Clinical trials: Vaccine Response Impaired
Covid19, Cancer
Immune Response to the COVID-19 Vaccine
Explore the effects on immune response to include a potential third vaccine for the cancer cohort.
- Conditions
- Covid19, Cancer, Malignancy, Vaccine Response Impaired
- Trial name
- NCT04936997
- Testing
- SARS-COV2 Pfizer Vaccine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Arizona
Vaccine Response Impaired, Allogeneic Stem Cell Transplantation
Role of Interferon-λ and Vaccine Response
The following observational study will investigate whether the vaccine response (antibodies, T and B cells) after allogeneic stem cell transplantation is influenced by genetic polymorphisms in the interferon lambda signal.
- Trial name
- NCT03467074
- Testing
- influenza A/B vaccine
- Where
- Switzerland
- Volunteers
- 200 people
- Sponsor
- University Hospital, Basel, Switzerland
Covid19, Hematologic Malignancy
Efficacy and Safety of the Anti- COVID-19 Vaccin in Clinical Hematology Patients
Coronavirus disease 2019 (COVID-19) is an emerging infectious disease that was first reported in December 2019 in Wuhan, China. Infection with this new coronavirus called SARS-CoV-2 can lead to fatal pneumonia associated with…
- Conditions
- Covid19, Hematologic Malignancy, Vaccine Response Impaired
- Trial name
- HEMVACO (NCT04852796)
- Testing
- Patients with hemopathy
- Where
- France
- Volunteers
- 1,000 people
- Sponsor
- Centre Hospitalier de Cornouaille
Malnutrition, Child, Enteropathy
Study of Environmental Enteropathy and Malnutrition in Pakistan
Environmental Enteropathy (EE) is an acquired sub-clinical inflammatory gut condition in which alterations in intestinal structure, function, and local and systemic immune activation lead to impaired vaccine responses, decreased…
- Conditions
- Malnutrition, Child, Enteropathy, Vaccine Response Impaired, Stunting
- Trial name
- SEEM (NCT03588013)
- Testing
- Nutritional education, Ready to Use Therapeutic Food, Upper gastrointestinal endoscopy with biopsy
- Where
- Pakistan
- Volunteers
- 416 people, healthy volunteers welcome
- Sponsor
- Aga Khan University
COVID-19, Vaccine Adverse Reaction
COVID19 Vaccine in SOT Adult Recipients
Background: ISHLT and AASLD guidelines recommend SARS-CoV2 vaccination in all individuals undergoing lung and liver transplantation, but there are currently scarce data on the safety and efficacy of these vaccines in this…
- Conditions
- COVID-19, Vaccine Adverse Reaction, Vaccine Response Impaired, Vaccine Reaction
- Trial name
- COVID19_VaxSOT (NCT05116748)
- Testing
- COVID19 mRNA vaccine
- Where
- Italy
- Volunteers
- 364 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
HIV Infections, Hepatitis B
Heplisav-B Revaccination for Hepatitis B Vaccine Nonresponders
The goal of this natural history study is to examine the immune responses to the Heplisav-B vaccine in Veterans living with HIV who were non-responders to prior HBV vaccination.
- Conditions
- HIV Infections, Hepatitis B, Vaccine Response Impaired
- Trial name
- HBR2 (NCT05791851)
- Where
- 2 sites in United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Solid Tumor, Hematologic Malignancy
COVID-19 Vaccine Efficacy in Patients With Malignant Pathologies
In the context of malignant disease, it is likely that vaccine efficacy and immunogenicity depends on the type of pathology, stage of the disease, immunosuppression induced by the treatments, in addition to more classic factors…
- Conditions
- Solid Tumor, Hematologic Malignancy, Thoracic Cancer, Cancer, Treatment-Related
- Trial name
- COVIDVAC OH (NCT04776005)
- Testing
- Data collection
- Where
- 2 sites in France
- Volunteers
- 500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Immunosuppression, Vaccine Response Impaired
Safety and Immunogenicity of Recombinant Zoster Vaccine for Transplant Recipients
The goal of this clinical trial is to compare responses to Varicella Zoster vaccination between transplant patients on different medication regimens, and their healthy co-habitants. The main questions it aims to answer are: 1.
- Trial name
- SIR ZOSTER (NCT06262776)
- Testing
- Recombinant zoster vaccine adjuvanted (SHINGRIX)
- Where
- Australia
- Volunteers
- 160 people
- Sponsor
- Central Adelaide Local Health Network Incorporated
Vaccine Response Impaired, Immune Suppression
Third Dose of Moderna COVID-19 Vaccine in Transplant Recipients
This study will be a randomized, double-blind, placebo-controlled trial of a third dose of Moderna vaccine versus placebo. Participants will be those that have received two doses of mRNA-1273 COVID vaccine (Moderna) at 0 and 1…
- Conditions
- Vaccine Response Impaired, Immune Suppression, Covid19
- Trial name
- NCT04885907
- Testing
- mRNA-1273 vaccine
- Where
- 2 sites in Canada
- Volunteers
- 120 people
- Sponsor
- University Health Network, Toronto
Vaccine Response Impaired
Immunogenicity of Co-administered Yellow Fever and Measles, Mumps, and Rubella (MMR) Vaccines
This study evaluates seroconversion against measles, mumps, rubella and yellow fever following vaccination. One-third of children will receive both yellow fever and measles, mumps, and rubella (MMR) vaccines on the same day; one…
- Trial name
- NCT03368495
- Testing
- Co-administration of MMR/YF, MMR followed by YF, YF followed by MMR
- Where
- 4 sites in Argentina
- Volunteers
- 851 people, healthy volunteers welcome
- Sponsor
- Alba Maria Ropero
Influenza, Human, SARS-CoV-2 Infection
Does Repeat Influenza Vaccination Constrain Influenza Immune Responses and Protection
The objectives of this study are to understand the long-term consequences of repeated annual influenza vaccination among healthcare workers (HCWs) and to use statistical and mathematical modelling to elucidate the immunological…
- Trial name
- NCT05110911
- Testing
- Influenza vaccination: Fluarix Tetra, Vaxigrip Tetra, Fluquadri, Fluad Quad, Afluia Quad, Flucelvax Quad, SARS-CoV-2 vaccination: Comirnaty or Vaxzevria
- Where
- 6 sites in Australia
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- University of Melbourne
Aging, Age-Related Immunodeficiency
Vaccination Efficacy With Metformin in Older Adults
With aging the immune system gets weaker. This makes older adults more susceptible to influenza (flu). Vaccinations help to prevent infection from the flu virus, however the immune system of older adults do not respond as well to…
- Conditions
- Aging, Age-Related Immunodeficiency, Vaccine Response Impaired
- Trial name
- VEME (NCT03996538)
- Testing
- Metformin Hydrochloride Extended-Release Tablets, Influenza Vaccine
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- UConn Health
Aging, Vaccine Response Impaired
Impact of Metformin on Immunity
To determine whether metformin (MET) can improve the immune response to the pneumococcal conjugate vaccine (PCV-13) in older adults.
- Trial name
- NCT03713801
- Testing
- Metformin
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Covid19, Kidney Diseases
RECOVAC Repeated Vaccination Study
Rationale: The humoral and cellular immune response after two mRNA vaccinations is severely attenuated in kidney transplant patients compared to controls, especially when their immunosuppressive regimen contains mycophenolate…
- Conditions
- Covid19, Kidney Diseases, Vaccine Response Impaired, SARS-CoV2 Infection
- Trial name
- NCT05030974
- Testing
- mRNA-1273, Ad26.COV2.S vaccine
- Where
- 4 sites in Netherlands
- Volunteers
- 336 people
- Sponsor
- University Medical Center Groningen
Hematologic Disorder
Lenalidomide as Immune Adjuvant in Patient's With Chronic Lymphocytic Leukemia (CLL)
The goal of this clinical research study is to learn if lenalidomide can increase the level of immunoglobulins (parts of the blood that may help to improve the immune system's function) and/or will improve the protective effect…
- Trial name
- NCT01924169
- Testing
- Lenalidomide, Influenza Vaccine, Pneumovax Vaccine
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- M.D. Anderson Cancer Center
Iron Deficiency Anemia, Vaccine Preventable Disease
Iron and Vaccine Response
Vaccines often underperform in Africa compared to high-income countries. Why vaccines do not work as well in Africa remains uncertain. Malnutrition likely plays a role.
- Conditions
- Iron Deficiency Anemia, Vaccine Preventable Disease, Vaccine Response Impaired, Iron Deficiency Anemia Treatment
- Trial name
- NCT04912661
- Testing
- Ferinject
- Where
- Kenya
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Swiss Federal Institute of Technology
Rotavirus Infection, Vaccine Response Impaired
The Effects of Increased Inoculum on Oral Rotavirus Vaccine Take and Immunogenicity
Rotavirus is the leading cause of diarrhea in children worldwide. Oral rotavirus vaccines work remarkably well in high-income countries, but for unclear reasons they underperform in low-income countries.
- Conditions
- Rotavirus Infection, Vaccine Response Impaired, Vaccine Virus Shedding
- Trial name
- NCT02992197
- Testing
- Rotarix, dose 1, Rotarix, dose 2
- Where
- Bangladesh
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Vaccine Response Impaired
Vaccine Hyporesponse in Healthy Elderly Participants (MK-0000-131 AM2)
This study evaluated whether it is possible in healthy elderly participants to generate baseline biomarker-based prediction rules (PdR) for vaccine response (post baseline absolute serum antibody titer) using each of the protocol…
- Trial name
- NCT01119703
- Testing
- Tetanus & Diphtheria booster vaccine (Td), TwinrixTM [Hepatitis A Inactivated & Hepatitis B (Recombinant) Vaccine], Dukoral® Traveler's Diarrhea Vaccine (WC/rBS)
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Multiple Sclerosis, Relapsing-Remitting, Vaccine Response Impaired
Immune Response to Seasonal Influenza Vaccination in Multiple Sclerosis Patients Receiving Cladribine
The primary objective of this study is to characterize the antibody response to seasonal influenza vaccine, in patients with active RRMS, treated with cladribine, compared to control individuals with basic immunomodulatory…
- Trial name
- CIRMS (NCT05019248)
- Testing
- Most recent vaccine to seasonal influenza
- Where
- Germany
- Volunteers
- 260 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Vaccine Response Impaired, Hepatitis B
Immunogenicity of the Hepatitis B Vaccine
More than five decades have passed since the identification of the etiologic agent of hepatitis B and yet this infection is a challenge for public health worldwide.
- Conditions
- Vaccine Response Impaired, Hepatitis B, Aging
- Trial name
- NCT04540653
- Testing
- Standard vaccination schedule, Reinforced vaccination schedule
- Where
- Brazil
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Goias