Ischemic StrokeNCT00867581
Magnetic Resonance Imaging (MRI) Study of the Hippocampus After Infarction in the Territory of the Middle Cerebral Artery
An observational study of Ischemic Stroke, run by Huazhong University of Science and Technology at 1 site in China.
Trial summary
The purpose of this study is to observe delayed neuronal death of hippocampus after middle cerebral artery infarction in human beings. Read more about this study
- Who is it for?
- Any ageHealthy volunteers can take part
- Conditions the study is for
- Ischemic Stroke
- How many people
- 80 participants
- Where
- 1 siteChina
- Study dates
- Sep 2008to Jul 2009
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- All sexes
- Healthy volunteers accepted
- Child, Adult, Older adult
Study population: chronic-stage patients of unilateral middle cerebral artery infarction
Who may be able to join
- Clinical diagnosis of middle cerebral artery infarction
- At least six months from the stroke
- Must be able to measure his(her) neuropsychologic function (by MMSE, AVLT)
Who cannot join
- Unable to undergo examinations due to disturbances of consciousness or medical conditions
- Severe dementia, apraxia, disturbances of sensation or perception
- Serious complications including severe heart failure, hepatic dysfunction, renal insufficiency,or shock
- Parkinson's disease, malignant tumor, autoimmune diseases
Trial locations and contacts
1 site in 1 country.
China1 site, 1 recruiting
- Recruiting
Department of Neurology of Tongji Hospital, Huazhong University of Science and Technology
Wuhan, Hubei
Wei Wang, Doctor, 86-027-8366-3648, wwang_tjh@126.com
Wei Wang, Doctor
About this study
Official title: To Observe Delayed Neuronal Death of Hippocampus After Middle Cerebral Artery Infarction Through Magnetic Resonance Imaging(MRI) Volume Measurement and Magnetic Resonance Spectroscopy(MRS) Study of Hippocampus
The purpose of this study is to observe delayed neuronal death of hippocampus after middle cerebral artery infarction in human beings.
Read the detailed description
40 patients with middle cerebral artery infarction and 40 healthy volunteers will be observed. All of them will receive MRI scan and the assessment of the neuropsychological function (MMSE, AVLT, HAMD) intending to observe delayed neuronal death of hippocampus after middle cerebral artery infarction in human beings.
- Conditions
- Ischemic Stroke
- Keywords
- middle cerebral artery, infarction, chronic stage, hippocampal volume, MRI, MRS, neuropsychologic assessment
- Medical subject headings
- Ischemic Stroke, Infarction
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| 1 | chronic-stage patients after infarction in the territory of unilateral middle cerebral artery | |
| 2 | age, sex and risk factor matched volunteers without ischemic stroke |
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Mar 2009 (estimated)
- Study startSep 2008
- Primary completionJul 2009 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Ischemic StrokeStudies of the same condition, open and under way.
- More trials run by Huazhong University of Science and TechnologyThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Case-control
- Time perspective
- Cross-sectional
- Enrolment
- 80 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Huazhong University of Science and Technology
- Sponsor type
- University, hospital or other
- Investigators
- Wei Wang, Doctor, Principal investigator, Tongji Hospital
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT00867581
- Sponsor's protocol ID
- 30725019-2
- Status last verified
- Mar 2009
- First submitted
- 23 Mar 2009
- Last updated
- 24 Mar 2009
- Results posted
- No
- Data monitoring committee
- Yes
Study at a glance
From the registry record, last updated by the sponsor on 24 Mar 2009. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- To Observe Delayed Neuronal Death of Hippocampus After Middle Cerebral Artery Infarction Through Magnetic Resonance Imaging(MRI) Volume Measurement and Magnetic Resonance Spectroscopy(MRS) Study of Hippocampus
- ClinicalTrials.gov ID
- NCT00867581
- Acronym / sponsor ID
- 30725019-2
- Conditions
- Ischemic Stroke
- Keywords
- middle cerebral artery, infarction, chronic stage, hippocampal volume, MRI, MRS, neuropsychologic assessment
- Study type
- Observational
- Recruitment status
- Unknown status
- Enrolment
- 80 participants (estimated)
- Lead sponsor
- Huazhong University of Science and TechnologyUniversity, hospital or other
- Study start
- Sep 2008
- Primary completion
- Jul 2009 (estimated)
- First posted
- 24 Mar 2009 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The purpose of this study is to observe delayed neuronal death of hippocampus after middle cerebral artery infarction in human beings.
Detailed description
40 patients with middle cerebral artery infarction and 40 healthy volunteers will be observed. All of them will receive MRI scan and the assessment of the neuropsychological function (MMSE, AVLT, HAMD) intending to observe delayed neuronal death of hippocampus after middle cerebral artery infarction in human beings.
Study design
- Observational model
- Case-control
- Time perspective
- Cross-sectional
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| 1 | – | –chronic-stage patients after infarction in the territory of unilateral middle cerebral artery |
| 2 | – | –age, sex and risk factor matched volunteers without ischemic stroke |
Who may qualify
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Child, Adult, Older adult
- Study population
- chronic-stage patients of unilateral middle cerebral artery infarction
Key inclusion criteria (3 listed)
- Clinical diagnosis of middle cerebral artery infarction
- At least six months from the stroke
- Must be able to measure his(her) neuropsychologic function (by MMSE, AVLT)
Key exclusion criteria (4 listed)
- Unable to undergo examinations due to disturbances of consciousness or medical conditions
- Severe dementia, apraxia, disturbances of sensation or perception
- Serious complications including severe heart failure, hepatic dysfunction, renal insufficiency,or shock
- Parkinson's disease, malignant tumor, autoimmune diseases
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Not reported in the source record.
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 24 Mar 2009.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Wei Wang, Doctor principal investigator
Tongji Hospital
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Ischemic Stroke, run by Huazhong University of Science and Technology at 1 site in China.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 4 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 24 Mar 2009. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in China. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
Contact Wei Wang, Doctor (86-027-8366-3648, wwang_tjh@126.com), or a site near the patient. AzTrials does not enrol participants or take referrals.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 24 Mar 2009.