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Prostatic NeoplasmsPhase 2PROSUTNCT00748358

An Open-label Phase II Study With SUTENT in Patients Suffering From Hormone Refractory Prostate Cancer

A Phase 2 study testing sunitinib in people with Prostatic Neoplasms and Neoplasms, Hormone-Dependent, run by Assistance Publique - Hôpitaux de Paris at 1 site in France.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

as second-line treatment in metastatic prostate cancer, the present study will investigate the efficacy of sunitinib (SUTENT) given orally at a dose of 37.5 mg continuously, for 6 cycles of 6 consecutive weeks .Patients who are still responders after 6 cycles will be treated until disease progression, pain… Read more about this study

Who is it for?
Ages 18 years and older, men only
What is being tested?
sunitinib
Type of treatment
Pill or oral medicine
Could I receive a placebo?
No, everyone receives an active treatment
How many people
50 participants
Where
1 siteFrance
Study dates
Mar 2008to Apr 2011
Phase
Phase 2
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • Men only
  • No healthy volunteers
  • Adult, Older adult

Who may be able to join

  • Signed and dated IRB/EC-approved informed consent
  • Age 18 years or older
  • Histologically confirmed prostate adenocarcinoma
  • Metastatic HRPC
  • Received prior castration by orchidectomy and/or LH-RH agonist with or without antiandrogen, antiandrogen withdrawal, monotherapy with estramustine, or other hormonal agents.
  • Tumor disease must be progressive after a first line using docetaxel based chemotherapy, eventually in association with estramustine. Docetaxel based regimen may have been interrupted and restarted. Patient must have either measurable (RECIST criteria) or non-measurable (bone) disease and/or clinical progression (bone pain) and/or biological progression (PSA Working Group criteria).
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  • Discontinuation from previous chemotherapy and/or radiation therapy at least 4 weeks prior to treatment initiation
  • Performance status of 0 to 2 on the Eastern Cooperative Oncology Group (ECOG) scale
  • Patient of child bearing potential must use effective contraception. Female partners of treated patients with child bearing potential must use oral contraceptives or intra uterine device (IUD)
  • Life expectancy of at least 3 months
  • Resolution of all acute toxic effects of any prior local treatment to NCI CTCAE grade 1
  • Patients must have adequate organ functions defined
  • Willingness and ability to comply with scheduled visits, treatment plans, laboratory tests, and other study procedures
  • Patient covered by the National Health System

Who cannot join

  • Prior treatment with sunitinib or other antiangiogenic agent
  • More than 1 line of chemotherapy
  • External beam radiotherapy for ≥ 50% of bone marrow
  • Uncontrolled hypertension (systolic blood pressure > 150 mm Hg or diastolic blood pressure > 90 mm Hg despite optimal medical management)
  • Any of the following within 12 months prior to treatment initiation: severe/unstable angina, myocardial infarction, coronary artery bypass graft, symptomatic congestive heart failure, thrombotic or embolic events such as cerebrovascular accident including transient ischemic attack
  • Ongoing cardiac dysrhythmias of grade 2, atrial fibrillation of any grade
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  • Treatment with anticonvulsant agents and treatment with therapeutic doses of coumarin-derivative anticoagulants such as warfarin currently or within 2 weeks prior to first day of Sunitinib administration. Low dose of warfarin for deep vein thrombosis prophylaxis is permitted (up to 2 mg/day) and low molecular weight heparin is allowed
  • Any medical condition that might interfere with oral medication absorption
  • Known or suspected brain metastasis, or carcinomatous meningitis, or spinal cord compression
  • Diagnosis of any second malignancy within the last 3 years, with the exception of treated basal cell or squamous cell carcinoma and pT1/a bladder cancer with no evidence of recurrent disease for 12 months
  • Any acute or chronic medical or psychiatric disorder incompatible with the study
  • Known human immunodeficiency virus or acquired immunodeficiency syndrome-related illness
  • Treatment with others investigational drugs or participation in another clinical trial within the past 4 weeks, or concomitantly with this trial

Trial locations and contacts

1 site in 1 country.

France1 site

  • Service Oncologie Médicale, Hopital Europeen Georges Pompidou

    Paris, 75015

Other trials in France

About this study

Official title: An Open Label Phase II Study of Oral Treatment With Sunitinib (SUTENT) in Patients Suffering From Hormone Refractory Prostate Cancer After Progression With Docetaxel Based Regimen

as second-line treatment in metastatic prostate cancer, the present study will investigate the efficacy of sunitinib (SUTENT) given orally at a dose of 37.5 mg continuously, for 6 cycles of 6 consecutive weeks .Patients who are still responders after 6 cycles will be treated until disease progression, pain progression, unacceptable toxicity or death due to any cause.

Dose increase or reduction of 12.5 mg increments and change of schedule is recommended based on individual safety and tolerability.

Follow-up for up to 1 year from the last dose of sunitinib.

Read the detailed description
  • Antitumor efficacy of sunitinib will be assessed as follows:
  • PSA response rate and PSA progression according Working Group Criteria,
  • Variation of PSA doubling time (PSADT) before and after initiation of the treatment,
  • Objective response rate (ORR) according to RECIST criteria,
  • Clinical benefit,
  • Overall survival (OS).
  • Pharmacokinetic endpoints will include sunitinib and its metabolite, SU012662, plasma levels and estimation of the population pharmacokinetic parameters as well as the inter-individual variability of these parameters, for a subgroup of 30 patients.
  • The biological effects of sunitinib in patients with metastatic prostate carcinoma will be evaluated by measurements of the different biological markers that could be modulated by this antiangiogenic therapeutic, and could then predict and monitor disease progression and response to treatment:
  • Bone tumor markers: bone resorption markers (uCTX, uCTX, ICTP, CTX-MMP and TRACP-5b), bone formation markers (OC, PINP and BALP), osteoclastogenesis markers (OPG and RANKL) and parameters as calcium, phosphate, creatinine, albumin, PTH and 25(OH)D.
  • Angiogenesis markers: bFGF, SDF-1, VEGF-A, VEGFR1 and VEGFR2, CECs and CEPs, endothelial and platelet microparticles.
Being tested
sunitinib
Keywords
metastatic prostate carcinoma, sunitinib [Substance Name], Clinical Trial, Phase II [Publication Type]
Medical subject headings
Prostatic Neoplasms, Neoplasms, Hormone-Dependent

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • sunitinibDrug

    37.5 mg orally once daily, continuously, for 6 cycles of 6 consecutive weeks.Dose increase or reduction of 12.5 mg increments and change of schedule is recommended based on individual safety and tolerability.

Study groups in NCT00748358
Study groupRoleWhat they receive
drugExperimentaldrug
Receives: Drug: sunitinib

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. progression-free survival (PFS) defined as the time from start of study treatment to first documentation of objective progressive disease, pain progression or to death on-study due to any cause.

    Measured: 18 months

Secondary outcomes (1)

  1. Incidence and intensity of Adverse Events (NCI CTCAE version 3.0).

    Measured: 9 months

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted8 Sep 2008 (estimated)
  2. Study startMar 2008
  3. Primary completionApr 2011
  4. Study completionApr 2011

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase 2
Primary purpose
Treatment
Allocation
Not applicable
Intervention model
Single group
Masking
None (open label)
Enrolment
50 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT00748358
Sponsor's protocol ID
P070404
Acronym
PROSUT
Status last verified
Sep 2008
First submitted
5 Sep 2008
Last updated
18 Sep 2013
Results posted
No
Data monitoring committee
Yes

Questions about this trial

What is this clinical trial studying?

A Phase 2 study testing sunitinib in people with Prostatic Neoplasms and Neoplasms, Hormone-Dependent, run by Assistance Publique - Hôpitaux de Paris at 1 site in France.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 14 inclusion and 13 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 18 Sep 2013. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

What does this phase mean?

Phase 2 studies give the treatment to a larger group to see whether it has the intended effect and to keep checking safety.

Not every study follows the same path, and some studies (observational studies, device studies) have no phase.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

progression-free survival (PFS) defined as the time from start of study treatment to first documentation of objective progressive disease, pain progression or to death on-study due to any cause. (time frame: 18 months). It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT00748358.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 18 Sep 2013.

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