Coronary Artery Disease Without Heart FailureCORANAENCT03491423
Short and Fast Step Test: Feasibility, Validity and Tolerance of a Functional Evaluation Test of Lactic Anaerobic Capacities in Patients With Coronary Artery Disease
A study testing Short and fast step test without measurement of pulmonary gas exchange, glucose meter and ECG / heart rate in people with Coronary Artery Disease Without Heart Failure, run by Centre Hospitalier Universitaire Dijon at 1 site in France.
Trial summary
Recommendations for cardiovascular rehabilitation (CVR) encourage exercise training, primarily involving the aerobic system, to allow patients to regain independence in daily activities. However, the lactic anaerobic process is also involved during these activities (stair climbing, carrying loads, etc.). Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Coronary Artery Disease Without Heart Failure
- What is being tested?
- Short and fast step test without measurement of pulmonary gas exchange, glucose meter and ECG / heart rate
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 44 participants
- Where
- 1 siteFrance
- Study dates
- 4 Jun 2018to 3 May 2019
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- Patient who has given oral consent Adult patient (male or female) with coronary artery disease without heart failure referred for rehabilitation program Left ventricular ejection fraction (Simpson method) > 45%.
Who cannot join
- Protected adult
- Patient not affiliated to a national health insurance scheme
- Pregnant or breastfeeding woman
- Orthostatic hypotension
- Severe obstructive heart disease
- aortic valve narrowing
Show all 14Show fewer
- Progressive severe cardiac rhythm or conduction disorders not requiring a device, detected during the initial stress test.
- intracavitary cardiac thrombus
- severe pulmonary arterial hypertension (systolic pulmonary hypertension >70mmHg)
- recent venous thromboembolic history (last 3 months)
- heart transplantation
- associated medical condition that can predominantly impair functional and respiratory capacities (examples: unstabilized metabolic disorders such as progressive renal failure, significant asthenia related to a severe unstabilized condition such as neoplasia, systemic disease, chronic obstructive pulmonary disease...)
- physical impairments of the lower limbs hindering the test, whether neurological (central or peripheral), arterial (in particular, arteriopathy of the lower limbs with systolic index < 0.6) or orthopedic (degenerative or inflammatory rheumatism)
- Treatment with Corticosteroids, Anabolics, or L-Carnitine.
Trial locations and contacts
1 site in 1 country.
About this study
Recommendations for cardiovascular rehabilitation (CVR) encourage exercise training, primarily involving the aerobic system, to allow patients to regain independence in daily activities. However, the lactic anaerobic process is also involved during these activities (stair climbing, carrying loads, etc.). Hence there is a major interest in accurately assessing patients' anaerobic capacities in order to tailor suitable exercise programs. However, there are no functional tests specifically dedicated to the evaluation of lactic anaerobic metabolism and adapted to people with coronary disease. The investigators offer a dedicated test, the short and fast test (SFST), which can be applied in current clinical practice and has already been evaluated in a population of healthy subjects. The purpose of this project is to evaluate the safety, feasibility and validity of SFST in a population of patients with coronary artery disease.
- Being tested
- Short and fast step test without measurement of pulmonary gas exchange, glucose meter, ECG / heart rate, questionnaires, Short and fast step test with measurement of pulmonary gas exchange
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Short and fast step test without measurement of pulmonary gas exchangeOther
For one minute, the patient should climb up and down a 17.5 cm high step as quickly as possible while holding onto a bar in front of the step.
glucose meterBiological
glucose meter to measure lactatemia
ECG / heart rateOther
ECG and heart rate (HR) collection by telemetry
questionnairesOther
VAS pain assessment and evaluation of effort perception according to Borg's scale
Short and fast step test with measurement of pulmonary gas exchangeOther
For one minute, the patient should climb up and down a 17.5 cm high step as quickly as possible while holding onto a bar in front of the step.
| Study group | Role | What they receive |
|---|---|---|
| Patients | Experimental | Not described Receives: Other: Short and fast step test without measurement of pulmonary gas exchange; Biological: glucose meter; Other: ECG / heart rate; Other: questionnaires; Other: Short and fast step test with measurement of pulmonary gas exchange |
What is being measured
The primary outcome is the main question the study is designed to answer.
percentage of patients who completed the SFST without complications
- Absence of muscular or bone-joint disorders quantified according to the VAS. The exercise will be considered as not tolerated if pain is reported during the test and/or at day 3 (VAS≥6).
AND no falls or stumbling related trauma
AND absence of cardiovascular or blood pressure events:
- Hypertension (systolic pressure greater than 250 mmHg (O'Brien et al. 2005) or hypotension with clinical consequences (malaise or feeling unwell)
- Discomfort, chest pain, onset of vascular claudication
- Rhythm or conduction disorders or repolarization abnormalities, at a higher frequency than that observed in the pre-inclusion stress test
- Abnormal increase in heart rate (greater than the maximum rate determined during the stress test).
Measured: through study completion, an average of 11 days
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted9 Apr 2018
- Study start4 Jun 2018
- Primary completion3 May 2019
- Study completion3 May 2019
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Coronary Artery Disease Without Heart FailureStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 44 participants (actual)
Sponsor and investigators
- Lead sponsor
- Centre Hospitalier Universitaire Dijon
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT03491423
- Sponsor's protocol ID
- HANNEQUIN APPARA 2016
- Acronym
- CORANAE
- Status last verified
- Feb 2026
- First submitted
- 30 Mar 2018
- Last updated
- 4 Feb 2026
- Results posted
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Besson D, Gouteron A, Sinssaine-Ayillo A, Casillas JM, Rigaud L, Ornetti P, Fournel I, Ksiazek E, Laroche D, Gueugnon M. Is the Short and Fast Step Test a safe and feasible tool for exploring anaerobic capacities of individuals with coronary heart disease in clinical practice? Eur J Phys Rehabil Med. 2021 Dec;57(6):977-984. doi: 10.23736/S1973-9087.21.06713-7. Epub 2021 Feb 23.
PubMed 33619946
Study at a glance
From the registry record, last updated by the sponsor on 4 Feb 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Short and Fast Step Test: Feasibility, Validity and Tolerance of a Functional Evaluation Test of Lactic Anaerobic Capacities in Patients With Coronary Artery Disease
- ClinicalTrials.gov ID
- NCT03491423
- Acronym / sponsor ID
- CORANAE / HANNEQUIN APPARA 2016
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 44 participants (actual)
- Lead sponsor
- Centre Hospitalier Universitaire DijonUniversity, hospital or other
- Study start
- 4 Jun 2018 (actual)
- Primary completion
- 3 May 2019 (actual)
- Study completion
- 3 May 2019 (actual)
- First posted
- 9 Apr 2018 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Recommendations for cardiovascular rehabilitation (CVR) encourage exercise training, primarily involving the aerobic system, to allow patients to regain independence in daily activities. However, the lactic anaerobic process is also involved during these activities (stair climbing, carrying loads, etc.). Hence there is a major interest in accurately assessing patients' anaerobic capacities in order to tailor suitable exercise programs. However, there are no functional tests specifically dedicated to the evaluation of lactic anaerobic metabolism and adapted to people with coronary disease. The investigators offer a dedicated test, the short and fast test (SFST), which can be applied in current clinical practice and has already been evaluated in a population of healthy subjects. The purpose of this project is to evaluate the safety, feasibility and validity of SFST in a population of patients with coronary artery disease.
Study design
- Primary purpose
- Other
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Patients | Experimental | Other: Short and fast step test without measurement of pulmonary gas exchange, Biological: glucose meter, Other: ECG / heart rate, Other: questionnaires, Other: Short and fast step test with measurement of pulmonary gas exchange |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- Patient who has given oral consent Adult patient (male or female) with coronary artery disease without heart failure referred for rehabilitation program Left ventricular ejection fraction (Simpson method) > 45%.
Key exclusion criteria (14 listed)
- Protected adult
- Patient not affiliated to a national health insurance scheme
- Pregnant or breastfeeding woman
- Orthostatic hypotension
- Severe obstructive heart disease
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Short and fast step test without measurement of pulmonary gas exchangeFor one minute, the patient should climb up and down a 17.5 cm high step as quickly as possible while holding onto a bar in front of the step. | Other | Patients |
| glucose meterglucose meter to measure lactatemia | Biological | Patients |
| ECG / heart rateECG and heart rate (HR) collection by telemetry | Other | Patients |
| questionnairesVAS pain assessment and evaluation of effort perception according to Borg's scale | Other | Patients |
| Short and fast step test with measurement of pulmonary gas exchangeFor one minute, the patient should climb up and down a 17.5 cm high step as quickly as possible while holding onto a bar in front of the step. | Other | Patients |
Primary outcome
percentage of patients who completed the SFST without complications
Time frame: through study completion, an average of 11 days
- Absence of muscular or bone-joint disorders quantified according to the VAS. The exercise will be considered as not tolerated if pain is reported during the test and/or at day 3 (VAS≥6). AND no falls or stumbling related trauma AND absence of cardiovascular or blood pressure events: * Hypertension (systolic pressure greater than 250 mmHg (O'Brien et al. 2005) or hypotension with clinical consequences (malaise or feeling unwell) * Discomfort, chest pain, onset of vascular claudication * Rhythm or conduction disorders or repolarization abnormalities, at a higher frequency than that observed in the pre-inclusion stress test * Abnormal increase in heart rate (greater than the maximum rate determined during the stress test).
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 4 Feb 2026.
- Results publication: PubMed 33619946Besson D, Gouteron A, Sinssaine-Ayillo A, Casillas JM, Rigaud L, Ornetti P, Fournel I, Ksiazek E, Laroche D, Gueugnon M. Is the Short and Fast Step Test a safe and feasible tool for exploring anaerobic capacities of individuals with coronary heart disease in clinical practice? Eur J Phys Rehabil Med. 2021 Dec;57(6):977-984. doi: 10.23736/S1973-9087.21.06713-7. Epub 2021 Feb 23.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
The record lists no contact. Use the official record to reach the sponsor.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Short and fast step test without measurement of pulmonary gas exchange, glucose meter and ECG / heart rate in people with Coronary Artery Disease Without Heart Failure, run by Centre Hospitalier Universitaire Dijon at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 14 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 4 Feb 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
percentage of patients who completed the SFST without complications (time frame: through study completion, an average of 11 days). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT03491423, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 4 Feb 2026.