Clinical trials: sponsored by Virginia Commonwealth University
Becker Muscular Dystrophy, Muscular Dystrophies
Defining Endpoints in Becker Muscular Dystrophy
This is a 24-month, observational study of 50 participants with Becker muscular dystrophy (BMD)
- Conditions
- Becker Muscular Dystrophy, Muscular Dystrophies, Muscular Dystrophy in Children, Muscular Dystrophy, Becker
- Trial name
- GRASP-01-002 (NCT05257473)
- Where
- 11 sites in United States, New Zealand and 1 more
- Volunteers
- 59 people
- Sponsor
- Virginia Commonwealth University
Acute Myeloid Leukemia
Olutasidenib Single Plus Combo Therapy in IDH1mut AML After Induction and Consolidation
Treatment with olutasidenib for isocitrate dehydrogenase 1 (IDH1) mutant acute myeloid leukemia (AML) after completion of traditional intensive induction/consolidation is likely to be safe, tolerable, and may provide clinical…
- Trial name
- NCT07130695
- Testing
- Olutasidenib Investigational Agent Administration
- Sponsor
- Virginia Commonwealth University
Knowledge, Attitudes
Quit and Screen Project
The Quit and Screen Project seeks to engage healthcare providers in helping adults who smoke to quit tobacco use, including menthol cigarettes and flavored cigars, and screen for lung cancer early as strategies to reduce multiple…
- Conditions
- Knowledge, Attitudes, Behavioral Intention
- Trial name
- NCT06350643
- Testing
- Quit and Screen Project training, G02 (Global Knowledge Center for Lung Cancer) Lung Cancer Screening training
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Cardiac Arrest, Out-Of-Hospital, Hypotension
Cardiac Arrest - Ultrasound Detection of Occult Perfusion
The goal of this study is to describe the population of patients presenting after out of hospital cardiac arrest with occult perfusion, defined as a patient without a palpable pulse but with some evidence of pulsatile arterial…
- Trial name
- NCT07897370
- Where
- 8 sites in United States
- Volunteers
- 1,400 people
- Sponsor
- University of Massachusetts, Worcester
Anorexia Nervosa
Neuroscience-informed Treatment to Remotely Target Reward Mechanisms in Post-acute Anorexia Nervosa
The investigators will recruit individuals with broadly-defined AN (n = 80) who are currently in or have recently participated in higher-level eating disorder treatment (e.g., residential, partial hospitalization/day treatment…
- Trial name
- NCT05799872
- Testing
- Positive Affect Treatment for Anorexia Nervosa (PAT-AN):, Psychoeducational and Behavioral Therapy (PBT)
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Virginia Commonwealth University
Tetraplegia/Tetraparesis
Transspinal Stimulation With and Without Blood Flow Restricted Exercise Via Telehealth in Persons With Tetraplegia
The purpose of the current study is to evaluate whether a home-based, telehealth-supported intervention combining Blood Flow Restricted Exercise (BES) and Transspinal Stimulation (TS) will improve motor and functional abilities…
- Trial name
- SCIMS Main (NCT05423600)
- Testing
- BES + TS
- Where
- 3 sites in United States
- Volunteers
- 44 people
- Sponsor
- Virginia Commonwealth University
Symptoms and Signs, Cancer
Heuristic Tool To Improve Symptom Self-Management in Adolescents and Young Adults With Cancer
Determine the effects of the Computerized Symptom Assessment Tool (C-SCAT) versus usual care on the primary outcomes of self-efficacy for symptom management and symptom self-management behaviors
- Conditions
- Symptoms and Signs, Cancer, Childhood Cancer
- Trial name
- NCT05958316
- Testing
- Computerized Symptom Capture Tool (C-SCAT) Intervention, Usual Care Control
- Where
- 5 sites in United States
- Volunteers
- 126 people
- Sponsor
- Virginia Commonwealth University
Breast Cancer
Single FrAction Interstitial BreaSt BracHytherApy
This phase 2, single arm prospective study has been designed to determine the safety of delivering accelerated partial breast irradiation (APBI) with a multicatheter interstitial implant in a single fraction over 1 day.
- Trial name
- SASHA (NCT07654257)
- Testing
- Partial Breast Irradiation
- Where
- United States
- Volunteers
- 134 people
- Sponsor
- Virginia Commonwealth University
Solid Tumor, Adult
Neratinib + Valproate in Advanced Solid Tumors, w/Expansion Cohort in Ras-Mutated Ca
To determine the recommended phase 2 dose (RP2D) of the combination of neratinib and sodium valproate when given to patients with advanced solid tumors.
- Trial name
- NCT03919292
- Testing
- Neratinib, Divalproex Sodium
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Virginia Commonwealth University
Young Adult-Mediated Intervention to Increase Colorectal Cancer Screening
Young Adult-Mediated Intervention to Increase Colorectal Cancer Screening
This study will garner preliminary data to develop a young adult-mediated intervention whereby a younger family member encourages their older family member to get colorectal cancer (CRC) screening.
- Trial name
- NCT05936931
- Testing
- Changes in CRC screening awareness and intentions
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Diabetes Mellitus Self Management Education, Hypertension Self-management
The Mobile Health and Wellness Program Remote Health Study
This clinical trial trial design will be a pretest-posttest comparison group pilot study that evaluates the implementation of team-based telemedicine visits and remote patient monitoring.
- Conditions
- Diabetes Mellitus Self Management Education, Hypertension Self-management, Self Management
- Trial name
- NCT07075978
- Testing
- Remote patient monitoring, Telephone
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Virginia Commonwealth University
Breast Cancer, Supportive Care in Cancer
EMBRACE (EMPA in BReast Cancer for Activity and Cardiac ProtEction)
The primary objective of this pilot study is to evaluate the feasibility and acceptability of a clinical trial protocol investigating 10 mg/day empagliflozin in breast cancer patients receiving anthracycline-based chemotherapy.
- Trial name
- EMBRACE (NCT07883512)
- Testing
- Empagliflozin
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Virginia Commonwealth University
Diabetic Neuropathy
Activity for Diabetic Polyneuropathy
The proposed study will randomize participants with diabetic peripheral neuropathy into two groups. One group of participants will receive standard-of-care counseling while the other group will undergo supervised exercise and…
- Trial name
- ADAPT (NCT02341261)
- Testing
- Standard Care Counseling, Supervised Exercise and Counseling
- Where
- 2 sites in United States
- Volunteers
- 197 people
- Sponsor
- University of Utah
DM1, Myotonic Dystrophy
Establishing Biomarkers and Clinical Endpoints in Myotonic Dystrophy Type 1 (END-DM1) Extension
Myotonic Dystrophy type 1 (DM1) is an autosomal dominant multisystemic disorder that causes progressive disability and shortened life expectancy.
- Conditions
- DM1, Myotonic Dystrophy, Myotonic Dystrophy 1, Myotonic Dystrophy Type 1
- Trial name
- END-EXT (NCT07700225)
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Virginia Commonwealth University
Dementia
Prescribing Trends and Associated Outcomes of Antiepileptic Drugs in US Nursing Homes Surrounding the COVID-19 Pandemic
Since the "National Partnership to Improve Dementia Care" debuted in 2012, almost all long-stay psychoactive prescribing has been graded by CMS, which has correlated to decreased use.
- Trial name
- NCT06095284
- Testing
- Pre-Extraction Phase, Extraction Phase, Post-Extraction Phase
- Where
- United States
- Volunteers
- 22,500,000 people
- Sponsor
- Virginia Commonwealth University
Violence
A Virtual Reality Brief Violence Intervention: Preventing Gun Violence Among Violently Injured Adults
The overall aim of the proposed project is to develop and evaluate the effectiveness of Brief Violence Intervention-Virtual Reality (BVI-VR) for reducing firearm-related violence, re-injury, and mortality among victims of…
- Trial name
- NCT06239285
- Testing
- Brief Violence Intervention VR (BVI-VR), Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 220 people
- Sponsor
- Virginia Commonwealth University
Inpatient Experience Survey Administration, Inpatient Experience Survey Response
FIQS Dissemination and Implementation
This study is testing Family Input for Quality and Safety (FIQS), a mobile-based survey tool that allows hospitalized children's families and adolescent patients to report safety concerns in real-time by responding to a text…
- Conditions
- Inpatient Experience Survey Administration, Inpatient Experience Survey Response, Inpatient Pediatric Care, Inpatient Pediatric Engagement and Shared Decision-Making
- Trial name
- FIQS DI (NCT07871136)
- Testing
- Text-Only Enrollment Strategy, Text Plus In-Person Enrollment Strategy, Anonymous Safety Reporting with Impact Website
- Where
- 8 sites in United States
- Volunteers
- 21,800 people
- Sponsor
- University of California, San Francisco
Nutrition, Health
Nutrition for Precision Health, Powered by the All of Us
The goal of this Nutrition for Precision Health (NPH) powered by All of Us research study is to develop Artificial Intelligence/Machine Learning (AI/ML) algorithms that predict individual responses to diet patterns using rich…
- Conditions
- Nutrition, Health, Dietary Habits
- Trial name
- NCT05701657
- Testing
- Diet A, Diet B, Diet C
- Where
- 14 sites in United States
- Volunteers
- 8,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Violence, Exposure to Violent Event
Evaluation of Violence Prevention Strategies to Prevent and Reduce Community Levels of Youth Violence
The goal of this research study is to implement and evaluate a comprehensive community-level approach, Healthy Communities for Youth, that includes both a selective hospital-based prevention strategy, Emerging Leaders, and…
- Conditions
- Violence, Exposure to Violent Event, Adolescent Behavior
- Trial name
- NCT06176300
- Testing
- PAR - the SEED Method, PAR-Youth Voices, Emerging Leaders hospital-based intervention
- Where
- United States
- Volunteers
- 3,390 people
- Sponsor
- Virginia Commonwealth University
High Grade Gliomas, Glioblastoma
Pre-Radiation Chemotherapy for Newly Diagnosed High-Grade Glioma.
Better treatments are needed for high-grade gliomas (HGG), and new ways of treating this disease should be tested. The investigators want to see if giving medicine before radiation works well.
- Conditions
- High Grade Gliomas, Glioblastoma, Astrocytoma, Oligodendroglioma
- Trial name
- PRC (NCT07439172)
- Testing
- Pre-radiation temozolomide.
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- The Cooper Health System