Clinical trials: sponsored by University of Zurich
Metastatic Melanoma
eFLASH for Skin Lesions of Malignant Melanomas
This prospective single center phase I trials aims to assess feasibility and safety of electron FLASH RT for treatment of melanoma skin metastases.
- Trial name
- Flash-Skin I (NCT06549439)
- Testing
- Electron FLASH radiotherapy
- Where
- Switzerland
- Volunteers
- 7 people
- Sponsor
- University of Zurich
Ventilator Lung
I-ASV in Cardiac Surgery
'POStoperative INTELLiVENT-adaptive support VEntilation in cardiac surgery patients II (POSITiVE II) is an investigator-initiated, international, multicenter, parallel, randomized clinical trial in patients after cardiac surgery.
- Trial name
- POSITiVE II (NCT06178510)
- Testing
- INTELLiVENT-ASV.
- Where
- Austria
- Volunteers
- 328 people
- Sponsor
- Medical University of Vienna
Pulmonary Embolism Acute
Reduced-Dose Versus Full-Dose Alteplase for High-Risk Pulmonary Embolism
High-risk pulmonary embolism is a life-threatening condition requiring immediate reperfusion therapy. Full-dose systemic thrombolysis is recommended as first-line treatment, but its use is limited by the risk of major bleeding…
- Trial name
- REDSTEM (NCT07816978)
- Testing
- Reduced-dose alteplase, Full-dose alteplase
- Where
- 23 sites in Denmark, Norway and 1 more
- Volunteers
- 400 people
- Sponsor
- Sahlgrenska University Hospital
Kidney Cancers
Tumor Heterogeneity of Renal Tumors Assessed by Multiparametric MRI With Direct Radiological-histopathological Correlation: an Explorative Study
In this study, high-resolution magnetic resonance imaging scans (MRI/mpMRI) were performed before surgical removal of the tumor and then compared with microscopic examinations of the tumor.
- Trial name
- NCT07713654
- Testing
- mpMRI
- Where
- Switzerland
- Volunteers
- 9 people
- Sponsor
- University of Zurich
Patients Operated on at the Neurosurgery Department
Neurophysiological Intraoperative or Epilepsy Monitoring
The investigators record the outcome of patients whose surgery involved intraoperative neurophysiological monitoring Trial with surgical intervention
- Trial name
- nphysdocu (NCT01630785)
- Testing
- Intraoperative Neurophysiological Monitoring IONM
- Where
- Switzerland
- Volunteers
- 10,000 people
- Sponsor
- University of Zurich
Patients Treated at the Neurosurgery Department
Patient Registry of the Neurosurgery Department
The investigators record all indications, treatments and outcomes from patients treated at the Neurosurgery Department. Trial with surgical intervention
- Trial name
- patregNCH (NCT01628406)
- Testing
- Treatment at the neurosurgery departement
- Where
- Switzerland
- Volunteers
- 24,000 people
- Sponsor
- University of Zurich
Substance Use Disorder (SUD)
Fighting Addictions, Improving Lives: COmprehensive Drug Rehabilitation With Music
FALCO is a parallel pragmatic randomized control trial addressing long-term effects of music therapy (MT) on substance use disorder (SUD). 600 participants will be recruited from multiple European countries (see Locations).
- Trial name
- FALCO (NCT07028983)
- Testing
- Active Music Group (AMG), Music Listening Group (MLG), Treatment as Usual (TAU)
- Where
- 11 sites in Austria, Israel and 6 more
- Volunteers
- 600 people
- Sponsor
- NORCE Norwegian Research Centre AS
Anatomy Education, Augmented Reality
Anatomy Learning With a 3D Platform on Personal Devices, Augmented Reality, or Traditional Resources
TEACHANATOMY II compared three ways of learning shoulder and hip anatomy among first-year medical students: a three-dimensional (3D) learning platform on personal devices, head-mounted augmented reality (AR), and curated…
- Conditions
- Anatomy Education, Augmented Reality, Anatomy Teaching Methods
- Trial name
- TEACHANATOMYII (NCT06552195)
- Testing
- Learning platform, then traditional resources, Traditional resources, then learning platform, Augmented reality, then traditional resources
- Where
- Switzerland
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Balgrist University Hospital
Postpartum Hemorrhage, Treatment Outcome
Long Term Outcome After Use of Vacuum-induced Tamponade for Postpartum Hemorrhage
This study will investigate all women treated with vacuum-induced tamponade (VIT) for PPH at a tertiary center, namely at the University Hospital Zurich (USZ), over a nine-year period (2017-2025).
- Conditions
- Postpartum Hemorrhage, Treatment Outcome, Pregnancy Outcome
- Trial name
- LOVIT (NCT07885072)
- Where
- Switzerland
- Volunteers
- 380 people
- Sponsor
- University of Zurich
Nervous System Diseases, Healthy Subjects
Functional Near-infrared Spectroscopy in Unconscious Patients
The study design is a single-center prospective pilot study. Hypothesis: Results of cerebral fNIRS examination in unconscious patients with severe hemorrhagic or ischemic stroke in the ICU are congruent with the results of SSEP…
- Trial name
- fNIRS (NCT04746820)
- Testing
- single-center prospective pilot study
- Where
- Switzerland
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Emanuela Keller
Postpartum Hemorrhage (Primary), Hemorrhage
U-CaVIT Versus Standard of Care for Prevention of Atonic Postpartum Hemorrhage After Cesarean Section in High-risk Women.
This pilot study aims to assess performance, safety and feasibility of U-CaVIT method (Uro-Catheter Vacuum Induced Tamponade), using the Rüsch® Brillant Silicone Balloon Catheter, an urological catheter, for the prevention of…
- Conditions
- Postpartum Hemorrhage (Primary), Hemorrhage, Postpartum Complication, Delivery ,Complications,Maternal
- Trial name
- UCaVIT Pilot (NCT07019623)
- Testing
- Rüsch® Balloon Catheter Ch. 24, Ultrasonography
- Where
- Switzerland
- Volunteers
- 32 people
- Sponsor
- Christian Haslinger
Lung Cancer
ARtificial Intelligence for Gross Tumour vOlume Segmentation
Identifying the outline of a Gross Tumour Volume (GTV) in lung cancer is an essential step in radiation treatment. Clinical research, such as radiomics and image-based prognostication, requires the GTV to be pre-defined on…
- Trial name
- ARGOS (NCT05775068)
- Testing
- Radiotherapy
- Where
- Netherlands
- Volunteers
- 2,000 people
- Sponsor
- Maastricht Radiation Oncology
Grief
A Grief Support App for Adults Experiencing Bereavement
Losing a loved one is a difficult experience. Some people may require psychological support, but even for those who do not, grief can often feel overwhelming.
- Trial name
- NCT07862244
- Testing
- Self-guided grief app (Daybreak), Waiting list
- Where
- United Kingdom
- Volunteers
- 80 people
- Sponsor
- Medical Research Council Cognition and Brain Sciences Unit
Treatment Resistant Psychosis, Psychosis
Stratification and Treatment in Early Psychosis Study -ASSIST
The purpose of this trial is: To investigate whether the response to clozapine treatment can be enhanced by adding cannabidiol (CBD), compared to placebo, in treatment resistant psychosis patients.
- Trial name
- STEP-ASSIST (NCT07326124)
- Testing
- CBD 100 mg/mL Oral Solution, Placeb
- Where
- 15 sites in Germany, Greece and 6 more
- Volunteers
- 250 people
- Sponsor
- University of Oxford
Oropharynx Cancer
Personalized Volume-deescalated Elective Nodal Irradiation in Oropharyngeal Head and Neck Squamous Cell Carcinoma
Multicentric prospective model-based de-escalation of the elective clinical target volumes (CTV) in radiotherapy of oropharyngeal carcinoma of all stages with the goal to reduce toxicity.
- Trial name
- DeEscO (NCT06563362)
- Testing
- De-escalation of irradiated volume
- Where
- 7 sites in Switzerland
- Volunteers
- 120 people
- Sponsor
- University of Zurich
Psychosis, First Episode Psychosis
Stratification and Treatment in Early Psychosis Study - ENHANCE
The purpose of this study is: To investigate whether the response to antipsychotic treatment can be enhanced by adding cannabidiol (CBD) to the existing treatment, compared to placebo, in participants with a first episode of…
- Conditions
- Psychosis, First Episode Psychosis, Psychotic Disorders, Psychotic Episode
- Trial name
- STEP-ENHANCE (NCT06778564)
- Testing
- CBD 100 mg/mL Oral Solution
- Where
- 17 sites in Austria, Germany and 7 more
- Volunteers
- 250 people
- Sponsor
- University of Oxford
Acute Low Back Pain, Chronic Low Back Pain (CLBP)
Exploring Multidimensional Trajectories in People With Low Back Pain
Low back pain (LBP) is a major health problem in Switzerland and worldwide. Globally, LBP remains the leading cause of years lived with disability and its incidence and associated socioeconomic consequences are predicted to…
- Trial name
- NCT07176845
- Testing
- Observational
- Where
- Switzerland
- Volunteers
- 600 people
- Sponsor
- Bern University of Applied Sciences
Sepsis, Long Term Care
Long-Term Recovery and Quality of Life in Sepsis Survivors
The goal of this observational study is to learn about the long-term outcomes and recovery of adult patients admitted to the intensive care unit (ICU) with sepsis.
- Conditions
- Sepsis, Long Term Care, Sepsis Scores, Long Term Follow-Up
- Trial name
- UNCOVER (NCT07863128)
- Testing
- Care for Sepsis
- Where
- Switzerland
- Volunteers
- 530 people
- Sponsor
- University of Geneva, Switzerland
Psoriasis (PsO)
Global Healthcare Study on Psoriasis
The Global Healthcare Study on Psoriasis (GHSP) is an international, multicenter observational study hosted by the University of Zurich (UZH) investigating healthcare access, treatment patterns, disease severity, and quality of…
- Trial name
- GHSP (NCT07634016)
- Where
- Switzerland
- Volunteers
- 9,600 people
- Sponsor
- Julia Tatjana Maul
Hidradenitis Suppurativa (HS), Hidradenitis Suppurativa (Acne Inversa)
Global Healthcare Study on Hidradenitis Suppurativa
The Global Healthcare Study on Hidradenitis Suppurativa (GHSHS) is an international, multicenter observational study hosted by the University of Zurich (UZH) investigating healthcare access, treatment patterns, disease severity…
- Trial name
- GHSHS (NCT07659769)
- Where
- Switzerland
- Volunteers
- 9,600 people
- Sponsor
- Julia Tatjana Maul
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