICONE (NCT05699005)
- Testing
- Packed Red Blood Cells (PRBCs)
- Where
- 4 sites in France
- Volunteers
- 236 people
- Sponsor
- University Hospital, Lille
Cardiac Surgery
Ticagrelor Hemoadsorption Using Cytosorb® for Reduction of Bleeding During Cardiac Surgery
Cardiac surgery is at high risk of intraoperative bleeding. Inhibitors of the P2Y12 platelet receptor, such as ticagrelor, are recommended in patients with acute coronary stroke (ACS) to reduce the incidence of major…
- Trial name
- TICAdSORB (NCT07822620)
- Testing
- Device: Cytosorb hemoadsorption
- Where
- France
- Volunteers
- 232 people
- Sponsor
- University Hospital, Rouen
Ankle Surgery
Quality of Recovery at Days 5-7 After Ankle Surgery: a Multicenter Study in Seine-Maritime
Ankle fractures are among the most common fractures in trauma care, with an estimated annual incidence of 100 to 150 per 100,000 inhabitants and a marked increase after age 40.
- Trial name
- QoR - CHEVILLE (NCT07814937)
- Testing
- Assessment of recovery quality on days 5-7 after ankle surgery
- Where
- 4 sites in France
- Volunteers
- 260 people
- Sponsor
- University Hospital, Rouen
Osteoporosis, Bullous Pemphigoid
Influence of Dermocorticoids on Bone Mineral Density in Patients With Bullous Pemphigoid
Bullous pemphigoid is the most common type of bullous skin disease and is clinically characterized by clear-tense bullae, which result in post-bullous cutaneous erosions, altering the skin barrier.
- Trial name
- DERMOS (NCT03926377)
- Testing
- bone densitometry, blood test, radiographs of the thoracic and lumbar spine
- Where
- 2 sites in France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Non-hospitalised Men and Women Over 70 Years of Age
Oral Microbiota and Muscle Function in the Ageing Subject
Ageing of the general population may be a risk factor for various complications, including sarcopenia. Sarcopenia is a progressive loss of muscle mass and muscle strength, leading to a decrease in functional capacities.
- Trial name
- MYOBIOTA (NCT07687511)
- Testing
- Salivary and fecal microbiota sampling and muscle strength assessment
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Hospital, Rouen