Vaccine Response ImpairedPhase 4NCT04540653
Immunogenicity of the Hepatitis B Vaccine
A Phase 4 study testing Standard vaccination schedule and Reinforced vaccination schedule in people with Vaccine Response Impaired and Hepatitis B, run by Universidade Federal de Goias at 1 site in Brazil.
Trial summary
More than five decades have passed since the identification of the etiologic agent of hepatitis B and yet this infection is a challenge for public health worldwide. The development and availability of the first hepatitis B vaccines, still in the 1980s, was a milestone for the prevention of the hepatitis B virus, and… Read more about this study
- Who is it for?
- Ages 50 years and olderHealthy volunteers can take part
- Conditions the study is for
- Vaccine Response Impaired, Hepatitis B, Aging
- What is being tested?
- Standard vaccination schedule and Reinforced vaccination schedule
- Type of treatment
- Vaccines
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 240 participants
- Where
- 1 siteBrazil
- Study dates
- 29 Jul 2017to 31 Mar 2022
- Phase
- Phase 4
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 50 years and older
- All sexes
- Healthy volunteers accepted
- Adult, Older adult
Who may be able to join
- person is 50 years of age or older.
Who cannot join
- people with chronic renal failure, cancer and HIV / AIDS, using corticosteroids;
- people with a history of hepatitis B vaccination (vaccination record of hepatitis B vaccine doses or previous report of hepatitis B vaccination);
- people who are positive for anti-HBs and / or total anti-HBc serological markers.
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Immunogenicity of the Hepatitis B Vaccine in Individuals 50 Years Old or More: Randomized Clinical Trial
More than five decades have passed since the identification of the etiologic agent of hepatitis B and yet this infection is a challenge for public health worldwide. The development and availability of the first hepatitis B vaccines, still in the 1980s, was a milestone for the prevention of the hepatitis B virus, and currently known as the gold standard strategy for the elimination of this infectious disease.
In several countries, the introduction of the immunobiological occurred gradually, by age groups and risk groups, and in general, started with newborns and children. This universal immunization strategy has contributed to reducing the incidence and changing the epidemiological profile of HBV worldwide. At the beginning of the 21st century, it was already possible to shift the epidemiological curve of the infection to parasitize with 50 years or more. On the other hand, despite vaccination against hepatitis B being the most assertive tool for the prevention of HBV, the low performance of the vaccine in older groups remains a challenge for public health and the object of this study. To our knowledge, there are no data showing the efficacy of doses of enhanced hepatitis B vaccines for older adults, and the purpose of this study is to investigate and compare the immunogenicity of the hepatitis B vaccine in adult adults aged 50 years and over, using conventional doses (20μg) versus (vs) booster doses.
Read the detailed description
More than five decades have passed since the identification of the etiologic agent of hepatitis B and yet this infection is a challenge for public health worldwide. The development and availability of the first hepatitis B vaccines, still in the 1980s, was a milestone for the prevention of the hepatitis B virus, and currently known as the gold standard strategy for the elimination of this infectious disease.
In several countries, the introduction of the immunobiological occurred gradually, by age groups and risk groups, and in general, started with newborns and children. In Brazil, only in 2015, a free offer of the hepatitis B vaccine expanded a population aged 50 years or older. This universal immunization strategy has contributed to reducing the incidence and changing the epidemiological profile of HBV worldwide. At the beginning of the 21st century, it was already possible to shift the epidemiological curve of the infection to parasitize with 50 years or more.
Consider this scenario of vulnerability to HBV in older adults, it is important to highlight some aspects. The increase in life expectancy around the world is real data and must be evaluated. In addition, contemporary aging is accompanied by an increase and improvement in sexual performance, overcoming myths about "asexual old age" and outdated stereotypes about sexuality for an adult population in the middle and late stages. On the other hand, sexual risk behavior in older people being observed, including unprotected sexual intercourse, multiple sexual partnerships, sexual intercourse with a sex worker, among others. Studies have been increasing the high prevalence of Sexually Transmitted Infections, especially hepatitis B in the elderly.
Given this situation, hepatitis B vaccination is the most assertive tool for preventing HBV. However, even in countries that expand the offer of the vaccine to the entire population, poor performance of the hepatitis B vaccine in older groups remains a challenge for public health and is the object of this study.
A study conducted by Meeren and collaborators, characterized the relationship age vs. age. vaccine response to hepatitis B in immunocompetent adults. The protection index identified, considering all age groups, was 94.5%. However, there was a continuous reduction in seroprotection associated with age, ranging from 98.6% for young adults aged 20-24 years to 64.8% for the elderly (≥65 years). In addition, this study suggested that the aging of the immune system starts in adulthood and is intensified after 50-60 years of age.
In the United States, research conducted with competence aged ≥50 years, showed lower rates of seroconversion compared to younger people, with protection rates ranging from 68% to 82.2%. Another study carried out in this country, elucidated the risk of non-response to the anti-HBV vaccine in 63% for products ≥40 years old (p = 0.046).
Finally, in Brazil, an investigation conducted by Caetano et al. with settlers in Goiás, also illustrated a low responsiveness to the hepatitis B vaccine in the older population. In the age group aged 40-49 years, seroprotection was identified in only 61.9% of the participants, and for the age group aged 50-59 years the rate of seroresponse was even lower, only 55.9% protective titles of anti- HBs. Another study with this same population in Mato Grosso do Sul, showed an average age above 40 years for our non-responders.
Thus, the program that supplants this limitation is necessary, until the cohort of children immunized at birth from a late adulthood. The use of third generation vaccines for this population seems to be difficult to implement due to the high cost of this immunogen. In this way, more frequent or more concentrated doses of the second generation vaccine can be a safe alternative for the older population.
To our knowledge, there are no data showing the efficacy of doses of enhanced hepatitis B vaccines for older adults, and the purpose of this study is to investigate and compare the immunogenicity of the hepatitis B vaccine in adult adults aged 50 years and over, using conventional doses (20μg) versus (vs) booster doses.
- Conditions
- Vaccine Response Impaired, Hepatitis B, Aging
- Being tested
- Standard vaccination schedule, Reinforced vaccination schedule
- Keywords
- Vaccine Response Impaired, Hepatitis B, Aging
- Medical subject headings
- Hepatitis B
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Standard vaccination scheduleBiological
Administer a standard vaccination schedule (three doses of 20 μg of the hepatitis B vaccine, in months 0, 1, 6) at an age of ≥50 years and evaluate a production kinetics after each dose administered in the period of about 30 to 60 days.
Reinforced vaccination scheduleBiological
Administer an enhanced vaccination schedule (three doses of 40 μg of the hepatitis B vaccine, in months 0, 1, 6) in individuals aged ≥50 years and assess the kinetics of antibody production after each dose administered in the period of approximately 30 to 60 days.
| Study group | Role | What they receive |
|---|---|---|
| Standard vaccination schedule | Other | To evaluate the immunogenicity of the monovalent hepatitis B vaccine, expressed in Hansenula polymorpha, aged ≥50 years old, using a standard vaccination schedule (three doses of 20 μg, in months 0, 1, 6). Receives: Biological: Standard vaccination schedule |
| Reinforced vaccination schedule | Experimental | To evaluate the immunogenicity of the monovalent hepatitis B vaccine, expressed in Hansenula polymorpha, in individuals aged ≥50 years, using a reinforced vaccination schedule (three doses of 40 μg, in months 0, 1, 6). Receives: Biological: Reinforced vaccination schedule |
What is being measured
The primary outcome is the main question the study is designed to answer.
More than 90% of the appropriate intervention sample of associated anti-HBs (≥10mUI / mL) after three doses of hepatitis B vaccine
Success of the proposed procedure, defined by the development of isolated anti-HBs titers (≥10mUI / mL) after three reinforced doses (40μg) of the hepatitis B vaccine, within 30 to 60 days after the end of the vaccination schedule.
Measured: Success of the proposed procedure, defined by the development of isolated anti-HBs titers (≥10mUI / mL) after three reinforced doses (40μg) of the hepatitis B vaccine, in 30 to 60 days after the end of the vaccination schedule.
Secondary outcomes (2)
About 20-30% of the appropriate intervention sample of associated anti-HBs (≥10mUI / mL) after first dose of hepatitis B vaccine
Success of the proposed procedure, defined by the development of isolated anti-HBs titers (≥10mUI / mL) after one reinforced dose (40μg) of the hepatitis B vaccine, within 30 to 60 days after the end of the vaccination schedule.
Measured: Success of the proposed procedure, defined by the development of isolated anti-HBs titers (≥10mUI / mL) after one reinforced dose (40μg) of the hepatitis B vaccine, within 30 to 60 days after the end of the vaccination schedule.
About 75-80% of the appropriate intervention sample of associated anti-HBs (≥10mUI / mL) after second dose of hepatitis B vaccine
Success of the proposed procedure, defined by the development of isolated anti-HBs titers (≥10mUI / mL) after two reinforced doses (40μg) of the hepatitis B vaccine, within 30 to 60 days after the end of the vaccination schedule.
Measured: Success of the proposed procedure, defined by the development of isolated anti-HBs titers (≥10mUI / mL) after two reinforced doses (40μg) of the hepatitis B vaccine, within 30 to 60 days after the end of the vaccination schedule.
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted7 Sep 2020
- Study start29 Jul 2017
- Primary completion3 Jul 2020
- Study completion31 Mar 2022 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (17)Papers the sponsor has linked to this study.
- Other trials for Vaccine Response ImpairedStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase 4
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Model description
- The intervention group (Reinforced Intervention Scheme - EIR) indicates 3 doses of 40 μg (2 mL) of hepatitis B vaccine, in months 0, 1 and 6, while the comparison group (Conventional Comparison Scheme - ECC) completes 3 doses of 20 μg (1 mL) of the vaccine, in months 0, 1 and 6. To evaluate the kinetics of the hepatitis B vaccine, after each dose administered, about 30 to 60 days, 5 mL of blood was again collected from the participants for quantitative detection of anti-HBs, using the Microparticle Chemiluminescent Immunoassay (CMIA) method, according to the manufacturer's instructions.
- Masking
- Single blind
- Who is masked
- Participant
- Enrolment
- 240 participants (actual)
Sponsor and investigators
- Lead sponsor
- Universidade Federal de Goias
- Sponsor type
- University, hospital or other
- Responsible party
- Principal investigator, Karlla Antonieta Amorim Caetano, Universidade Federal de Goias
- Investigators
- Karlla Caetano, PhD, Principal investigator, Universidade Federal de Goiás
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04540653
- Sponsor's protocol ID
- PI02102-2017
- Status last verified
- Sep 2020
- First submitted
- 31 Aug 2020
- Last updated
- 9 Sep 2020
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Aguiar RB, Leal MCC, Marques APO, Torres KMS, Tavares MTDB. [Elderly people living with HIV - behavior and knowledge about sexuality: an integrative review]. Cien Saude Colet. 2020 Feb;25(2):575-584. doi: 10.1590/1413-81232020252.12052018. Epub 2018 Jun 27. Portuguese.
PubMed 32022197Bastos LM, Tolentino JMS, Frota MAO, Tomaz WC, Fialho MLS, Batista ACB, Teixeira AKM, Barbosa FCB. [Evaluation of the level of knowledge about Aids and syphilis among the elderly from a city in the interior of the state of Ceara, Brazil]. Cien Saude Colet. 2018 Aug;23(8):2495-2502. doi: 10.1590/1413-81232018238.10072016. Portuguese.
PubMed 30137119BLUMBERG BS, ALTER HJ, VISNICH S. A "NEW" ANTIGEN IN LEUKEMIA SERA. JAMA. 1965 Feb 15;191:541-6. doi: 10.1001/jama.1965.03080070025007. No abstract available.
PubMed 14239025Caetano KA, Del-Rios NH, Pinheiro RS, Bergamaschi FP, Carneiro MA, Teles SA. Low Immunogenicity of Recombinant Hepatitis B Vaccine Derived from Hansenula polymorpha in Adults Aged Over 40 Years. Am J Trop Med Hyg. 2017 Jan 11;96(1):118-121. doi: 10.4269/ajtmh.16-0475. Epub 2016 Oct 31.
PubMed 27799647Gerlich WH. Prophylactic vaccination against hepatitis B: achievements, challenges and perspectives. Med Microbiol Immunol. 2015 Feb;204(1):39-55. doi: 10.1007/s00430-014-0373-y. Epub 2014 Dec 19.
PubMed 25523195Gilbert CL, Klopfer SO, Martin JC, Schodel FP, Bhuyan PK. Safety and immunogenicity of a modified process hepatitis B vaccine in healthy adults >/=50 years. Hum Vaccin. 2011 Dec;7(12):1336-42. doi: 10.4161/hv.7.12.18333. Epub 2011 Dec 1.
PubMed 22185811Liu Z, Yang Q, Shi O, Ye W, Chen X, Zhang T. The epidemiology of hepatitis B and hepatitis C infections in China from 2004 to 2014: An observational population-based study. J Viral Hepat. 2018 Dec;25(12):1543-1554. doi: 10.1111/jvh.12938. Epub 2018 Jun 20.
PubMed 29851287Lyons A, Heywood W, Fileborn B, Minichiello V, Barrett C, Brown G, Hinchliff S, Malta S, Crameri P. The Sex, Age, and Me study: recruitment and sampling for a large mixed-methods study of sexual health and relationships in an older Australian population. Cult Health Sex. 2017 Sep;19(9):1038-1052. doi: 10.1080/13691058.2017.1288268. Epub 2017 Feb 21.
PubMed 28276921Van Der Meeren O, Crasta P, Cheuvart B, De Ridder M. Characterization of an age-response relationship to GSK's recombinant hepatitis B vaccine in healthy adults: An integrated analysis. Hum Vaccin Immunother. 2015;11(7):1726-9. doi: 10.1080/21645515.2015.1039758.
PubMed 25996260Minichiello V, Rahman S, Hawkes G, Pitts M. STI epidemiology in the global older population: emerging challenges. Perspect Public Health. 2012 Jul;132(4):178-81. doi: 10.1177/1757913912445688.
PubMed 22729008Monsell E, McLuskey J. Factors influencing STI transmission in middle-aged heterosexual individuals. Br J Nurs. 2016 Jun 23;25(12):676-80. doi: 10.12968/bjon.2016.25.12.676.
PubMed 27345071Rosenberg C, Bovin NV, Bram LV, Flyvbjerg E, Erlandsen M, Vorup-Jensen T, Petersen E. Age is an important determinant in humoral and T cell responses to immunization with hepatitis B surface antigen. Hum Vaccin Immunother. 2013 Jul;9(7):1466-76. doi: 10.4161/hv.24480. Epub 2013 Apr 9.
PubMed 23571167Sagnelli E, Stroffolini T, Sagnelli C, Morisco F, Coppola N, Smedile A, Pisaturo M, Colloredo G, Babudieri S, Licata A, Brancaccio G, Andriulli A, Almasio PL, Gaeta GB; EPACRON study group. Influence of universal HBV vaccination on chronic HBV infection in Italy: Results of a cross-sectional multicenter study. J Med Virol. 2017 Dec;89(12):2138-2143. doi: 10.1002/jmv.24873. Epub 2017 Aug 29.
PubMed 28608566Sharma R, Ahlm C, Ostergaard L, Dowell A, Tran C, Thomas S, Eymin C. Persistence of immunity in healthy adults aged >/= 50 years primed with a hepatitis B vaccine 3 years previously. Hum Vaccin Immunother. 2015;11(7):1709-16. doi: 10.1080/21645515.2015.1019187.
PubMed 25996838Szmuness W, Stevens CE, Harley EJ, Zang EA, Oleszko WR, William DC, Sadovsky R, Morrison JM, Kellner A. Hepatitis B vaccine: demonstration of efficacy in a controlled clinical trial in a high-risk population in the United States. N Engl J Med. 1980 Oct 9;303(15):833-41. doi: 10.1056/NEJM198010093031501.
PubMed 6997738
Study at a glance
From the registry record, last updated by the sponsor on 9 Sep 2020. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Immunogenicity of the Hepatitis B Vaccine in Individuals 50 Years Old or More: Randomized Clinical Trial
- ClinicalTrials.gov ID
- NCT04540653
- Acronym / sponsor ID
- PI02102-2017
- Conditions
- Vaccine Response Impaired, Hepatitis B, Aging
- Keywords
- Vaccine Response Impaired, Hepatitis B, Aging
- Phase
- Phase 4
- Study type
- Interventional
- Recruitment status
- Unknown status
- Enrolment
- 240 participants (actual)
- Lead sponsor
- Universidade Federal de GoiasUniversity, hospital or other
- Study start
- 29 Jul 2017 (actual)
- Primary completion
- 3 Jul 2020 (actual)
- Study completion
- 31 Mar 2022 (estimated)
- First posted
- 7 Sep 2020 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
More than five decades have passed since the identification of the etiologic agent of hepatitis B and yet this infection is a challenge for public health worldwide. The development and availability of the first hepatitis B vaccines, still in the 1980s, was a milestone for the prevention of the hepatitis B virus, and currently known as the gold standard strategy for the elimination of this infectious disease.
In several countries, the introduction of the immunobiological occurred gradually, by age groups and risk groups, and in general, started with newborns and children. This universal immunization strategy has contributed to reducing the incidence and changing the epidemiological profile of HBV worldwide. At the beginning of the 21st century, it was already possible to shift the epidemiological curve of the infection to parasitize with 50 years or more. On the other hand, despite vaccination against hepatitis B being the most assertive tool for the prevention of HBV, the low performance of the vaccine in older groups remains a challenge for public health and the object of this study. To our knowledge, there are no data showing the efficacy of doses of enhanced hepatitis B vaccines for older adults, and the purpose of this study is to investigate and compare the immunogenicity of the hepatitis B vaccine in adult adults aged 50 years and over, using conventional doses (20μg) versus (vs) booster doses.
Detailed description
More than five decades have passed since the identification of the etiologic agent of hepatitis B and yet this infection is a challenge for public health worldwide. The development and availability of the first hepatitis B vaccines, still in the 1980s, was a milestone for the prevention of the hepatitis B virus, and currently known as the gold standard strategy for the elimination of this infectious disease.
In several countries, the introduction of the immunobiological occurred gradually, by age groups and risk groups, and in general, started with newborns and children. In Brazil, only in 2015, a free offer of the hepatitis B vaccine expanded a population aged 50 years or older. This universal immunization strategy has contributed to reducing the incidence and changing the epidemiological profile of HBV worldwide. At the beginning of the 21st century, it was already possible to shift the epidemiological curve of the infection to parasitize with 50 years or more.
Consider this scenario of vulnerability to HBV in older adults, it is important to highlight some aspects. The increase in life expectancy around the world is real data and must be evaluated. In addition, contemporary aging is accompanied by an increase and improvement in sexual performance, overcoming myths about "asexual old age" and outdated stereotypes about sexuality for an adult population in the middle and late stages. On the other hand, sexual risk behavior in older people being observed, including unprotected sexual intercourse, multiple sexual partnerships, sexual intercourse with a sex worker, among others. Studies have been increasing the high prevalence of Sexually Transmitted Infections, especially hepatitis B in the elderly.
Given this situation, hepatitis B vaccination is the most assertive tool for preventing HBV. However, even in countries that expand the offer of the vaccine to the entire population, poor performance of the hepatitis B vaccine in older groups remains a challenge for public health and is the object of this study.
A study conducted by Meeren and collaborators, characterized the relationship age vs. age. vaccine response to hepatitis B in immunocompetent adults. The protection index identified, considering all age groups, was 94.5%. However, there was a continuous reduction in seroprotection associated with age, ranging from 98.6% for young adults aged 20-24 years to 64.8% for the elderly (≥65 years). In addition, this study suggested that the aging of the immune system starts in adulthood and is intensified after 50-60 years of age.
In the United States, research conducted with competence aged ≥50 years, showed lower rates of seroconversion compared to younger people, with protection rates ranging from 68% to 82.2%. Another study carried out in this country, elucidated the risk of non-response to the anti-HBV vaccine in 63% for products ≥40 years old (p = 0.046).
Finally, in Brazil, an investigation conducted by Caetano et al. with settlers in Goiás, also illustrated a low responsiveness to the hepatitis B vaccine in the older population. In the age group aged 40-49 years, seroprotection was identified in only 61.9% of the participants, and for the age group aged 50-59 years the rate of seroresponse was even lower, only 55.9% protective titles of anti- HBs. Another study with this same population in Mato Grosso do Sul, showed an average age above 40 years for our non-responders.
Thus, the program that supplants this limitation is necessary, until the cohort of children immunized at birth from a late adulthood. The use of third generation vaccines for this population seems to be difficult to implement due to the high cost of this immunogen. In this way, more frequent or more concentrated doses of the second generation vaccine can be a safe alternative for the older population.
To our knowledge, there are no data showing the efficacy of doses of enhanced hepatitis B vaccines for older adults, and the purpose of this study is to investigate and compare the immunogenicity of the hepatitis B vaccine in adult adults aged 50 years and over, using conventional doses (20μg) versus (vs) booster doses.
Study design
- Primary purpose
- Prevention
- Allocation
- Randomised
- Intervention model
- Parallel groups
- Masking
- Single blind (participant)
- Number of arms
- 2
- Model description
- The intervention group (Reinforced Intervention Scheme - EIR) indicates 3 doses of 40 μg (2 mL) of hepatitis B vaccine, in months 0, 1 and 6, while the comparison group (Conventional Comparison Scheme - ECC) completes 3 doses of 20 μg (1 mL) of the vaccine, in months 0, 1 and 6. To evaluate the kinetics of the hepatitis B vaccine, after each dose administered, about 30 to 60 days, 5 mL of blood was again collected from the participants for quantitative detection of anti-HBs, using the Microparticle Chemiluminescent Immunoassay (CMIA) method, according to the manufacturer's instructions.
| Arm | Type | Receives |
|---|---|---|
| Standard vaccination schedule | Other | Biological: Standard vaccination scheduleTo evaluate the immunogenicity of the monovalent hepatitis B vaccine, expressed in Hansenula polymorpha, aged ≥50 years old, using a standard vaccination schedule (three doses of 20 μg, in months 0, 1, 6). |
| Reinforced vaccination schedule | Experimental | Biological: Reinforced vaccination scheduleTo evaluate the immunogenicity of the monovalent hepatitis B vaccine, expressed in Hansenula polymorpha, in individuals aged ≥50 years, using a reinforced vaccination schedule (three doses of 40 μg, in months 0, 1, 6). |
Who may qualify
- Ages
- 50 years and older
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (1 listed)
- person is 50 years of age or older.
Key exclusion criteria (3 listed)
- people with chronic renal failure, cancer and HIV / AIDS, using corticosteroids;
- people with a history of hepatitis B vaccination (vaccination record of hepatitis B vaccine doses or previous report of hepatitis B vaccination);
- people who are positive for anti-HBs and / or total anti-HBc serological markers.
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Standard vaccination scheduleAdminister a standard vaccination schedule (three doses of 20 μg of the hepatitis B vaccine, in months 0, 1, 6) at an age of ≥50 years and evaluate a production kinetics after each dose administered in the period of about 30 to 60 days. | Biological | Standard vaccination schedule |
| Reinforced vaccination scheduleAdminister an enhanced vaccination schedule (three doses of 40 μg of the hepatitis B vaccine, in months 0, 1, 6) in individuals aged ≥50 years and assess the kinetics of antibody production after each dose administered in the period of approximately 30 to 60 days. | Biological | Reinforced vaccination schedule |
Primary outcome
More than 90% of the appropriate intervention sample of associated anti-HBs (≥10mUI / mL) after three doses of hepatitis B vaccine
Time frame: Success of the proposed procedure, defined by the development of isolated anti-HBs titers (≥10mUI / mL) after three reinforced doses (40μg) of the hepatitis B vaccine, in 30 to 60 days after the end of the vaccination schedule.
Success of the proposed procedure, defined by the development of isolated anti-HBs titers (≥10mUI / mL) after three reinforced doses (40μg) of the hepatitis B vaccine, within 30 to 60 days after the end of the vaccination schedule.
2 secondary outcomes
About 20-30% of the appropriate intervention sample of associated anti-HBs (≥10mUI / mL) after first dose of hepatitis B vaccine
Time frame: Success of the proposed procedure, defined by the development of isolated anti-HBs titers (≥10mUI / mL) after one reinforced dose (40μg) of the hepatitis B vaccine, within 30 to 60 days after the end of the vaccination schedule.
About 75-80% of the appropriate intervention sample of associated anti-HBs (≥10mUI / mL) after second dose of hepatitis B vaccine
Time frame: Success of the proposed procedure, defined by the development of isolated anti-HBs titers (≥10mUI / mL) after two reinforced doses (40μg) of the hepatitis B vaccine, within 30 to 60 days after the end of the vaccination schedule.
Results and safety
Results are not available in the source record.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 9 Sep 2020.
- Background: PubMed 32022197Aguiar RB, Leal MCC, Marques APO, Torres KMS, Tavares MTDB. [Elderly people living with HIV - behavior and knowledge about sexuality: an integrative review]. Cien Saude Colet. 2020 Feb;25(2):575-584. doi: 10.1590/1413-81232020252.12052018. Epub 2018 Jun 27. Portuguese.
- Background: PubMed 30137119Bastos LM, Tolentino JMS, Frota MAO, Tomaz WC, Fialho MLS, Batista ACB, Teixeira AKM, Barbosa FCB. [Evaluation of the level of knowledge about Aids and syphilis among the elderly from a city in the interior of the state of Ceara, Brazil]. Cien Saude Colet. 2018 Aug;23(8):2495-2502. doi: 10.1590/1413-81232018238.10072016. Portuguese.
- Background: PubMed 14239025BLUMBERG BS, ALTER HJ, VISNICH S. A "NEW" ANTIGEN IN LEUKEMIA SERA. JAMA. 1965 Feb 15;191:541-6. doi: 10.1001/jama.1965.03080070025007. No abstract available.
- Background: PubMed 27799647Caetano KA, Del-Rios NH, Pinheiro RS, Bergamaschi FP, Carneiro MA, Teles SA. Low Immunogenicity of Recombinant Hepatitis B Vaccine Derived from Hansenula polymorpha in Adults Aged Over 40 Years. Am J Trop Med Hyg. 2017 Jan 11;96(1):118-121. doi: 10.4269/ajtmh.16-0475. Epub 2016 Oct 31.
- Background: PubMed 25523195Gerlich WH. Prophylactic vaccination against hepatitis B: achievements, challenges and perspectives. Med Microbiol Immunol. 2015 Feb;204(1):39-55. doi: 10.1007/s00430-014-0373-y. Epub 2014 Dec 19.
- Background: PubMed 22185811Gilbert CL, Klopfer SO, Martin JC, Schodel FP, Bhuyan PK. Safety and immunogenicity of a modified process hepatitis B vaccine in healthy adults >/=50 years. Hum Vaccin. 2011 Dec;7(12):1336-42. doi: 10.4161/hv.7.12.18333. Epub 2011 Dec 1.
- Background: PubMed 29851287Liu Z, Yang Q, Shi O, Ye W, Chen X, Zhang T. The epidemiology of hepatitis B and hepatitis C infections in China from 2004 to 2014: An observational population-based study. J Viral Hepat. 2018 Dec;25(12):1543-1554. doi: 10.1111/jvh.12938. Epub 2018 Jun 20.
- Background: PubMed 28276921Lyons A, Heywood W, Fileborn B, Minichiello V, Barrett C, Brown G, Hinchliff S, Malta S, Crameri P. The Sex, Age, and Me study: recruitment and sampling for a large mixed-methods study of sexual health and relationships in an older Australian population. Cult Health Sex. 2017 Sep;19(9):1038-1052. doi: 10.1080/13691058.2017.1288268. Epub 2017 Feb 21.
- Background: PubMed 25996260Van Der Meeren O, Crasta P, Cheuvart B, De Ridder M. Characterization of an age-response relationship to GSK's recombinant hepatitis B vaccine in healthy adults: An integrated analysis. Hum Vaccin Immunother. 2015;11(7):1726-9. doi: 10.1080/21645515.2015.1039758.
- Background: PubMed 22729008Minichiello V, Rahman S, Hawkes G, Pitts M. STI epidemiology in the global older population: emerging challenges. Perspect Public Health. 2012 Jul;132(4):178-81. doi: 10.1177/1757913912445688.
- Background: PubMed 27345071Monsell E, McLuskey J. Factors influencing STI transmission in middle-aged heterosexual individuals. Br J Nurs. 2016 Jun 23;25(12):676-80. doi: 10.12968/bjon.2016.25.12.676.
- Background: PubMed 23571167Rosenberg C, Bovin NV, Bram LV, Flyvbjerg E, Erlandsen M, Vorup-Jensen T, Petersen E. Age is an important determinant in humoral and T cell responses to immunization with hepatitis B surface antigen. Hum Vaccin Immunother. 2013 Jul;9(7):1466-76. doi: 10.4161/hv.24480. Epub 2013 Apr 9.
- WHO; World Health Organization. Global Hepatitis Report 2017. Geneva: WHO; 2017.Link provided by the sponsor.
- Bergamaschi FPR. Epidemiologia da infecção pelo vírus da hepatite b em assentamento rural em Mato Grosso do Sul, Brasil Central \[Tese\]. Goiânia-GO: Universidade Federal de Goiás; 2013. 95pLink provided by the sponsor.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Karlla Caetano, PhD principal investigator
Universidade Federal de Goiás
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A Phase 4 study testing Standard vaccination schedule and Reinforced vaccination schedule in people with Vaccine Response Impaired and Hepatitis B, run by Universidade Federal de Goias at 1 site in Brazil.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 1 inclusion and 3 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: status not confirmed, as of the sponsor's last update on 9 Sep 2020. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in Brazil. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
What does this phase mean?
Phase 4 studies take place after a treatment is approved, to learn more about its long-term benefits and risks in everyday use.
Not every study follows the same path, and some studies (observational studies, device studies) have no phase.
Are results available for this study?
Results are not available in the source record.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
More than 90% of the appropriate intervention sample of associated anti-HBs (≥10mUI / mL) after three doses of hepatitis B vaccine (time frame: Success of the proposed procedure, defined by the development of isolated anti-HBs titers (≥10mUI / mL) after three reinforced doses (40μg) of the hepatitis B vaccine, in 30 to 60 days after the end of the vaccination schedule.). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT04540653, which also lists 17 linked publications.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 9 Sep 2020.