Clinical trials: sponsored by University of Nottingham
Long Term Care
Identifying Key Attributes and Learning From a Local Falls Prevention Ambassador Programme
Managing falls for care home residents can be challenging for care home staff who work in complex settings and with residents with complex needs.
- Trial name
- NCT06946303
- Testing
- Survey, Interview, Observation
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- University of Nottingham
Peripheral Arterial Disease, Chronic Kidney Diseases
Preventing Kidney Injury Using Carbon Dioxide as Contrast Medium in Patients With Peripheral Arterial Disease (PAD) and Chronic Kidney Disease (CKD) Having Arterial Intervention
This research trial will test whether using carbon dioxide as a contrast medium during surgery to open blocked leg arteries can prevent kidney injury.
- Conditions
- Peripheral Arterial Disease, Chronic Kidney Diseases, Acute Kidney Injury
- Trial name
- KID (NCT07891988)
- Testing
- Iodinated contrast medium, CO2 automated injector contrast medium
- Where
- 6 sites in United Kingdom
- Volunteers
- 184 people
- Sponsor
- University of Leicester
Type 2 Diabetes, Chronic Kidney Disease 5D
A Multi-centre Trial to Assess the Efficacy and Safety of the Omnipod 5 System in People With Type 2 Diabetes Undergoing Haemodialysis
Diabetes is the leading cause of kidney failure in the UK. Many people with diabetes and advanced kidney failure inject themselves with insulin and do finger-prick blood glucose tests.
- Trial name
- AID-HD (NCT07422532)
- Testing
- Omnipod 5, Insulin injections
- Where
- 4 sites in United Kingdom
- Volunteers
- 84 people
- Sponsor
- Imperial College London
Psychological, Stress
Psychological and Lifestyle Factors on Health Outcomes
Psychosocial and lifestyle factors in Army recruits likely contribute to increased susceptibility to infection and injury during basic Army training.
- Conditions
- Psychological, Stress, Immune Health, Vaccination
- Trial name
- NCT04780867
- Testing
- Delayed vaccination
- Where
- United Kingdom
- Volunteers
- 1,188 people, healthy volunteers welcome
- Sponsor
- Liverpool John Moores University
Critical Illness, Vitamin D Deficiency
The VITDALIZE Study: Effect of High-dose Vitamin D3 on 28-day Mortality in Adult Critically Ill Patients
In the VITdAL-ICU trial using a large oral dose of vitamin D3 in 480 adult critically ill patients, there was no benefit regarding the primary endpoint hospital length of stay.
- Conditions
- Critical Illness, Vitamin D Deficiency, Covid19
- Trial name
- VITDALIZE (NCT03188796)
- Testing
- Cholecalciferol
- Where
- 18 sites in Austria, Belgium and 2 more
- Volunteers
- 2,400 people
- Sponsor
- Medical University of Graz
Hearing Loss, Hearing Aids
New Hearing Aid Users and Their Social Participation
Does first-ever hearing aid fitting change social participation? Using a mixed methods approach made up of audiological assessments (hearing test and examination of the ear canal and eardrum), questionnaires, semi-structured…
- Conditions
- Hearing Loss, Hearing Aids, Social Participation
- Trial name
- NCT07866586
- Testing
- Observation
- Volunteers
- 32 people
- Sponsor
- University of Nottingham
Asthma
Co-morbidity and Refractory Asthma - UK Severe Asthma Registry
A "Clinical Registry" is a database which contains clinical information about people with different medical conditions. They are used in many countries throughout the world to help medical teams to better understand specific…
- Trial name
- UKSAR (NCT04553276)
- Where
- United Kingdom
- Volunteers
- 4,800 people
- Sponsor
- Queen's University, Belfast
Multiple Sclerosis, Relapsing-Remitting
Identifying Immune Biomarkers of Disease and Disease Control in Autoimmune Neurological Disease Using Autologous Haematopoietic Stem Cell Transplantation
The underlying disease mechanisms which occur in patients with immune mediation neurological diseases, such as Multiple Sclerosis (MS), are incompletely understood.
- Trial name
- BIO-MS (NCT06195800)
- Where
- United Kingdom
- Volunteers
- 15 people
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Fatty Liver, Nutritional and Metabolic Disease
Low GI Diet Effects on Non-Alcoholic Fatty Liver Disease
A 2 x 2 cross-over dietary intervention trial designed to investigate the effects of low glycemic index (LGI) versus high glycemic index (HGI) diet on hepatic fat accumulation and gut microbiota composition in participants with…
- Trial name
- LGI-NAFLD (NCT04415632)
- Testing
- low glycemic index diet, High glycemic index diet
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University of Nottingham
Autism Spectrum Disorder (ASD
Experiences of Healthcare for Autistic TGD Adults
To explore the experiences of autistic gender diverse adults that have attempted or are attempting to access, have accessed or are currently accessing gender identity healthcare in the United Kingdom
- Trial name
- NCT06850948
- Testing
- Qualitative
- Where
- United Kingdom
- Volunteers
- 13 people
- Sponsor
- University of Nottingham
Fracture, Scoliosis Idiopathic Adolescent
Opioid Analgesia Impacts on Neurological Development
Background: Pain in childhood - whether from injuries like fractures or long-term conditions like scoliosis - is often treated with opioid medicines. These drugs are effective for pain relief.
- Conditions
- Fracture, Scoliosis Idiopathic Adolescent, Traumatic Injury, Adolescent
- Trial name
- OPAL (NCT07855952)
- Where
- United Kingdom
- Volunteers
- 30 people
- Sponsor
- University of Nottingham
Major Depression
Individual Narratives of Stimulation (ECT and TMS)
Electroconvulsive therapy (ECT) and transcranial magnetic stimulation (TMS) are two evidence-based treatments for major depressive disorder.
- Trial name
- INSight (NCT07807930)
- Testing
- There is no intervention in this observation study (qualitative interviews about past treatment experiences)
- Where
- 2 sites in United Kingdom
- Volunteers
- 12 people
- Sponsor
- University of Nottingham
Lower Respiratory Tract Infection (LRTI), Chest Infection
Quality of Life After Lower Respiratory Tract Infection
Lower respiratory tract infections (LRTIs) are any infections below the vocal cords which affect the airways or the air sacs in the lungs.
- Conditions
- Lower Respiratory Tract Infection (LRTI), Chest Infection, Quality of Life
- Trial name
- NCT07807917
- Where
- United Kingdom
- Volunteers
- 200 people
- Sponsor
- University of Nottingham
Postoperative Delirium, Hip Fracture Surgery
Cytokines, POD, Health Status, Older Hip Fracture
An investigation of the change in inflammation marker levels across hip fracture surgery and an exploration of any association with change in self reported health status and incidence of postoperative delirium
- Conditions
- Postoperative Delirium, Hip Fracture Surgery, Older People
- Trial name
- NCT05096507
- Testing
- Hip fracture Surgery (Primary)
- Where
- United Kingdom
- Volunteers
- 49 people
- Sponsor
- University of Nottingham
Internet Gaming Disorder
Collective Motivational Interviewing (CMI) for Adolescents With Internet Gaming Disorder
The present study examines the efficacy of CMI in reducing adolescent IGD symptoms and enhancing social support given by CSOs among adolescents with high risk of IGD (probable IGD cases screened positive by validated tools).
- Trial name
- NCT05917977
- Testing
- Collective Motivational Interviewing plus Education Materials, Control group (Education Materials)
- Where
- Hong Kong
- Volunteers
- 172 people
- Sponsor
- Hong Kong College of Technology
Asthma in Children
N-WATCH: Nottingham Wheeze Assessment in Tidal Children
Children with long-term lung diseases like asthma need better techniques for diagnosis and monitoring of their disease. With better monitoring, it is anticipated that children and their carers will be able to manage their disease…
- Trial name
- N-WATCH (NCT07833826)
- Testing
- N-Tidal
- Where
- 2 sites in United Kingdom
- Volunteers
- 340 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
Chronic Pain, Pain, Chronic
Pain-at-Work Toolkit (Definitive Trial)
The Pain-at-Work Toolkit has been created together with people who live with chronic pain, employers, healthcare professionals, and a national pain charity.
- Trial name
- NCT07600892
- Testing
- The Pain-at-Work Toolkit is an web-based digital resource, providing education and information about behaviour change related to the self-management of chronic pain in the workplace., Control (Standard treatment)
- Where
- United Kingdom
- Volunteers
- 685 people
- Sponsor
- University of Nottingham
Multiple Sclerosis, Relapsing-Remitting
Determining the Effectiveness of earLy Intensive Versus Escalation Approaches for RRMS
The DELIVER-MS study seeks to answer the question: Does early treatment with highly effective DMT improve the prognosis for people with MS? This is an area of significant controversy and no data currently exist to guide treatment…
- Trial name
- DELIVER-MS (NCT03535298)
- Testing
- Early Highly Effective Therapies Group, Escalation Therapies Group
- Where
- 30 sites in United States, United Kingdom
- Volunteers
- 800 people
- Sponsor
- The Cleveland Clinic
Cystic Fibrosis (CF)
MRI Parameters as Biomarkers in Cystic Fibrosis (FEMPTO)
Cystic fibrosis (CF) is an inherited condition that affects several organs, including the gut. People with CF often experience uncomfortable digestive symptoms such as bloating, gas, abdominal pain, and constipation.
- Trial name
- FEMPTO (NCT07780344)
- Testing
- Linaclotide 290 micrograms
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University of Nottingham
Enteral Nutrition (Food for Special Medical Purposes), Enteral Feeds
Plant-Protein Dominant Tube Feed Study
This study aims to determine whether a reformulated plant-protein dominant protein blend in four existing enteral tube feeds is as effective as animal-protein dominant formulations in patients who are tube fed at home.
- Trial name
- NCT07422935
- Testing
- Plant-protein dominant enteral feed, Animal-protein dominant enteral feed
- Where
- United Kingdom
- Volunteers
- 110 people
- Sponsor
- Nutricia UK Ltd