Clinical trials: sponsored by Wake Forest University Health Sciences
Nutrient Deficiency
PROmega Pilot Study of Clinic-based DHA Blood Screening in Early Pregnancy
This pilot study will explore feasibility of routine implementation of the recommended blood-based screening of DHA status in early pregnancy in routine clinical care.
- Trial name
- PROmega (NCT07271758)
- Testing
- DHA blood screening
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Wake Forest University Health Sciences
Colorectal Cancer, Sarcopenia
Myopenia and Mechanisms of Chemotherapy Toxicity in Older Adults With Colorectal Cancer
This study will examine the association between low muscle mass (myopenia) at diagnosis and chemotherapy toxicity in older adults with newly diagnosed advanced colorectal cancer.
- Trial name
- M&M (NCT03998202)
- Where
- 147 sites in United States
- Volunteers
- 300 people
- Sponsor
- Wake Forest University Health Sciences
Postural; Strain, Healthy
Resident Posture Biofeedback Study
While a majority of surgical ergonomic studies have been evaluating attending surgeons, few have evaluated surgical ergonomics within the surgical resident.
- Trial name
- NCT06564519
- Testing
- Posture Biofeedback Device
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Wake Forest University Health Sciences
Remote vs. In-Person, Remote Visits
Remote vs. In-Person Study Evaluation (RISE) Trials: RISE Above Smoking (Trial 1 of 3)
The study will employ a randomized, parallel-group design with two-stage randomization. After an initial brief screen for basic eligibility, participants will be randomized (within site) to either Remote (R) or In-Person (IP)…
- Conditions
- Remote vs. In-Person, Remote Visits, In-person Visits
- Trial name
- NCT06822049
- Testing
- Combination Nicotine Replacement Therapy (patch and lozenge)
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Obesity, Obesity; Drug
Long-term Effectiveness of the Antiobesity Medication Phentermine
The purpose of this research study is to understand the long-term effects of the drug phentermine on weight, blood pressure, other health outcomes, and safety.
- Conditions
- Obesity, Obesity; Drug, Lifestyle, Healthy
- Trial name
- LEAP (NCT05176626)
- Testing
- Online Lifestyle Behavioral Therapy, Phentermine Hydrochloride 8 MG
- Where
- 4 sites in United States
- Volunteers
- 870 people
- Sponsor
- Wake Forest University Health Sciences
Psoriasis
Assessing Psoriasis Treatment Outcomes
To assess the feasibility of AIGPP video interactions with psoriasis patients. To explore patient attitudes, trust, and comfort levels concerning AIGPP interactions in a healthcare setting, and to understand their influence on…
- Trial name
- NCT07391423
- Testing
- Artificial intelligence, Human, Standard of Care
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Wake Forest University Health Sciences
Breast Cancer, Fatigue in Cancer Survivors
Evaluation of Massage Therapy for Cancer Related Fatigue in Breast Cancer Survivors
The purpose of this study is to better understand how massage therapy helps reduce fatigue related to cancer and its treatment in breast cancer survivors.
- Trial name
- NCT07917845
- Testing
- Massage therapy
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Wake Forest University Health Sciences
Xerosis Due to Atopic Dermatitis
Xerosis and Use of Topical Moisturizer
The primary hypothesis is that routine measurement of trans epidermal water loss (TEWL) rates and stratum corneum (SC) hydration levels will promote patient adherence to maintenance moisturizer therapy and prevent disease…
- Trial name
- NCT04341623
- Testing
- Cetaphil Pro Eczema moisturizer, Electronic interaction, GPSkin
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Wake Forest University Health Sciences
Myeloma
Wearable Core Body Temperature Monitoring for Early Detection of Cytokine Release Syndrome in Outpatients Receiving CAR T-Cell Therapy
The purpose of this research study is to see if a wearable temperature monitoring patch can detect cytokine release syndrome earlier than traditional oral temperature monitoring.
- Trial name
- NCT07911540
- Testing
- TempShield Continuous Temperature Monitoring, Standard of Care
- Where
- 2 sites in United States
- Volunteers
- 105 people
- Sponsor
- Wake Forest University Health Sciences
Androgenic Alopecia
Evaluating the Efficacy of Platelet-rich Plasma Therapy in the Treatment of Androgenic Alopecia
The study team will assess the efficacy of platelet-rich plasma therapy, a special blood product which is from the participant's own body, in the treatment of androgenic alopecia (also known as male pattern hair loss) in females.
- Trial name
- NCT03474718
- Testing
- Platelet-rich Plasma Left Side, Platelet-rich Plasma Right Side
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Wake Forest University Health Sciences
Pseudofolliculitis Barbae
Shaving Satisfaction in Males With Skin Irritation From Shaving
The purpose of this research study is to evaluate the improvement in overall shave satisfaction, the appearance of skin irritation from shaving, and the razor related inflammation of the hair follicles when using a new razor…
- Trial name
- NCT03569956
- Testing
- 556 Razor
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Breast Carcinoma, Colorectal Carcinoma
Assessing Benefits and Harms of Cannabis/Cannabinoid Use Among Cancer Patients Treated in Community Oncology Clinics
This is a multi-site clinical study enrolling 2000 newly diagnosed patients with breast, colorectal, melanoma, non-Hodgkin lymphoma, or non-small cell lung cancer, who are planning to receive one or more systemic cancer directed…
- Conditions
- Breast Carcinoma, Colorectal Carcinoma, Lung Non-Small Cell Carcinoma, Melanoma
- Trial name
- COSMIC (NCT06418204)
- Testing
- Non-interventional Study
- Where
- 491 sites in United States, Puerto Rico
- Volunteers
- 2,000 people
- Sponsor
- Wake Forest University Health Sciences
Malignant Digestive System Neoplasm, Malignant Female Reproductive System Neoplasm
Surgical Thromboprophylaxis Practices in Oncology Patients Within the NCORP Network, STOP-VTE Study
This study evaluates the use of extended venous thromboembolism prophylaxis (ePPx) following abdominopelvic cancer surgery within the NCI Community Oncology Research Program (NCORP) network, targeting surgeons and surgical…
- Conditions
- Malignant Digestive System Neoplasm, Malignant Female Reproductive System Neoplasm, Malignant Genitourinary System Neoplasm
- Trial name
- STOP-VTE (NCT07215624)
- Testing
- Non-Interventional Study
- Where
- 104 sites in United States, Puerto Rico
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Pain Management
Methadone Versus Standard of Care for Pain Control in Minimally Invasive Lung Resection Surgery
This study is being done to find out if methadone is more effective in controlling pain in patients presenting for minimally invasive lung resection surgery compared to the standard of care.
- Trial name
- NCT07914751
- Testing
- Methadone, Standard of Care
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Wake Forest University Health Sciences
Osteosarcoma in Children, Osteosarcoma in Adolescents and Young Adults
The CATSINDO Trial - Clinical and Translational Study in Newly Diagnosed Osteosarcoma
The goal of this study is to learn whether children, adolescents, and young adults with newly diagnosed high-grade osteosarcoma can be safely discharged from the hospital at slightly higher methotrexate blood levels after…
- Trial name
- NCT07560826
- Testing
- High-dose Methotrexate
- Where
- 9 sites in United States
- Volunteers
- 46 people
- Sponsor
- Wake Forest University Health Sciences
Refusal of Transport
Physician Engagement in EMS Transport Refusal Rates
The primary goal of this study is to find out if patients who speak with an EMS physician over the phone are less likely to refuse care compare to patients who do not speak with an EMS physician.
- Trial name
- NCT07107737
- Testing
- Physician Consultation, Standard of Care
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Wake Forest University Health Sciences
Remote vs. In-Person, Remote Visits
Remote vs. In-Person Study Evaluation (RISE) Trials: RISE Above Depression (Trial 2 of 3)
The study will employ a randomized, parallel-group design with two-stage randomization. After an initial brief screen for basic eligibility, participants will be randomized (within site) to either Remote (R) or In-Person (IP)…
- Conditions
- Remote vs. In-Person, Remote Visits, In-person Visits
- Trial name
- NCT07854301
- Testing
- mobile health application (Moodivate)
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Esophagogastric Junction Distensibility, Hiatal Hernia
Esophagogastric Junction Distensibility During Hiatal Hernia Repair
The investigators aim to ascertain the effects of hiatal hernia repair and fundoplication on the distensibility of the esophagogastric junction (EGJ) as measured by FLIP topography/impedance planimetry.
- Trial name
- NCT04450628
- Testing
- EndoFLIP
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Wake Forest University Health Sciences
Type 2 Diabetes Mellitus (T2D)
Culturally Tailored Program for Food-Insecure Adults: SPICE-D
The goal of this pilot intervention study is to learn if culturally appropriate food bundles and nutrition education can help people with diabetes who struggle to afford healthy food in patients with diabetes receiving care at…
- Trial name
- SPICE-D (NCT07361341)
- Testing
- Food Bundle Intervention
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Wake Forest University Health Sciences
Cortical Blindness
Multisensory Rehabilitation of Vision Loss After Cortical Damage
Damage to visual cortex on one side of the brain frequently produces a profound and permanent blindness in contralesional space (hemianopia), a debilitating condition that causes enormous suffering for patients and their families.
- Trial name
- NCT07659691
- Testing
- Multisensory Rehabilitation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Wake Forest University Health Sciences
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