Clinical trials: sponsored by Yale University
Opioid Use Disorder, Opioid Withdrawal
Sublingual Dexmedetomidine for Treating Opioid Withdrawal
A major challenge to seeking treatment for opioid use disorder (OUD) is the withdrawal symptoms associated with cessation of opioid use.
- Trial name
- NCT05712707
- Testing
- BXCL501 (180 micrograms), BXCL501 (240 micrograms), Lofexidine (Positive Control)
- Where
- 4 sites in United States
- Volunteers
- 160 people
- Sponsor
- New York State Psychiatric Institute
Insulin Resistance, Hypertriglyceridemia
Metabolic Heterogeneity Underlying Hypertriglyceridemia: Hepatic Triglyceride Biosynthesis in Humans With Different Insulin Resistance Phenotypes
The focus of this cross-sectional study is to determine the effects of tissue-specific (adipose tissue or muscle) vs global (combined) insulin resistance (IR) on hepatic triglyceride biosynthesis in humans, and to determine…
- Trial name
- NCT05743868
- Testing
- Standardized Dinner, Premeal exercise
- Where
- Netherlands
- Volunteers
- 8 people
- Sponsor
- Yale University
Abdominal Pain/ Discomfort, Irritable Bowel Syndrome
The Mechanism Underlying the Analgesic Effect of the Music of IBS Pain
The proposed pilot study aims to assess the underlying mechanisms of the MBI on IBS pain and the feasibility of using novel technology in the outcome measurements.
- Trial name
- NCT06706778
- Testing
- Music intervention
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Yale University
HIV Infections
An AI-based mHealth Intervention to Improve HIV Testing
The purpose of this study is to develop an artificial intelligence (AI)-chatbot-based mobile health (mHealth) intervention to promote HIV testing in Malaysia.
- Trial name
- NCT05335096
- Testing
- An AI-chatbot-based mHealth intervention, An attention-chatbot-based mHealth intervention, Educational materials
- Where
- Malaysia
- Volunteers
- 307 people, healthy volunteers welcome
- Sponsor
- Yale University
Tobacco Use, Tobacco Use Cessation
Adaptation and Testing of a Novel Text-based Tobacco Cessation and Education Intervention in Kenyan Emergency Department Patients
In this study, investigators will adapt and implement Text2Quit in a Kenyan ED population will increase knowledge and cessation.
- Trial name
- Text2Quit (NCT07734727)
- Testing
- Text2Quit-Kenya
- Where
- Kenya
- Volunteers
- 285 people
- Sponsor
- Yale University
Asthma in Children
Community Health Equity Accelerator (CHEA) Pediatric Asthma Intervention
The purpose of this pilot is to initiate an academic-community partnership and launch a multi-level intervention that includes an asthma exposure pathway (an online decision support and resource) and a health Promotora program…
- Trial name
- NCT06507943
- Testing
- Promotora Home Visit
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Yale University
Diabetes Type 2, Overweight or Obesity
Effect of the Thrive AI Health App on Lifestyle Behaviors and Quality of Life
The goals of this randomized trial is to learn: 1. If the Thrive AI Health app will help adults improve their everyday habits (diet, exercise, and sleep). 2.
- Trial name
- NCT07376655
- Testing
- App
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Yale University
Heart Failure
Mechanisms Underlying Hypotensive Response to ARB/NEP Inhibition - Aim 3
This is a double-blind, randomized, two x two crossover (aprepitant vs placebo) during both initiation of Entresto, LCZ696, (50 mg dose) and at steady-state of Entresto (200 mg bid dose or the highest tolerated dose).
- Trial name
- NCT04649229
- Testing
- LCZ 696, Para-aminohippurate, Iohexol
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Yale University
Stroke Recurrence, Myocardial Infarction
Cilostazol for Prevention of Recurrent Stroke Trial
The goal of this clinical study is to learn if adding a medicine called cilostazol to usual treatment can help prevent another stroke, a heart attack, or death in patients who had a stroke caused by a blocked blood vessel, or a…
- Conditions
- Stroke Recurrence, Myocardial Infarction, Vascular Death, Ischemic Stroke
- Trial name
- Clarity (NCT07174414)
- Testing
- Cilostazol 100 mg Tablets
- Where
- 52 sites in United States
- Volunteers
- 2,000 people
- Sponsor
- Stanford University
HIV, Pregnancy
Evaluating the Healthy Families PrEP Program for Women at Risk for HIV
Study investigators developed and piloted a counselling intervention, Healthy Families-PrEP, that supports women to use HIV prevention strategies while trying for and during pregnancy.
- Conditions
- HIV, Pregnancy, Pre-Exposure Prophylaxis of HIV Infection
- Trial name
- HFPT (NCT06746675)
- Testing
- Healthy Families PrEP Counselling Intervention
- Where
- Uganda
- Volunteers
- 660 people, healthy volunteers welcome
- Sponsor
- Yale University
Pleuropulmonary Blastoma, Sertoli-Leydig Cell Tumor
International PPB/DICER1 Registry
PPB has strong genetic implications, with a unique set of conditions in an individual or their family, occurring mostly in childhood and adolescence.
- Conditions
- Pleuropulmonary Blastoma, Sertoli-Leydig Cell Tumor, DICER1 Syndrome, Cystic Nephroma
- Trial name
- NCT03382158
- Where
- United States
- Volunteers
- 3,400 people, healthy volunteers welcome
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Type 1 Diabetes
T1CARE: A Trial of a Novel Intervention to Address Social Determinants of Health in Young Adults With Type 1 Diabetes
Randomized controlled trial with a wait list control arm. Participants will be randomized 2:1 to T1CARE or wait list usual care arm. Participants will be recruited from the Yale Adult and Pediatric Diabetes Centers.
- Trial name
- T1CARE (NCT07059806)
- Testing
- T1CARE
- Where
- 2 sites in United States
- Volunteers
- 114 people
- Sponsor
- Yale University
Domestic Violence
Project INSPIRE: INtervention Support Groups: Peers Inspiring Resilience and Empowerment
The investigators will develop a new, integrated, group intervention to enhance safety, support, and empowerment for survivors of intimate partner violence in the community.
- Trial name
- NCT05826041
- Testing
- (INSPIRE) INtervention Support groups: Peers Inspiring Resilience and Empowerment., Traditional Domestic Violence Support Group
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Yale University
Chronic Low Back Pain (CLBP), Physical Therapy
Psilocybin-Assisted Physical Therapy in Chronic Low Back Pain
The purpose of this research study is to investigate whether a single administration of psilocybin can improve interoceptive awareness (awareness of bodily sensations) in individuals with chronic low back pain undergoing physical…
- Conditions
- Chronic Low Back Pain (CLBP), Physical Therapy, Psilocybin
- Trial name
- NCT07306364
- Testing
- Psilocybin 10 mg, Psilocybin 25 mg, Niacin 100 mg
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Yale University
RSV Infection
Real-World Effectiveness of Perinatal RSV Immunoprophylaxis
The purpose of this study is to continue evaluating how well the RSV vaccines work as they are currently being used in routine clinical practice.
- Trial name
- NCT06172660
- Testing
- Nirsevimab
- Where
- United States
- Volunteers
- 3,750 people
- Sponsor
- Yale University
Osteoporosis, Lumbar Disc Herniation
Baduanjin With Resistance Training Program
The purpose of this study is to improve symptoms of Lumbar Disc Herniation (LDH) and Osteoporosis (OP) by implementing an evidence-based Baduanjin exercise to reduce pain and increase muscle strength and quality of life in…
- Trial name
- NCT06853132
- Testing
- Baduanjin with Resistance Training Program
- Where
- China
- Volunteers
- 136 people
- Sponsor
- Yale University
Ischemia and No Obstructive Coronary Artery Disease, Coronary Microvascular Dysfunction
The DISCOVER INOCA Prospective Multi-center Registry
The overall objective of this multi-center registry is to identify specific phenotypes of INOCA with both an anatomic evaluation (coronary angiography and intravascular imaging) and physiologic assessment with the Abbott…
- Conditions
- Ischemia and No Obstructive Coronary Artery Disease, Coronary Microvascular Dysfunction, Coronary Vasospasm, Endothelial Dysfunction
- Trial name
- DISCOVER INOCA (NCT05288361)
- Testing
- Coroventis Coroflow Cardiovascular System and PressureWire™ X Guidewire
- Where
- 9 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Yale University
Readmission, Readmission Rates
A Clinician-Patient Dual Behavior Change Framework to Leverage Informed Digital Nudges to Reduce Hospital Readmissions and Improve Patient Outcomes: A Trial for Scalable Strategy to Reduce Readmissions (PREVENT-R)
The PREVENT-R trial will evaluate an intervention targeting both clinician and patient behavior. The clinician-focused piece consists of an electronic medical record-based digital nudge presented to emergency department…
- Conditions
- Readmission, Readmission Rates, Readmission, Hospital, Elderly (People Aged 65 or More)
- Trial name
- PREVENT-R (NCT07890961)
- Testing
- Digital nudge prompting
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- Yale University
Diabetes Mellitus, Type 2
Adolescent-mediated Family Diabetes Intervention: American Samoa
The goal of this project is to test the feasibility, acceptability, and preliminary efficacy of an adolescent-mediated intervention designed to improve the glycemic control and self-care practices of a parent/grandparent.
- Trial name
- NCT05356884
- Testing
- Diabetes Intervention, Leadership & Life Skills
- Where
- American Samoa
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Yale University
Borderline Personality Disorder
MDMA in Borderline Personality Disorder
The purpose of this study is to test the effects of MDMA (3,4-methylenedioxymethamphetamine) on social cognition in adults with Borderline Personality Disorder.
- Trial name
- MDMA in BPD (NCT06683014)
- Testing
- MDMA
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Yale University
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