Clinical trials: sponsored by University of Toronto
Sarcoma, Giant Cell Tumor of Bone
Activation Sarcoma: PROMIS and Mobility Evaluation in Sarcoma Patients
Sarcoma is a rare form of bone and soft tissue cancer, making up about 1% of all adult cancers. Management typically involves radiation therapy, chemotherapy, and surgical resection.
- Trial name
- NCT07227961
- Testing
- Surgery
- Where
- 4 sites in United States, Canada
- Volunteers
- 800 people
- Sponsor
- University of Calgary
Ascending Aortic Aneurysm Enlargement, Ascending Aorta Aneurysm
Treatment in Thoracic Aortic Aneurysm: Surgery vs Surveillance
The ascending aorta conducts blood from the heart to the rest of the body. The ascending aorta can become enlarged, and the risk of tearing and rupturing becomes higher with larger aorta.
- Trial name
- TITAN:SvS (NCT03536312)
- Testing
- Thoracic Aortic Surgery
- Where
- 31 sites in United States, Canada and 1 more
- Volunteers
- 610 people
- Sponsor
- Ottawa Heart Institute Research Corporation
Organ Donation After Circulatory Death, Organ Donation
Improving Deceased Organ Donation and Transplantation Using the Donation Advisor Clinical Decision Support Tool
Every year, thousands of Canadians receive life-saving, cost-effective organ transplants, while thousands more still wait or die because not enough organs are available.
- Conditions
- Organ Donation After Circulatory Death, Organ Donation, Clinical Decision Support Tool
- Trial name
- DART (NCT07903428)
- Testing
- Donation Advisor clinical decision-support tool
- Volunteers
- 10 people
- Sponsor
- OBS Medical Ltd
PARKINSON DISEASE (Disorder)
Singing Therapy for Rehabilitating Facial Mimicry in Parkinson's Disease: A Randomised Controlled Trial
Parkinson's disease can reduce facial expression and change the voice, making it harder to communicate emotions. This study examined whether practising facial and vocal imitation through speech and singing could improve facial…
- Trial name
- NCT07905612
- Testing
- Singing Imitation Therapy, Singing Observation Therapy
- Where
- Canada
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Toronto Metropolitan University
Vaccine Response Impaired, Respiratory Syncytial Virus Infections
RSV Vaccine in Transplant Recipients
Adjuvant, non-live RSV vaccine will be administered to adult lung and allogeneic hematopoietic stem cell transplant recipients. The safety and immunogenicity of this intervention will be studied.
- Conditions
- Vaccine Response Impaired, Respiratory Syncytial Virus Infections, Immune Suppression
- Trial name
- RSVax (NCT06593210)
- Testing
- Adjuvant, non-live RSV vaccine
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- University Health Network, Toronto
Smoking Cessation
Contingency Management to Promote Smoking Cessation Study
Adherence to medication and counseling are strong predictors of smoking cessation success. To provide these two components of care, healthcare providers typically provide people who smoke with prescriptions for cessation…
- Trial name
- NCT07685899
- Testing
- Health Rewards, Control
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Kansas Medical Center
Spinal Cord Injury, Spinal Cord Injury at C5-C7 Level
Nerve Transfer Surgery to Restore Upper-limb Function After Cervical Spinal Cord Injury
The goal of this prospective, open-label cohort study is to assess functional outcomes in individuals with cervical spinal cord injury who have undergone nerve transfer surgery to restore upper limb function.
- Conditions
- Spinal Cord Injury, Spinal Cord Injury at C5-C7 Level, SCI - Spinal Cord Injury, Upper Extremity Paralysis
- Trial name
- NCT05638191
- Testing
- Nerve transfer surgery
- Where
- 4 sites in Canada
- Volunteers
- 40 people
- Sponsor
- University of British Columbia
Liver Cirrhosis
AI-SC Multi-center Study
To examined the opportunity for Artificial Intelligence (AI) agents to evaluate transplant candidacy objectively at LT-SC, with a large language models (LLM) representing the expertise of each individual specialist (hepatologist…
- Trial name
- NCT07885007
- Testing
- evaluate the alignment between AI-SC recommendations and LT-SC decisions, Multi AI-SC model
- Where
- Canada
- Volunteers
- 1,000 people
- Sponsor
- University Health Network, Toronto
Multiple Ground Glass Opacities (GGOs)
A Registry for Patients With Multifocal Ground Glass Opacities (GGOs)
The purpose of this registry study is to actively monitor people with GGOs and collect information about them, so that investigators can learn more about these lesions and about the risk of developing lung cancer in study…
- Trial name
- NCT03802981
- Where
- 32 sites in United States, Canada
- Volunteers
- 338 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Bipolar Disorder, Multiple Mental Health Conditions
Narrative Enhancement and Cognitive Therapy for Self-Stigma in Youth
The goal of this pilot clinical trial is to assess the feasibility of conducting a full-scale study to learn if a new youth-adapted Narrative Enhancement and Cognitive Therapy (NECT-Y) reduces self-stigma in youth living with…
- Trial name
- NCT06672562
- Testing
- Narrative Enhancement and Cognitive Therapy, Usual care
- Where
- Canada
- Volunteers
- 97 people
- Sponsor
- Centre for Addiction and Mental Health
Tuberculosis (TB)
Research on Key Interventional Technologies for Controlling the Epidemic in High-prevalence Areas of Tuberculosis in Guangxi, China
The goal of this study is to find out if using mobile vans with advanced technology can help reduce tuberculosis (TB) in rural Guangxi, China. The study will also examine how practical and cost-effective this approach is.
- Trial name
- NCT06702774
- Testing
- Active case finding
- Where
- China
- Volunteers
- 43,067 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Traumatic Hemorrhage, Coagulopathy
Factor In the Initial Resuscitation of Severe Trauma 2 Patients
Injury is the leading cause of death for people between the ages of 1-44. This is especially true in trauma patients who have bleeding complications.
- Conditions
- Traumatic Hemorrhage, Coagulopathy, Massive Hemorrhage
- Trial name
- FiiRST-2 (NCT04534751)
- Testing
- Fibrinogen + PCC, Frozen Plasma
- Where
- 6 sites in Canada
- Volunteers
- 142 people
- Sponsor
- University Health Network, Toronto
Major Depressive Disorder
Microdosing Psychedelics to Improve Mood
This trial aims to examine the safety and efficacy of small (2mg) sub-hallucinogenic doses of psilocybin in people with Major Depressive Disorder.
- Trial name
- NCT05259943
- Testing
- Psilocybin first
- Where
- Canada
- Volunteers
- 39 people
- Sponsor
- Rotem Petranker
Sepsis
Clinical Outcomes Using Molecular Prediction in Acute Suspected Sepsis and Infection
Sepsis is a complex syndrome that affects the functioning of multiple organ systems and is caused by an uncontrolled response to infection.
- Trial name
- COMPASS-I (NCT07874698)
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Hypertrophic Cardiomyopathy (HCM)
HCMR Re-Imaging Study
This study aims to learn what might predict heart problems (like sudden death from a fast heart rhythm or heart failure) in people with a genetic condition called hypertrophic cardiomyopathy (HCM).
- Trial name
- NCT07054073
- Testing
- None - observational study
- Where
- 8 sites in United States, United Kingdom
- Volunteers
- 314 people
- Sponsor
- Christopher Kramer
Gingivitis
Efficacy of SALI-10 Oral Probiotics in Experimental Gingivitis
Gingivitis is among the most prevalent oral diseases worldwide, affecting an estimated 50-90% of adults. It is a reversible condition primarily caused by microbial plaque accumulation on teeth and gingival surfaces, which…
- Trial name
- NCT07256743
- Testing
- SALI-10 lozenge
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ostia Sciences
Achilles Insertional Tendinopathy, Achilles Tendinopathy
Single-Row Versus Double-Row Repair for Achilles Insertional Tendinopathy
Achilles insertional tendinopathy may require surgical debridement and tendon reattachment when non-operative treatment fails. Single-row and double-row repairs are used, with biomechanical studies favoring double-row, but…
- Trial name
- STRIDE (NCT07323875)
- Testing
- Single-row repair of the Achilles tendon at its calcaneal insertion, Double-row repair of the Achilles tendon at its calcaneal insertion
- Where
- Canada
- Volunteers
- 166 people
- Sponsor
- Women's College Hospital
Non-melanoma Skin Cancer, Carcinoma, Squamous Cell
Nicotinamide Chemoprevention for Keratinocyte Carcinoma in Solid Organ Transplant Recipients - Pivotal Trial
As patients live longer after receiving an organ transplant, there is a need to reduce the long-term side effects of the drugs used to prevent organ rejection.
- Conditions
- Non-melanoma Skin Cancer, Carcinoma, Squamous Cell, Carcinoma, Basal Cell, Keratinocyte Carcinoma
- Trial name
- SPRINTR (NCT05955924)
- Testing
- Nicotinamide
- Where
- 7 sites in Canada
- Volunteers
- 396 people
- Sponsor
- Women's College Hospital
Inpatient Internal Medicine Patients, Patient Discharge
A Pragmatic Trial of AI-Assisted Discharge Summary Generation
The goal of this study is to learn whether an artificial intelligence (AI) tool built into the electronic health record helps hospital physicians write discharge summaries.
- Conditions
- Inpatient Internal Medicine Patients, Patient Discharge, Documentation, Artificial Intelligence (AI)
- Trial name
- DRAFT-AI (NCT07866001)
- Testing
- Epic Discharge Summary Hospital Course Generator
- Volunteers
- 80 people
- Sponsor
- Unity Health Toronto
Hereditary Cancer Syndrome
CfDNA in Hereditary And High-risk Malignancies 2
The goal of this study is to understand the performance of an experimental blood test that aims to detect early tumors in patients with hereditary cancer syndromes.
- Trial name
- CHARM2 (NCT06726642)
- Testing
- Cell-free DNA analysis
- Where
- 8 sites in Canada
- Volunteers
- 1,000 people
- Sponsor
- University Health Network, Toronto
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