Memory, EpisodicSHIPNCT04562974
Representational Approach to Hippocampal Functions : a fMRI Study
A study testing MRI-scanner in people with Memory, Episodic and Form Perception, run by University Hospital, Grenoble at 1 site in France.
Trial summary
Although traditional neuropsychological models associate medial temporal lobe (MTL) regions to memory, and the hippocampus to episodic memory, there is growing evidence supporting an alternative view. Read more about this study
- Who is it for?
- Ages 18 to 35 yearsHealthy volunteers can take part
- Conditions the study is for
- Memory, Episodic, Form Perception
- What is being tested?
- MRI-scanner
- Type of treatment
- Medical device
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 60 participants
- Where
- 1 siteFrance
- Study dates
- 3 Sep 2021to 2 Mar 2022
- Phase
- Interventional
- Are there results?
- None posted in the registry
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 to 35 years
- All sexes
- Healthy volunteers accepted
- Adult
Who may be able to join
- Affiliation to French Healthcare system
- No contraindication to MRI examination
- Age between 18 and 35 years-old
- Visual acuity permitting normal perception of stimuli or corrected sight
Who cannot join
- Existence of a pathology incompatible with the protocol : Heart, respiratory, haematological, caner, neurological disorder...
- Brain-modulating medical treatment
- Alcohol intake before examination
- Uncorrected visual disorder
- Cognitive deficit (criterion MMSE < 27)
- People protected by articles L1121-5 to L1121-8 of the CSP (pregnant women, under-18 subjects, people under judiciary or administrative surveillance)
Trial locations and contacts
1 site in 1 country.
About this study
Official title: Approche représentationnelle de l'Hippocampe Dans la Cognition : Étude en IRMf
Although traditional neuropsychological models associate medial temporal lobe (MTL) regions to memory, and the hippocampus to episodic memory, there is growing evidence supporting an alternative view. The representational view of the MTL proposes that such regions depends on the representations processed rather than the cognitive processes. The aim of this project is to characterise the role played by MTL areas, and particularly the hippocampus, in mnemonic and non-mnemonic cognition. Hypotheses stemming from the representational view will thus be tested, using functional MRI among young healthy participants.
Read the detailed description
Traditional neuropsychological models associate the medial temporal lobe (MTL) with episodic memory. Further, the hippocampus would be responsible for recollection, or the rich and contextualised retrieval of a memory; whereas the perirhinal cortex (PRC) would process familiarity, or the feeling that a stimulus has been encountered before, without remembering where or when it happened. However, there is growing evidence questioning this view, and supporting an alternative proposal. The representational view of the MTL proposes that such regions would not be organised according to cognitive processes, but rather according to the representations (or the mnemonic content, represented by a pattern of neuronal spikes. A 2018-fMRI study demonstrated that the engagement of the hippocampus in recollection depends on the presence of a spatial scene in the memory that is retrieved, and not on the reconstructive nature of the retrieval. However, this demonstration is incomplete, as the only process that was investigated is recollection. The current project aims to extend such results to memory processes such as familiarity, and even to non-mnemonic processes such as visual discrimination. A fMRI study will thus be conducted, where 30 healthy participants will first perform a visual-discrimination task on scenes and objects, before taking a recognition task, in which images will either be presented in full or in the form of circular cues only. Multivariate-Pattern Analyses (MVPA) will complete traditional fMRI analyses, in order to determine whether activity in the MTL can be categorised on the basis of representations through a machine-learning classifier.
- Conditions
- Memory, Episodic, Form Perception
- Being tested
- MRI-scanner
- Keywords
- memory, neuropsychology, hippocampus, perception, neuroimaging
- Medical subject headings
- Recurrence
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
MRI-scannerDevice
Only one group of 30 participants is constituted. All participants will perform perception and memory tasks inside a MRI-scanner. Functional activity (BOLD signal) will be registered, as well as anatomical and behavioural data.
| Study group | Role | What they receive |
|---|---|---|
| One group of 30 healthy subjects | Experimental | Perception and memory tasks inside a MRI-scanner for all participants Receives: Device: MRI-scanner |
What is being measured
The primary outcome is the main question the study is designed to answer.
Hippocampal activity during behavioural tasks in the MRI scanner
Activity will be recorded through the MRI whereas participants will perform the tasks. Outcome criteria consist in significant activity observed in participants hippocampus, depending on the experimental conditions.
Measured: through study completion, an average of 1 year
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted24 Sep 2020
- Study start3 Sep 2021
- Primary completion2 Mar 2022
- Study completion2 Mar 2022
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Memory, EpisodicStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 60 participants (actual)
Sponsor and investigators
- Lead sponsor
- University Hospital, Grenoble
- Sponsor type
- University, hospital or other
- Collaborators
- Laboratoire de Psychologie et NeuroCognition, University Grenoble Alps, Université Savoie Mont Blanc
- Responsible party
- Sponsor
- Investigators
- Olivier Moreaud, Principal investigator, University Hospital, Grenoble
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04562974
- Sponsor's protocol ID
- 2020-A01592-37
- Other IDs
- 2020-A01592-37
- Acronym
- SHIP
- Status last verified
- Dec 2025
- First submitted
- 4 Sep 2020
- Last updated
- 22 Dec 2025
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Publications
Gardette J, Cousin E, Bourgin J, Torlay L, Pichat C, Moreaud O, Hot P. Hippocampal activity during memory and visual perception: The role of representational content. Cortex. 2022 Dec;157:14-29. doi: 10.1016/j.cortex.2022.09.004. Epub 2022 Sep 28.
PubMed 36272329
Study at a glance
From the registry record, last updated by the sponsor on 22 Dec 2025. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Approche représentationnelle de l'Hippocampe Dans la Cognition : Étude en IRMf
- ClinicalTrials.gov ID
- NCT04562974
- Acronym / sponsor ID
- SHIP / 2020-A01592-37
- Conditions
- Memory, Episodic, Form Perception
- Keywords
- memory, neuropsychology, hippocampus, perception, neuroimaging
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 60 participants (actual)
- Lead sponsor
- University Hospital, GrenobleUniversity, hospital or other
- Collaborators
- Laboratoire de Psychologie et NeuroCognition, University Grenoble Alps, Université Savoie Mont Blanc
- Study start
- 3 Sep 2021 (actual)
- Primary completion
- 2 Mar 2022 (actual)
- Study completion
- 2 Mar 2022 (actual)
- First posted
- 24 Sep 2020 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Although traditional neuropsychological models associate medial temporal lobe (MTL) regions to memory, and the hippocampus to episodic memory, there is growing evidence supporting an alternative view. The representational view of the MTL proposes that such regions depends on the representations processed rather than the cognitive processes. The aim of this project is to characterise the role played by MTL areas, and particularly the hippocampus, in mnemonic and non-mnemonic cognition. Hypotheses stemming from the representational view will thus be tested, using functional MRI among young healthy participants.
Detailed description
Traditional neuropsychological models associate the medial temporal lobe (MTL) with episodic memory. Further, the hippocampus would be responsible for recollection, or the rich and contextualised retrieval of a memory; whereas the perirhinal cortex (PRC) would process familiarity, or the feeling that a stimulus has been encountered before, without remembering where or when it happened. However, there is growing evidence questioning this view, and supporting an alternative proposal. The representational view of the MTL proposes that such regions would not be organised according to cognitive processes, but rather according to the representations (or the mnemonic content, represented by a pattern of neuronal spikes. A 2018-fMRI study demonstrated that the engagement of the hippocampus in recollection depends on the presence of a spatial scene in the memory that is retrieved, and not on the reconstructive nature of the retrieval. However, this demonstration is incomplete, as the only process that was investigated is recollection. The current project aims to extend such results to memory processes such as familiarity, and even to non-mnemonic processes such as visual discrimination. A fMRI study will thus be conducted, where 30 healthy participants will first perform a visual-discrimination task on scenes and objects, before taking a recognition task, in which images will either be presented in full or in the form of circular cues only. Multivariate-Pattern Analyses (MVPA) will complete traditional fMRI analyses, in order to determine whether activity in the MTL can be categorised on the basis of representations through a machine-learning classifier.
Study design
- Primary purpose
- Basic science
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| One group of 30 healthy subjects | Experimental | Device: MRI-scannerPerception and memory tasks inside a MRI-scanner for all participants |
Who may qualify
- Ages
- 18 to 35 years
- Sex
- All
- Healthy volunteers
- Accepted
- Age groups
- Adult
Key inclusion criteria (4 listed)
- Affiliation to French Healthcare system
- No contraindication to MRI examination
- Age between 18 and 35 years-old
- Visual acuity permitting normal perception of stimuli or corrected sight
Key exclusion criteria (6 listed)
- Existence of a pathology incompatible with the protocol : Heart, respiratory, haematological, caner, neurological disorder...
- Brain-modulating medical treatment
- Alcohol intake before examination
- Uncorrected visual disorder
- Cognitive deficit (criterion MMSE < 27)
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| MRI-scannerOnly one group of 30 participants is constituted. All participants will perform perception and memory tasks inside a MRI-scanner. Functional activity (BOLD signal) will be registered, as well as anatomical and behavioural data. | Device | One group of 30 healthy subjects |
Primary outcome
Hippocampal activity during behavioural tasks in the MRI scanner
Time frame: through study completion, an average of 1 year
Activity will be recorded through the MRI whereas participants will perform the tasks. Outcome criteria consist in significant activity observed in participants hippocampus, depending on the experimental conditions.
Results and safety
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 22 Dec 2025.
- Results publication: PubMed 36272329Gardette J, Cousin E, Bourgin J, Torlay L, Pichat C, Moreaud O, Hot P. Hippocampal activity during memory and visual perception: The role of representational content. Cortex. 2022 Dec;157:14-29. doi: 10.1016/j.cortex.2022.09.004. Epub 2022 Sep 28.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Olivier Moreaud principal investigator
University Hospital, Grenoble
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing MRI-scanner in people with Memory, Episodic and Form Perception, run by University Hospital, Grenoble at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 4 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 22 Dec 2025. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Hippocampal activity during behavioural tasks in the MRI scanner (time frame: through study completion, an average of 1 year). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT04562974, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 22 Dec 2025.