Cardiovascular Disease Risk FactorsGERSNCT00976742
Gene - Exercise Research Study
A study testing Endurance exercise training in people with Cardiovascular Disease Risk Factors, run by University of Maryland, College Park at 1 site in United States.
Trial summary
The investigators hypothesize that the degree to which older generally healthy but sedentary men and women improve a number of cardiovascular (CV) disease risk factors with 6 months of highly-standardized endurance exercise training will be a function of common genetic variations in candidate genes. Read more about this study
- Who is it for?
- Ages 50 to 75 years
- Conditions the study is for
- Cardiovascular Disease Risk Factors
- What is being tested?
- Endurance exercise training
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 225 participants
- Where
- 1 siteUnited States
- Study dates
- Jun 1998to Dec 2004
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 50 to 75 years
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- generally healthy
- free from CV disease
- ability to undergo exercise training
Who cannot join
- previous history of CV disease
Trial locations and contacts
1 site in 1 country.
United States1 site
University of Maryland Dept of Kinesiology
College Park, Maryland, 20742-2611
About this study
Official title: Impact of Common Genetic Polymorphisms on CV Disease Risk Factor Changes With Endurance Exercise Training
The investigators hypothesize that the degree to which older generally healthy but sedentary men and women improve a number of cardiovascular (CV) disease risk factors with 6 months of highly-standardized endurance exercise training will be a function of common genetic variations in candidate genes.
- Conditions
- Cardiovascular Disease Risk Factors
- Being tested
- Endurance exercise training
- Keywords
- plasma lipoprotein lipids, body composition, glucose tolerance, inflammation markers, insulin sensitivity, coagulation markers
- Medical subject headings
- Insulin Resistance
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Endurance exercise trainingBehavioural
| Study group | Role | What they receive |
|---|---|---|
| Endurance Exercise Training | Experimental | Not described Receives: Behavioral: Endurance exercise training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Cardiovascular Disease Risk Factors
Measured: ~9 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Sep 2009 (estimated)
- Study startJun 1998
- Primary completionDec 2004
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Cardiovascular Disease Risk FactorsStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Prevention
- Allocation
- Not applicable
- Intervention model
- Single group
- Enrolment
- 225 participants (actual)
Sponsor and investigators
- Lead sponsor
- University of Maryland, College Park
- Sponsor type
- University, hospital or other
- Collaborators
- University of Pittsburgh, University of Maryland, Baltimore
- Responsible party
- Principal investigator, Jim Hagberg, University of Maryland, College Park
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT00976742
- Sponsor's protocol ID
- AG17474
- Acronym
- GERS
- Status last verified
- Mar 2025
- First submitted
- 11 Sep 2009
- Last updated
- 3 Apr 2025
- Results posted
- No
- Data monitoring committee
- No
Publications
Halverstadt A, Phares DA, Wilund KR, Goldberg AP, Hagberg JM. Endurance exercise training raises high-density lipoprotein cholesterol and lowers small low-density lipoprotein and very low-density lipoprotein independent of body fat phenotypes in older men and women. Metabolism. 2007 Apr;56(4):444-50. doi: 10.1016/j.metabol.2006.10.019.
PubMed 17378998
Study at a glance
From the registry record, last updated by the sponsor on 3 Apr 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Impact of Common Genetic Polymorphisms on CV Disease Risk Factor Changes With Endurance Exercise Training
- ClinicalTrials.gov ID
- NCT00976742
- Acronym / sponsor ID
- GERS / AG17474
- Conditions
- Cardiovascular Disease Risk Factors
- Keywords
- plasma lipoprotein lipids, body composition, glucose tolerance, inflammation markers, insulin sensitivity, coagulation markers
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 225 participants (actual)
- Lead sponsor
- University of Maryland, College ParkUniversity, hospital or other
- Collaborators
- University of Pittsburgh, University of Maryland, Baltimore
- Study start
- Jun 1998
- Primary completion
- Dec 2004 (actual)
- First posted
- 14 Sep 2009 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
The investigators hypothesize that the degree to which older generally healthy but sedentary men and women improve a number of cardiovascular (CV) disease risk factors with 6 months of highly-standardized endurance exercise training will be a function of common genetic variations in candidate genes.
Study design
- Primary purpose
- Prevention
- Allocation
- Not applicable
- Intervention model
- Single group
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Endurance Exercise Training | Experimental | Behavioral: Endurance exercise training |
Who may qualify
- Ages
- 50 to 75 years
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (3 listed)
- generally healthy
- free from CV disease
- ability to undergo exercise training
Key exclusion criteria (1 listed)
- previous history of CV disease
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Endurance exercise training | Behavioural | Endurance Exercise Training |
Primary outcome
Cardiovascular Disease Risk Factors
Time frame: ~9 months
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 3 Apr 2025.
- Results publication: PubMed 17378998Halverstadt A, Phares DA, Wilund KR, Goldberg AP, Hagberg JM. Endurance exercise training raises high-density lipoprotein cholesterol and lowers small low-density lipoprotein and very low-density lipoprotein independent of body fat phenotypes in older men and women. Metabolism. 2007 Apr;56(4):444-50. doi: 10.1016/j.metabol.2006.10.019.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Endurance exercise training in people with Cardiovascular Disease Risk Factors, run by University of Maryland, College Park at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 3 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 3 Apr 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Cardiovascular Disease Risk Factors (time frame: ~9 months). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT00976742, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Apr 2025.