Hot FlashesNCT01161823
Influence of Nebivolol on Postmenopausal Women
An observational study of Hot Flashes and Heart Rate, run by Medical University of Vienna at 1 site in Austria.
Trial summary
After menopause the coronary artery disease (CAD) risk increases rapidly to an equivalent risk of men with the same age. The rising incidence of CAD could be a subsequent decline of endogenous estrogen blood levels after the menopause. Read more about this study
- Who is it for?
- Any age, women only
- Conditions the study is for
- Hot Flashes, Heart Rate, Blood Pressure
- Type of treatment
- Pill or oral medicine
- How many people
- 60 participants
- Where
- 1 siteAustria
- Study dates
- Jan 2010to not given
- Phase
- Observational
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages Any age
- Women only
- No healthy volunteers
- Child, Adult, Older adult
Study population: 60 Postmenopausal women
Who may be able to join
- Menopausal patients (estrogen <20 pg/ml and FSH >35 mIU/ml)
- The patients are sexually active
- The patients have hot flushes
- The patients have palpitations or extrasystoles
Who cannot join
- Contraindications for a beta-blocker therapy such as:
- Patients with COPD
- Patients with an AV-block
- Patients with a bradycardia (meaning a heart rate <50 beats per minute)
- Patients with hypotension (RR <100/80 mmHg)
- Patients with a PAD (stage III, IV)
Show all 11Show fewer
- Patients with Asthma
- Patients with Morbus Raynaud
- Patients with a carcinoma
- Patients, who have already been treated because of hypertension
- Patients, who receive hormone replacement therapy
Trial locations and contacts
1 site in 1 country.
Austria1 site, 1 recruiting
- Recruiting
Department of Cardiology, Medical University of Vienna
Vienna, State of Vienna, 1090
Jeanette Strametz-Juranek, MD, 0043140400 ext. 4618, jeanette.strametz-juranek@meduniwien.ac.at
Jeanette Strametz-Juranek, MD
About this study
Official title: Effect of Nebivolol on Climacteric Disorders in Postmenopausal Women. A Randomized, Open Label Trial
After menopause the coronary artery disease (CAD) risk increases rapidly to an equivalent risk of men with the same age. The rising incidence of CAD could be a subsequent decline of endogenous estrogen blood levels after the menopause. Estrogen leads to vasodilation and vasoprotection through an increase of Nitric Oxide (NO). NO deficiency results in endothelial stiffness and dysfunction with a subsequent initiation of atherosclerosis. Menopausal status is associated with an increase of the sympathetic nerve activity leading to hypertension, increased heart rate and palpitations. Recent studies show an importance of vasoactive substances (e.g. NO) in the physiology of hot flashes. Thus, hot flashes may be associated with a decreased NO production and release. Additionally, it is well known that during and after menopause women experience a change in sexual function (declined libido and increased dyspareunia) due to decreasing estrogen blood levels. Recently, a new angiostatic parameter - Endostatin (ENST) - has been shown to be involved in EC function. There is also evidence that ENST levels increase during NO stimulation. Nebivolol, a ß-blocker of the third generation, has been shown to release NO to a significant amount in the EC. It is safe and effective in reducing blood pressure to the target level. However, there is no data of the effect of Nebivolol on sexual function, on clinical symptoms (palpitations, increased heart rate and hot flashes) and ENST in postmenopausal women. The present study investigates the effect of a NO-releasing ß-blocker compared to a phytoestrogen therapy considering clinical signs of menopause such as palpitations, hot flashes and sexual functioning in postmenopausal women. Therefore, the use of a ß-blocker treatment is warranted. Further, this study tries to elucidate the role of NO release in postmenopausal symptoms and may gain new insights in the pathophysiology of hot flashes and increased sympathetic nerve activity. Thus, this trial should explore an advantage of Nebivolol therapy in contrast to a phytoestrogen therapy.
Null hypothesis: Climacteric disorders as measured by the MRS-II in patients with a Nebivolol therapy is not lower than in patients with phytoestrogen therapy. Alternative hypothesis: Climacteric disorders in patients as measured by the MRS-II with a Nebivolol therapy is lower than in patients with phytoestrogen therapy.
Read the detailed description
- Background CAD is the leading cause of mortality for women in US as well as in Austria and most developed countries. Major risk factors are hypertension, diabetes and the postmenopausal status. After the menopause the CAD risk increases rapidly to an equivalent risk of men with the same age. In all ethnic groups, hypertension is more prevalent among women than men after the age of 59. Over 75 years 75,2 % of females and 63,7% of males perform a hypertensive vascular status. Menopausal status is associated with a decline of endogenous estrogen levels resulting in a manifest estrogen deficiency. This estrogen decline is also associated with a subsequent increased risk for CAD. The main effect of estrogen is a vasodilatation and an anti-atherosclerotic action through different mechanisms. Recent studies are describing that the estrogen deficiency and the subsequently NO deficiency results in a disordered endothelial function and a permanent vasoconstriction, that is one of the major reasons for postmenopausal hypertension and CAD. Clinical symptoms of postmenopausal women:
- Palpitations and tachycardia Postmenopausal women complain about heart palpitations, throbbing and subjective sensed high heart rate and tachycardia, which can be explained by a sympathetic over activity in postmenopausal women. This clinical symptoms are associated with a significant decrease in quality of life and well- being in postmenopausal women.
- Hot flashes Hot flashes are the most common symptom and occur in most postmenopausal women (75%). Hot flashes are experienced as a feeling of intense heat with sweating and rapid heartbeat. The typical duration is between two and thirty minutes. Risk factors for hot flashes are - equal to CVD - high body mass index and smoking. Furthermore, it can be supposed that the NO decrease in postmenopausal women is responsible for the hot flashes.
- Sexuality Sexuality is an important quality-of-life issue, also in elderly. Therefore, sexual dysfunction is considered a serious quality-of-life-related health problem. Furthermore increasing dyspareunia and decreasing libido and responsivity correlated with decreasing estrogen levels.
- Endostatin (ENST) ENST, a 20-kDa C-terminal fragment cleaved from type XVIII collagen, is a naturally occurring protein that blocks the formation of blood vessels, inhibits EC proliferation, migration and angiogenesis. Furthermore, there is evidence that ENST induces an acute NO release and finally leads to vasodilation and therefore works against endothelial dysfunction. However, since there is no data on ENST serum levels in postmenopausal women as well of the effect of Nebivolol on ENST serum levels, we will investigate baseline ENST levels and after 3 month of treatment compared to patients treated with phytohormones.
- Nebivolol Nebivolol, a ß-blocker of the third generation, has been shown to lower blood pressure with great safety and efficacy in men as well in women and was well tolerated. Beneath its specific beta-1-receptor blockade Nebivolol has a NO-releasing effect through a ß3-receptor-agonism. Nebivolol combines a potent ß1-adrenoreceptor-blocking activity (mostly ascribed to its D-enantiomer) with additional vasodilating properties (attributed to its L-enantiomer and also D-enantiomer). Nebivolol causes a vasodilatation of the vessels and reduces the progress of atherosclerosis which is a main risk factor for CVD and hypertension. The current general guidelines for hypertension recommend treatment with a Thiazide Diuretic as a first line medication in hypertension. In contrary to Diuretics and ACE-blockers - ß-blockers also reduce the heart rate and have positive antagonistic influence on the sympathetic nerve system. The augmentation of the heart rate during the menopause is sensed as a very unpleasant and unbearable situation for most of the postmenopausal women. Thus, the increase in sympathetic nerve activity and clinical symptoms of palpitations or increased heart rate warrant the use of a ß-blocker for the treatment in our cohort. Additionally, we hypothesise, that through an improvement of the endothelial function with Nebivolol the number of hot flashes in postmenopausal women can be reduced. Recent studies have shown positive effects on the erectile dysfunction in men during treatment with Nebivolol. As the physiologic and embryologic conditions are almost similar in men and women, so we expect similar improving effects on the sexual dysfunction in our female study group. Therefore, we want to investigate the effect of Nebivolol on blood pressure, heart rate, hot flashes, sexual function, ENST, testosterone levels in postmenopausal women with menopausal disorders. 1.2 Rationale of the study We want to investigate the effect of Nebivolol in comparison to a phytoestrogen therapy on climacteric disorders as measured by the Menopausal rating scale II (MRS-II). In addition we will investigate the following:
- the heart rate
- the number of palpitations
- the number of hot flushes
- the sexual function
- the blood pressure
- the serum level of Endostatin
- the serum level of Testosterone in postmenopausal women. 2 METHODS 2.1 Measurement of the blood pressure Measurement of the blood pressure according to Riva Rocci will be performed at the beginning and after 12 weeks (end of the study). Measurements will be taken in sitting position after five minutes rest. Three consecutive measurements will be taken and the average of these measurements will be recorded. 2.2 ECG A 12-lead ECG will be written to rule out AV-block and bradycardia (<50/min). 2.3 Blood parameters Prestudy screening:
- FSH
- TSH
- testosterone
- estrogen
- DHEA
- SHBG
- prolactin
- BNP
- hsCRP
- liver parameters
- kidney parameters
- electrolytes
- blood glucose Our patients have to show a blood level of estrogen <20pg/ml and FSH >35 mIU/ml to verify the status of menopause. To rule out another endocrine cause of a possible sexual function alteration we check the blood levels of TSH, Prolactin, DHEA (Dehydroepiandrosterone) and SHBG (Sex Hormon Binding Globulin). 2.4 Analysis of Endostatin Within the routine blood analysis we will also detect the blood level of ENST. The RD191076100 Human Endostatin ELISA is a sandwich enzyme immunoassay for the quantitative measurement of endostatin protein in human serum. 2.5 Female Sexual Function Index We will use the German version of the female sexual function index (FSFI-D) that was validated in 2004. This questionnaire is a proven instrument to evaluate the female sexual function especially in (post)menopausal women. We will hand out this questionnaire twice: At the beginning and after our study (12 weeks later). During the completion of the questionnaire by the study participant, a gynecologist will be attendant to help the women to complete the questionnaire. This way we want to analyze if the treatment with Nebivolol has an effect on the sexual function of women. We have added the questionnaire to the appendix. 2.6 Menopausal Rating Scale II We are going to use the Menopause Rating Scale II (MRS II). This self-assessment scale to quantify menopausal symptoms includes 11 questions to evaluate the "quality of life" in our cohort. We will hand out this questionnaire twice: At the beginning and after our study (12 weeks later). During the completion of the questionnaire by the study participant, a gynecologist will be attendant to help the women to complete the questionnaire. 2.7 Hot flashes/palpitations diary At the beginning of our study, the diary will be introduced to the patients by the treating physician. There the number of hot flashes and palpitations per day should be written down. The diary contains 12 pages, one page a week. At the beginning we will perform an anamnesis to get informed about the average number of hot flashes and palpitations per day before the medication.
- Conditions
- Hot Flashes, Heart Rate, Blood Pressure, Endostatin, Sexual Function
- Medical subject headings
- Hot Flashes
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
| Study group | Role | What they receive |
|---|---|---|
| Nebivolol | 2,5mg or maximum 5mg per day | |
| Menoflavon | 2 times 1 pill at 40mg Isoflavone per day |
What is being measured
The primary outcome is the main question the study is designed to answer.
Number of hot flashes/palpitations
Number of hot flashes/palpitations during month one and month three compared between nebivolol and phytoestrogens
Measured: 3 Months, 4 appointments
Secondary outcomes (4)
Hemodynamic changes
Measurement of blood pressure and heart rate at baseline and every four weeks.
Measured: 3 Months, 4 appointments
Sexual function
Sexual function will be investigated by the Female Sexual Function Index (FSFI-D)
Measured: before and after 3 months of treatment
Endostatin
Blood sample of Endostatin will be drawn before and after 3 months of treatment. Endostatin, a cleavage product of collagen XVIII, inhibits angiogenesis. By decreasing neovascualtrization of atherosclerotic plaques, Endostatin might be able to stop the progression of atherosclerosis.
Measured: Baseline and after 3 months
Quality of life
Menopause Rating Scale II (MRS II) is a self-assessment scale to quantify menopausal symptoms includes 11 questions to evaluate the "quality of life" in our cohorts.
Measured: baseline and after 3 months
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted14 Jul 2010 (estimated)
- Study startJan 2010
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Hot FlashesStudies of the same condition, open and under way.
- More trials run by Medical University of ViennaThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Observational
- Observational model
- Cohort
- Time perspective
- Prospective
- Enrolment
- 60 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Medical University of Vienna
- Sponsor type
- University, hospital or other
- Investigators
- Jeanette Strametz-Juranek, MD, Principal investigator, MUV, Department of Internal Medicine II, Division of Cardiology
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT01161823
- Sponsor's protocol ID
- 451/2009
- Other IDs
- 2009-011527-31, 2009
- Status last verified
- Apr 2010
- First submitted
- 16 Apr 2010
- Last updated
- 12 Jan 2016
- Results posted
- No
- Data monitoring committee
- Yes
Study at a glance
From the registry record, last updated by the sponsor on 12 Jan 2016. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Effect of Nebivolol on Climacteric Disorders in Postmenopausal Women. A Randomized, Open Label Trial
- ClinicalTrials.gov ID
- NCT01161823
- Acronym / sponsor ID
- 451/2009
- Conditions
- Hot Flashes, Heart Rate, Blood Pressure, Endostatin, Sexual Function
- Study type
- Observational
- Recruitment status
- Unknown status
- Enrolment
- 60 participants (estimated)
- Lead sponsor
- Medical University of ViennaUniversity, hospital or other
- Study start
- Jan 2010
- First posted
- 14 Jul 2010 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
After menopause the coronary artery disease (CAD) risk increases rapidly to an equivalent risk of men with the same age. The rising incidence of CAD could be a subsequent decline of endogenous estrogen blood levels after the menopause. Estrogen leads to vasodilation and vasoprotection through an increase of Nitric Oxide (NO). NO deficiency results in endothelial stiffness and dysfunction with a subsequent initiation of atherosclerosis. Menopausal status is associated with an increase of the sympathetic nerve activity leading to hypertension, increased heart rate and palpitations. Recent studies show an importance of vasoactive substances (e.g. NO) in the physiology of hot flashes. Thus, hot flashes may be associated with a decreased NO production and release. Additionally, it is well known that during and after menopause women experience a change in sexual function (declined libido and increased dyspareunia) due to decreasing estrogen blood levels. Recently, a new angiostatic parameter - Endostatin (ENST) - has been shown to be involved in EC function. There is also evidence that ENST levels increase during NO stimulation. Nebivolol, a ß-blocker of the third generation, has been shown to release NO to a significant amount in the EC. It is safe and effective in reducing blood pressure to the target level. However, there is no data of the effect of Nebivolol on sexual function, on clinical symptoms (palpitations, increased heart rate and hot flashes) and ENST in postmenopausal women. The present study investigates the effect of a NO-releasing ß-blocker compared to a phytoestrogen therapy considering clinical signs of menopause such as palpitations, hot flashes and sexual functioning in postmenopausal women. Therefore, the use of a ß-blocker treatment is warranted. Further, this study tries to elucidate the role of NO release in postmenopausal symptoms and may gain new insights in the pathophysiology of hot flashes and increased sympathetic nerve activity. Thus, this trial should explore an advantage of Nebivolol therapy in contrast to a phytoestrogen therapy.
Null hypothesis: Climacteric disorders as measured by the MRS-II in patients with a Nebivolol therapy is not lower than in patients with phytoestrogen therapy. Alternative hypothesis: Climacteric disorders in patients as measured by the MRS-II with a Nebivolol therapy is lower than in patients with phytoestrogen therapy.
Detailed description
- Background CAD is the leading cause of mortality for women in US as well as in Austria and most developed countries. Major risk factors are hypertension, diabetes and the postmenopausal status. After the menopause the CAD risk increases rapidly to an equivalent risk of men with the same age. In all ethnic groups, hypertension is more prevalent among women than men after the age of 59. Over 75 years 75,2 % of females and 63,7% of males perform a hypertensive vascular status. Menopausal status is associated with a decline of endogenous estrogen levels resulting in a manifest estrogen deficiency. This estrogen decline is also associated with a subsequent increased risk for CAD. The main effect of estrogen is a vasodilatation and an anti-atherosclerotic action through different mechanisms. Recent studies are describing that the estrogen deficiency and the subsequently NO deficiency results in a disordered endothelial function and a permanent vasoconstriction, that is one of the major reasons for postmenopausal hypertension and CAD. Clinical symptoms of postmenopausal women:
- Palpitations and tachycardia Postmenopausal women complain about heart palpitations, throbbing and subjective sensed high heart rate and tachycardia, which can be explained by a sympathetic over activity in postmenopausal women. This clinical symptoms are associated with a significant decrease in quality of life and well- being in postmenopausal women.
- Hot flashes Hot flashes are the most common symptom and occur in most postmenopausal women (75%). Hot flashes are experienced as a feeling of intense heat with sweating and rapid heartbeat. The typical duration is between two and thirty minutes. Risk factors for hot flashes are - equal to CVD - high body mass index and smoking. Furthermore, it can be supposed that the NO decrease in postmenopausal women is responsible for the hot flashes.
- Sexuality Sexuality is an important quality-of-life issue, also in elderly. Therefore, sexual dysfunction is considered a serious quality-of-life-related health problem. Furthermore increasing dyspareunia and decreasing libido and responsivity correlated with decreasing estrogen levels.
- Endostatin (ENST) ENST, a 20-kDa C-terminal fragment cleaved from type XVIII collagen, is a naturally occurring protein that blocks the formation of blood vessels, inhibits EC proliferation, migration and angiogenesis. Furthermore, there is evidence that ENST induces an acute NO release and finally leads to vasodilation and therefore works against endothelial dysfunction. However, since there is no data on ENST serum levels in postmenopausal women as well of the effect of Nebivolol on ENST serum levels, we will investigate baseline ENST levels and after 3 month of treatment compared to patients treated with phytohormones.
- Nebivolol Nebivolol, a ß-blocker of the third generation, has been shown to lower blood pressure with great safety and efficacy in men as well in women and was well tolerated. Beneath its specific beta-1-receptor blockade Nebivolol has a NO-releasing effect through a ß3-receptor-agonism. Nebivolol combines a potent ß1-adrenoreceptor-blocking activity (mostly ascribed to its D-enantiomer) with additional vasodilating properties (attributed to its L-enantiomer and also D-enantiomer). Nebivolol causes a vasodilatation of the vessels and reduces the progress of atherosclerosis which is a main risk factor for CVD and hypertension. The current general guidelines for hypertension recommend treatment with a Thiazide Diuretic as a first line medication in hypertension. In contrary to Diuretics and ACE-blockers - ß-blockers also reduce the heart rate and have positive antagonistic influence on the sympathetic nerve system. The augmentation of the heart rate during the menopause is sensed as a very unpleasant and unbearable situation for most of the postmenopausal women. Thus, the increase in sympathetic nerve activity and clinical symptoms of palpitations or increased heart rate warrant the use of a ß-blocker for the treatment in our cohort. Additionally, we hypothesise, that through an improvement of the endothelial function with Nebivolol the number of hot flashes in postmenopausal women can be reduced. Recent studies have shown positive effects on the erectile dysfunction in men during treatment with Nebivolol. As the physiologic and embryologic conditions are almost similar in men and women, so we expect similar improving effects on the sexual dysfunction in our female study group. Therefore, we want to investigate the effect of Nebivolol on blood pressure, heart rate, hot flashes, sexual function, ENST, testosterone levels in postmenopausal women with menopausal disorders. 1.2 Rationale of the study We want to investigate the effect of Nebivolol in comparison to a phytoestrogen therapy on climacteric disorders as measured by the Menopausal rating scale II (MRS-II). In addition we will investigate the following:
- the heart rate
- the number of palpitations
- the number of hot flushes
- the sexual function
- the blood pressure
- the serum level of Endostatin
- the serum level of Testosterone in postmenopausal women. 2 METHODS 2.1 Measurement of the blood pressure Measurement of the blood pressure according to Riva Rocci will be performed at the beginning and after 12 weeks (end of the study). Measurements will be taken in sitting position after five minutes rest. Three consecutive measurements will be taken and the average of these measurements will be recorded. 2.2 ECG A 12-lead ECG will be written to rule out AV-block and bradycardia (<50/min). 2.3 Blood parameters Prestudy screening:
- FSH
- TSH
- testosterone
- estrogen
- DHEA
- SHBG
- prolactin
- BNP
- hsCRP
- liver parameters
- kidney parameters
- electrolytes
- blood glucose Our patients have to show a blood level of estrogen <20pg/ml and FSH >35 mIU/ml to verify the status of menopause. To rule out another endocrine cause of a possible sexual function alteration we check the blood levels of TSH, Prolactin, DHEA (Dehydroepiandrosterone) and SHBG (Sex Hormon Binding Globulin). 2.4 Analysis of Endostatin Within the routine blood analysis we will also detect the blood level of ENST. The RD191076100 Human Endostatin ELISA is a sandwich enzyme immunoassay for the quantitative measurement of endostatin protein in human serum. 2.5 Female Sexual Function Index We will use the German version of the female sexual function index (FSFI-D) that was validated in 2004. This questionnaire is a proven instrument to evaluate the female sexual function especially in (post)menopausal women. We will hand out this questionnaire twice: At the beginning and after our study (12 weeks later). During the completion of the questionnaire by the study participant, a gynecologist will be attendant to help the women to complete the questionnaire. This way we want to analyze if the treatment with Nebivolol has an effect on the sexual function of women. We have added the questionnaire to the appendix. 2.6 Menopausal Rating Scale II We are going to use the Menopause Rating Scale II (MRS II). This self-assessment scale to quantify menopausal symptoms includes 11 questions to evaluate the "quality of life" in our cohort. We will hand out this questionnaire twice: At the beginning and after our study (12 weeks later). During the completion of the questionnaire by the study participant, a gynecologist will be attendant to help the women to complete the questionnaire. 2.7 Hot flashes/palpitations diary At the beginning of our study, the diary will be introduced to the patients by the treating physician. There the number of hot flashes and palpitations per day should be written down. The diary contains 12 pages, one page a week. At the beginning we will perform an anamnesis to get informed about the average number of hot flashes and palpitations per day before the medication.
Study design
- Observational model
- Cohort
- Time perspective
- Prospective
- Number of arms
- 2
| Arm | Type | Receives |
|---|---|---|
| Nebivolol | – | –2,5mg or maximum 5mg per day |
| Menoflavon | – | –2 times 1 pill at 40mg Isoflavone per day |
Who may qualify
- Sex
- Female only
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
- Study population
- 60 Postmenopausal women
Key inclusion criteria (4 listed)
- Menopausal patients (estrogen <20 pg/ml and FSH >35 mIU/ml)
- The patients are sexually active
- The patients have hot flushes
- The patients have palpitations or extrasystoles
Key exclusion criteria (11 listed)
- Patients with COPD
- Patients with an AV-block
- Patients with a bradycardia (meaning a heart rate <50 beats per minute)
- Patients with hypotension (RR <100/80 mmHg)
- Patients with a PAD (stage III, IV)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Primary outcome
Number of hot flashes/palpitations
Time frame: 3 Months, 4 appointments
Number of hot flashes/palpitations during month one and month three compared between nebivolol and phytoestrogens
4 secondary outcomes
Hemodynamic changes
Time frame: 3 Months, 4 appointments
Sexual function
Time frame: before and after 3 months of treatment
Endostatin
Time frame: Baseline and after 3 months
Quality of life
Time frame: baseline and after 3 months
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 12 Jan 2016.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Department of Cardiology, Medical University of Vienna
Vienna, Austria
Jeanette Strametz-Juranek, MD principal investigator
MUV, Department of Internal Medicine II, Division of Cardiology
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
An observational study of Hot Flashes and Heart Rate, run by Medical University of Vienna at 1 site in Austria.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 11 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 12 Jan 2016. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Austria. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
Each site lists its own contact: choose the nearest one under Trial locations. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Number of hot flashes/palpitations (time frame: 3 Months, 4 appointments). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 12 Jan 2016.