AzTrials
AzTrials

Chronic Plaque PsoriasisVALUENCT03982394

Observational Study of Patients With Moderate to Severe Chronic Plaque Psoriasis

An observational study of Chronic Plaque Psoriasis, run by AbbVie at 302 sites in 21 countries.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

This study will assess the use of risankizumab in adult patients with moderate to severe chronic plaque psoriasis and compare risankizumab to other commonly used biologics. Read more about this study

Who is it for?
Ages 18 years and older
Conditions the study is for
Chronic Plaque Psoriasis
How many people
2,759 participants
Where
302 sitesin 21 countries
Study dates
1 Jul 2019to 2 Sep 2025
Phase
Observational
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 years and older
  • All sexes
  • No healthy volunteers
  • Adult, Older adult

Study population: This study will enroll adult subjects with moderate to severe plaque psoriasis.

Who may be able to join

  • Confirmed diagnosis of moderate to severe chronic plaque-type psoriasis diagnosed by a specialist and presence of moderate to severe psoriasis symptoms according to physician's judgement at time of recruitment.
  • Participant starting any approved treatment for psoriasis and physician's decision must be reached prior to recruitment in the study.
  • Participant willing to continue with study documentation after cessation of therapy.

Who cannot join

  • Unwillingness or inability to comply with study requirements.
  • Participation in an interventional clinical trial, concurrently or within the last 30 days. Participation in a post-market observational study (PMOS) or Registry is acceptable.

Trial locations and contacts

302 sites in 21 countries.

302 sites in 21 countries

Germany76 sites

  • Bell, Andernach, DE /ID# 214545

    Andernach, Rhineland-Palatinate, 56626

  • Praxis Dr. Mihaescu /ID# 213483

    Augsburg, 86150

  • Mauer, Bad Kreuznach, DE /ID# 224876

    Bad Kreuznach, 55543

  • Hautmedizin Bad Soden /ID# 213956

    Bad Soden am Taunus, 65812

  • Timmel/Timm/Vorwerk, Bergen /ID# 214552

    Bergen, 18528

  • Hasert & Hasert, Berlin, DE /ID# 213641

    Berlin, 10117

  • Hautzentrum Friedrichshain /ID# 213981

    Berlin, 10247

  • Weihe/Stavermann, Berlin, DE /ID# 214550

    Berlin, 12353

  • Praxis Dr. med. Alexander Zich /ID# 245751

    Berlin, 12681

  • Hautarztzentrum Tegel /ID# 214849

    Berlin, 13507

  • Klinikum Rosenhoehe /ID# 215520

    Bielefeld, North Rhine-Westphalia, 33647

  • Praxis fuer Innere Medizin/Rheumatologie /ID# 213653

    Blaubeuren Abbey, 89143

  • Praxis T. Schadeck /ID# 213957

    Bogen, 94327

  • Barth, Borna, DE /ID# 213643

    Borna, 04552

  • Studienzentrum an der Hase GbR Dr. Weyergraf/Dr. Frick/Thomas Heiber /ID# 214466

    Bramsche, Lower Saxony, 49565

  • Schwichtenberg, Bremen, DE /ID# 213650

    Bremen, 28779

  • Elbe Klinikum Buxtehude /ID# 213366

    Buxtehude, 21614

  • Praxis Herbst /ID# 222024

    Darmstadt, 64283

  • Praxis Dr. Sbornik /ID# 213668

    Deggendorf, 94469

  • Heidlas, Dessau-Rosslau, DE /ID# 217691

    Dessau, 06842

  • Richter-Huhn, Dresden, DE /ID# 213659

    Dresden, 01219

  • Praxis Dr. Korge /ID# 213475

    Düren, 52349

  • Universitaetsklinikum Erlangen /ID# 213669

    Erlangen, Bavaria, 91054

  • Dres. Cesko u. Körber /ID# 214850

    Essen, 45130

  • Kurzen, Freising, DE /ID# 214567

    Freising, Bavaria, 85354

  • Gemeinschaftspraxis Rietkoetter und Jablonka /ID# 213482

    Gelsenkirchen, 45899

  • Praxis Dr. Lange /ID# 213984

    Gera, 07548

  • Loth, Gernsbach, DE /ID# 214848

    Gernsbach, 76593

  • Gross/Braeu, Giessen, DE /ID# 213367

    Giessen, Hesse, 35390

  • Hautarztpraxis Dr. Viehmann /ID# 213675

    Giessen, 35390

  • Brinkmann & Partner, Gladbeck, /ID# 214247

    Gladbeck, 45964

  • Universitaetsklinikum Hamburg-Eppendorf /ID# 222464

    Hamburg, 20246

  • Dermatologikum Hamburg /ID# 213978

    Hamburg, 20354

  • Goldbek Medical /ID# 214570

    Hamburg, 22303

  • Praxis Dres. Kaspari /Schenck /ID# 213649

    Hanover, Lower Saxony, 30159

  • Hautarztpraxis Haßberge /ID# 213644

    Haßfurt, 97437

  • Gemeinschaftspraxis Dres. Anika Hünermund/Mario Pawlak /ID# 213113

    Heilbad Heiligenstadt, 37308

  • Reinecke, Holzminden, DE /ID# 215081

    Holzminden, 37603

  • Universitaetsklinikum Jena /ID# 214259

    Jena, Thuringia, 07747

  • Derma Sana /ID# 214544

    Karlsruhe, 76133

  • Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 213670

    Kiel, Schleswig-Holstein, 24105

  • DermaKiel Allergie und Haut Centrum /ID# 213977

    Kiel, Schleswig-Holstein, 24148

  • Grossmann, Koblenz, DE /ID# 214245

    Koblenz, Rhineland-Palatinate, 56068

  • Praxis Dres. Bornemann/Reinerth /ID# 213368

    Krefeld, 47798

  • Dres. Jacobs & Kollegen /ID# 213652

    Kulmbach, 95326

  • Hautarztpraxis Langenau /ID# 213651

    Langenau, Baden-Wurttemberg, 89129

  • Neubauer, Leipzig, DE /ID# 214548

    Leipzig, Saxony, 04209

  • Noack-Wiemers, Leipzig, DE /ID# 213654

    Leipzig, Saxony, 04289

  • Hagemeier, Loehne, DE /ID# 214845

    Löhne, 32584

  • Dlugosz-Wolf, Luedenscheid, DE /ID# 222000

    Lüdenscheid, 58507

  • Bruecher, Magdeburg, DE /ID# 213476

    Magdeburg, Saxony-Anhalt, 39104

  • Praxis Dr. Raschke /ID# 225213

    Magdeburg, Saxony-Anhalt, 39104

  • Universitaetsklinikum Magdeburg /ID# 215080

    Magdeburg, 39120

  • Universitaetsmedizin Mainz /ID# 222025

    Mainz, Rhineland-Palatinate, 55131

  • Dermatologie Quist-BAG Dres. med. Quist PartG /ID# 214249

    Mainz, 55128

  • Universitatsklinikum Mannheim /ID# 214569

    Mannheim, Baden-Wurttemberg, 68167

  • Beldio Research GmbH /ID# 213958

    Memmingen, Bavaria, 87700

  • HMS GmbH Zimmer /ID# 225219

    Merzig, Saarland, 66663

  • ZENTderma /ID# 213959

    Mönchengladbach, 41061

  • Zentrum fur Hautgesundheit /ID# 222001

    Neuwied, Rhineland-Palatinate, 56564

  • Duplicate_Praxis Dres. Kloss/Peterburgskiy /ID# 213960

    Neuwied, 56564

  • Voelkel, Nuremberg, DE /ID# 213671

    Nuremberg, Bavaria, 90419

  • Praxis Dr. Konstantin Ertner /ID# 213640

    Nuremberg, 90402

  • Breitsprecher, Osnabrueck, DE /ID# 213672

    Osnabrück, Lower Saxony, 49074

  • Kramer/Mortazawi, Remscheid /ID# 213477

    Remscheid, North Rhine-Westphalia, 42897

  • Praxis Dr. Fränken /ID# 214546

    Schwelm, 58332

  • Praxis Dr. Langhoff /ID# 214253

    Schwerin, 19053

  • CMS3 Company for Medical Study /ID# 213676

    Selters, Rhineland-Palatinate, 56242

  • Karl, Soest, DE /ID# 214547

    Soest, North Rhine-Westphalia, 59494

  • Praxis Dres. Ziegler & Partner /ID# 213647

    Stuttgart, 70190

  • Braun, Ueberlingen, DE /ID# 213646

    Überlingen, 88662

  • Barnikol, Waltershausen, DE /ID# 213219

    Waltershausen, 99880

  • Pfennig, Werdau, DE /ID# 213657

    Werdau, 08412

  • Moeller, Wiesbaden, DE /ID# 213955

    Wiesbaden, 65185

  • Hautarztpraxis Dr. med. Matthias Hoffmann /ID# 213444

    Witten, 58453

  • Franz, Wolfenbuettel, DE /ID# 215355

    Wolfenbüttel, 38300

Other trials in Germany

Canada27 sites

  • CCA Medical Research /ID# 214446

    Ajax, Ontario, L1S 7K8

  • SimcoDerm Medical and Surgical Dermatology Center /ID# 213081

    Barrie, Ontario, L4M 7G1

  • SKIN Clinics /ID# 213082

    Brandon, Manitoba, R7A 0L5

  • Beacon Dermatology Inc /ID# 213524

    Calgary, Alberta, T3A 2N1

  • Duplicate_Stratica Medical /ID# 213526

    Edmonton, Alberta, T5K 1X3

  • Alberta DermaSurgery Centre /ID# 230114

    Edmonton, Alberta, T6G 1C3

  • Dr. Irina Turchin PC Inc. /ID# 212128

    Fredericton, New Brunswick, E3B 1G9

  • LEADER Research /ID# 249701

    Hamilton, Ontario, L8L 3C3

  • Lima's Excellence in Allergy and Dermatology Research Inc /ID# 231973

    Hamilton, Ontario, L8L 3C3

  • Hamilton Health Sciences Corporation /ID# 214053

    Hamilton, Ontario, L8L 8E7

  • Dermatrials Research /ID# 213523

    Hamilton, Ontario, L8N 1Y2

  • Clinique D /ID# 212126

    Laval, Quebec, H7N 6L2

  • Lynderm Research Inc /ID# 212124

    Markham, Ontario, L3P 1X2

  • Al-Mohammedi Medicine Professional Corporation /ID# 215408

    Mississauga, Ontario, L4W 0C2

  • DermEdge - Queensway East /ID# 213525

    Mississauga, Ontario, L4Y 4C5

  • Angela Montgomery Medicine Professional Corporation /ID# 213615

    Ottawa, Ontario, K1H 7X3

  • Dr Melinda Gooderham Medicine Professional Corporation /ID# 212133

    Peterborough, Ontario, K9J 5K2

  • Centre de Recherche St-Louis /ID# 216325

    Québec, Quebec, G1W 4R4

  • Karma Clinical Trials /ID# 213522

    St. John's, Newfoundland and Labrador, A1A 4Y3

  • NewLab Clinical Research Inc. /ID# 213521

    St. John's, Newfoundland and Labrador, A1C 2H5

  • Dr. Brown-Maher PMC INC. /ID# 212136

    St. John's, Newfoundland and Labrador, A1E 1V4

  • Farheen Mussani Medicine Professional Corporation /ID# 213811

    Stoney Creek, Ontario, L8G 1H1

  • North York Research Inc /ID# 213486

    Toronto, Ontario, M2N 3A6

  • University of British Columbia - Eye Care Centre, Vancouver General Hospital /ID# 213507

    Vancouver, British Columbia, V5Z 3N9

  • Private Practice - Dr. Kim Papp Clinical Research /ID# 212130

    Waterloo, Ontario, N2J 1C4

  • Dr Maksym Breslavets Medicine Professional Corporation /ID# 213338

    Whitby, Ontario, L1N 8M7

  • Winnipeg Clinic /ID# 212134

    Winnipeg, Manitoba, R3C 0N2

Other trials in Canada

France27 sites

  • CH du Pays d'AIX /ID# 216440

    Aix-en-Provence, 13616

  • CHU Amiens-Picardie Site Sud /ID# 216170

    Amiens, Somme, 80054

  • Chu Angers /Id# 216244

    Angers, 49933

  • Ch Auxerre /Id# 216175

    Auxerre, Yonne, 89011

  • Hopital Ambroise Pare /ID# 216439

    Boulogne-Billancourt, 92104

  • Hopital de la Cavale Blanche /ID# 216495

    Brest, Finistere, 29200

  • CHU de CAEN - Hopital de la Cote de Nacre /ID# 216245

    Caen, Calvados, 14033

  • Cabinet Dermatologie et Esthetique /ID# 229132

    Cannes, 06400

  • CH William Morey /ID# 225441

    Chalon-sur-Saône, 71321

  • Ch Chalons En Champagne /Id# 216668

    Châlons-en-Champagne, Marne, 51000

  • Centre Hospitalier Métropole Savoie - Site Hôpital de Chambéry /ID# 217572

    Chambéry, Savoie, 73007

  • CHU Dijon /ID# 216247

    Dijon, Cote-d Or, 21000

  • CH Annecy Genevois - Site Annecy /ID# 225786

    Epagny Metz Tessy, 74370

  • CHU Grenoble - Hopital Michallon /ID# 218437

    La Tronche, Isere, 38700

  • Centre Hospitalier du Mans /ID# 225729

    Le Mans, Sarthe, 72037

  • C.H. de Bretagne Sud /ID# 216243

    Lorient, 56322

  • Hopital Saint Joseph /ID# 223149

    Marseille, Bouches-du-Rhone, 13008

  • CH Georges Renon /ID# 216174

    Niort, Deux-Sevres, 79028

  • CH Pontoise - Hopital René Dubos /ID# 216169

    Pontoise, Val-d Oise, 95300

  • CHU de Rennes - PONTCHAILLOU /ID# 218248

    Rennes, Brittany Region, 35000

  • Hopitaux Drome Nord /ID# 222586

    Romans-sur-Isère, Drome, 26100

  • Hôpital d'instruction des armées Bégin /ID# 216167

    Saint-Mandé, 94163

  • Centre Hospitalier Universitaire de Saint Etienne - Hopital Nord /ID# 216663

    St-Priest-en-Jarez, Pays de la Loire Region, 42270

  • CH Bigorre - Site de la Gespe /ID# 218563

    Tarbes, Hautes-Pyrenees, 65013

  • CHR Metz-Thionville - Hopital Bel-Air /ID# 225691

    Thionville, Moselle, 57100

  • Hôpital d'Instruction des Armées Sainte-Anne /ID# 218888

    Toulon, Var, 83800

  • CH Valence /ID# 225877

    Valence, Drome, 26000

Other trials in France

Japan27 sites

  • Asahikawa Medical University Hospital /ID# 213409

    Asahikawa-shi, Hokkaido, 078-8510

  • Nippon Medical School Hospital /ID# 213391

    Bunkyo-ku, Tokyo, 113-8603

  • St. Lukes International Hospital /ID# 213392

    Chuo-ku, Tokyo, 104-8560

  • Fukuoka University Hospital /ID# 213395

    Fukuoka, Fukuoka, 814-0180

  • University of the Ryukyus Hospital /ID# 213394

    Ginowan-shi, Okinawa, 901-2725

  • Kansai Medical University Hospital /ID# 213388

    Hirakata-shi, Osaka, 573-1191

  • Imamura General Hospital /ID# 228450

    Kagoshima, Kagoshima-ken, 890-0064

  • Kurume University Hospital /ID# 215034

    Kurume-shi, Fukuoka, 830-0011

  • University Hospital Kyoto Prefectural University of Medicine /ID# 213396

    Kyoto, Kyoto, 602-8566

  • Kyoto University Hospital /ID# 213404

    Kyoto, Kyoto, 606-8507

  • Shinshu University Hospital /ID# 213408

    Matsumoto-shi, Nagano, 390-8621

  • Matsuyama Red Cross Hospital /ID# 224745

    Matsuyama, Ehime, 790-8524

  • Chukyo Hospital /ID# 213405

    Nagoya, Aichi-ken, 457-8510

  • Nagoya City University Hospital /ID# 213363

    Nagoya, Aichi-ken, 467-8602

  • Takagi Dermatological Clinic /ID# 213407

    Obihiro-Shi, Hokkaido, 080-0013

  • Nippon Life Saiseikai Public Interest Foundation Nippon Life Hospital /ID# 224743

    Osaka, 550-0006

  • JR Sapporo Hospital /ID# 213406

    Sapporo, Hokkaido, 060-0033

  • Jichi Medical University Hospital /ID# 213403

    Shimotsuke-shi, Tochigi, 329-0498

  • Tokyo Medical University Hospital /ID# 217125

    Shinjuku-ku, Tokyo, 160-0023

  • Japan Community Health care Organization Tokyo Yamate Medical Center /ID# 213389

    Shinjuku-ku, Tokyo, 169-0073

  • Shizuoka General Hospital /ID# 224744

    Shizuoka, Shizuoka, 420-8527

  • Takamatsu Red Cross Hospital /ID# 222875

    Takamatsu, Kagawa-ken, 760-0017

  • Takamatsu Red Cross Hospital /ID# 241120

    Takamatsu, Kagawa-ken, 760-0017

  • The Jikei University School of Medicine /ID# 213393

    Tokyo, 105-8461

  • Teikyo University Hospital /ID# 213362

    Tokyo, 173-8605

  • Duplicate_Fujita Health University Hospital /ID# 224742

    Toyoake-shi, Aichi-ken, 470-1192

  • Mie University Hospital /ID# 213387

    Tsu, Mie-ken, 514-8507

Other trials in Japan

Spain27 sites

  • Hospital Universitario Principe de Asturias /ID# 225085

    Alcalá de Henares, Madrid, 28805

  • Hospital Universitario del Sureste /ID# 226561

    Arganda, Madrid, 28500

  • Hospital Universitario de Bajadoz /ID# 225091

    Badajoz, 06080

  • Hospital Santa María del Rosell /ID# 225100

    Cartagena, Murcia, 30203

  • Hospital Universitario de Getafe /ID# 225086

    Getafe, Madrid, 28905

  • Hospital Universitario Virgen de las Nieves /ID# 225107

    Granada, 18014

  • Hospital Juan Ramon Jimenez /ID# 225105

    Huelva, 21005

  • Hospital Universitario Severo Ochoa /ID# 225087

    Leganés, Madrid, 28911

  • Hospital de Leon /ID# 226559

    León, 24071

  • Hospital Universitario Lucus Augusti /ID# 233282

    Lugo, 27003

  • Hospital General Universitario Gregorio Maranon /ID# 231664

    Madrid, 28007

  • Hospital Universitario Ramon y Cajal /ID# 225093

    Madrid, 28034

  • Hospital Universitario 12 de Octubre /ID# 238474

    Madrid, 28041

  • Hospital Universitario Puerta de Hierro - Majadahonda /ID# 225084

    Majadahonda, Madrid, 28222

  • Hospital de Manacor /ID# 225083

    Manacor, Balearic Islands, 07500

  • Hospital General de Mostoles /ID# 225088

    Móstoles, Madrid, 28935

  • Hospital San Telmo /ID# 233283

    Palencia, 34004

  • Hospital Universitari Son Espases /ID# 233286

    Palma de Mallorca, Balearic Islands, 07120

  • Hospital Universitario de Puerto Real /ID# 225103

    Puerto Real, Cadiz, 11510

  • Hospital Universitario de Salamanca /ID# 225078

    Salamanca, 37711

  • Complejo Hospitalario Universitario de Santiago (CHUS) /ID# 225076

    Santiago de Compostela, A Coruna, 15706

  • Hospital Universitario Virgen de Valme /ID# 225104

    Seville, 41014

  • Hospital Alvaro Cunqueiro CHUVI /ID# 225077

    Vigo, Pontevedra, 36213

  • Hospital Virgen de la Concha /ID# 233285

    Zamora, 49022

  • Hospital Clinico Universitario Lozano Blesa /ID# 231663

    Zaragoza, 50009

  • Hospital Universitario Miguel Servet /ID# 225080

    Zaragoza, 50009

  • Hospital Royo Villanova /ID# 231665

    Zaragoza, 50015

Other trials in Spain

Italy20 sites

  • Azienda Ospedaliero Universitaria delle Marche /ID# 218720

    Ancona, 60020

  • A.O.U. Consorziale Policlinico di Bari /ID# 218558

    Bari, 70124

  • ASST degli Spedali Civili di Brescia /ID# 218717

    Brescia, 25123

  • AOU Policlinico G. Rodolico - San Marco /ID# 219032

    Catania, 95123

  • Università degli Studi di Firenze /ID# 221383

    Florence, Firenze, 50122

  • Ospedale San Martino /ID# 218844

    Genoa, Genova, 16132

  • Azienda Ospedaliera Universitaria Mater Domini- Campus Salvatore Venuta /ID# 218902

    Germaneto, Catanzaro, 88100

  • ASL 1 Abruzzo - Ospedale regionale San Salvatore /ID# 218719

    L’Aquila, L Aquila, 67100

  • IRCCS Policlinico San Donato /ID# 222002

    Milan, 20097

  • IRCCS Istituto Ortopedico Galeazzi /ID# 218867

    Milan, 20161

  • Azienda Ospedaliera Universitaria Federico II /ID# 218808

    Naples, Napoli, 80131

  • Azienda Ospedaliera Universitaria Luigi Vanvitelli /ID# 218546

    Naples, Napoli, 80138

  • Azienda Ospedale-Universita Padova /ID# 221299

    Padova, 35128

  • Azienda Ospedaliera di Perugia - Ospedale S. Maria della Misericordia /ID# 219033

    Perugia, 06156

  • Azienda Ospedaliero Universitaria Pisana /ID# 218555

    Pisa, 56126

  • Azienda Ospedaliera Universitaria Policlinico Tor Vergata /ID# 219031

    Rome, Roma, 00133

  • Presidio Columbus-Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Un /ID# 218718

    Rome, Roma, 00168

  • IRCCS Istituto Clinico Humanitas /ID# 218560

    Rozzano, Lombardy, 20089

  • Sapienza University of Rome - Polo Pontino /ID# 218557

    Terracina, Latina, 04019

  • Azienda ULSS 8 Berica /ID# 218845

    Vicenza, 36100

Other trials in Italy

United Kingdom16 sites

  • Ulster Hospital - South Eastern Health & Social Care Trust /ID# 215477

    Belfast, BT16 1RH

  • Cwm Taf Morgannwg University Health Board /ID# 215974

    Bridgend, Wales, CF31 1RQ

  • West Suffolk Hospital /ID# 249283

    Bury St Edmunds, Suffolk, IP33 2QZ

  • Frimley Health NHS Foundation Trust /ID# 215976

    Camberley, Surrey, GU16 7UJ

  • Addenbrookes Hospital /ID# 215972

    Cambridge, Cambridgeshire, CB2 2QQ

  • The Dudley Group NHS Foundation Trust /ID# 215839

    Dudley, DY1 2HQ

  • Western General Hospital - NHS Lothian /ID# 249287

    Edinburgh, Edinburgh, City of, EH4 2XU

  • The Queen Elizabeth Hospital, Kings Lynn NHS Foundation Trust /ID# 215476

    Kings Lynn, Norfolk, PE30 4ET

  • Kingston Hospital NHS Foundation Trust /ID# 215973

    Kingston upon Thames, Surrey, KT2 7QB

  • Kingston Hospital NHS Foundation Trust /ID# 230856

    Kingston upon Thames, Surrey, KT2 7QB

  • Hammersmith Hospital /ID# 215978

    London, England, W12 0HS

  • Sandwell and West Birmingham Hospitals NHS Trust /ID# 249294

    Lyndon, B71 4HJ

  • Northern Care Alliance NHS Group /ID# 218589

    Manchester, M8 5RB

  • The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 215479

    Newcastle upon Tyne, NE3 3HD

  • Northampton General Hospital NHS Trust /ID# 249297

    Northampton, Northamptonshire, NN1 5BD

  • York Hospital /ID# 227940

    York, North Yorkshire, YO31 8HE

Other trials in United Kingdom

Argentina11 sites

  • Professional Skin Care /ID# 218514

    Buenos Aires, 1024

  • Hospital Italiano /ID# 217000

    CABA, C1199ABB

  • Stringa Dermatologia /ID# 218450

    Ciudad Autonoma Buenos Aires, Buenos Aires F.D., 1114

  • Private Office Cristina Echeverria /ID# 222082

    Ciudad Autonoma Buenos Aires, Buenos Aires F.D., 1425

  • Stat Research /ID# 217185

    Ciudad Autonoma de Buenos Aire, Buenos Aires F.D., 1023

  • Buenos Aires Skin /ID# 217657

    Ciudad Autonoma de Buenos Aire, Buenos Aires F.D., 1055

  • CEDIC Centro de Investigaciones Clinicas /ID# 217184

    Ciudad Autonoma de Buenos Aire, Buenos Aires F.D., 1425

  • Instituto de Neumonologia y Dermatologia /ID# 217429

    Ciudad Autonoma de Buenos Aire, Buenos Aires F.D., 1425

  • Psoriahue Med Interdisciplinar /ID# 217182

    Ciudad Autonoma de Buenos Aire, Buenos Aires F.D., 1425

  • Emiliano Baccarini Priv Practice /ID# 218581

    Lomas de Zamora, Buenos Aires, 1832

  • Hospital Universitario Austral /ID# 217540

    Pilar, Buenos Aires, 1629

Other trials in Argentina

Austria9 sites

  • Hautarzt Dr. Lukas Kraus /ID# 216139

    Dornbirn, Vorarlberg, 6850

  • Medizinische Universitaet Graz /ID# 217702

    Graz, Styria, 8010

  • Haut Trattner Dermatologie /ID# 216138

    Hainfeld, 3170

  • Klinik Landstrasse /ID# 217684

    Vienna, State of Vienna, 1030

  • Medizin am Hauptbahnhof /ID# 218837

    Vienna, State of Vienna, 1100

  • EZW HAUT Entzuendungszentrum Wien /ID# 215488

    Vienna, State of Vienna, 1130

  • Klinik Hietzing /ID# 217685

    Vienna, State of Vienna, 1130

  • Klinik Donaustadt /ID# 218842

    Vienna, State of Vienna, 1220

  • Klinikum Wels-Grieskirchen GmbH /ID# 216140

    Wels, Upper Austria, 4600

Other trials in Austria

Colombia9 sites

  • Ciensalud IPS S.A.S /ID# 244608

    Barranqulla, 080016

  • Sociedad de Cirugía de Bogotá- Hospital de San José /ID# 222683

    Bogota, Cundinamarca, 111711

  • Caja de Compensación Familiar Cafam, Sede Centro de Atención En Salud Cafam Flor /ID# 222660

    Bogotá, Cundinamarca, 110221

  • Centro Dermatológico Federico Lleras Acosta E.S.E /ID# 222686

    Bogotá, Cundinamarca, 111511

  • Fundacion hospitalaria San Vicente de Paul /ID# 222680

    Medellín, Antioquia, 050010

  • Centro de Inmunología y Genética CIGE SAS /ID# 222685

    Medellín, Antioquia, 055422

  • IPS Universitaria /ID# 241832

    Medellín, Antioquia, 50010

  • Fundacion Hospital Universidad del Norte /ID# 223428

    Soledad, Atlántico, 83001

  • Healthy Medical Center S.A.S /ID# 231909

    Zipaquirá, Cundinamarca, 250252

Other trials in Colombia

Mexico8 sites

  • Centro Dermatologico Del Country S de Rl de Cv /Id# 225460

    Guadalajara, Jalisco, 44610

  • Grupo Clinico Catei Sociedad Civil /Id# 216978

    Guadalajara, Jalisco, 44657

  • RM Pharma Specialists S.A de C.V. /ID# 225458

    Mexico City, Mexico City, 03100

  • Consultorio Privado /Id# 225457

    Mexico City, Mexico City, 06500

  • Clinica Los Arcos Iztapalapa /Id# 216982

    Mexico City, Mexico City, 09260

  • Centro Especializado en Diabetes, Obesidad y Prevención Cardiovascular (Cedopec) /ID# 216979

    Mexico City, Mexico City, 11650

  • Dermatologica Sc /Id# 225449

    Tijuana, Estado de Baja California, 22010

  • Neki Servicios Medicos Profesionales S D Rl de Cv /Id# 216977

    Toluca, 50120

Other trials in Mexico

Australia6 sites

  • Skin Health Institute Inc /ID# 217619

    Carlton, Victoria, 3053

  • Northern Dermatology /ID# 218374

    Chermside, Queensland, 4032

  • Fremantle Dermatology /ID# 217617

    Fremantle, Western Australia, 6160

  • Premier Specialist /ID# 218158

    Kogarah, New South Wales, 2217

  • Kingsway Dermatology & Aesthetics /ID# 217616

    Miranda, New South Wales, 2228

  • Veracity Clinical Research /ID# 217618

    Woolloongabba, Queensland, 4102

Other trials in Australia

Czechia6 sites

  • Nemocnice Ceske Budejovice a.s. /ID# 216310

    České Budějovice, 370 01

  • Fakultní nemocnice Hradec Králové - Sokolská /ID# 222670

    Hradec Králové, Hradec Kralove, 500 05

  • Fakultni nemocnice Olomouc /ID# 215901

    Olomouc, 779 00

  • Fakultni nemocnice Kralovske Vinohrady /ID# 233184

    Prague, 100 34

  • Sanatorium profesora Arenbergera /ID# 215489

    Prague, 110 00

  • Duplicate_Fakultni Nemocnice v Motole /ID# 215484

    Prague, 150 00

Other trials in Czechia

Switzerland5 sites

  • University Hospital Basel /ID# 212744

    Basel Town, Canton of Basel-City, 4031

  • Inselspital, Universitaetsspital Bern /ID# 212741

    Bern, 3010

  • Waldhotel Health & Medical Excellence /Id# 212743

    Obbürgen, Canton of Nidwalden, 6363

  • Haut. Venen. Allergie. Zentrum Brunnehof /ID# 212742

    Uster, Canton of Zurich, 8610

  • University Hospital Zurich /ID# 216539

    Zurich, Canton of Zurich, 8091

Other trials in Switzerland

United Arab Emirates5 sites

  • Mediclinic Khalifa Branch /ID# 217871

    Abu Dhabi

  • New Medical Center Hospital /ID# 223681

    Abu Dhabi

  • Skmc /Id# 217873

    Abu Dhabi

  • Tawam Hospital /ID# 217872

    Abu Dhabi

  • Mediclinic Welcare Hospital /ID# 223683

    Dubai

Other trials in United Arab Emirates

Hungary4 sites

  • Debreceni Egyetem-Klinikai Kozpont /ID# 212959

    Debrecen, Hajdú-Bihar, 4032

  • Pecsi Tudomanyegyetem Klinikai Kozpont /ID# 212960

    Pécs, Baranya, 7624

  • Szegedi Tudomanyegyetem /ID# 212958

    Szeged, 6720

  • Vas Varmegyei Markusovszky Egyetemi Oktatokorhaz /ID# 212961

    Szombathely, Vas County, 9700

Other trials in Hungary

Netherlands4 sites

  • Medisch Centrum Leeuwarden /ID# 215779

    Leeuwarden, Provincie Friesland, 8934 AD

  • Radboud Universitair Medisch Centrum /ID# 213592

    Nijmegen, Gelderland, 6525 GA

  • Laurentius Ziekenhuis /ID# 230503

    Roermond, Limburg, 6043 CV

  • Haaglanden Medisch Centrum /ID# 232063

    The Hague, 2512 VA

Other trials in Netherlands

Poland4 sites

  • COPERNICUS Podmiot Leczniczy Sp. z o.o. - Szpital sw. Wojciecha Adalberta /ID# 225446

    Gdansk, Pomeranian Voivodeship, 80-462

  • Labderm S.C. Beata Bergler-Czop, Barbara Sido-Bergler /Id# 225447

    Ożarowice, Silesian Voivodeship, 42-624

  • KSW nr1 w Rzeszowie /ID# 225444

    Rzeszów, Podkarpackie Voivodeship, 35-055

  • Panstwowy Instytut Medyczny MSWiA w Warszawie /ID# 225415

    Warsaw, Masovian Voivodeship, 02-507

Other trials in Poland

Romania4 sites

  • Spitalul Clinic Colentina /ID# 214307

    Bucharest, 020121

  • Spitalul Clinic Colentina /ID# 224810

    Bucharest, 020121

  • Spitalul Clinic Colentina /ID# 224811

    Bucharest, 020121

  • Spitalul Clinic Județean de Urgențe "Sfântul Spiridon" /ID# 214335

    Iași, 700111

Other trials in Romania

Saudi Arabia4 sites

  • Heraa General Hospital /ID# 217214

    Mecca

  • King Abdulaziz Medical City- National Guard Hospital /ID# 224354

    Riyadh, Riyadh Region, 11426

  • King Saud University Med City /ID# 219065

    Riyadh, 12372

  • Security Forces Hospital /ID# 221073

    Riyadh, 12625

Other trials in Saudi Arabia

Ireland3 sites

  • South Infirmary Victoria University Hospital /ID# 213001

    Cork, T12 X23H

  • University Hospital Limerick /ID# 216997

    Limerick, V94 F858

  • Tallaght University Hospital /ID# 212999

    Tallaght, Dublin, Dublin, D24 NR0A

Other trials in Ireland

About this study

Official title: Multi-Country Prospective ObserVAtionaL, Cohort Study of Patients With Moderate to Severe Chronic PlaqUE Psoriasis (VALUE)

This study will assess the use of risankizumab in adult patients with moderate to severe chronic plaque psoriasis and compare risankizumab to other commonly used biologics.

Keywords
Chronic Plaque Psoriasis Risankizumab Biologics Psoriasis Vulgaris

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

Study groups in NCT03982394
Study groupRoleWhat they receive
Participants treated with other approved biological therapiesTreatment decision independently made of study enrollment
Participants treated with RisankizumabTreatment decision independently made of study enrollment

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Percentage of participants who achieved Psoriasis Area and Severity Index (PASI) 90

    PASI is a composite score based on the degree of effect on body surface area of psoriasis and the extension of erythema (reddening), induration (plaque thickness), desquamation (scaling) of the lesions and area affected as observed on the day of examination.

    Measured: From Month 4 to 3 years

  2. Time to first treatment change

    Identify time to first treatment change including discontinuation, dose escalation and dosing interval shortening

    Measured: From Week 0 (Baseline) to first treatment change

Secondary outcomes (13)

  1. Time to first treatment change rate

    Time to first treatment change including discontinuation, dose escalation and dose interval shortening.

    Measured: At 1 year, 2 year, and 3 year

  2. Percentage of participants who achieved Static Physicians Global Assessment (sPGA) 0/1 or sPGA 0

    The sPGA is the physician's current assessment of the average thickness, erythema, and scaling of all psoriatic lesions. sPGA scores demonstrate overall psoriatic disease with a lower score indicating less body coverage. The assessment is considered "static" which refers to the patients disease state at the time of the assessments, without comparison to any of the patient's previous disease states, whether at Baseline or at a previous visit.

    Measured: Monthly for up to 3 years

  3. Percentage of participants who achieved Psoriasis Area and Severity Index (PASI) 75, 90, or 100

    PASI is a composite score based on the degree of effect on body surface area of psoriasis and the extension of erythema (reddening), induration (plaque thickness), desquamation (scaling) of the lesions and area affected as observed on the day of examination. Each threshold will be analyzed separately.

    Measured: Monthly for up to 3 years

  4. Percentage of participants who achieved Absolute PASI<=5, <=3 or <=1

    Used to assess the benefit of psoriasis therapy. Each threshold will be analyzed separately.

    Measured: Monthly for up to 3 years

  5. Time to achieve sPGA 0/1 or sPGA 0

    The sPGA is the assessment by the Investigator of the overall disease severity at the time of evaluation. The National Psoriasis Foundation Psoriasis Score version of a static PGA is calculated by averaging the total body erythema, induration, and desquamation scores.

    Measured: Up to 3 years

  6. Time to achieve PASI 75, 90,or 100

    PASI 75, 90, or 100 defined as at least a 75%/ 90%/ 100% reduction in PASI relative to Week 0 (Baseline). Each threshold will be analyzed separately.

    Measured: Up to 3 years

  7. Percentage of participants who achieve sPGA 0/1 or sPGA 0 at 4 Months and maintained the response status at 1 Year, 2 Years and 3 Years without increasing the dose or shortening the dose interval

    Percentage of participants who achieve sPGA 0/1 or sPGA 0 at 4 Months and maintained the response status at 1 Year, 2 Years and 3 Years without increasing the dose or shortening the dose interval.

    Measured: At 4 months to 1 year, 2 years, and 3 years

  8. Percentage of participants who achieved PASI 90 or PASI 100 at 4 Months and maintained the response status at 1 Year, 2 Years, and 3 Years without changing the indicated dose or dosing interval

    Percentage of participants who achieved PASI 90 or PASI 100 demonstrating a 90 or 100% reduction in PASI at 4 Months and maintained the response status at 1 Year, 2 Years, and 3 Years without changing the indicated dose or dosing interval.

    Measured: At 4 months and 1 year, 2 years, and 3 years

  9. Change in PASI

    PASI is a composite score based on the degree of effect on body surface area of psoriasis and the extension of erythema (reddening), induration (plaque thickness), desquamation (scaling) of the lesions and area affected as observed on the day of examination.

    Measured: From Week 0 to up to 3 years

  10. Change in Body Surface Area (BSA)

    BSA can be used to quantify the severity of psoriasis. A decrease in BSA affected by psoriasis indicates improvement.

    Measured: From Week 0 to up to 3 years

  11. Change in Dermatology Quality of Life Index (DLQI) Score

    The Dermatology Life Quality Index (DLQI) is the most commonly used quality of life (QoL) assessment tool. The DLQI is a self-administered, ten-question questionnaire used to assess the effect of different skin diseases on a subject's quality of life, overall health, and disability status. Scores range from 0 (not relevant/not at all) to 3 (very much).

    Measured: From Week 0 to up to 3 years

  12. Percentage of participants who achieve DLQI 0/1

    The Dermatology Life Quality Index (DLQI) is the most commonly used quality of life (QoL) assessment tool. The DLQI is a self-administered, ten-question questionnaire used to assess the effect of different skin diseases on a subject's quality of life, overall health, and disability status. The higher the DLQI score, the more quality of life is impaired.

    Measured: Monthly for up to 3 years

  13. Change in Treatment Satisfaction Questionnaire for Medication (TSQM) score

    The Treatment Satisfaction Questionnaire for Medication (TSQM) is a widely used generic measure to assess treatment satisfaction with their medication. This is a 100-point scale with higher scores indicating greater satisfaction with medication and provides scores on four scales - side effects, effectiveness, convenience and global satisfaction.

    Measured: From Week 0 to up to 3 years

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted11 Jun 2019
  2. Study start1 Jul 2019
  3. Primary completion2 Sep 2025
  4. Study completion2 Sep 2025

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Observational
Observational model
Cohort
Time perspective
Prospective
Enrolment
2,759 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT03982394
Sponsor's protocol ID
P19-377
Acronym
VALUE
Status last verified
Nov 2025
First submitted
10 Jun 2019
Last updated
17 Nov 2025
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
Undecided

Publications

  • Thaci D, Ohtsuki M, Maul JT, Szegedi A, Luna PC, Lynde CW, Soliman AM, Wang H, Kaufmann C, Ashley DG, Madihlaba T, Rubant S, Papp KA. Real-World Effectiveness of Risankizumab in Patients with Moderate-to-Severe Psoriasis: Interim Analysis from the VALUE Global Prospective Post-marketing Observational Study at 25 Months. Dermatol Ther (Heidelb). 2025 Feb;15(2):381-394. doi: 10.1007/s13555-025-01342-0. Epub 2025 Feb 4.

    PubMed 39904971

Questions about this trial

What is this clinical trial studying?

An observational study of Chronic Plaque Psoriasis, run by AbbVie at 302 sites in 21 countries.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 3 inclusion and 2 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 17 Nov 2025. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 302 sites in Germany, Canada, France, Japan, Spain and 16 more countries. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Percentage of participants who achieved Psoriasis Area and Severity Index (PASI) 90 (time frame: From Month 4 to 3 years). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT03982394, which also lists 1 linked publication.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 17 Nov 2025.

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