Deep Vein ThrombosisEPREVUPNCT04917328
Compression Ultrasonography in Non-high Probability of Deep Vein Thrombosis
A study testing compression ultrasound in people with Deep Vein Thrombosis, run by University Hospital, Strasbourg, France at 1 site in France.
Trial summary
Compression ultrasound is commonly used in emergency department. Accuracy to rule out deep vein thrombosis is excellent but lower then Ddimer assessment which is actually gold standard. Read more about this study
- Who is it for?
- Ages 18 years and older
- Conditions the study is for
- Deep Vein Thrombosis
- What is being tested?
- compression ultrasound
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 700 participants
- Where
- 1 siteFrance
- Study dates
- 21 Feb 2022to 28 Feb 2028
- Phase
- Interventional
- Are there results?
- Not yet: the study is under way
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 18 years and older
- All sexes
- No healthy volunteers
- Adult, Older adult
Who may be able to join
- adult patient
- Patient presenting to the emergency department with clinical suspicion of DVT (i.e. pain and/or lower extremity edema).
- Patient with a non-high probability according to the modified Wells score, i.e. a score of 0 or 1
- Subject with a social health insurance plan
- Subject able to understand the objectives and risks of the research and to give a signed and dated informed consent
Who cannot join
- Patient with suspected pulmonary embolism
- Patient with a high probability of DVT
- Impossible to perform a whole leg doppler ultrasound within 5 days
- Pregnant or breast-feeding woman, on patient's declaration
- Subject under court protection
- Subject under guardianship or curatorship
Trial locations and contacts
1 site in 1 country. Contact the study team or a site near you to ask about taking part.
France1 site, 1 recruiting
- Recruiting
CHU Strasbourg
Strasbourg
Pierrick LE BORGNE, MD, 0388128690, pierrick.leborgne@chru-strasbourg.fr
Mathieu OBERLIN, 0388127985, mathieu.oberlin@chru-strasbourg.fr
About this study
Official title: Evaluation of the Predictive Value of Compression Venous Ultrasound by the Emergency Physician for Excluding the Diagnosis of Proximal Deep Vein Thrombosis (DVT) in Patients With Non-high Clinical Pretest Probability
Compression ultrasound is commonly used in emergency department. Accuracy to rule out deep vein thrombosis is excellent but lower then Ddimer assessment which is actually gold standard. With progress in formation of emergency physicians (EP), quality of material used, the investigators hypothesize that compression ultrasound can rule out deep vein thrombosis in case of non high probability, as standard care and DDimer assay.
- Conditions
- Deep Vein Thrombosis
- Being tested
- compression ultrasound
- Medical subject headings
- Venous Thrombosis
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
compression ultrasoundOther
performing a compression ultrasound
| Study group | Role | What they receive |
|---|---|---|
| Patient with clinical suspicion of deep vein thrombosis | Experimental | Not described Receives: Other: compression ultrasound |
What is being measured
The primary outcome is the main question the study is designed to answer.
Negative predictive value of compression ultrasound for diagnosis of deep vein thrombosis
Measured: The measurement is assessed during ED stay or in 5 days if DD is positive with no DVT in compression ultrasound
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted8 Jun 2021
- Study start21 Feb 2022
- Primary completion28 Feb 2027 (estimated)
- Study completion28 Feb 2028 (estimated)
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Other trials for Deep Vein ThrombosisStudies of the same condition, open and under way.
- More trials run by University Hospital, Strasbourg, FranceThe sponsor's other registered studies.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Diagnosis
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 700 participants (estimated)
Sponsor and investigators
- Lead sponsor
- University Hospital, Strasbourg, France
- Sponsor type
- University, hospital or other
- Responsible party
- Sponsor
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT04917328
- Sponsor's protocol ID
- 8114
- Acronym
- EPREVUP
- Status last verified
- Aug 2026
- First submitted
- 1 Jun 2021
- Last updated
- 19 Aug 2026
- Results posted
- No
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
Study at a glance
From the registry record, last updated by the sponsor on 19 Aug 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Evaluation of the Predictive Value of Compression Venous Ultrasound by the Emergency Physician for Excluding the Diagnosis of Proximal Deep Vein Thrombosis (DVT) in Patients With Non-high Clinical Pretest Probability
- ClinicalTrials.gov ID
- NCT04917328
- Acronym / sponsor ID
- EPREVUP / 8114
- Conditions
- Deep Vein Thrombosis
- Study type
- Interventional
- Recruitment status
- Recruiting
- Enrolment
- 700 participants (estimated)
- Lead sponsor
- University Hospital, Strasbourg, FranceUniversity, hospital or other
- Study start
- 21 Feb 2022 (actual)
- Primary completion
- 28 Feb 2027 (estimated)
- Study completion
- 28 Feb 2028 (estimated)
- First posted
- 8 Jun 2021 (actual)
- Results
- Not posted in the source record
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
Compression ultrasound is commonly used in emergency department. Accuracy to rule out deep vein thrombosis is excellent but lower then Ddimer assessment which is actually gold standard. With progress in formation of emergency physicians (EP), quality of material used, the investigators hypothesize that compression ultrasound can rule out deep vein thrombosis in case of non high probability, as standard care and DDimer assay.
Study design
- Primary purpose
- Diagnosis
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| Patient with clinical suspicion of deep vein thrombosis | Experimental | Other: compression ultrasound |
Who may qualify
- Ages
- 18 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Adult, Older adult
Key inclusion criteria (5 listed)
- adult patient
- Patient presenting to the emergency department with clinical suspicion of DVT (i.e. pain and/or lower extremity edema).
- Patient with a non-high probability according to the modified Wells score, i.e. a score of 0 or 1
- Subject with a social health insurance plan
- Subject able to understand the objectives and risks of the research and to give a signed and dated informed consent
Key exclusion criteria (6 listed)
- Patient with suspected pulmonary embolism
- Patient with a high probability of DVT
- Impossible to perform a whole leg doppler ultrasound within 5 days
- Pregnant or breast-feeding woman, on patient's declaration
- Subject under court protection
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| compression ultrasoundperforming a compression ultrasound | Other | Patient with clinical suspicion of deep vein thrombosis |
Primary outcome
Negative predictive value of compression ultrasound for diagnosis of deep vein thrombosis
Time frame: The measurement is assessed during ED stay or in 5 days if DD is positive with no DVT in compression ultrasound
Results and safety
This study is still under way. Results are not available in the source record yet.
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 19 Aug 2026.
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part.
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing compression ultrasound in people with Deep Vein Thrombosis, run by University Hospital, Strasbourg, France at 1 site in France.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 6 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: looking for participants now, as of the sponsor's last update on 19 Aug 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in France. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
This study is still under way. Results are not available in the source record yet.
How can a doctor refer a patient or contact the research team?
Contact Pierrick LE BORGNE, MD (03.88.12.86.90, pierrick.leborgne@chru-strasbourg.fr), or a site near the patient. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Negative predictive value of compression ultrasound for diagnosis of deep vein thrombosis (time frame: The measurement is assessed during ED stay or in 5 days if DD is positive with no DVT in compression ultrasound). It is what the study was designed to measure, not a finding.
Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 19 Aug 2026.