Homonymous HemianopiaNCT06136169
Reminder-cue Scanning Training for Homonymous Visual Field Loss
A study testing Reminder-cue scanning training in people with Homonymous Hemianopia and Homonymous Quadrantanopia, run by Massachusetts Eye and Ear Infirmary at 1 site in United States.
Trial summary
This study will evaluate a new approach to training people with visual field loss to scan when driving Read more about this study
- Who is it for?
- Ages 16 years and older
- Conditions the study is for
- Homonymous Hemianopia, Homonymous Quadrantanopia
- What is being tested?
- Reminder-cue scanning training
- Type of treatment
- Lifestyle or therapy programme
- Could I receive a placebo?
- No, everyone receives an active treatment
- How many people
- 16 participants
- Where
- 1 siteUnited States
- Study dates
- 14 May 2024to 1 Aug 2026
- Phase
- Interventional
- Are there results?
- Yes, posted in the registrySummary in the doctors' view
Key requirements
Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.
- Ages 16 years and older
- All sexes
- No healthy volunteers
- Child, Adult, Older adult
Who may be able to join
- Homonymous hemianopia or homonymous quadrantanopia for at least 3 months
- Binocular visual acuity of at least 20/40
- Prior or current driving experience
- Able to attend multiple study visits
- Able to communicate in English sufficiently to understand the study procedures
Who cannot join
- Physical or general health problems that could impair the ability to operate the controls of the driving simulator or participate in the training
Trial locations and contacts
1 site in 1 country.
United States1 site
Schepens Eye Research Institute of Mass Eye and Ear
Boston, Massachusetts, 02114
About this study
Official title: Reminder-cue Scanning Training for People With Homonymous Visual Field Loss
This study will evaluate a new approach to training people with visual field loss to scan when driving
Read the detailed description
Homonymous visual field loss is the loss of vision on the same side in both eyes. The most common types are hemianopia (the loss of one half of the field of vision) and quadrantanopia (the loss of one quarter of the field of vision). Hemianopia and quadrantanopia may cause difficulties in seeing objects on the side of the field loss. People with these types of field loss can compensate by scanning (looking) toward the side of the field loss. However, sometimes they might not scan sufficiently well resulting in delayed responses to hazards when driving. The purpose of this research study is to evaluate a new approach, "reminder-cue scanning training", to training people with homonymous visual field loss to scan when driving.
Participants will receive reminder-cue scanning training in the driving simulator.Typically there will be three training sessions within about a 2-week period. In addition, participants will complete an evaluation in the driving simulator before and after the training.
- Conditions
- Homonymous Hemianopia, Homonymous Quadrantanopia
- Being tested
- Reminder-cue scanning training
- Medical subject headings
- Hemianopsia
What participants receive
What participants receive. In a randomised study each person is assigned to one group by chance.
Reminder-cue scanning trainingBehavioural
Auditory reminders to scan when scanning to the side of the field loss is inadequate
| Study group | Role | What they receive |
|---|---|---|
| StudyArm | Experimental | Participants will receive reminder-cue scanning training in a driving simulator. Receives: Behavioral: Reminder-cue scanning training |
What is being measured
The primary outcome is the main question the study is designed to answer.
Rate of Early Large Head Scans to the Side of the Field Loss
Percentage of intersections at which an early large head scan was made to the side of the field loss
Measured: Pre-training, post-training (1 week)
Detection Rate for Hazards on the Side of the Field Loss
Percentage of hazards detected out of the total number of hazards on the side of the field loss
Measured: Pre-training, Post-training (1 week)
Secondary outcomes (3)
Number of Head Scans to the Side of the Field Loss
Number of head scans per intersection to the side of the field loss. A validated algorithm was used to detect head scans, defined as lateral rotations of the head away from the straight ahead position toward either the left or the right, which exceeded a predefined threshold based on the participant's distance to the intersection: ≥ 4° (100 to 50 m to intersection), ≥ 6° (50 to 20m), ≥ 10° (20 to 0m).
Savage SW, Zhang L, Swan G, Bowers AR (2020) The effects of age on the contributions of head and eye movements to scanning behavior at intersections. Transp Res Part F Traffic Psychol Behav. 73:128-142.
Swan G, Goldstein RB, Savage SW, Zhang L, Ahmadi A, Bowers AR (2021) Automatic processing of gaze movements to quantify gaze scanning behaviors in a driving simulator. Behav Res Methods. 53(2): 487-506
Measured: Pre-training, Post-training (1 week)
Magnitude of Head Scans to the Side of the Field Loss
Mean magnitude (in degrees) of head scans to the side of the field loss. A validated algorithm was used to detect head scans, defined as lateral rotations of the head away from the straight ahead position toward either the left or the right, which exceeded a predefined threshold based on the participant's distance to the intersection: ≥ 4° (100 to 50 m to intersection), ≥ 6° (50 to 20m), ≥ 10° (20 to 0m). The magnitude is the lateral angular extent of the scan measured from the straight-ahead position to the furthest lateral position to the left or right.
Savage SW, Zhang L, Swan G, Bowers AR (2020) The effects of age on the contributions of head and eye movements to scanning behavior at intersections. Transp Res Part F Traffic Psychol Behav. 73:128-142.
Swan G, Goldstein RB, Savage SW, Zhang L, Ahmadi A, Bowers AR (2021) Automatic processing of gaze movements to quantify gaze scanning behaviors in a driving simulator. Behav Res Methods. 53(2): 487-506
Measured: Pre-training, Post-training (1 week)
Response Times to Hazards on the Side of the Field Loss
Mean time (in seconds) between the hazard appearing and the horn-press response
Measured: Pre-training, Post-training (1 week)
Timeline
From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.
- First posted18 Nov 2023
- Study start14 May 2024
- Primary completion11 May 2025
- Study completion1 Aug 2026
Resources
- Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
- Posted resultsParticipant flow, outcome measures and adverse events reported by the sponsor.
- Publications (1)Papers the sponsor has linked to this study.
- Other trials for Homonymous HemianopiaStudies of the same condition, open and under way.
- What the trial phases meanHow a treatment moves from first tests in people to approval.
More details
For doctors and researchers: how the study is designed, who runs it, and its registry IDs.
Study design
- Study type
- Interventional
- Phase
- Phase N/A
- Primary purpose
- Other
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Enrolment
- 16 participants (actual)
Sponsor and investigators
- Lead sponsor
- Massachusetts Eye and Ear Infirmary
- Sponsor type
- University, hospital or other
- Collaborators
- National Eye Institute (NEI)
- Responsible party
- Principal investigator, Alexandra Bowers, Massachusetts Eye and Ear Infirmary
- Investigators
- Alex Bowers, PhD, Principal investigator, Schepens Eye Research Institute of Mass Eye and Ear
IDs, dates and publications
- ClinicalTrials.gov ID
- NCT06136169
- Sponsor's protocol ID
- 2023P003033
- Other IDs
- R01EY025677
- Status last verified
- Aug 2026
- First submitted
- 9 Nov 2023
- Last updated
- 18 Sep 2026
- Results posted
- Yes, on ClinicalTrials.gov
- Data monitoring committee
- No
- FDA-regulated drug
- No
- FDA-regulated device
- No
- Individual data sharing
- No
Publications
Toh YN, Xu J, Baker P, Bowers AR. Reinforcement-Based Head Scan Training for Drivers With Homonymous Visual Field Loss: Improves Blind-Side Detection. Arch Phys Med Rehabil. 2026 May 14:S0003-9993(26)00709-4. doi: 10.1016/j.apmr.2026.04.038. Online ahead of print.
PubMed 42140549
Study at a glance
From the registry record, last updated by the sponsor on 18 Sep 2026. Recruitment status is as the sponsor reported it: confirm with the study team.
- Official title
- Reminder-cue Scanning Training for People With Homonymous Visual Field Loss
- ClinicalTrials.gov ID
- NCT06136169
- Acronym / sponsor ID
- 2023P003033
- Conditions
- Homonymous Hemianopia, Homonymous Quadrantanopia
- Study type
- Interventional
- Recruitment status
- Completed
- Enrolment
- 16 participants (actual)
- Lead sponsor
- Massachusetts Eye and Ear InfirmaryUniversity, hospital or other
- Collaborators
- National Eye Institute (NEI)
- Study start
- 14 May 2024 (actual)
- Primary completion
- 11 May 2025 (actual)
- Study completion
- 1 Aug 2026 (actual)
- First posted
- 18 Nov 2023 (actual)
- Results
- Posted 12 May 2026
Clinical summary
The research question as the sponsor registered it. This describes what the study plans to test, not what it found.
This study will evaluate a new approach to training people with visual field loss to scan when driving
Detailed description
Homonymous visual field loss is the loss of vision on the same side in both eyes. The most common types are hemianopia (the loss of one half of the field of vision) and quadrantanopia (the loss of one quarter of the field of vision). Hemianopia and quadrantanopia may cause difficulties in seeing objects on the side of the field loss. People with these types of field loss can compensate by scanning (looking) toward the side of the field loss. However, sometimes they might not scan sufficiently well resulting in delayed responses to hazards when driving. The purpose of this research study is to evaluate a new approach, "reminder-cue scanning training", to training people with homonymous visual field loss to scan when driving.
Participants will receive reminder-cue scanning training in the driving simulator.Typically there will be three training sessions within about a 2-week period. In addition, participants will complete an evaluation in the driving simulator before and after the training.
Study design
- Primary purpose
- Other
- Allocation
- Not applicable
- Intervention model
- Single group
- Masking
- None (open label)
- Number of arms
- 1
| Arm | Type | Receives |
|---|---|---|
| StudyArm | Experimental | Behavioral: Reminder-cue scanning trainingParticipants will receive reminder-cue scanning training in a driving simulator. |
Who may qualify
- Ages
- 16 years and older
- Sex
- All
- Healthy volunteers
- Not accepted
- Age groups
- Child, Adult, Older adult
Key inclusion criteria (5 listed)
- Homonymous hemianopia or homonymous quadrantanopia for at least 3 months
- Binocular visual acuity of at least 20/40
- Prior or current driving experience
- Able to attend multiple study visits
- Able to communicate in English sufficiently to understand the study procedures
Key exclusion criteria (1 listed)
- Physical or general health problems that could impair the ability to operate the controls of the driving simulator or participate in the training
Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.
Interventions
| Intervention | Type | Arms |
|---|---|---|
| Reminder-cue scanning trainingAuditory reminders to scan when scanning to the side of the field loss is inadequate | Behavioural | StudyArm |
Primary outcome
Rate of Early Large Head Scans to the Side of the Field Loss
Time frame: Pre-training, post-training (1 week)
Percentage of intersections at which an early large head scan was made to the side of the field loss
Detection Rate for Hazards on the Side of the Field Loss
Time frame: Pre-training, Post-training (1 week)
Percentage of hazards detected out of the total number of hazards on the side of the field loss
3 secondary outcomes
Number of Head Scans to the Side of the Field Loss
Time frame: Pre-training, Post-training (1 week)
Magnitude of Head Scans to the Side of the Field Loss
Time frame: Pre-training, Post-training (1 week)
Response Times to Hazards on the Side of the Field Loss
Time frame: Pre-training, Post-training (1 week)
Results and safety
Loading the posted results from ClinicalTrials.gov…
Research links
- Official record on ClinicalTrials.govLast updated by the sponsor 18 Sep 2026.
- Posted resultsParticipant flow, baseline, all outcome measures and adverse events.
- Results publication: PubMed 42140549Toh YN, Xu J, Baker P, Bowers AR. Reinforcement-Based Head Scan Training for Drivers With Homonymous Visual Field Loss: Improves Blind-Side Detection. Arch Phys Med Rehabil. 2026 May 14:S0003-9993(26)00709-4. doi: 10.1016/j.apmr.2026.04.038. Online ahead of print.
- Individual participant dataSharing planned: No
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Referral and contact
AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.
Alex Bowers, PhD principal investigator
Schepens Eye Research Institute of Mass Eye and Ear
1 site in 1 country: see every site and its status.
Questions about this trial
What is this clinical trial studying?
A study testing Reminder-cue scanning training in people with Homonymous Hemianopia and Homonymous Quadrantanopia, run by Massachusetts Eye and Ear Infirmary at 1 site in United States.
The full registered description is in the About this study section and the official record.
Who may be eligible to take part?
The sponsor lists 5 inclusion and 1 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.
Is this clinical trial currently recruiting?
The record says: finished, as of the sponsor's last update on 18 Sep 2026. Status can change between updates, so confirm with the study contact before making plans.
Where is the study taking place?
The record lists 1 site in United States. Whether a site is taking part right now should be confirmed with that site. See every site.
What are the possible benefits and risks?
They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.
Are results available for this study?
Yes. Results are posted in the registry (first posted 12 May 2026). A summary is in the For doctors view, and the full results are on ClinicalTrials.gov.
How can a doctor refer a patient or contact the research team?
The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.
What does the primary outcome measure?
Rate of Early Large Head Scans to the Side of the Field Loss (time frame: Pre-training, post-training (1 week)). The study lists 2 primary outcomes in all. It is what the study was designed to measure, not a finding.
Where can I read the original study information?
On the ClinicalTrials.gov record for NCT06136169, which also lists 1 linked publication.
Does a listing mean the treatment is approved or proven to work?
No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.
How often is this information updated?
AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 18 Sep 2026.