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Overweight and ObesityNCT05622149

Is Strength Training a Viable Exercise Modality for Fat Loss?

A study testing Diet Only, Training Only and Diet plus Training in people with Overweight and Obesity, run by George Washington University.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

The purpose of this study is to determine whether strength training can be used as a viable exercise modality for the purpose of inducing fat loss. Read more about this study

Who is it for?
Ages 25 to 40 years, women onlyHealthy volunteers can take part
Conditions the study is for
Overweight and Obesity
What is being tested?
Diet Only, Training Only and Diet plus Training
Could I receive a placebo?
No, everyone receives an active treatment
How many people
40 participants
Where
No sites listed yet
Study dates
18 Mar 2016to 1 Oct 2016
Phase
Interventional
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 25 to 40 years
  • Women only
  • Healthy volunteers accepted
  • Adult

Who may be able to join

  • BMI 25-29.9 normally menstruating bodyfat >30%

Who cannot join

  • currently dieting to lose weight currently engaged in structured exercise using dietary weight loss supplements Resting Metabolic Rate not within 10% of predicted value

About this study

The purpose of this study is to determine whether strength training can be used as a viable exercise modality for the purpose of inducing fat loss.

Read the detailed description

Aerobic exercise (AE) is commonly recommended as the most effective exercise modality for weight loss. The Centers for Disease Control (CDC) recommends 150 minutes of AE for weight maintenance, and an unspecified greater amount required for weight loss. Similarly, the American College of Sports Medicine (ACSM) position stand on physical activity for weight loss recommends 150-250 minutes per week of moderate intensity physical activity. While the ACSM promotes resistance training (RT) as a means of increasing fat free mass, which should lead to improved body composition, it does not promote RT for losing significant amounts of body fat. Similarly, the CDC physical activity guidelines for weight loss do not mention RT at all as a viable exercise modality for weight loss. This is not surprising, as there is a paucity of research examining the effects of RT on weight loss. Furthermore, the few studies that have explored RT for weight loss generally show that it is ineffective. The effectiveness of any weight loss program is dependent on the size of the caloric deficit that is created over time, and since AE generally burns more calories per unit of time than RT, it stands to reason that AE would be the most commonly prescribed type of exercise for weight loss. Contributing to the exclusion of RT for weight loss is a widespread belief among dietitians, nutritionists and exercise professionals that it is not possible to induce muscle growth while in a caloric deficit, and since the creation of a caloric deficit is essential for fat loss, the use of RT for muscle growth in a caloric deficit is counter intuitive.

However, RT has been shown to elevate resting metabolism for an extended period of time following cessation of the training session. Additionally, having a greater muscle mass should lead to a greater resting metabolism. Unlike RT, chronic AE performed in a caloric deficit (which is often the recommendation for effective weight loss) has the potential to lead to significant decreases in muscle mass, thereby hampering improvements in body composition. Ideally, a program designed to improve body composition should do so through fat losses alone, with muscle mass being maintained or increased.

Several reasons could exist for the lack of effectiveness of RT shown in most studies. These reasons include, but are not limited to, 1) Body mass being the measured outcome and not body composition, 2) lack of control and/or measurement of caloric intake, 3) failure to adjust dietary protein needs to support muscle growth, 4) ineffective RT program design. Case studies of clients from our lab have routinely shown that profound decreases in bodyfat can be induced with RT as the exclusive form of exercise. Furthermore, these decreases in bodyfat occur with concomitant increases in muscle mass, while in a caloric deficit. Therefore, the specific aims of this proposal are:

  1. To determine whether RT combined with dietary intervention (RT+DIET) results in greater decreases in fat mass than (RT) or dietary intervention (DIET) alone.
  2. To determine whether RT combined with dietary intervention (RT+DIET) results in greater improvements in body composition than (RT) or dietary intervention (DIET) alone.
  3. To determine whether concomitant increases in muscle mass and decreases in fat mass can occur while in a caloric deficit.

The goal of this project is to serve to generate pilot data to determine whether RT can be used as a viable exercise mode for fat loss and muscle gain. We will then pursue funding for a subsequent study that compares the effects of RT versus AE on body composition and fat loss when 1) the caloric intake is monitored to ensure the creation of a caloric deficit, and 2) dietary protein is appropriately increased to support muscle retention/growth.

Being tested
Diet Only, Training Only, Diet plus Training
Keywords
resistance training; metabolism
Medical subject headings
Overweight, Obesity

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Diet OnlyBehavioural

    Food tracking based on macronutrient goals.

  • Training OnlyBehavioural

    Subjects completed 16 weeks of supervised resistance training

  • Diet plus TrainingBehavioural

    Food tracking plus resistance training.

Study groups in NCT05622149
Study groupRoleWhat they receive
ControlNo interventionNo intervention
Diet OnlyExperimentalSubjects were given calorie and macronutrient intake goals and were told to hit those goals as closely as possible on a daily basis for 16 weeks.
Receives: Behavioral: Diet Only
Training OnlyExperimentalSubjects were given a 3 times per week supervised resistance training program for 16 weeks
Receives: Behavioral: Training Only
Diet plus TrainingExperimentalSubjects were given calorie and macronutrient intake goals and were told to hit those goals as closely as possible on a daily basis for 16 weeks. Subjects were given a 3 times per week supervised resistance training program for 16 weeks
Receives: Behavioral: Diet plus Training

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Change in Fat Free Mass

    Fat Free Mass as measured from DXA and recorded in Kg

    Measured: 0 and 16 weeks

  2. Change in Fat Mass

    Fat Mass as measured from DXA and recorded in Kg

    Measured: 0, 4, 8, 12, 16 weeks

  3. Change in Resting Metabolic Rate

    Resting Metabolic Rate measured via indirect calorimetry and recorded in kcal / day

    Measured: 0 and 16 weeks

  4. Change in Visceral Fat

    Fat in the Visceral Depot measured from DXA and recorded in Kg

    Measured: 0, 4, 8, 12, 16 weeks

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted18 Nov 2022
  2. Study start18 Mar 2016
  3. Primary completion1 Oct 2016
  4. Study completion1 Oct 2016

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Treatment
Allocation
Randomised
Intervention model
Parallel groups
Masking
None (open label)
Enrolment
40 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT05622149
Sponsor's protocol ID
011638
Status last verified
Nov 2022
First submitted
19 Mar 2018
Last updated
18 Nov 2022
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No

Questions about this trial

What is this clinical trial studying?

A study testing Diet Only, Training Only and Diet plus Training in people with Overweight and Obesity, run by George Washington University.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 1 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 18 Nov 2022. Status can change between updates, so confirm with the study contact before making plans.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Change in Fat Free Mass (time frame: 0 and 16 weeks). The study lists 4 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 18 Nov 2022.

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