Carbohydrate Oxidation and Glycogen Utilization During and Following ExerciseCHO-useNCT01709617
Carbohydrate Use During and Following Exercise
A study testing Carbohydrate ingestion in people with Carbohydrate Oxidation and Glycogen Utilization During and Following Exercise, run by Maastricht University Medical Center at 1 site in Netherlands.
Trial summary
Carbohydrates are an integral component of sports nutrition. Providing carbohydrate (CHO) during exercise delays the onset of fatigue and improves exercise performance by maintaining high rates of CHO oxidation. Traditionally, glucose, or glucose polymers have been the preferential CHO source found in sports drinks. Read more about this study
- Who is it for?
- Ages 18 to 40 years, men onlyHealthy volunteers can take part
- Conditions the study is for
- Carbohydrate Oxidation and Glycogen Utilization During and Following Exercise
- What is being tested?
- Carbohydrate ingestion
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 17 participants
- Where
- 1 siteNetherlands
- Study dates
- Nov 2012to Jan 2014
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 40 years
- Men only
- Healthy volunteers accepted
- Adult
Who may be able to join
- Healthy
- Male
- 18 - 40 years of age
- Endurance trained cyclist/triathlete
- VO2 max ≥ 50 ml/kg/min
- BMI < 25 kg/m2
Who cannot join
- Use of medication
- Smoking
Trial locations and contacts
1 site in 1 country.
Netherlands1 site
Maastricht University
Maastricht, Limburg, 6200MD
ncermak@gmail.com
About this study
Official title: Sucrose as a Preferred Carbohydrate in Sports Nutrition
Carbohydrates are an integral component of sports nutrition. Providing carbohydrate (CHO) during exercise delays the onset of fatigue and improves exercise performance by maintaining high rates of CHO oxidation. Traditionally, glucose, or glucose polymers have been the preferential CHO source found in sports drinks. However, during the intestinal absorption of large amounts of glucose (>1.2 g/min), sodium-dependent glucose transporters (SGLT1) may become fully saturated, potentially limiting the rate of exogenous CHO oxidation. In an effort to evade this limitation, research has suggested using multiple transportable carbohydrates in the composition of sports drinks. Multiple transportable carbohydrates are combinations of simple sugars that use different intestinal transporters during the absorption process. Ingesting multiple transportable carbohydrates may enhance the capacity for total intestinal CHO absorption, leading to an increase in the rate of exogenous CHO oxidation. Our purpose will be to examine the disaccharide sucrose in it's ability to provide exogenous fuel during and following prolonged exercise.
- Being tested
- Carbohydrate ingestion
- Keywords
- carbohydrate, glycogen, glucose
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Carbohydrate ingestionDietary supplement
Various types of carbohydrate ingested during and following exercise
| Study group | Role | What they receive |
|---|---|---|
| Glucose-glucose | Experimental | Glucose ingestion Receives: Dietary Supplement: Carbohydrate ingestion |
| Glucose-Fructose | Active comparator | glucose-fructose ingestion Receives: Dietary Supplement: Carbohydrate ingestion |
| disaccharide | Active comparator | Disaccharide ingestion Receives: Dietary Supplement: Carbohydrate ingestion |
What is being measured
The primary outcome is the main question the study is designed to answer.
Exogenous carbohydrate oxidation rate (Part A)
Carbohydrate oxidation as measured by breath samples
Measured: 0 min during trials 1-3
Endogenous carbohydrate oxidation (Part A)
endogenous carbohydrate oxidation as measured through breath samples during trials 1-3
Measured: 0 min during trials 1-3
Glycogen utilization (Part B)
Glycogen utilization measured through a muscle biopsy sample at post (~90 min), 3 and 6 h post exercise.
Part B; trials 4-6.
Measured: immediately post exercise (~90min), during trials 4-6
Exogenous carbohydrate oxidation rate (Part A)
Carbohydrate oxidation as measured by breath samples
Measured: 30 min during trials 1-3
Exogenous carbohydrate oxidation rate (Part A)
Carbohydrate oxidation as measured by breath samples
Measured: 60 min during trials 1-3
Exogenous carbohydrate oxidation rate (Part A)
Carbohydrate oxidation as measured by breath samples
Measured: 90 min during trials 1-3
Exogenous carbohydrate oxidation rate (Part A)
Carbohydrate oxidation as measured by breath samples
Measured: 120 min during trials 1-3
Exogenous carbohydrate oxidation rate (Part A)
Carbohydrate oxidation as measured by breath samples
Measured: 150 min during trials 1-3
Exogenous carbohydrate oxidation rate (Part A)
Carbohydrate oxidation as measured by breath samples
Measured: 180 min during trials 1-3
Endogenous carbohydrate oxidation (Part A)
endogenous carbohydrate oxidation as measured through breath samples during trials 1-3
Measured: 30 min during trials 1-3
Endogenous carbohydrate oxidation (Part A)
endogenous carbohydrate oxidation as measured through breath samples during trials 1-3
Measured: 60 min during trials 1-3
Endogenous carbohydrate oxidation (Part A)
endogenous carbohydrate oxidation as measured through breath samples during trials 1-3
Measured: 90 min during trials 1-3
Endogenous carbohydrate oxidation (Part A)
endogenous carbohydrate oxidation as measured through breath samples during trials 1-3
Measured: 120 min during trials 1-3
Endogenous carbohydrate oxidation (Part A)
endogenous carbohydrate oxidation as measured through breath samples during trials 1-3
Measured: 150 min during trials 1-3
Endogenous carbohydrate oxidation (Part A)
endogenous carbohydrate oxidation as measured through breath samples during trials 1-3
Measured: 180 min during trials 1-3
Glycogen utilization (Part B)
Glycogen utilization measured through a muscle biopsy sample at post (~90 min), 3 and 6 h post exercise.
Part B; trials 4-6.
Measured: 3 h post exercise during trials 4-6
Glycogen utilization (Part B)
Glycogen utilization measured through a muscle biopsy sample at post (~90 min), 3 and 6 h post exercise.
Part B; trials 4-6.
Measured: 6 h post exercise during trials 4-6
Secondary outcomes (3)
Indirect calorimetry (Part A)
Measurements of VO2, VCO2 and RER through indirect calorimetry measured every 30 minutes during trials 1-3
Measured: every 30 min up to 180 min during trials 1-3
Plasma glucose
Plasma glucose measurements
Measured: every 30 min up to 180 min during trials 1-6
Plasma insulin
plasma insulin measurements
Measured: every 30 minutes up to 180 min during trials 1-6
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Oct 2012 (estimated)
- Study startNov 2012
- Primary completionSep 2013 (estimated)
- Study completionJan 2014 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Carbohydrate Oxidation and Glycogen Utilization During and Following ExerciseStudies of the same condition, open and under way.
- More trials run by Maastricht University Medical CenterThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Double blind
- Who is masked
- Participant, Investigator
- Enrolment
- 17 participants (estimated)
Sponsor and investigators
- Lead sponsor
- Maastricht University Medical Center
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
- Investigators
- Luc van Loon, Ph.D., Principal investigator, Maastricht University
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT01709617
- Sponsor's protocol ID
- 12-3-048
- Acronym
- CHO-use
- Status last verified
- Oct 2012
- First submitted
- 11 Oct 2012
- Last updated
- 18 Oct 2012
- Results posted
- No
- Data monitoring committee
- No
Study at a glance
From the registry record, last updated by the sponsor on 18 Oct 2012. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Sucrose as a Preferred Carbohydrate in Sports Nutrition
- ClinicalTrials.gov ID
- NCT01709617
- Acronym / sponsor ID
- CHO-use / 12-3-048
- Keywords
- carbohydrate, glycogen, glucose
- Study type
- Interventional
- Recruitment status
- Unknown status
- Enrolment
- 17 participants (estimated)
- Lead sponsor
- Maastricht University Medical CenterUniversity, hospital or other
- Study start
- Nov 2012
- Primary completion
- Sep 2013 (estimated)
- Study completion
- Jan 2014 (estimated)
- First posted
- 18 Oct 2012 (estimated)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Carbohydrates are an integral component of sports nutrition. Providing carbohydrate (CHO) during exercise delays the onset of fatigue and improves exercise performance by maintaining high rates of CHO oxidation. Traditionally, glucose, or glucose polymers have been the preferential CHO source found in sports drinks. However, during the intestinal absorption of large amounts of glucose (>1.2 g/min), sodium-dependent glucose transporters (SGLT1) may become fully saturated, potentially limiting the rate of exogenous CHO oxidation. In an effort to evade this limitation, research has suggested using multiple transportable carbohydrates in the composition of sports drinks. Multiple transportable carbohydrates are combinations of simple sugars that use different intestinal transporters during the absorption process. Ingesting multiple transportable carbohydrates may enhance the capacity for total intestinal CHO absorption, leading to an increase in the rate of exogenous CHO oxidation. Our purpose will be to examine the disaccharide sucrose in it's ability to provide exogenous fuel during and following prolonged exercise.
Study design
- Allocation
- Randomised
- Intervention model
- Crossover
- Masking
- Double blind (participant, investigator)
- Number of arms
- 3
| Arm | Type | Receives |
|---|---|---|
| Glucose-glucose | Experimental | Dietary Supplement: Carbohydrate ingestionGlucose ingestion |
| Glucose-Fructose | Active comparator | Dietary Supplement: Carbohydrate ingestionglucose-fructose ingestion |
| disaccharide | Active comparator | Dietary Supplement: Carbohydrate ingestionDisaccharide ingestion |
Who may qualify
- Ages
- 18 to 40 years
- Sex
- Male only
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (6 listed)
- Healthy
- Male
- 18 - 40 years of age
- Endurance trained cyclist/triathlete
- VO2 max ≥ 50 ml/kg/min
Key exclusion criteria (2 listed)
- Use of medication
- Smoking
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Carbohydrate ingestionVarious types of carbohydrate ingested during and following exercise | Dietary supplement | Glucose-Fructose, Glucose-glucose, disaccharide |
Primary outcome
Exogenous carbohydrate oxidation rate (Part A)
Time frame: 0 min during trials 1-3
Carbohydrate oxidation as measured by breath samples
Endogenous carbohydrate oxidation (Part A)
Time frame: 0 min during trials 1-3
endogenous carbohydrate oxidation as measured through breath samples during trials 1-3
Glycogen utilization (Part B)
Time frame: immediately post exercise (~90min), during trials 4-6
Glycogen utilization measured through a muscle biopsy sample at post (~90 min), 3 and 6 h post exercise. Part B; trials 4-6.
Exogenous carbohydrate oxidation rate (Part A)
Time frame: 30 min during trials 1-3
Carbohydrate oxidation as measured by breath samples
Exogenous carbohydrate oxidation rate (Part A)
Time frame: 60 min during trials 1-3
Carbohydrate oxidation as measured by breath samples
Exogenous carbohydrate oxidation rate (Part A)
Time frame: 90 min during trials 1-3
Carbohydrate oxidation as measured by breath samples
Exogenous carbohydrate oxidation rate (Part A)
Time frame: 120 min during trials 1-3
Carbohydrate oxidation as measured by breath samples
Exogenous carbohydrate oxidation rate (Part A)
Time frame: 150 min during trials 1-3
Carbohydrate oxidation as measured by breath samples
Exogenous carbohydrate oxidation rate (Part A)
Time frame: 180 min during trials 1-3
Carbohydrate oxidation as measured by breath samples
Endogenous carbohydrate oxidation (Part A)
Time frame: 30 min during trials 1-3
endogenous carbohydrate oxidation as measured through breath samples during trials 1-3
Endogenous carbohydrate oxidation (Part A)
Time frame: 60 min during trials 1-3
endogenous carbohydrate oxidation as measured through breath samples during trials 1-3
Endogenous carbohydrate oxidation (Part A)
Time frame: 90 min during trials 1-3
endogenous carbohydrate oxidation as measured through breath samples during trials 1-3
Endogenous carbohydrate oxidation (Part A)
Time frame: 120 min during trials 1-3
endogenous carbohydrate oxidation as measured through breath samples during trials 1-3
Endogenous carbohydrate oxidation (Part A)
Time frame: 150 min during trials 1-3
endogenous carbohydrate oxidation as measured through breath samples during trials 1-3
Endogenous carbohydrate oxidation (Part A)
Time frame: 180 min during trials 1-3
endogenous carbohydrate oxidation as measured through breath samples during trials 1-3
Glycogen utilization (Part B)
Time frame: 3 h post exercise during trials 4-6
Glycogen utilization measured through a muscle biopsy sample at post (~90 min), 3 and 6 h post exercise. Part B; trials 4-6.
Glycogen utilization (Part B)
Time frame: 6 h post exercise during trials 4-6
Glycogen utilization measured through a muscle biopsy sample at post (~90 min), 3 and 6 h post exercise. Part B; trials 4-6.
3 secondary outcomes
Indirect calorimetry (Part A)
Time frame: every 30 min up to 180 min during trials 1-3
Plasma glucose
Time frame: every 30 min up to 180 min during trials 1-6
Plasma insulin
Time frame: every 30 minutes up to 180 min during trials 1-6
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 18 Oct 2012.
Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Luc van Loon, Ph.D. principal investigator
Maastricht University
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Carbohydrate ingestion in people with Carbohydrate Oxidation and Glycogen Utilization During and Following Exercise, run by Maastricht University Medical Center at 1 site in Netherlands.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 6 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 18 Oct 2012. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Netherlands. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
Contact Naomi Cermak, Ph.D. (31433881393, naomi.cermak@maastrichtuniversity.nl), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Exogenous carbohydrate oxidation rate (Part A) (time frame: 0 min during trials 1-3). The study lists 17 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 18 Oct 2012.