Clinical trials: sponsored by University of Manitoba
Reverse Shoulder Arthroplasty
Comparison of Lateralized RTSA With and Without Subscapularis Repair
The purpose of this double-blind randomized controlled trial is to compare patient-reported, clinical, and functional outcomes in patients undergoing RTSA with and without subscapularis repair after placement of a modern…
- Trial name
- NCT04728282
- Testing
- RTSA with subscapularis repair, RTSA without subscapularis repair
- Where
- 6 sites in Canada
- Volunteers
- 284 people
- Sponsor
- Panam Clinic
Chronic Kidney Diseases, Metabolic Acidosis
Reducing Dietary Acid With Food Versus Oral Alkali in People With Chronic Kidney Disease (ReDACKD)
Metabolic acidosis is a common problem that occurs with worsening chronic kidney disease. Dietary acid can build up when the kidneys are not working well.
- Trial name
- ReDACKD (NCT05113641)
- Testing
- Alkalizing Fruit and Vegetables, Sodium bicarbonate
- Where
- 2 sites in Canada
- Volunteers
- 37 people
- Sponsor
- Dylan MacKay
Late-Onset Neonatal Sepsis, Extreme Prematurity
Dopamine vs. Norepinephrine for Hypotension in Very Preterm Infants With Late-onset Sepsis
Fluid-unresponsive hypotension needing cardiotropic drug treatment is a serious complication in very preterm neonates with suspected late-onset sepsis (LOS; defined as culture positive or negative bloodstream infection or…
- Conditions
- Late-Onset Neonatal Sepsis, Extreme Prematurity, Neonatal Hypotension
- Trial name
- NCT05347238
- Testing
- Dopamine, Norepinephrine
- Where
- 22 sites in United States, Canada and 3 more
- Volunteers
- 550 people
- Sponsor
- Mount Sinai Hospital, Canada
Mental Health Care, Anxiety and Depression
Feasibility and Acceptability of Group Medical Visits for Anxiety and Depression
The goal of this clinical trial is to evaluate the feasibility and acceptability of the intervention, Group Medical Visits (GMVs), for patients with depression and anxiety.
- Conditions
- Mental Health Care, Anxiety and Depression, Pilot Study
- Trial name
- NCT06651801
- Testing
- Group Medical Visits
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Manitoba
Neonatal Opioid Withdrawal Syndrome, Prenatal Opioid Exposure
Recorded Parent/Caregiver Voice for Infants With Neonatal Opioid Withdrawal Syndrome
Neonatal opioid withdrawal syndrome (NOWS) can affect a newborn infant's ability to eat, sleep, and be consoled after exposure to opioids before birth.
- Conditions
- Neonatal Opioid Withdrawal Syndrome, Prenatal Opioid Exposure, Opioid Withdrawal, Neonatal Abstinence Syndrome
- Trial name
- VOICE-NAS (NCT07864493)
- Testing
- Recorded Parent/Caregiver Voice Playback
- Where
- 2 sites in Canada
- Volunteers
- 20 people
- Sponsor
- University of Manitoba
Osteoradionecrosis of the Jaw
Platelet-Rich Fibrin for Preventing Osteoradionecrosis After Dental Extractions
The goal of this clinical trial is to learn whether platelet-rich fibrin (PRF) can help prevent osteoradionecrosis (ORN) after dental extractions in adults who previously received radiation therapy to the head and neck.
- Trial name
- NCT07856875
- Testing
- Platelet-rich fibrin (PRF), Standard Dental Extraction Care
- Where
- 2 sites in Canada
- Volunteers
- 112 people
- Sponsor
- University of Manitoba
Premature Infant, Respiratory Distress Syndrome in Premature Infant
30% or 60% Oxygen at Birth to Improve Neurodevelopmental Outcomes in Very Low Birthweight Infants
Preterm birth, or birth before 37 weeks' gestation, is increasingly common, occurring in 8 percent of pregnancies in Canada. Preterm birth is associated with many health complications, particularly when the birth happens before…
- Conditions
- Premature Infant, Respiratory Distress Syndrome in Premature Infant, Neurodevelopmental Outcome
- Trial name
- HiLo (NCT03825835)
- Testing
- 30% oxygen group, 60% oxygen group
- Where
- 14 sites in Canada, Ireland
- Volunteers
- 1,203 people
- Sponsor
- University of Alberta
Advance Dementia
Investigating the Efficacy of an Augmented Virtual Reality Driving Simulator on Institutionalized Dementia Patients
The improvement in health and welfare in modern society has led to an increase in life expectancy. Alternatively, the longer one lives, the more likely to experience deterioration in memory, cognitive ability, and executive…
- Trial name
- NCT06419257
- Testing
- VRDS
- Where
- Canada
- Volunteers
- 20 people
- Sponsor
- University of Manitoba
Community-acquired Pneumonia
AntiThrombotic Therapy to Ameliorate Clinical Complications in Community Acquired Pneumonia
This is an international, open-label, stratified randomized controlled trial with Bayesian adaptive stopping rules to compare the effects of therapeutic-dose heparin vs.
- Trial name
- ATTACC-CAP (NCT05848713)
- Testing
- Heparin
- Where
- 68 sites in United States, Brazil and 2 more
- Volunteers
- 4,000 people
- Sponsor
- University of Manitoba
Obstructive Sleep Apnea
Acoustic OSA Prediction During Wakefulness and Monitoring During Sleep
The purpose of this study is to investigate the feasibility of sound analysis for: a) sleep apnea detection both during wakefulness and sleep, and b) flow-sound relationship during both wakefulness and sleep in patients and…
- Trial name
- NCT04112927
- Where
- Canada
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Erectile Dysfunction
Shockwave Therapy on Treating Erectile Dysfunction Following Nerve-sparing Radical Prostatectomy.
This study will investigate whether low-intensity extracorporeal shockwave therapy (LiESWT) can help men recover erectile function after nerve-sparing prostate cancer surgery.
- Trial name
- REVIVE (NCT07819084)
- Testing
- Low-Intensity Extracorporeal Shockwave Therapy, Standard of Care
- Where
- Canada
- Volunteers
- 80 people
- Sponsor
- University of Manitoba
Syphilis
Investigational Study to Evaluate the DPP® Syphilis Screen & Confirm Antibody Point-of-care Test (POCT) to Diagnose Infectious Syphilis
The goal of this observational study is to evaluate the sensitivity, specificity, and utility of the DPP® Syphilis Screen \& Confirm antibody point-of-care test (POCT) to diagnose infectious syphilis in participants attending the…
- Trial name
- NCT06927843
- Testing
- point of care test
- Where
- Canada
- Volunteers
- 312 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Tennis Elbow Syndrome, Golfer's Elbow
Effects of Peripheral Repetitive Peripheral Magnetic Stimulation on Individuals With Elbow or Wrist Chronic Pain
This pilot, randomized, sham-controlled, single-blind study will evaluate the effectiveness of repetitive peripheral magnetic stimulation (rPMS) in reducing pain in adults with tennis/golfer's elbow or carpal tunnel syndrome.
- Conditions
- Tennis Elbow Syndrome, Golfer's Elbow, Carpal Tunnel Syndrome (CTS)
- Trial name
- rPMS (NCT07544914)
- Testing
- Two days Active rPMS
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Manitoba
Vomiting in Infants and/or Children, Nausea
RCT of Olanzapine for Control of CIV in Children Receiving Highly Emetogenic Chemotherapy
Chemotherapy-induced nausea and vomiting (CINV) are among the most bothersome symptoms during cancer treatment according to children and their parents.
- Conditions
- Vomiting in Infants and/or Children, Nausea, Hematopoietic System--Cancer, Oncology
- Trial name
- NCT03118986
- Testing
- Olanzapine
- Where
- 9 sites in United States, Canada and 1 more
- Volunteers
- 161 people
- Sponsor
- The Hospital for Sick Children
Depression and Anxiety Symptom, Anger
Implementing BEAM: A Scalable Digital Mental Health Program, for Families of Children Referred to Neurodevelopmental Services
Families of children with neurodevelopmental differences (NDDs) experience disproportionately high levels of parenting stress and mental health difficulties, including elevated depression, anxiety, and caregiver burden.
- Conditions
- Depression and Anxiety Symptom, Anger, Parenting, Stress (Psychology)
- Trial name
- NCT07837791
- Testing
- The Building Emotional Awareness and Mental Health (BEAM) Program
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Weight Loss
Feasibility Testing of Plant-Based Supplemented Food Products Made With Manitoba Crop Ingredients for Weight Loss
The purpose of this study is to advance the development of the WI/CDIC supplemented foods by evaluating the acceptance and feasibility of the supplemented food bars within the Wellness Institute's Weight Loss Clinic program (WLC)…
- Trial name
- NCT06614543
- Testing
- Supplemented Food
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- University of Manitoba
Post Prandial Blood Glucose, Feasibility Pilot Study
Relaxing Virtual Reality Use and Blood Glucose Response to Food (ReViR) Study
This randomized cross-over pilot clinical trial aims to evaluate the feasibility and effect of a relaxing virtual reality (VR) experience on glucose response after white bread consumption, compared to a stress-inducing VR, a VR…
- Trial name
- NCT07541794
- Testing
- A relaxing VR environment, A stress-inducing VR game, A VR clinical room
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Diabetes Type 2
Evaluation of Pharmacist Intervention for Individuals With Uncontrolled Type 2 Diabetes
Type 2 diabetes is a chronic disease that can lead to a number of complications if uncontrolled and there is a projected increase of 33% patients living with diabetes over the next 10 years.
- Trial name
- NCT05442840
- Testing
- Behavioral and drugs already approved and available for diabetes management
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of Manitoba
Chronic Kidney Disease, Hyperkalemia
Dietary Potassium Liberalization in Pre-Dialysis Patients
The study will look at the impact of the potassium content in fruits and vegetables, on serum potassium concentrations in people with Chronic Kidney Disease (CKD) using a randomized crossover design.
- Trial name
- DK-LIB (NCT05090865)
- Testing
- Liberalized dietary potassium via fruits and vegetables, Standard dietary potassium restriction
- Where
- 2 sites in Canada
- Volunteers
- 30 people
- Sponsor
- University of Manitoba
Mental Health Issue, Family Dynamics
Single-Session Psychotherapy for Young Kids Through Patient Engagement Techniques
The goal of this clinical trial is to compare outcomes between participants in the single-session psychotherapy for young kids (SPYKids) conditions and participants in the services as usual (SAU) condition.
- Conditions
- Mental Health Issue, Family Dynamics, Stress, Psychological, Stress, Emotional
- Trial name
- SPYKids (NCT05857865)
- Testing
- SPYKids, Services as Usual (SAU)
- Where
- Canada
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Manitoba