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CaffeineNCT06039358

Effects of Caffeine Ingestion on the Biomechanics of Healthy Young Subjects

A study testing Caffeine. and Cellulose. in people with Caffeine and Biomechanics, run by University of Vic - Central University of Catalonia at 1 site in Spain.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record
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Trial summary

Caffeine is one of the few supplements that have enough scientific evidence to state that can notably improve performance, as different remarkable organizations in the sports nutrition context have classified it as an ergogenic aid with strong evidence regarding its efficacy and that is apparently safe. Read more about this study

Who is it for?
Ages 18 to 30 yearsHealthy volunteers can take part
Conditions the study is for
Caffeine, Biomechanics, Fatigue
What is being tested?
Caffeine. and Cellulose.
Type of treatment
Pill or oral medicine
Could I receive a placebo?
No, everyone receives an active treatment
How many people
15 participants
Where
1 siteSpain
Study dates
6 Oct 2023to 23 Dec 2023
Phase
Interventional
Are there results?
None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

  • Ages 18 to 30 years
  • All sexes
  • Healthy volunteers accepted
  • Adult

Who may be able to join

  • An uninterrupted training time of at least 1 year in the subjects' regular exercise modality (either the person is still training or interrupted the training period during the last year, and with no more than 4 months of detraining).
  • A good exercise technique of the assessed movement patterns (running, squatting, and jumping).

Who cannot join

  • Not being 18-30 years old.
  • Having any relevant medical condition.
  • Pregnancy.
  • Smoking.
  • Regular medication consumption / Medication consumption the days before the sessions during the study.
  • Other supplementation regular consumption / Other supplementation consumption during the study (excluding sports foods, provided that their goal and nutrients have the objective of substituting the ingestion of regular food (e.g., isotonic drinks, carbohydrates gels, protein powder...), without adding other components that may act as ergogenic substances).
  • Habitual caffeine consumption of >25mg/day-0,99mg/kg/day.

Trial locations and contacts

1 site in 1 country.

Spain1 site
  • University of Vic - Central University of Catalonia.

    Vic, Barcelona., 08500.

Other trials in Spain

About this study

Official title: Influence of 6mg/kg of Caffeine Supplementation on the Technical Execution of General Movement Patterns Performed by Healthy Subjects, With and Without Neuromuscular Fatigue: a Randomized, Double-blind, Placebo-controlled, Crossover Trial

Caffeine is one of the few supplements that have enough scientific evidence to state that can notably improve performance, as different remarkable organizations in the sports nutrition context have classified it as an ergogenic aid with strong evidence regarding its efficacy and that is apparently safe. The beneficial effect of this substance on physical and cognitive performance has been identified in aerobic and anaerobic efforts, including aerobic and muscular endurance, power, or strength.

However, it seems that the benefits of caffeine are usually measured only by its effect on performance, while a comprehensive analysis of its impact on other aspects of the movement technique of the exercise is not considered. Therefore, although caffeine generates better performance, a null or negative effect may occur on technique execution. As such, some consequences might arise (e.g., an increase in injury risk or a decrease in energy efficiency).

Read more

The objective of this randomized controlled trial is to assess the influence of caffeine on certain biomechanical parameters of the technique of physical exercises in circumstances without fatigue and under neuromuscular fatigue. The study hypothesis is that caffeine generates modifications in the technical execution of certain movements in fatigued and unfatigued circumstances due to its physiological effects, which may be beneficial for performance and injury prevention.

The participants will have to attend 5 sessions (enrollment, familiarization, control, placebo, and caffeine), at least 7 days apart. In the last 3 sessions, different measurements will be done to their technique while jumping, squatting, and running, without fatigue and with it. Other data will be collected throughout the study to contextualize and analyze in more detail the obtained information.

Read the detailed description

A detailed description of the study can be found in the protocol uploaded with this registry entry.

Being tested
Caffeine., Cellulose.
Keywords
Ergogenic aids, Kinematics, Kinetics, Neuromuscular fatigue, Acute and chronic injuries, Jump, Squat, Running
Medical subject headings
Fatigue, Wounds and Injuries, Motor Activity

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

  • Caffeine.Dietary supplement

    Ingestion of opaque capsules with a total dose of 6mg/kg of caffeine, 60 minutes before the beginning of the assessed exercises. A crossover with the other intervention will be done in the next/previous session (depending on the arm).

  • Cellulose.Drug

    Also called Placebo.

    Ingestion of opaque capsules with cellulose, 60 minutes before the beginning of the assessed exercises. A crossover with the other intervention will be done in the next/previous session (depending on the arm).

Study groups in NCT06039358
Study groupRoleWhat they receive
Control - caffeine - placebo.ExperimentalThe order of the assessed sessions will be first the control one, then the caffeine one, and then the placebo one.
Receives: Dietary Supplement: Caffeine.; Drug: Cellulose.
Control - placebo - caffeine.ExperimentalThe order of the assessed sessions will be first the control one, then the placebo one, and then the caffeine one.
Receives: Dietary Supplement: Caffeine.; Drug: Cellulose.

What is being measured

The primary outcome is the main question the study is designed to answer.

  1. Knee flexion angle at the midstance while running.

    Assessment of the knee flexion angle (in degrees). The measurement will be done before and after a fatiguing protocol. Assessed using kinematic instruments.

    Measured: During the control, placebo, and caffeine sessions (at least 7 days between them). The length of each session will be approximately 3 hours.

  2. Ankle dorsiflexion angle at the midstance while running.

    Assessment of the ankle dorsiflexion angle (in degrees). The measurement will be done before and after a fatiguing protocol. Assessed using kinematic instruments.

    Measured: During the control, placebo, and caffeine sessions (at least 7 days between them). The length of each session will be approximately 3 hours.

  3. Step rate while running.

    Assessment of the step rate (in steps/minute). The measurement will be done before and after a fatiguing protocol. Assessed using kinematic instruments.

    Measured: During the control, placebo, and caffeine sessions (at least 7 days between them). The length of each session will be approximately 3 hours.

  4. Contact time while running.

    Assessment of the time the foot is in contact with the ground (in seconds). The measurement will be done before and after a fatiguing protocol. Assessed using kinematic instruments.

    Measured: During the control, placebo, and caffeine sessions (at least 7 days between them). The length of each session will be approximately 3 hours.

  5. Stride length while running.

    Assessment of the distance between two successive placements of the same foot (in meters). The measurement will be done before and after a fatiguing protocol. Assessed using kinematic instruments.

    Measured: During the control, placebo, and caffeine sessions (at least 7 days between them). The length of each session will be approximately 3 hours.

  6. Flight time while running.

    Assessment of the time the foot is not in contact with the ground (in seconds). The measurement will be done before and after a fatiguing protocol. Assessed using kinematic instruments.

    Measured: During the control, placebo, and caffeine sessions (at least 7 days between them). The length of each session will be approximately 3 hours.

  7. Running performance modification.

    Assessment of the time (in seconds) required to complete a specific distance running on a treadmill. The measurement will be done before and after a fatiguing protocol. Assessed using a stopwatch.

    Measured: During the control, placebo, and caffeine sessions (at least 7 days between them). The length of each session will be approximately 3 hours.

  8. Hip angle while squatting, at the initial position, bottom position, and final position, and the eccentric and the concentric range of movement.

    Assessment of the hip angle (in degrees). The measurement will be done before and after a fatiguing protocol. Assessed using kinematic instruments.

    Measured: During the control, placebo, and caffeine sessions (at least 7 days between them). The length of each session will be approximately 3 hours.

  9. Knee angle while squatting, at the initial position, bottom position, and final position, and the eccentric and the concentric range of movement.

    Assessment of the knee angle (in degrees). The measurement will be done before and after a fatiguing protocol. Assessed using kinematic instruments.

    Measured: During the control, placebo, and caffeine sessions (at least 7 days between them). The length of each session will be approximately 3 hours.

  10. Ankle angle while squatting, at the initial position, bottom position, and final position, and the eccentric and the concentric range of movement.

    Assessment of the ankle angle (in degrees). The measurement will be done before and after a fatiguing protocol. Assessed using kinematic instruments.

    Measured: During the control, placebo, and caffeine sessions (at least 7 days between them). The length of each session will be approximately 3 hours.

  11. Execution time while squatting, for the eccentric and the concentric phases of the movement.

    Assessment of the execution time to perform the eccentric and the concentric phases of the squat (in seconds). The measurement will be done before and after a fatiguing protocol. Assessed using a linear position transducer.

    Measured: During the control, placebo, and caffeine sessions (at least 7 days between them). The length of each session will be approximately 3 hours.

  12. Peak vertical force while squatting, for the eccentric and the concentric phases of the movement.

    Assessment of the peak vertical force (in Newtons). The measurement will be done before and after a fatiguing protocol. Assessed using a linear position transducer.

    Measured: During the control, placebo, and caffeine sessions (at least 7 days between them). The length of each session will be approximately 3 hours.

  13. Rate of force development while squatting, for the eccentric and the concentric phases of the movement.

    Assessment of the rate of force development (in Newtons/seconds). The measurement will be done before and after a fatiguing protocol. Assessed using a linear position transducer.

    Measured: During the control, placebo, and caffeine sessions (at least 7 days between them). The length of each session will be approximately 3 hours.

  14. Squatting performance modification.

    Assessment of the mean propulsive bar velocity (in meters/seconds) for a specific weight lifted in barbell back squats. The measurement will be done before and after a fatiguing protocol. Assessed using a linear position transducer.

    Measured: During the control, placebo, and caffeine sessions (at least 7 days between them). The length of each session will be approximately 3 hours.

  15. Contralateral pelvic drop angle while jumping, at the initial contact of the landing phase.

    Assessment of the contralateral pelvic drop angle (in degrees). The measurement will be done before and after a fatiguing protocol. Assessed using kinematic instruments.

    Measured: During the control, placebo, and caffeine sessions (at least 7 days between them). The length of each session will be approximately 3 hours.

  16. Knee valgus while jumping, at the initial contact and the deepest landing position of the landing phase, and the range of movement between these two moments.

    Assessment of the knee valgus angle (in degrees). The measurement will be done before and after a fatiguing protocol. Assessed using kinematic instruments.

    Measured: During the control, placebo, and caffeine sessions (at least 7 days between them). The length of each session will be approximately 3 hours.

  17. Unweighting phase duration while jumping (jumping phase).

    Assessment of the unweighting phase duration (in seconds). The measurement will be done before and after a fatiguing protocol. Assessed using force plates.

    Measured: During the control, placebo, and caffeine sessions (at least 7 days between them). The length of each session will be approximately 3 hours.

  18. Braking phase duration while jumping (jumping phase).

    Assessment of the braking phase duration (in seconds). The measurement will be done before and after a fatiguing protocol. Assessed using force plates.

    Measured: During the control, placebo, and caffeine sessions (at least 7 days between them). The length of each session will be approximately 3 hours.

  19. Propulsive phase duration while jumping (jumping phase).

    Assessment of the propulsive phase duration (in seconds). The measurement will be done before and after a fatiguing protocol. Assessed using force plates.

    Measured: During the control, placebo, and caffeine sessions (at least 7 days between them). The length of each session will be approximately 3 hours.

  20. Relative peak power output while jumping (jumping phase).

    Assessment of the relative peak power output (in Watts/kg). The measurement will be done before and after a fatiguing protocol. Assessed using force plates.

    Measured: During the control, placebo, and caffeine sessions (at least 7 days between them). The length of each session will be approximately 3 hours.

  21. Jumping performance modification.

    Assessment of the height (in meters) of countermovement jumps. The measurement will be done before and after a fatiguing protocol. Assessed using force plates.

    Measured: During the control, placebo, and caffeine sessions (at least 7 days between them). The length of each session will be approximately 3 hours.

Secondary outcomes (2)
  1. Supplementation identification.

    Assessment of the participants' perception regarding the ingested substance. They will have to complete a questionnaire immediately before (1 hour post-supplementation) and after the assessed exercises, indicating what substance they believe that they have consumed, with the options "caffeine", "placebo", or "I don't know", as well as the reason why they have chosen that answer.

    Measured: During the placebo and caffeine sessions (at least 7 days between them). The length of each session will be approximately 3 hours.

  2. Side effects.

    Assessment of the participant's side effects related to caffeine consumption. In the morning of the day after the sessions, they will be requested to complete a questionnaire comprised of 8 questions with a yes/no answer, to evaluate the side effects of caffeine consumption during the hours after the sessions.

    Measured: During the day after the placebo and caffeine sessions (at least 7 days between them). The length of each session will be approximately 3 hours.

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

  1. First posted15 Sep 2023
  2. Study start6 Oct 2023
  3. Primary completion22 Dec 2023
  4. Study completion23 Dec 2023

Resources

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design
Study type
Interventional
Phase
Phase N/A
Primary purpose
Basic science
Allocation
Randomised
Intervention model
Crossover
Model description
The assessed sessions, which will be identical, will be the control, the caffeine, and the placebo ones. The last two sessions mentioned will be performed in a randomized order.
Masking
Triple blind
Who is masked
Participant, Investigator, Outcomes assessor
Enrolment
15 participants (actual)
IDs, dates and publications
ClinicalTrials.gov ID
NCT06039358
Sponsor's protocol ID
CAFBIOM001
Status last verified
Aug 2025
First submitted
1 Sep 2023
Last updated
3 Sep 2025
Results posted
No
Data monitoring committee
No
FDA-regulated drug
No
FDA-regulated device
No
Individual data sharing
No

Questions about this trial

What is this clinical trial studying?

A study testing Caffeine. and Cellulose. in people with Caffeine and Biomechanics, run by University of Vic - Central University of Catalonia at 1 site in Spain.

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 2 inclusion and 7 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 3 Sep 2025. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Spain. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Knee flexion angle at the midstance while running. (time frame: During the control, placebo, and caffeine sessions (at least 7 days between them). The length of each session will be approximately 3 hours.). The study lists 21 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?
Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 3 Sep 2025.

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