Clinical trials: sponsored by University Medical Centre Ljubljana
Head and Neck Cancer (H&N)
Lidocaine Infiltration and Neuroimmunomodulation in Head and Neck Cancer Surgery
This study aims to investigate whether different doses of locally infiltrated lidocaine affect inflammation, neurological biomarkers, and cognitive function in patients undergoing major head and neck cancer surgery.
- Trial name
- NCT07922759
- Testing
- Lidocaine HCl 1%
- Where
- Slovenia
- Volunteers
- 20 people
- Sponsor
- University Medical Centre Ljubljana
Pre Diabetic, Obesity & Overweight
The Impact of Continuous Glucose Monitoring on Glucose Variability and Weight Loss in Individuals With Prediabetes and Obesity
This randomized, crossover interventional study evaluates the effects of real-time (open) versus blinded continuous glucose monitoring (CGM) on glycemic variability, lifestyle behaviors, and metabolic outcomes in adults with…
- Trial name
- CGM (NCT07423065)
- Testing
- Continuous Glucose Monitoring (CGM)
- Where
- 3 sites in Slovenia
- Volunteers
- 34 people
- Sponsor
- University of Primorska
Tako Tsubo Cardiomyopathy, Microvascular Dysfunction
The Role of CD34+ Stem Cells in the Pathogenesis of Takotsubo Syndrome
The underlying mechanisms of microvascular dysfunction in Takotsubo cardiomyopathy remain incompletely understood. As CD34+ cells are essential to coronary microvascular homeostasis we will investigate the potential association…
- Trial name
- STRESS (NCT07604467)
- Where
- Slovenia
- Volunteers
- 40 people
- Sponsor
- University Medical Centre Ljubljana
Periodontal Diseases Inflammation, Periodontal Disease
Timing of Oral Hygiene Improvement Relative to Subgingival Instrumentation
This single-centre, randomized split-mouth trial assessed clinical periodontal changes and acute systemic inflammatory responses when supra- and subgingival instrumentation was performed concurrently with oral hygiene instruction…
- Conditions
- Periodontal Diseases Inflammation, Periodontal Disease, Periodontal Attachment Loss, Periodontal Pocket
- Trial name
- NCT07914400
- Testing
- Nonsurgical periodontal treatment
- Where
- Slovenia
- Volunteers
- 10 people
- Sponsor
- University of Ljubljana
Ovarian Cancer, Ovarian Cancer Recurrent
Longitudinal Plasma Proteomic Remodeling in Ovarian Cancer
This longitudinal observational study investigates treatment-associated changes in the circulating plasma proteome of patients with ovarian cancer undergoing standard treatment.
- Trial name
- TLPPROC (NCT07684846)
- Testing
- Longitudinal Plasma Biomarker Assessment
- Where
- Slovenia
- Volunteers
- 33 people
- Sponsor
- University Medical Centre Ljubljana
Nutritional Status, Nutrient Deficiency
Dietary Challenges in the Population of Nursing Homes' Residents
To obtain up-to-date data on nutritional status of older adults, a national dietary survey will be conducted in 2022/2023, providing data on the consumption of foods and enabling the assessment intakes of energy and specific…
- Conditions
- Nutritional Status, Nutrient Deficiency, Micronutrient Deficiency, Vitamin D Deficiency
- Trial name
- NUTRICARE (NCT05389618)
- Testing
- Diagnostic Tests
- Where
- Slovenia
- Volunteers
- 387 people
- Sponsor
- Institute of Nutrition, Slovenia (Nutris)
Traumatic Brain Injury, Intracranial Hemorrhages
Andexanet Alfa for Reversal of Factor Xa Inhibitors in Traumatic Brain Injury: A Retrospective Single-Centre Study
Elderly patients on direct oral anticoagulants (DOACs), specifically factor Xa (FXa) inhibitors such as apixaban and rivaroxaban are at elevated risk of haematoma expansion following traumatic brain injury (TBI).
- Trial name
- AA-TBI (NCT07898982)
- Where
- Slovenia
- Volunteers
- 34 people
- Sponsor
- University Medical Centre Ljubljana
Cervical Vertebral Disc Degeneration, Intervertebral Disc Displacement
Cervical Movement Control Before and After Anterior Cervical Discectomy and Fusion
Degenerative cervical disc disease can cause neck pain, nerve symptoms, dizziness, and problems with balance and head movement control.
- Trial name
- MOVE-ACDF (NCT07425613)
- Testing
- Anterior Cervical Discectomy and Fusion
- Where
- Slovenia
- Volunteers
- 50 people
- Sponsor
- University of Ljubljana
Out-of-Hospital Cardiac Arrest, Hypoxic-Ischemic Brain Injury
Minimal Sedation Versus Standard Continuous Sedation After Out-of-Hospital Cardiac Arrest
Most patients resuscitated from out-of-hospital cardiac arrest (OHCA) remain comatose on hospital admission and are routinely managed with continuous sedation.
- Conditions
- Out-of-Hospital Cardiac Arrest, Hypoxic-Ischemic Brain Injury, Post-Cardiac Arrest Syndrome
- Trial name
- NCT07895771
- Testing
- Minimal sedation, Standard continuous sedation
- Where
- Slovenia
- Volunteers
- 100 people
- Sponsor
- University Medical Centre Ljubljana
Atrial Fibrillation (AF)
Assessment of Catheter Tissue Contact in PFA
Pulmonary vein isolation remains the cornerstone of invasive treatment for atrial fibrlllation. Despite recent technological advances in the field of pulsed field ablation (PFA) pulmonary vein isolation durability and arrhythmia…
- Trial name
- ASSESS PFA (NCT07721948)
- Testing
- Electrode tissue contact assessment during pulsed field ablation
- Where
- Slovenia
- Volunteers
- 60 people
- Sponsor
- University Medical Centre Ljubljana
Acute Coronary Syndromes, Chest Pain
AI-ECG Detection of Occlusion Myocardial Infarction at Emergency Department Triage (TRIACS)
Chest pain is among the most common reasons people attend an emergency department, and the electrocardiogram (ECG) recorded at triage is the first test used to decide who needs urgent treatment for a blocked coronary artery.
- Conditions
- Acute Coronary Syndromes, Chest Pain, Myocardial Infarction (MI), NSTEMI - Non-ST Segment Elevation MI
- Trial name
- TRIACS-MB (NCT07882849)
- Where
- Slovenia
- Volunteers
- 1,000 people
- Sponsor
- University Medical Centre Maribor
Prosthodontics, Dental Adhesives/Restorations Performance
Evaluation of Ceramic Dental Crown Clinical Performance After Conventional Hydrofluoric Acid Etching or Gaseous Plasma Pretreatment
In this randomized, controlled, double-blind clinical trial, we will follow adult participants who receive partial or full dental crowns made of lithium disilicate ceramic (LDC).
- Conditions
- Prosthodontics, Dental Adhesives/Restorations Performance, Crowned Posterior Teeth
- Trial name
- NCT07876167
- Testing
- Hydrofluoric Acid-Etched Lithium Disilicate Ceramic Dental Crowns, Atmospheric-Pressure Plasma-Treated Lithium Disilicate Ceramic Dental Crowns
- Where
- Slovenia
- Volunteers
- 30 people
- Sponsor
- University of Ljubljana, Faculty of Medicine
Vascular Malformations
Treatment of Low-flow Vascular Malformations With Bleomycin Electrosclerotherapy (BEST)
In biomedical applications, electroporation is used not only for cancer treatment but also for vaccinations, treatment of cardiac arrhythmias and, more recently, for the treatment of vascular malformations.
- Trial name
- BEST (NCT07579962)
- Testing
- Bleomycin Sulfate
- Where
- Slovenia
- Volunteers
- 140 people
- Sponsor
- Institute of Oncology Ljubljana
Lumbar Spinal Stenosis
EFFECTS OF EXERCISE AND EXERCISE COUNSELLING IN PATIENTS WITH LUMBAR SPINAL STENOSIS
Lumbar spinal stenosis is a condition in which narrowing of the spinal canal can cause pain, neurogenic claudication, reduced walking ability, and limitations in daily activities.
- Trial name
- NCT07861334
- Testing
- Individualized Multimodal Exercise and Exercise-Counselling Program
- Where
- Slovenia
- Volunteers
- 87 people
- Sponsor
- University Medical Centre Ljubljana
Brain Injuries, Traumatic
Early Redox Biomarker Changes After Stellate Ganglion Block in Traumatic Brain Injury
Oxidative stress is a key mediator of secondary brain injury after traumatic brain injury (TBI). The stellate ganglion block (SGB) has been shown to modulate cerebral hemodynamics and neuroinflammation in brain-injured patients…
- Trial name
- NCT07844811
- Testing
- Ultrasound-guided stellate ganglion block (parent study)
- Where
- Slovenia
- Volunteers
- 20 people
- Sponsor
- University Medical Centre Ljubljana
Heart Failure With Reduced Ejection Fraction (HFrEF), Chronic Heart Failure
Vericiguat and Reverse Remodeling Indices in Heart Failure
The goal of this clinical trial is to investigate how vericiguat benefits adults with stable heart failure with reduced ejection fraction (HFrEF) who are already receiving guideline-directed medical therapy.
- Trial name
- VERI-PATH (NCT07405944)
- Testing
- Vericiguat, Guideline Directed Medical Therapy for Heart Failure (GDMT)
- Where
- 4 sites in Slovenia
- Volunteers
- 70 people
- Sponsor
- University Medical Centre Ljubljana
POTS - Postural Orthostatic Tachycardia Syndrome
RESET-POTS: Multimodal Phenotyping and Stellate Ganglion Block in Postural Orthostatic Tachycardia Syndrome
RESET-POTS is a pilot study for adults with postural orthostatic tachycardia syndrome (POTS), a condition that can cause a rapid increase in heart rate, dizziness, weakness, fatigue and other symptoms when standing.
- Trial name
- RESET-POTS (NCT07837804)
- Testing
- Bilateral Sequential Stellate Ganglion Block
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Breast Cancer Stage IV, Oligometastatic Disease
Stereotactic Ablative Radiotherapy for OligoMetastatic Breast Cancer
TAORMINA is an international, multicentre, randomised phase 3 trial for patients with oligometastatic breast cancer (OMBC) that will be allocated to combined stereotactic ablative radiotherapy (SABR) + systemic therapy…
- Trial name
- TAORMINA (NCT05377047)
- Testing
- SABR
- Where
- 19 sites in Ireland, Israel and 4 more
- Volunteers
- 345 people
- Sponsor
- Vastra Gotaland Region
PICC Line Placement, Vessels; Anomaly
Image-Guided Central Catheter Insertion With Concurrent Assessment of Vascular Wall Integrity
The insertion of peripherally inserted central catheters (PICCs) represents a minimally invasive and safe method for establishing long-term central venous access in patients requiring prolonged intravenous therapy, including…
- Trial name
- NCT07466472
- Volunteers
- 80 people
- Sponsor
- University Medical Centre Ljubljana
Coarctation of the Aorta, Coarctation of Aorta
Effects of Exercise in Patients With Repaired Coarctation of the Aorta
This interventional study will investigate the effects of high-intensity interval training (HIIT) in adults with repaired coarctation of the aorta.
- Trial name
- KOREKT (NCT07771023)
- Testing
- Outpatient high-intensity interval training (HIIT), Home-based high-intensity interval training (HIIT)
- Where
- 2 sites in Slovenia
- Volunteers
- 45 people
- Sponsor
- University Medical Centre Ljubljana