Noise ExposureBioVibNCT06260254

Effects of Railway Vibration on Sleep and Disease

A study testing Railway noise, Low level railway vibration and Intermediate level railway vibration in people with Noise Exposure and Sleep Disturbance, run by Göteborg University at 1 site in Sweden.

Completed

Finished. The study has ended and is not enrolling. Results may be posted on the official record.

Official record

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Trial summary

Who is it for?: Ages 18 to 30 yearsHealthy volunteers can take part
Conditions the study is for: Noise Exposure, Sleep Disturbance, Sleep Hygiene
What is being tested?: Railway noise, Low level railway vibration and Intermediate level railway vibration
Type of treatment: Surgery or procedure
Could I receive a placebo?: No, everyone receives an active treatment
How many people: 23 participants
Where: 1 siteSweden
Study dates: 5 Feb 2024to 31 Oct 2024
Phase: Interventional
Are there results?: None posted in the registry

Key requirements

Who can take part, as listed by the sponsor. Only the study team can confirm whether you are eligible, so take this list to your doctor.

Ages 18 to 30 years
All sexes
Healthy volunteers accepted
Adult

Who may be able to join

1) live in or around the city of Gothenburg area (Sweden)

Who cannot join

aged <18 or >30 years;
habitual sleep and wake timings more than ±1 hour different from the study sleep times (i.e. habitual sleep time should be 22:00-00:00 and habitual wake time should be 06:00-08:00);
BMI>25 kg/m2;
regular sleep medication use (prescribed or "over-the-counter");
poor hearing acuity (measured during screening via pure tone audiometry);
diagnosed with sleep disorders;

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diagnosed with diabetes
indications of sleep apnea on the STOP-BANG questionnaire;
shift work;
smoking, vaping, snus, or other nicotine use;
pregnant or breastfeeding

Trial locations and contacts

1 site in 1 country.

Sweden1 site

University of Gothenburg
Gothenburg, Västra Götaland County, 42650

Other trials in Sweden

About this study

This study will investigate the biological mechanisms linking sleep disruption by vibration and noise, and the development of cardiometabolic disease. In a laboratory sleep study, the investigators will play railway vibration of different levels during the night. The investigators will also measure objective sleep quality and quantity, cognitive performance across multiple domains, self-reported sleep and wellbeing outcomes, and blood samples. Blood samples will be analyzed to identify metabolic changes and indicators of diabetes risk in different nights. Identifying biomarkers that are impacted by sleep fragmentation will establish the currently unclear pathways by which railway vibration exposure at night can lead to the development of diseases in the long term, especially metabolic disorders including diabetes.

Read the detailed description

The experimental sleep study has the overarching goal of deepening understanding of sleep disruption by railway vibration and noise and changes in cardiometabolic and cognitive function. To this end, the study will address the following study aim:

Aim 1: Determine the biological and neurobehavioral consequences of sleep disruption by railway vibration. The investigators will measure the sleep of healthy volunteers, and each morning will obtain blood samples for metabolomics metabolic function analysis and administer a neurocognitive test battery. The investigators will compare effects on sleep, metabolomics, metabolic function and cognitive function between quiet nights and nights with railway traffic vibration and noise. Dose-response relationships will be determined by comparing nights with different levels of vibration.

This study will take place in the sound environment laboratory (SEL) at the University of Gothenburg Department of Occupational and Environmental Medicine. The SEL is a high fidelity research laboratory equipped to simulate a typical apartment, including three individually light-, sound- and vibration-isolated private bedrooms. Ceiling mounted speakers in each room and electrodynamic transducers mounted to the underside of each bed allow the investigators to create a realistic acoustic environment by transmitting sound and vibration exposures from the control room to each bedroom individually. The investigators have shown previously that results from this lab with high ecological validity are comparable with results from the field.

This study has a prospective within-subjects cross-over design. Participants (total N=24) will each spend five consecutive nights in the SEL, with a sleep opportunity between 23:00-07:00. Daytime sleep will be prohibited, confirmed with measures of daytime activity via wrist actigraphy monitors worn continuously throughout the study. Three subjects will take part concurrently, in separate bedrooms. The first night is a habituation period to the study protocol and for familiarization with the test procedures. The second night will be a quiet condition without noise or vibration, to determine normal baseline sleep, cardiometabolic profile, and cognitive performance. Study nights 3-5 are the vibration nights and will be randomly assigned across participants using a Latin square design to avoid first-order carryover effects. In these vibration nights, vibration and noise from railway freight will be played into the bedrooms to determine the effects of vibration and noise on sleep, cardiometabolic function and cognitive performance. Thirty six trains will occur each night, randomly distributed across the 8-hour sleep period.

For railway vibration the investigators will use synthesized signals based on measured data, used in previous laboratory studies. It is necessary to use synthesized vibration, rather than recorded signals, so that the investigators can accurately adjust the acoustical character of the exposure as needed. Railway vibration will be accompanied by high fidelity recordings of railway freight noise. This is to maximize ecological validity of the exposures since vibration rarely occurs without noise, and to mask any mechanical sounds from the vibration transducers.

Vibration and noise exposures will reflect realistic railway freight traffic noise levels that occur in dwellings alongside railway lines in Sweden. The maximum Wm-weighted vibration amplitudes in the three vibration nights will be 0.5 mm/s, 0.7 mm/s and 0.9 mm/s respectively. Maximum sound pressure levels of individual train passages will not exceed 49.8 dB LAF,max. Trains will vary from 11.5 s to 56.9 s in duration. All vibration amplitudes will be calibrated on the mattress of the bed, under a 75 kg reference weight to simulate the bed being occupied. All sound pressure levels will be calibrated to 10 cm above the pillow in each bedroom prior to the study, so that these levels accurately reflect the noise exposure of the subjects during sleep.

Each night the investigators will record physiologic sleep with polysomnography (PSG) and cardiac activity with electrocardiography (ECG). Each study morning, subjects will provide a 2ml blood sample and answer questionnaires and will depart the SEL to follow their normal daytime routine. They will return to the SEL at 20:00 each evening to prepare for sleep measurements. Caffeine will be prohibited after 15:00 and alcohol will be prohibited at all times. Because extreme and/or variable dietary behavior can affect the metabolome/lipoprotein profile, participants will be given guidance that they should eat a similar evening meal on each day of the laboratory study, confirmed with a food diary. The actual meal itself can be different for different study participants, because the study has a within-subjects design.

Sleep will be recorded with ambulatory polysomnography (PSG) and cardiac activity with electrocardiography (ECG) and finger pulse photoplethysmogram. Data are recorded offline onto the sleep recorder, and will be downloaded and checked every study morning to ensure data quality. In addition to traditional sleep analysis, raw PSG data will be used to calculate the Odds Ratio Project, a novel metric of sleep depth and stability.

Each study morning subjects will provide a 2 ml blood sample for plasma metabolomics analysis. To ensure reliable data, blood samples will be taken at the same time every day to mitigate circadian effects, before eating or drinking anything except water, and each sample will be handled in the same way i.e. centrifuged, aliquoted and stored in -80C freezers. Subjects will eat the same food each study evening to mitigate within-subject dietary effects on the blood metabolome. Furthermore, a 2-hour oral glucose tolerance test (OGTT) will be performed in the mornings after the quiet control night (i.e. after study night 2) and after the third vibration exposure night (i.e. after study night 5). The investigators will measure response to a 75g glucose bolus at timepoints 10, 20, 30, 60, 90 and 120 minutes after the glucose administration.

Each evening, subjects will complete a computerized cognitive test battery taking approximately 20 minutes, that includes 10 tests across a range of cognitive domains (motor praxis, visual object learning, fractal 2-back, abstract matching, line orientation, emotion recognition, matrix reasoning, digit symbol substitution, balloon analog risk, psychomotor vigilance). Cognition data will be analyzed to determine key measures of cognitive speed and accuracy, adjusting for practice effects and the difficulty of the stimulus set.

Subjects will complete a battery of one-time validated questionnaires to measure their general health (SF-36), chronotype, noise sensitivity, habitual sleep quality, environmental sensitivity, and annoyance and sleep disturbance by noise. Subjects will also answer a questionnaire each study evening and morning, involving questions on sleepiness (Karolinska Sleepiness Scale), auditory fatigue, sleep disturbance by noise, and validated sleep and disturbance questions.

Conditions: Noise Exposure, Sleep Disturbance, Sleep Hygiene, Metabolic Disturbance, Cognitive Change, Glucose Metabolism Disorders (Including Diabetes Mellitus)
Being tested: Railway noise, Low level railway vibration, Intermediate level railway vibration, High level railway vibration
Keywords: neurobehavioral performance, Traffic noise, auditory fatigue, polysomnography, metabolomics, vibration
Medical subject headings: Parasomnias, Sleep Hygiene, Glucose Metabolism Disorders

What participants receive

What participants receive. In a randomised study each person is assigned to one group by chance.

Railway noiseRadiation
Low level railway noise, not exceeding 50 dB LAF,max. Thirty six single railway noise events.
Low level railway vibrationRadiation
36 single railway noise events at 0.5 mm/s, varying from 11.5 s to 56.9 s in duration. Vibration always occurs concurrently with the noise exposure.
Intermediate level railway vibrationRadiation
36 single railway noise events at 0.7 mm/s, varying from 11.5 s to 56.9 s in duration. Vibration always occurs concurrently with the noise exposure.
High level railway vibrationRadiation
36 single railway noise events at 0.9 mm/s, varying from 11.5 s to 56.9 s in duration. Vibration always occurs concurrently with the noise exposure.

Study groups in NCT06260254
Study group	Role	What they receive
Control Night	No intervention	Single study night with no noise exposure, to determine normal baseline sleep.
Low Vibration Night	Experimental	Single study night with railway vibration and noise events, to determine consequences of sleep disturbance by railway vibration at a lower level Receives: Radiation: Railway noise; Radiation: Low level railway vibration
Intermediate Vibration Night	Experimental	Single study night with railway vibration and noise events, to determine consequences of sleep disturbance by railway vibration at an intermediate level Receives: Radiation: Railway noise; Radiation: Intermediate level railway vibration
High Vibration Night	Experimental	Single study night with railway vibration and noise events, to determine consequences of sleep disturbance by railway vibration at a higher level Receives: Radiation: Railway noise; Radiation: High level railway vibration

What is being measured

The primary outcome is the main question the study is designed to answer.

Fasting insulin resistance in the morning immediately after the Control night
Calculated using the Homeostatic model of insulin resistance (HOMA-IR)
Measured: One night
Fasting insulin resistance in the morning immediately after the low vibration night
Calculated using the Homeostatic model of insulin resistance (HOMA-IR)
Measured: One night
Fasting insulin resistance in the morning immediately after the intermediate vibration night
Calculated using the Homeostatic model of insulin resistance (HOMA-IR)
Measured: One night
Fasting insulin resistance in the morning immediately after the high vibration night
Calculated using the Homeostatic model of insulin resistance (HOMA-IR)
Measured: One night
Total sleep time during the Control night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Measured: One night
Total sleep time during the low vibration night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Measured: One night
Total sleep time during the intermediate vibration night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Measured: One night
Total sleep time during the high vibration night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Measured: One night
Total amount of N1 sleep during the Control night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Measured: One night
Total amount of N2 sleep during the Control night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Measured: One night
Total amount of N3 sleep during the Control night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Measured: One night
Total amount of rapid eye movement (REM) sleep during the Control night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Measured: One night
Total amount of N1 sleep during the low vibration night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Measured: One night
Total amount of N2 sleep during the low vibration night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Measured: One night
Total amount of N3 sleep during the low vibration night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Measured: One night
Total amount of rapid eye movement (REM) sleep during the low vibration night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Measured: One night
Total amount of N1 sleep during the intermediate vibration night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Measured: One night
Total amount of N2 sleep during the intermediate vibration night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Measured: One night
Total amount of N3 sleep during the intermediate vibration night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Measured: One night
Total amount of rapid eye movement (REM) sleep during the intermediate vibration night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Measured: One night
Total amount of N1 sleep during the high vibration night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Measured: One night
Total amount of N2 sleep during the high vibration night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Measured: One night
Total amount of N3 sleep during the high vibration night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Measured: One night
Total amount of rapid eye movement (REM) sleep during the high vibration night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Measured: One night
Wakefulness after sleep onset (WASO) during the Control night
Total number of minutes awake during the night after the first appearance of sleep of any stage. Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines.
Measured: One night
Wakefulness after sleep onset (WASO) during the low vibration night
Total number of minutes awake during the night after the first appearance of sleep of any stage. Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines.
Measured: One night
Wakefulness after sleep onset (WASO) during the intermediate night
Total number of minutes awake during the night after the first appearance of sleep of any stage. Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines.
Measured: One night
Wakefulness after sleep onset (WASO) during the high vibration night
Total number of minutes awake during the night after the first appearance of sleep of any stage. Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines.
Measured: One night
Number of awakenings during the Control night
Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines.
Measured: One night
Number of awakenings during exposure to low vibration
Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines.
Measured: One night
Number of awakenings during exposure to intermediate vibration
Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines.
Measured: One night
Number of awakenings during exposure to high vibration
Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines.
Measured: One night
Sleep onset latency (SOL) during the Control Night
Defined as the time from lights out to the first epoch of sleep. Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines.
Measured: One night
Sleep onset latency (SOL) during the low vibration night
Defined as the time from lights out to the first epoch of sleep. Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines.
Measured: One night
Sleep onset latency (SOL) during the intermediate vibration night
Defined as the time from lights out to the first epoch of sleep. Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines.
Measured: One night
Sleep onset latency (SOL) during the high vibration night
Defined as the time from lights out to the first epoch of sleep. Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines.
Measured: One night
Sleep efficiency during the Control night
Defined as the percentage of time in bed spent in a non-wake sleep stage, measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines.
Measured: One night
Sleep efficiency during the low vibration night
Defined as the percentage of time in bed spent in a non-wake sleep stage, measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines.
Measured: One night
Sleep efficiency during the intermediate vibration night
Defined as the percentage of time in bed spent in a non-wake sleep stage, measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines.
Measured: One night
S Sleep efficiency during the high vibration night
Defined as the percentage of time in bed spent in a non-wake sleep stage, measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines.
Measured: One night
Sleep depth assessed using the odds ratio product (ORP) during the Control night
Average ORP over the full night, from 0 (never occurs during wake) to 2.5 (only occurs during wake). Derived via polysomnography/EEG measurements.
Measured: One night
Sleep depth assessed using the odds ratio product (ORP) during the low vibration night
Average ORP over the full night, from 0 (never occurs during wake) to 2.5 (only occurs during wake). Derived via polysomnography/EEG measurements.
Measured: One night
Sleep depth assessed using the odds ratio product (ORP) during the intermediate vibration night
Average ORP over the full night, from 0 (never occurs during wake) to 2.5 (only occurs during wake). Derived via polysomnography/EEG measurements.
Measured: One night
Sleep depth assessed using the odds ratio product (ORP) during the high vibration night
Average ORP over the full night, from 0 (never occurs during wake) to 2.5 (only occurs during wake). Derived via polysomnography/EEG measurements.
Measured: One night
Maximal change of odds ratio product (ORP) during exposure to railway vibration events
Measure of acute sleep disruption by noise, calculated as the difference between the ORP in the 30s prior to noise onset and the maximum ORP during railway vibration. Averaged over 36 vibration events during the night.
Measured: One night
Area under the curve of odds ratio product (ORP) during exposure to railway vibration events, calculated using the trapezoid rule
Measure of acute sleep disruption by noise, calculated as the difference between the ORP in the 30s prior to noise onset and the maximum ORP during railway vibration. Averaged over 36 vibration events during the night.
Measured: One night
N-acetylglucosamine/galactosamine (GlycA) concentration after the Control night
Determined from NMR analysis of blood plasma
Measured: One night
N-acetylglucosamine/galactosamine (GlycA) concentration after exposure to low vibration night
Determined from NMR analysis of blood plasma
Measured: One night
N-acetylglucosamine/galactosamine (GlycA) concentration after exposure to intermediate vibration
Determined from NMR analysis of blood plasma
Measured: One night
N-acetylglucosamine/galactosamine (GlycA) concentration after exposure to high vibration
Determined from NMR analysis of blood plasma
Measured: One night
Sialic acid (GlycB) concentration after the Control night
Determined from NMR analysis of blood plasma
Measured: One night
Sialic acid (GlycB) concentration after exposure to low vibration
Determined from NMR analysis of blood plasma
Measured: One night
Sialic acid (GlycB) concentration after exposure to intermediate vibration
Determined from NMR analysis of blood plasma
Measured: One night
Sialic acid (GlycB) concentration after exposure to high vibration
Determined from NMR analysis of blood plasma
Measured: One night
Supramolecular phospholipid composite (SPC) concentration after the Control night
Determined from NMR analysis of blood plasma
Measured: One night
Supramolecular phospholipid composite (SPC) concentration after exposure to low vibration
Determined from NMR analysis of blood plasma
Measured: One night
Supramolecular phospholipid composite (SPC) concentration after exposure to intermediate vibration
Determined from NMR analysis of blood plasma
Measured: One night
Supramolecular phospholipid composite (SPC) concentration after exposure to high vibration
Determined from NMR analysis of blood plasma
Measured: One night
Ethanol concentration (mmol/L) after the Control night
Determined from NMR analysis of blood plasma
Measured: One night
Ethanol concentration (mmol/L) after exposure to low vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Ethanol concentration (mmol/L) after exposure to intermediate vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Ethanol concentration (mmol/L) after exposure to high vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Trimethylamine-N-oxide concentration (mmol/L) after exposure to Control night
Determined from NMR analysis of blood plasma
Measured: One night
Trimethylamine-N-oxide concentration (mmol/L) after exposure to low vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Trimethylamine-N-oxide concentration (mmol/L) after exposure to intermediate vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Trimethylamine-N-oxide concentration (mmol/L) after exposure to high vibration night
Determined from NMR analysis of blood plasma
Measured: One night
2-Aminobutyric acid concentration (mmol/L) after exposure to Control night
Determined from NMR analysis of blood plasma
Measured: One
2-Aminobutyric acid concentration (mmol/L) after exposure to low vibration night
Determined from NMR analysis of blood plasma
Measured: One
2-Aminobutyric acid concentration (mmol/L) after exposure to intermediate vibration night
Determined from NMR analysis of blood plasma
Measured: One
2-Aminobutyric acid concentration (mmol/L) after exposure to high vibration night
Determined from NMR analysis of blood plasma
Measured: One
Alanine concentration (mmol/L) after exposure to Control night
Determined from NMR analysis of blood plasma
Measured: One night
Alanine concentration (mmol/L) after exposure to low vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Alanine concentration (mmol/L) after exposure to intermediate vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Alanine concentration (mmol/L) after exposure to high vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Asparagine concentration (mmol/L) after exposure to Control night
Determined from NMR analysis of blood plasma
Measured: One night
Asparagine concentration (mmol/L) after exposure to low vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Asparagine concentration (mmol/L) after exposure to intermediate vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Asparagine concentration (mmol/L) after exposure to high vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Creatine concentration (mmol/L) after exposure to Control night
Determined from NMR analysis of blood plasma
Measured: One night
Creatine concentration (mmol/L) after exposure to low vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Creatine concentration (mmol/L) after exposure to intermediate vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Creatine concentration (mmol/L) after exposure to high vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Creatinine concentration (mmol/L) after exposure to Control night
Determined from NMR analysis of blood plasma
Measured: One night
Creatinine concentration (mmol/L) after exposure to low vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Creatinine concentration (mmol/L) after exposure to intermediate vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Creatinine concentration (mmol/L) after exposure to high vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Glutamic acid concentration (mmol/L) after exposure to Control night
Determined from NMR analysis of blood plasma
Measured: One night
Glutamic acid concentration (mmol/L) after exposure to low vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Glutamic acid concentration (mmol/L) after exposure to intermediate vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Glutamic acid concentration (mmol/L) after exposure to high vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Glutamine concentration (mmol/L) after exposure to Control night
Determined from NMR analysis of blood plasma
Measured: One night
Glutamine concentration (mmol/L) after exposure to low vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Glutamine concentration (mmol/L) after exposure to intermediate vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Glutamine concentration (mmol/L) after exposure to high vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Glycine concentration (mmol/L) after exposure to Control night
Determined from NMR analysis of blood plasma
Measured: One night
Glycine concentration (mmol/L) after exposure to low vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Glycine concentration (mmol/L) after exposure to intermediate vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Glycine concentration (mmol/L) after exposure to high vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Histidine concentration (mmol/L) after exposure to Control night
Determined from NMR analysis of blood plasma
Measured: One night
Histidine concentration (mmol/L) after exposure to low vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Histidine concentration (mmol/L) after exposure to intermediate vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Histidine concentration (mmol/L) after exposure to high vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Isoleucine concentration (mmol/L) after exposure to Control night
Determined from NMR analysis of blood plasma
Measured: One night
Isoleucine concentration (mmol/L) after exposure to low vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Isoleucine concentration (mmol/L) after exposure to intermediate vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Isoleucine concentration (mmol/L) after exposure to high vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Leucine concentration (mmol/L) after exposure to Control night
Determined from NMR analysis of blood plasma
Measured: One night
Leucine concentration (mmol/L) after exposure to low vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Leucine concentration (mmol/L) after exposure to intermediate vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Leucine concentration (mmol/L) after exposure to high vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Lysine concentration (mmol/L) after exposure to Control night
Determined from NMR analysis of blood plasma
Measured: One night
Lysine concentration (mmol/L) after exposure to low vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Lysine concentration (mmol/L) after exposure to intermediate vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Lysine concentration (mmol/L) after exposure to high vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Methionine concentration (mmol/L) after exposure to Control night
Determined from NMR analysis of blood plasma
Measured: One night
Methionine concentration (mmol/L) after exposure to low vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Methionine concentration (mmol/L) after exposure to intermediate vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Methionine concentration (mmol/L) after exposure to high vibration night
Determined from NMR analysis of blood plasma
Measured: One night
N,N-Dimethylglycine concentration (mmol/L) after Control night
Determined from NMR analysis of blood plasma
Measured: One night
N,N-Dimethylglycine concentration (mmol/L) after exposure to low vibration night
Determined from NMR analysis of blood plasma
Measured: One night
N,N-Dimethylglycine concentration (mmol/L) after exposure to intermediate vibration night
Determined from NMR analysis of blood plasma
Measured: One night
N,N-Dimethylglycine concentration (mmol/L) after exposure to high vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Ornithine concentration (mmol/L) after exposure to Control night
Determined from NMR analysis of blood plasma
Measured: One night
Ornithine concentration (mmol/L) after exposure to low vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Ornithine concentration (mmol/L) after exposure to intermediate vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Ornithine concentration (mmol/L) after exposure to high vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Phenylalanine concentration (mmol/L) after exposure to Control night
Determined from NMR analysis of blood plasma
Measured: One night
Phenylalanine concentration (mmol/L) after exposure to low vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Phenylalanine concentration (mmol/L) after exposure to intermediate vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Phenylalanine concentration (mmol/L) after exposure to high vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Proline concentration (mmol/L) after exposure to Control night
Determined from NMR analysis of blood plasma
Measured: One night
Proline concentration (mmol/L) after exposure to low vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Proline concentration (mmol/L) after exposure to intermediate vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Proline concentration (mmol/L) after exposure to high vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Sarcosine concentration (mmol/L) after exposure to Control night
Determined from NMR analysis of blood plasma
Measured: One night
Sarcosine concentration (mmol/L) after exposure to low vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Sarcosine concentration (mmol/L) after exposure to intermediate vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Sarcosine concentration (mmol/L) after exposure to high vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Threonine concentration (mmol/L) after exposure to Control night
Determined from NMR analysis of blood plasma
Measured: One night
Threonine concentration (mmol/L) after exposure to low vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Threonine concentration (mmol/L) after exposure to intermediate vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Threonine concentration (mmol/L) after exposure to high vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Tyrosine concentration (mmol/L) after exposure toControl night
Determined from NMR analysis of blood plasma
Measured: One night
Tyrosine concentration (mmol/L) after exposure to low vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Tyrosine concentration (mmol/L) after exposure to intermediate vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Tyrosine concentration (mmol/L) after exposure to high vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Valine concentration (mmol/L) after Control night
Determined from NMR analysis of blood plasma
Measured: One night
Valine concentration (mmol/L) after exposure to low vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Valine concentration (mmol/L) after exposure to intermediate vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Valine concentration (mmol/L) after exposure to high vibration night
Determined from NMR analysis of blood plasma
Measured: One night
2-Hydroxybutyric acid concentration (mmol/L) after exposure to Control night
Determined from NMR analysis of blood plasma
Measured: One night
2-Hydroxybutyric acid concentration (mmol/L) after exposure to low vibration night
Determined from NMR analysis of blood plasma
Measured: One night
2-Hydroxybutyric acid concentration (mmol/L) after exposure to intermediate vibration night
Determined from NMR analysis of blood plasma
Measured: One night
2-Hydroxybutyric acid concentration (mmol/L) after exposure to high vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Acetic acid concentration (mmol/L) after exposure to Control night
Determined from NMR analysis of blood plasma
Measured: One night
Acetic acid concentration (mmol/L) after exposure to low vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Acetic acid concentration (mmol/L) after exposure to intermediate vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Acetic acid concentration (mmol/L) after exposure to high vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Citric acid concentration (mmol/L) after Control night
Determined from NMR analysis of blood plasma
Measured: One night
Citric acid concentration (mmol/L) after exposure to low vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Citric acid concentration (mmol/L) after exposure to intermediate vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Citric acid concentration (mmol/L) after exposure to high vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Formic acid concentration (mmol/L) after exposure to Control night
Determined from NMR analysis of blood plasma
Measured: One night
Formic acid concentration (mmol/L) after exposure to low vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Formic acid concentration (mmol/L) after exposure to intermediate vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Formic acid concentration (mmol/L) after exposure to high vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Lactic acid concentration (mmol/L) after exposure to Control night
Determined from NMR analysis of blood plasma
Measured: One night
Lactic acid concentration (mmol/L) after exposure to low vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Lactic acid concentration (mmol/L) after exposure to intermediate vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Lactic acid concentration (mmol/L) after exposure to high vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Succinic acid concentration (mmol/L) after exposure to Control night
Determined from NMR analysis of blood plasma
Measured: One night
Succinic acid concentration (mmol/L) after exposure to low vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Succinic acid concentration (mmol/L) after exposure to intermediate vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Succinic acid concentration (mmol/L) after exposure to high vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Choline concentration (mmol/L) after exposure to Control night
Determined from NMR analysis of blood plasma
Measured: One night
Choline concentration (mmol/L) after exposure to low vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Choline concentration (mmol/L) after exposure to intermediate vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Choline concentration (mmol/L) after exposure to high vibration night
Determined from NMR analysis of blood plasma
Measured: One night
2-Oxoglutaric acid concentration (mmol/L) after exposure to Control night
Determined from NMR analysis of blood plasma
Measured: One night
2-Oxoglutaric acid concentration (mmol/L) after exposure to low vibration night
Determined from NMR analysis of blood plasma
Measured: One night
2-Oxoglutaric acid concentration (mmol/L) after exposure to intermediate vibration night
Determined from NMR analysis of blood plasma
Measured: One night
2-Oxoglutaric acid concentration (mmol/L) after exposure to high vibration night
Determined from NMR analysis of blood plasma
Measured: One night
3-Hydroxybutyric acid concentration (mmol/L) after exposure to Control night
Determined from NMR analysis of blood plasma
Measured: One night
3-Hydroxybutyric acid concentration (mmol/L) after exposure to low vibration night
Determined from NMR analysis of blood plasma
Measured: One night
3-Hydroxybutyric acid concentration (mmol/L) after exposure to intermediate vibration night
Determined from NMR analysis of blood plasma
Measured: One night
3-Hydroxybutyric acid concentration (mmol/L) after exposure to high vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Acetoacetic acid concentration (mmol/L) after exposure to Control night
Determined from NMR analysis of blood plasma
Measured: One night
Acetoacetic acid concentration (mmol/L) after exposure to low vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Acetoacetic acid concentration (mmol/L) after exposure to intermediate vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Acetoacetic acid concentration (mmol/L) after exposure to high vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Acetone concentration (mmol/L) after exposure to Control night
Determined from NMR analysis of blood plasma
Measured: One night
Acetone concentration (mmol/L) after exposure to low vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Acetone concentration (mmol/L) after exposure to intermediate vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Acetone concentration (mmol/L) after exposure to high vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Pyruvic acid concentration (mmol/L) after exposure to Control night
Determined from NMR analysis of blood plasma
Measured: One night
Pyruvic acid concentration (mmol/L) after exposure to low vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Pyruvic acid concentration (mmol/L) after exposure to intermediate vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Pyruvic acid concentration (mmol/L) after exposure to high vibration night
Determined from NMR analysis of blood plasma
Measured: One night
D-Galactose concentration (mmol/L) after exposure to Control night
Determined from NMR analysis of blood plasma
Measured: One night
D-Galactose concentration (mmol/L) after exposure to low vibration night
Determined from NMR analysis of blood plasma
Measured: One night
D-Galactose concentration (mmol/L) after exposure to intermediate vibration night
Determined from NMR analysis of blood plasma
Measured: One night
D-Galactose concentration (mmol/L) after exposure to high vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Glucose concentration (mmol/L) after exposure to Control night
Determined from NMR analysis of blood plasma
Measured: One night
Glucose concentration (mmol/L) after exposure to low vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Glucose concentration (mmol/L) after exposure to intermediate vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Glucose concentration (mmol/L) after exposure to high vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Glycerol concentration (mmol/L) after exposure to Control night
Determined from NMR analysis of blood plasma
Measured: One night
Glycerol concentration (mmol/L) after exposure to low vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Glycerol concentration (mmol/L) after exposure to intermediate vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Glycerol concentration (mmol/L) after exposure to high vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Dimethylsulfone concentration (mmol/L) after exposure to Control night
Determined from NMR analysis of blood plasma
Measured: One night
Dimethylsulfone concentration (mmol/L) after exposure to low vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Dimethylsulfone concentration (mmol/L) after exposure to intermediate vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Dimethylsulfone concentration (mmol/L) after exposure to high vibration night
Determined from NMR analysis of blood plasma
Measured: One night
Response to an oral glucose bolus, calculated as area under curve for glucose, in the morning after the control night
Area under the curve (AUC) calculated using the trapezoidal rule, from glucose samples collected 10, 20, 30, 60, 90 and 120 minutes after the glucose bolus.
Measured: One night
Response to an oral glucose bolus, calculated as area under curve for glucose, in the morning after the low vibration night
Area under the curve (AUC) calculated using the trapezoidal rule, from glucose samples collected 10, 20, 30, 60, 90 and 120 minutes after the glucose bolus.
Measured: One night
Response to an oral glucose bolus, calculated as area under curve for glucose, in the morning after the intermediate vibration night
Area under the curve (AUC) calculated using the trapezoidal rule, from glucose samples collected 10, 20, 30, 60, 90 and 120 minutes after the glucose bolus.
Measured: One night
Response to an oral glucose bolus, calculated as area under curve for glucose, in the morning after the high vibration night
Area under the curve (AUC) calculated using the trapezoidal rule, from glucose samples collected 10, 20, 30, 60, 90 and 120 minutes after the glucose bolus.
Measured: One night
Response to an oral glucose load calculated as area under curve for insulin, in the morning after the low vibration night
Area under the curve (AUC) calculated using the trapezoidal rule, from insulin samples collected 10, 20, 30, 60, 90 and 120 minutes after the glucose bolus
Measured: One night
Response to an oral glucose load calculated as area under curve for insulin, in the morning after the intermediate vibration night
Area under the curve (AUC) calculated using the trapezoidal rule, from insulin samples collected 10, 20, 30, 60, 90 and 120 minutes after the glucose bolus
Measured: One night
Response to an oral glucose load calculated as area under curve for insulin, in the morning after the high vibration night
Area under the curve (AUC) calculated using the trapezoidal rule, from insulin samples collected 10, 20, 30, 60, 90 and 120 minutes after the glucose bolus
Measured: One night
Early response to an oral glucose load calculated as area under curve for insulin, in the morning after the control night
Area under the curve (AUC) calculated using the trapezoidal rule, from insulin samples collected 10, 20 and 30 minutes after the glucose bolus
Measured: One night
Early response to an oral glucose load calculated as area under curve for insulin, in the morning after the low vibration night
Area under the curve (AUC) calculated using the trapezoidal rule, from insulin samples collected 10, 20 and 30 minutes after the glucose bolus
Measured: One night
Early response to an oral glucose load calculated as area under curve for insulin, in the morning after the intermediate vibration night
Area under the curve (AUC) calculated using the trapezoidal rule, from insulin samples collected 10, 20 and 30 minutes after the glucose bolus
Measured: One night
Early response to an oral glucose load calculated as area under curve for insulin, in the morning after the high vibration night
Area under the curve (AUC) calculated using the trapezoidal rule, from insulin samples collected 10, 20 and 30 minutes after the glucose bolus
Measured: One night
Glucose tolerance in the morning after exposure to low vibration, assessed as glucose concentration 120 minutes after a glucose bolus
Glucose concentrations determined from plasma samples with the Hexokinase/G-6-PDH method
Measured: One night
Glucose tolerance in the morning after exposure to intermediate vibration, assessed as glucose concentration 120 minutes after a glucose bolus
Glucose concentrations determined from plasma samples with the Hexokinase/G-6-PDH method
Measured: One night
Glucose tolerance in the morning after exposure to high vibration, assessed as glucose concentration 120 minutes after a glucose bolus
Glucose concentrations determined from plasma samples with the Hexokinase/G-6-PDH method
Measured: One night
Glucose tolerance in the morning after Control night, assessed as glucose concentration 120 minutes after a glucose bolus
Glucose concentrations determined from plasma samples with the Hexokinase/G-6-PDH method
Measured: One night
Stumvoll Insulin sensitivity Index in the morning after control
.226 - 0.0032 × BMI - 0.0000645 × I120 - 0.00375 × G90, where I120 and G90 represent insulin concentration 120 minutes after the glucose bolus, and glucose concentration 90 minutes after the glucose bolus, respectively.
Measured: One night
Stumvoll Insulin sensitivity Index in the morning after exposure to low vibration
.226 - 0.0032 × BMI - 0.0000645 × I120 - 0.00375 × G90, where I120 and G90 represent insulin concentration 120 minutes after the glucose bolus, and glucose concentration 90 minutes after the glucose bolus, respectively.
Measured: One night
Stumvoll Insulin sensitivity Index in the morning after exposure to intermediate vibration
.226 - 0.0032 × BMI - 0.0000645 × I120 - 0.00375 × G90, where I120 and G90 represent insulin concentration 120 minutes after the glucose bolus, and glucose concentration 90 minutes after the glucose bolus, respectively.
Measured: One night
Stumvoll Insulin sensitivity Index in the morning after exposure to high vibration
.226 - 0.0032 × BMI - 0.0000645 × I120 - 0.00375 × G90, where I120 and G90 represent insulin concentration 120 minutes after the glucose bolus, and glucose concentration 90 minutes after the glucose bolus, respectively.
Measured: One night
Matsuda insulin sensitivity index in the morning after control exposure
Calculated as 10,000/square root of [fasting glucose × fasting insulin] × [mean glucose × mean insulin during oral glucose tolerance test])
Measured: One night
Matsuda insulin sensitivity index in the morning after exposure to low vibration
Calculated as 10,000/square root of [fasting glucose × fasting insulin] × [mean glucose × mean insulin during oral glucose tolerance test])
Measured: One night
Matsuda insulin sensitivity index in the morning after exposure to intermediate vibration
Calculated as 10,000/square root of [fasting glucose × fasting insulin] × [mean glucose × mean insulin during oral glucose tolerance test])
Measured: One night
Matsuda insulin sensitivity index in the morning after exposure to high vibration
Calculated as 10,000/square root of [fasting glucose × fasting insulin] × [mean glucose × mean insulin during oral glucose tolerance test])
Measured: One night

Secondary outcomes (34)

Evening subjective sleepiness, assessed using the Karolinska Sleepiness Scale after exposure to control
The scale is a 9-level verbal scale from 1 - "Extremely alert" (best outcome) to 9 - "Very sleepy. great effort to keep alert, fighting sleep" (worst outcome)
Measured: One night
Evening subjective sleepiness, assessed using the Karolinska Sleepiness Scale after exposure to low vibration
The scale is a 9-level verbal scale from 1 - "Extremely alert" (best outcome) to 9 - "Very sleepy. great effort to keep alert, fighting sleep" (worst outcome)
Measured: One night
Evening subjective sleepiness, assessed using the Karolinska Sleepiness Scale after exposure to intermediate vibration
The scale is a 9-level verbal scale from 1 - "Extremely alert" (best outcome) to 9 - "Very sleepy. great effort to keep alert, fighting sleep" (worst outcome)
Measured: One night
Evening subjective sleepiness, assessed using the Karolinska Sleepiness Scale after exposure to high vibration
The scale is a 9-level verbal scale from 1 - "Extremely alert" (best outcome) to 9 - "Very sleepy. great effort to keep alert, fighting sleep" (worst outcome)
Measured: One night
Morning subjective sleepiness, assessed using the Karolinska Sleepiness Scale after exposure to control
The scale is a 9-level verbal scale from 1 - "Extremely alert" (best outcome) to 9 - "Very sleepy. great effort to keep alert, fighting sleep" (worst outcome)
Measured: One night
Morning subjective sleepiness, assessed using the Karolinska Sleepiness Scale after exposure to low vibration
The scale is a 9-level verbal scale from 1 - "Extremely alert" (best outcome) to 9 - "Very sleepy. great effort to keep alert, fighting sleep" (worst outcome)
Measured: One night
Morning subjective sleepiness, assessed using the Karolinska Sleepiness Scale after exposure to intermediate vibration
The scale is a 9-level verbal scale from 1 - "Extremely alert" (best outcome) to 9 - "Very sleepy. great effort to keep alert, fighting sleep" (worst outcome)
Measured: One night
Morning subjective sleepiness, assessed using the Karolinska Sleepiness Scale after exposure to high vibration
The scale is a 9-level verbal scale from 1 - "Extremely alert" (best outcome) to 9 - "Very sleepy. great effort to keep alert, fighting sleep" (worst outcome)
Measured: One night
Self-reported sleep disturbance by vibration after control exposure
Assessed on a 0-10 numerical scale, from "Not at all" to "Extremely"
Measured: One night
Self-reported sleep disturbance by vibration after exposure to low vibration
Assessed on a 0-10 numerical scale, from "Not at all" to "Extremely"
Measured: One night
Self-reported sleep disturbance by vibration after exposure to intermediate vibration
Assessed on a 0-10 numerical scale, from "Not at all" to "Extremely"
Measured: One night
Self-reported sleep disturbance by vibration after exposure to high vibration
Assessed on a 0-10 numerical scale, from "Not at all" to "Extremely"
Measured: One night
Morning positive affect, assessed using the Positive and Negative Affect Schedule (PANAS) after control exposure
PANAS is a 20-item instrument in which 20 words describing current mood and emotional state are rated on a 5-point Likert scale from "Not at all" to "Extremely". A composite positive affect score is calculated from 10 of these.
Measured: One night.
Morning positive affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to low vibration
PANAS is a 20-item instrument in which 20 words describing current mood and emotional state are rated on a 5-point Likert scale from "Not at all" to "Extremely". A composite positive affect score is calculated from 10 of these.
Measured: One night.
Morning positive affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to intermediate vibration
PANAS is a 20-item instrument in which 20 words describing current mood and emotional state are rated on a 5-point Likert scale from "Not at all" to "Extremely". A composite positive affect score is calculated from 10 of these.
Measured: One night.
Morning positive affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to high vibration
PANAS is a 20-item instrument in which 20 words describing current mood and emotional state are rated on a 5-point Likert scale from "Not at all" to "Extremely". A composite positive affect score is calculated from 10 of these.
Measured: One night.
Morning negative affect, assessed using the Positive and Negative Affect Schedule (PANAS) after control exposure
PANAS is a 20-item instrument in which 20 words describing current mood and emotional state are rated on a 5-point Likert scale from "Not at all" to "Extremely". A composite positive affect score is calculated from 10 of these.
Measured: One night.
Morning negative affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to low vibration
PANAS is a 20-item instrument in which 20 words describing current mood and emotional state are rated on a 5-point Likert scale from "Not at all" to "Extremely". A composite positive affect score is calculated from 10 of these.
Measured: One night.
Morning negative affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to intermediate vibration
PANAS is a 20-item instrument in which 20 words describing current mood and emotional state are rated on a 5-point Likert scale from "Not at all" to "Extremely". A composite positive affect score is calculated from 10 of these.
Measured: One night.
Morning negative affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to high vibration
PANAS is a 20-item instrument in which 20 words describing current mood and emotional state are rated on a 5-point Likert scale from "Not at all" to "Extremely". A composite positive affect score is calculated from 10 of these.
Measured: One night.
Evening negative affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to control
PANAS is a 20-item instrument in which 20 words describing current mood and emotional state are rated on a 5-point Likert scale from "Not at all" to "Extremely". A composite positive affect score is calculated from 10 of these.
Measured: One night.
Evening negative affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to low vibration
PANAS is a 20-item instrument in which 20 words describing current mood and emotional state are rated on a 5-point Likert scale from "Not at all" to "Extremely". A composite positive affect score is calculated from 10 of these.
Measured: One night.
Evening negative affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to intermediate vibration
PANAS is a 20-item instrument in which 20 words describing current mood and emotional state are rated on a 5-point Likert scale from "Not at all" to "Extremely". A composite positive affect score is calculated from 10 of these.
Measured: One night.
Evening negative affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to high vibration
PANAS is a 20-item instrument in which 20 words describing current mood and emotional state are rated on a 5-point Likert scale from "Not at all" to "Extremely". A composite positive affect score is calculated from 10 of these.
Measured: One night.
Evening positive affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to control
PANAS is a 20-item instrument in which 20 words describing current mood and emotional state are rated on a 5-point Likert scale from "Not at all" to "Extremely". A composite positive affect score is calculated from 10 of these.
Measured: One night.
Evening positive affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to low vibration
PANAS is a 20-item instrument in which 20 words describing current mood and emotional state are rated on a 5-point Likert scale from "Not at all" to "Extremely". A composite positive affect score is calculated from 10 of these.
Measured: One night.
Evening positive affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to intermediate vibration
PANAS is a 20-item instrument in which 20 words describing current mood and emotional state are rated on a 5-point Likert scale from "Not at all" to "Extremely". A composite positive affect score is calculated from 10 of these.
Measured: One night.
Evening positive affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to high vibration
PANAS is a 20-item instrument in which 20 words describing current mood and emotional state are rated on a 5-point Likert scale from "Not at all" to "Extremely". A composite positive affect score is calculated from 10 of these.
Measured: One night.
Event-related cardiovascular activation in response to control
Change in heart rate (ECG)
Measured: One night
Event-related cardiovascular activation in response to low vibration
Change in heart rate (ECG)
Measured: One night
Event-related cardiovascular activation in response to intermediate vibration
Change in heart rate (ECG)
Measured: One night
Event-related cardiovascular activation in response to high vibration
Change in heart rate (ECG)
Measured: One night
Evening neurobehavioural speed
Average of one key speed indicator from each of 10 cognitive tests (motor praxis, visual object learning, fractal 2-back, abstract matching, line orientation, emotion recognition, matrix reasoning, digit symbol substitution, balloon analog risk, psychomotor vigilance)
Measured: One night
Evening neurobehavioural accuracy
Average of one key accuracy indicator from each of 9 cognitive tests (motor praxis, visual object learning, fractal 2-back, abstract matching, line orientation, emotion recognition, matrix reasoning, digit symbol substitution, psychomotor vigilance)
Measured: One night

Timeline

From the start of the study to its completion; the mark is today. Estimated dates are the sponsor’s plan.

5 Feb 202431 Oct 2024

First posted15 Feb 2024
Study start5 Feb 2024
Primary completion14 Jun 2024
Study completion31 Oct 2024

Resources

Official record on ClinicalTrials.govThe registry entry this page is built from, with its full change history.
Other trials for Noise ExposureStudies of the same condition, open and under way.
More trials run by Göteborg UniversityThe sponsor's other registered studies.
What the trial phases meanHow a treatment moves from first tests in people to approval.

More details

For doctors and researchers: how the study is designed, who runs it, and its registry IDs.

Study design

Study type: Interventional
Phase: Phase N/A
Primary purpose: Basic science
Allocation: Randomised
Intervention model: Crossover
Model description: All participants will be exposed to each of the different vibration conditions. Each study night is treated as a separate arm of the crossover study. The order of the vibration exposure conditions will be be randomly assigned across participants using a Latin square design to avoid first-order carryover effects. Each subject will be exposed to one night of each of the following: Quiet night: No noise or vibration will be played, serving as a control night to assess individual baseline sleep, metabolic profile, and cognitive performance; Three railway vibration nights to determine consequences of noise-disrupted sleep. The vibration level in these three nights will be 0.5 mm/s, 0.7 mm/s and 0.9 mm/s respectively, so that exposure-response relationships can be derived.
Masking: Double blind
Who is masked: Participant, Outcomes assessor
Enrolment: 23 participants (actual)

IDs, dates and publications

ClinicalTrials.gov ID: NCT06260254
Sponsor's protocol ID: 244826201
Acronym: BioVib
Status last verified: Mar 2025
First submitted: 7 Feb 2024
Last updated: 13 Mar 2025
Results posted: No
Data monitoring committee: No
FDA-regulated drug: No
FDA-regulated device: No

Want to know more?

The sponsor has not listed a contact. The official record may have more details.

Talk to your doctor first and take this page with you. Only the study team can confirm whether you can join.

Questions to ask the study team

What is the study trying to find out?
What would I need to do, and how often would I visit?
Could I receive a placebo instead of the treatment?
What are the possible risks and benefits for me?
Will it cost me anything? Are travel or time paid for?
Can I keep seeing my own doctor during the study?
What happens when the study ends?

See locations

Active, not recruitingObservational study
Federal Aviation Administration (FAA) National Sleep Study
Noise Exposure
Recruiting
Ambient Air and Noise Effect on Cardiovascular Health Risk and Lifestyle Intervention to Attenuate It (METSGREEN)
Cardiovascular Diseases (CVD), Metabolic Syndrome
RecruitingObservational study
Effect of Operating Room Noise on BIS and Hemodynamics Under General Anesthesia
General Anesthesia, Hemodynamics
Not yet recruitingObservational study
OCCUPATIONAL NOISE AND CHEMICAL EXPOSURE EFFECTS ON AUDITORY AND VESTIBULAR FUNCTION
Occupational Noise Exposure
Enrolling by invitation
Comparative Efficacy of Earplug Usage Instruction
Noise-Induced Hearing Loss, Hearing Protection Device Use

All Noise Exposure trials

Study at a glance

From the registry record, last updated by the sponsor on 13 Mar 2025. Recruitment status is as the sponsor reported it: confirm with the study team.

Official title: Effects of Railway Vibration on Sleep and Disease
ClinicalTrials.gov ID: NCT06260254
Acronym / sponsor ID: BioVib / 244826201
Conditions: Noise Exposure, Sleep Disturbance, Sleep Hygiene, Metabolic Disturbance, Cognitive Change, Glucose Metabolism Disorders (Including Diabetes Mellitus)
Keywords: neurobehavioral performance, Traffic noise, auditory fatigue, polysomnography, metabolomics, vibration
Study type: Interventional
Recruitment status: Completed
Enrolment: 23 participants (actual)
Lead sponsor: Göteborg UniversityUniversity, hospital or other
Collaborators: University of Pennsylvania, University of Manitoba
Study start: 5 Feb 2024 (actual)
Primary completion: 14 Jun 2024 (actual)
Study completion: 31 Oct 2024 (actual)
First posted: 15 Feb 2024 (actual)
Results: Not posted in the source record

Clinical summary

The research question as the sponsor registered it. This describes what the study plans to test, not what it found.

Detailed description

Study design

Primary purpose: Basic science
Allocation: Randomised
Intervention model: Crossover
Masking: Double blind (participant, outcomes assessor)
Number of arms: 4
Model description: All participants will be exposed to each of the different vibration conditions. Each study night is treated as a separate arm of the crossover study. The order of the vibration exposure conditions will be be randomly assigned across participants using a Latin square design to avoid first-order carryover effects. Each subject will be exposed to one night of each of the following: Quiet night: No noise or vibration will be played, serving as a control night to assess individual baseline sleep, metabolic profile, and cognitive performance; Three railway vibration nights to determine consequences of noise-disrupted sleep. The vibration level in these three nights will be 0.5 mm/s, 0.7 mm/s and 0.9 mm/s respectively, so that exposure-response relationships can be derived.

Arm	Type	Receives
Control Night	No intervention	–Single study night with no noise exposure, to determine normal baseline sleep.
Low Vibration Night	Experimental	Radiation: Railway noise, Radiation: Low level railway vibrationSingle study night with railway vibration and noise events, to determine consequences of sleep disturbance by railway vibration at a lower level
Intermediate Vibration Night	Experimental	Radiation: Railway noise, Radiation: Intermediate level railway vibrationSingle study night with railway vibration and noise events, to determine consequences of sleep disturbance by railway vibration at an intermediate level
High Vibration Night	Experimental	Radiation: Railway noise, Radiation: High level railway vibrationSingle study night with railway vibration and noise events, to determine consequences of sleep disturbance by railway vibration at a higher level

Who may qualify

Ages: 18 to 30 years
Sex: All
Healthy volunteers: Accepted
Age groups: Adult

Key inclusion criteria (1 listed)

1) live in or around the city of Gothenburg area (Sweden)

Key exclusion criteria (11 listed)

aged <18 or >30 years;
habitual sleep and wake timings more than ±1 hour different from the study sleep times (i.e. habitual sleep time should be 22:00-00:00 and habitual wake time should be 06:00-08:00);
BMI>25 kg/m2;
regular sleep medication use (prescribed or "over-the-counter");
poor hearing acuity (measured during screening via pure tone audiometry);

Eligibility is decided by the study team after screening; this overview does not establish that a patient qualifies. Full inclusion and exclusion criteria.

Interventions

Intervention	Type	Arms
Railway noiseLow level railway noise, not exceeding 50 dB LAF,max. Thirty six single railway noise events.	Radiation	High Vibration Night, Intermediate Vibration Night, Low Vibration Night
Low level railway vibration36 single railway noise events at 0.5 mm/s, varying from 11.5 s to 56.9 s in duration. Vibration always occurs concurrently with the noise exposure.	Radiation	Low Vibration Night
Intermediate level railway vibration36 single railway noise events at 0.7 mm/s, varying from 11.5 s to 56.9 s in duration. Vibration always occurs concurrently with the noise exposure.	Radiation	Intermediate Vibration Night
High level railway vibration36 single railway noise events at 0.9 mm/s, varying from 11.5 s to 56.9 s in duration. Vibration always occurs concurrently with the noise exposure.	Radiation	High Vibration Night

Primary outcome

Fasting insulin resistance in the morning immediately after the Control night
Time frame: One night
Calculated using the Homeostatic model of insulin resistance (HOMA-IR)
Fasting insulin resistance in the morning immediately after the low vibration night
Time frame: One night
Calculated using the Homeostatic model of insulin resistance (HOMA-IR)
Fasting insulin resistance in the morning immediately after the intermediate vibration night
Time frame: One night
Calculated using the Homeostatic model of insulin resistance (HOMA-IR)
Fasting insulin resistance in the morning immediately after the high vibration night
Time frame: One night
Calculated using the Homeostatic model of insulin resistance (HOMA-IR)
Total sleep time during the Control night
Time frame: One night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Total sleep time during the low vibration night
Time frame: One night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Total sleep time during the intermediate vibration night
Time frame: One night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Total sleep time during the high vibration night
Time frame: One night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Total amount of N1 sleep during the Control night
Time frame: One night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Total amount of N2 sleep during the Control night
Time frame: One night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Total amount of N3 sleep during the Control night
Time frame: One night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Total amount of rapid eye movement (REM) sleep during the Control night
Time frame: One night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Total amount of N1 sleep during the low vibration night
Time frame: One night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Total amount of N2 sleep during the low vibration night
Time frame: One night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Total amount of N3 sleep during the low vibration night
Time frame: One night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Total amount of rapid eye movement (REM) sleep during the low vibration night
Time frame: One night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Total amount of N1 sleep during the intermediate vibration night
Time frame: One night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Total amount of N2 sleep during the intermediate vibration night
Time frame: One night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Total amount of N3 sleep during the intermediate vibration night
Time frame: One night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Total amount of rapid eye movement (REM) sleep during the intermediate vibration night
Time frame: One night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Total amount of N1 sleep during the high vibration night
Time frame: One night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Total amount of N2 sleep during the high vibration night
Time frame: One night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Total amount of N3 sleep during the high vibration night
Time frame: One night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Total amount of rapid eye movement (REM) sleep during the high vibration night
Time frame: One night
Measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines
Wakefulness after sleep onset (WASO) during the Control night
Time frame: One night
Total number of minutes awake during the night after the first appearance of sleep of any stage. Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines.
Wakefulness after sleep onset (WASO) during the low vibration night
Time frame: One night
Total number of minutes awake during the night after the first appearance of sleep of any stage. Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines.
Wakefulness after sleep onset (WASO) during the intermediate night
Time frame: One night
Total number of minutes awake during the night after the first appearance of sleep of any stage. Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines.
Wakefulness after sleep onset (WASO) during the high vibration night
Time frame: One night
Total number of minutes awake during the night after the first appearance of sleep of any stage. Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines.
Number of awakenings during the Control night
Time frame: One night
Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines.
Number of awakenings during exposure to low vibration
Time frame: One night
Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines.
Number of awakenings during exposure to intermediate vibration
Time frame: One night
Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines.
Number of awakenings during exposure to high vibration
Time frame: One night
Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines.
Sleep onset latency (SOL) during the Control Night
Time frame: One night
Defined as the time from lights out to the first epoch of sleep. Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines.
Sleep onset latency (SOL) during the low vibration night
Time frame: One night
Defined as the time from lights out to the first epoch of sleep. Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines.
Sleep onset latency (SOL) during the intermediate vibration night
Time frame: One night
Defined as the time from lights out to the first epoch of sleep. Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines.
Sleep onset latency (SOL) during the high vibration night
Time frame: One night
Defined as the time from lights out to the first epoch of sleep. Measured via Polysomnography /EEG, scored according to American Academy of Sleep Medicine guidelines.
Sleep efficiency during the Control night
Time frame: One night
Defined as the percentage of time in bed spent in a non-wake sleep stage, measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines.
Sleep efficiency during the low vibration night
Time frame: One night
Defined as the percentage of time in bed spent in a non-wake sleep stage, measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines.
Sleep efficiency during the intermediate vibration night
Time frame: One night
Defined as the percentage of time in bed spent in a non-wake sleep stage, measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines.
S Sleep efficiency during the high vibration night
Time frame: One night
Defined as the percentage of time in bed spent in a non-wake sleep stage, measured via polysomnography/EEG, scored according to American Academy of Sleep Medicine guidelines.
Sleep depth assessed using the odds ratio product (ORP) during the Control night
Time frame: One night
Average ORP over the full night, from 0 (never occurs during wake) to 2.5 (only occurs during wake). Derived via polysomnography/EEG measurements.
Sleep depth assessed using the odds ratio product (ORP) during the low vibration night
Time frame: One night
Average ORP over the full night, from 0 (never occurs during wake) to 2.5 (only occurs during wake). Derived via polysomnography/EEG measurements.
Sleep depth assessed using the odds ratio product (ORP) during the intermediate vibration night
Time frame: One night
Average ORP over the full night, from 0 (never occurs during wake) to 2.5 (only occurs during wake). Derived via polysomnography/EEG measurements.
Sleep depth assessed using the odds ratio product (ORP) during the high vibration night
Time frame: One night
Average ORP over the full night, from 0 (never occurs during wake) to 2.5 (only occurs during wake). Derived via polysomnography/EEG measurements.
Maximal change of odds ratio product (ORP) during exposure to railway vibration events
Time frame: One night
Measure of acute sleep disruption by noise, calculated as the difference between the ORP in the 30s prior to noise onset and the maximum ORP during railway vibration. Averaged over 36 vibration events during the night.
Area under the curve of odds ratio product (ORP) during exposure to railway vibration events, calculated using the trapezoid rule
Time frame: One night
Measure of acute sleep disruption by noise, calculated as the difference between the ORP in the 30s prior to noise onset and the maximum ORP during railway vibration. Averaged over 36 vibration events during the night.
N-acetylglucosamine/galactosamine (GlycA) concentration after the Control night
Time frame: One night
Determined from NMR analysis of blood plasma
N-acetylglucosamine/galactosamine (GlycA) concentration after exposure to low vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
N-acetylglucosamine/galactosamine (GlycA) concentration after exposure to intermediate vibration
Time frame: One night
Determined from NMR analysis of blood plasma
N-acetylglucosamine/galactosamine (GlycA) concentration after exposure to high vibration
Time frame: One night
Determined from NMR analysis of blood plasma
Sialic acid (GlycB) concentration after the Control night
Time frame: One night
Determined from NMR analysis of blood plasma
Sialic acid (GlycB) concentration after exposure to low vibration
Time frame: One night
Determined from NMR analysis of blood plasma
Sialic acid (GlycB) concentration after exposure to intermediate vibration
Time frame: One night
Determined from NMR analysis of blood plasma
Sialic acid (GlycB) concentration after exposure to high vibration
Time frame: One night
Determined from NMR analysis of blood plasma
Supramolecular phospholipid composite (SPC) concentration after the Control night
Time frame: One night
Determined from NMR analysis of blood plasma
Supramolecular phospholipid composite (SPC) concentration after exposure to low vibration
Time frame: One night
Determined from NMR analysis of blood plasma
Supramolecular phospholipid composite (SPC) concentration after exposure to intermediate vibration
Time frame: One night
Determined from NMR analysis of blood plasma
Supramolecular phospholipid composite (SPC) concentration after exposure to high vibration
Time frame: One night
Determined from NMR analysis of blood plasma
Ethanol concentration (mmol/L) after the Control night
Time frame: One night
Determined from NMR analysis of blood plasma
Ethanol concentration (mmol/L) after exposure to low vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Ethanol concentration (mmol/L) after exposure to intermediate vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Ethanol concentration (mmol/L) after exposure to high vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Trimethylamine-N-oxide concentration (mmol/L) after exposure to Control night
Time frame: One night
Determined from NMR analysis of blood plasma
Trimethylamine-N-oxide concentration (mmol/L) after exposure to low vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Trimethylamine-N-oxide concentration (mmol/L) after exposure to intermediate vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Trimethylamine-N-oxide concentration (mmol/L) after exposure to high vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
2-Aminobutyric acid concentration (mmol/L) after exposure to Control night
Time frame: One
Determined from NMR analysis of blood plasma
2-Aminobutyric acid concentration (mmol/L) after exposure to low vibration night
Time frame: One
Determined from NMR analysis of blood plasma
2-Aminobutyric acid concentration (mmol/L) after exposure to intermediate vibration night
Time frame: One
Determined from NMR analysis of blood plasma
2-Aminobutyric acid concentration (mmol/L) after exposure to high vibration night
Time frame: One
Determined from NMR analysis of blood plasma
Alanine concentration (mmol/L) after exposure to Control night
Time frame: One night
Determined from NMR analysis of blood plasma
Alanine concentration (mmol/L) after exposure to low vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Alanine concentration (mmol/L) after exposure to intermediate vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Alanine concentration (mmol/L) after exposure to high vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Asparagine concentration (mmol/L) after exposure to Control night
Time frame: One night
Determined from NMR analysis of blood plasma
Asparagine concentration (mmol/L) after exposure to low vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Asparagine concentration (mmol/L) after exposure to intermediate vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Asparagine concentration (mmol/L) after exposure to high vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Creatine concentration (mmol/L) after exposure to Control night
Time frame: One night
Determined from NMR analysis of blood plasma
Creatine concentration (mmol/L) after exposure to low vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Creatine concentration (mmol/L) after exposure to intermediate vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Creatine concentration (mmol/L) after exposure to high vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Creatinine concentration (mmol/L) after exposure to Control night
Time frame: One night
Determined from NMR analysis of blood plasma
Creatinine concentration (mmol/L) after exposure to low vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Creatinine concentration (mmol/L) after exposure to intermediate vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Creatinine concentration (mmol/L) after exposure to high vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Glutamic acid concentration (mmol/L) after exposure to Control night
Time frame: One night
Determined from NMR analysis of blood plasma
Glutamic acid concentration (mmol/L) after exposure to low vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Glutamic acid concentration (mmol/L) after exposure to intermediate vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Glutamic acid concentration (mmol/L) after exposure to high vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Glutamine concentration (mmol/L) after exposure to Control night
Time frame: One night
Determined from NMR analysis of blood plasma
Glutamine concentration (mmol/L) after exposure to low vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Glutamine concentration (mmol/L) after exposure to intermediate vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Glutamine concentration (mmol/L) after exposure to high vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Glycine concentration (mmol/L) after exposure to Control night
Time frame: One night
Determined from NMR analysis of blood plasma
Glycine concentration (mmol/L) after exposure to low vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Glycine concentration (mmol/L) after exposure to intermediate vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Glycine concentration (mmol/L) after exposure to high vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Histidine concentration (mmol/L) after exposure to Control night
Time frame: One night
Determined from NMR analysis of blood plasma
Histidine concentration (mmol/L) after exposure to low vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Histidine concentration (mmol/L) after exposure to intermediate vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Histidine concentration (mmol/L) after exposure to high vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Isoleucine concentration (mmol/L) after exposure to Control night
Time frame: One night
Determined from NMR analysis of blood plasma
Isoleucine concentration (mmol/L) after exposure to low vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Isoleucine concentration (mmol/L) after exposure to intermediate vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Isoleucine concentration (mmol/L) after exposure to high vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Leucine concentration (mmol/L) after exposure to Control night
Time frame: One night
Determined from NMR analysis of blood plasma
Leucine concentration (mmol/L) after exposure to low vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Leucine concentration (mmol/L) after exposure to intermediate vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Leucine concentration (mmol/L) after exposure to high vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Lysine concentration (mmol/L) after exposure to Control night
Time frame: One night
Determined from NMR analysis of blood plasma
Lysine concentration (mmol/L) after exposure to low vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Lysine concentration (mmol/L) after exposure to intermediate vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Lysine concentration (mmol/L) after exposure to high vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Methionine concentration (mmol/L) after exposure to Control night
Time frame: One night
Determined from NMR analysis of blood plasma
Methionine concentration (mmol/L) after exposure to low vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Methionine concentration (mmol/L) after exposure to intermediate vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Methionine concentration (mmol/L) after exposure to high vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
N,N-Dimethylglycine concentration (mmol/L) after Control night
Time frame: One night
Determined from NMR analysis of blood plasma
N,N-Dimethylglycine concentration (mmol/L) after exposure to low vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
N,N-Dimethylglycine concentration (mmol/L) after exposure to intermediate vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
N,N-Dimethylglycine concentration (mmol/L) after exposure to high vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Ornithine concentration (mmol/L) after exposure to Control night
Time frame: One night
Determined from NMR analysis of blood plasma
Ornithine concentration (mmol/L) after exposure to low vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Ornithine concentration (mmol/L) after exposure to intermediate vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Ornithine concentration (mmol/L) after exposure to high vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Phenylalanine concentration (mmol/L) after exposure to Control night
Time frame: One night
Determined from NMR analysis of blood plasma
Phenylalanine concentration (mmol/L) after exposure to low vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Phenylalanine concentration (mmol/L) after exposure to intermediate vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Phenylalanine concentration (mmol/L) after exposure to high vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Proline concentration (mmol/L) after exposure to Control night
Time frame: One night
Determined from NMR analysis of blood plasma
Proline concentration (mmol/L) after exposure to low vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Proline concentration (mmol/L) after exposure to intermediate vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Proline concentration (mmol/L) after exposure to high vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Sarcosine concentration (mmol/L) after exposure to Control night
Time frame: One night
Determined from NMR analysis of blood plasma
Sarcosine concentration (mmol/L) after exposure to low vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Sarcosine concentration (mmol/L) after exposure to intermediate vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Sarcosine concentration (mmol/L) after exposure to high vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Threonine concentration (mmol/L) after exposure to Control night
Time frame: One night
Determined from NMR analysis of blood plasma
Threonine concentration (mmol/L) after exposure to low vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Threonine concentration (mmol/L) after exposure to intermediate vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Threonine concentration (mmol/L) after exposure to high vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Tyrosine concentration (mmol/L) after exposure toControl night
Time frame: One night
Determined from NMR analysis of blood plasma
Tyrosine concentration (mmol/L) after exposure to low vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Tyrosine concentration (mmol/L) after exposure to intermediate vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Tyrosine concentration (mmol/L) after exposure to high vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Valine concentration (mmol/L) after Control night
Time frame: One night
Determined from NMR analysis of blood plasma
Valine concentration (mmol/L) after exposure to low vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Valine concentration (mmol/L) after exposure to intermediate vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Valine concentration (mmol/L) after exposure to high vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
2-Hydroxybutyric acid concentration (mmol/L) after exposure to Control night
Time frame: One night
Determined from NMR analysis of blood plasma
2-Hydroxybutyric acid concentration (mmol/L) after exposure to low vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
2-Hydroxybutyric acid concentration (mmol/L) after exposure to intermediate vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
2-Hydroxybutyric acid concentration (mmol/L) after exposure to high vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Acetic acid concentration (mmol/L) after exposure to Control night
Time frame: One night
Determined from NMR analysis of blood plasma
Acetic acid concentration (mmol/L) after exposure to low vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Acetic acid concentration (mmol/L) after exposure to intermediate vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Acetic acid concentration (mmol/L) after exposure to high vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Citric acid concentration (mmol/L) after Control night
Time frame: One night
Determined from NMR analysis of blood plasma
Citric acid concentration (mmol/L) after exposure to low vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Citric acid concentration (mmol/L) after exposure to intermediate vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Citric acid concentration (mmol/L) after exposure to high vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Formic acid concentration (mmol/L) after exposure to Control night
Time frame: One night
Determined from NMR analysis of blood plasma
Formic acid concentration (mmol/L) after exposure to low vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Formic acid concentration (mmol/L) after exposure to intermediate vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Formic acid concentration (mmol/L) after exposure to high vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Lactic acid concentration (mmol/L) after exposure to Control night
Time frame: One night
Determined from NMR analysis of blood plasma
Lactic acid concentration (mmol/L) after exposure to low vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Lactic acid concentration (mmol/L) after exposure to intermediate vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Lactic acid concentration (mmol/L) after exposure to high vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Succinic acid concentration (mmol/L) after exposure to Control night
Time frame: One night
Determined from NMR analysis of blood plasma
Succinic acid concentration (mmol/L) after exposure to low vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Succinic acid concentration (mmol/L) after exposure to intermediate vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Succinic acid concentration (mmol/L) after exposure to high vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Choline concentration (mmol/L) after exposure to Control night
Time frame: One night
Determined from NMR analysis of blood plasma
Choline concentration (mmol/L) after exposure to low vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Choline concentration (mmol/L) after exposure to intermediate vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Choline concentration (mmol/L) after exposure to high vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
2-Oxoglutaric acid concentration (mmol/L) after exposure to Control night
Time frame: One night
Determined from NMR analysis of blood plasma
2-Oxoglutaric acid concentration (mmol/L) after exposure to low vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
2-Oxoglutaric acid concentration (mmol/L) after exposure to intermediate vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
2-Oxoglutaric acid concentration (mmol/L) after exposure to high vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
3-Hydroxybutyric acid concentration (mmol/L) after exposure to Control night
Time frame: One night
Determined from NMR analysis of blood plasma
3-Hydroxybutyric acid concentration (mmol/L) after exposure to low vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
3-Hydroxybutyric acid concentration (mmol/L) after exposure to intermediate vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
3-Hydroxybutyric acid concentration (mmol/L) after exposure to high vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Acetoacetic acid concentration (mmol/L) after exposure to Control night
Time frame: One night
Determined from NMR analysis of blood plasma
Acetoacetic acid concentration (mmol/L) after exposure to low vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Acetoacetic acid concentration (mmol/L) after exposure to intermediate vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Acetoacetic acid concentration (mmol/L) after exposure to high vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Acetone concentration (mmol/L) after exposure to Control night
Time frame: One night
Determined from NMR analysis of blood plasma
Acetone concentration (mmol/L) after exposure to low vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Acetone concentration (mmol/L) after exposure to intermediate vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Acetone concentration (mmol/L) after exposure to high vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Pyruvic acid concentration (mmol/L) after exposure to Control night
Time frame: One night
Determined from NMR analysis of blood plasma
Pyruvic acid concentration (mmol/L) after exposure to low vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Pyruvic acid concentration (mmol/L) after exposure to intermediate vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Pyruvic acid concentration (mmol/L) after exposure to high vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
D-Galactose concentration (mmol/L) after exposure to Control night
Time frame: One night
Determined from NMR analysis of blood plasma
D-Galactose concentration (mmol/L) after exposure to low vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
D-Galactose concentration (mmol/L) after exposure to intermediate vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
D-Galactose concentration (mmol/L) after exposure to high vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Glucose concentration (mmol/L) after exposure to Control night
Time frame: One night
Determined from NMR analysis of blood plasma
Glucose concentration (mmol/L) after exposure to low vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Glucose concentration (mmol/L) after exposure to intermediate vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Glucose concentration (mmol/L) after exposure to high vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Glycerol concentration (mmol/L) after exposure to Control night
Time frame: One night
Determined from NMR analysis of blood plasma
Glycerol concentration (mmol/L) after exposure to low vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Glycerol concentration (mmol/L) after exposure to intermediate vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Glycerol concentration (mmol/L) after exposure to high vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Dimethylsulfone concentration (mmol/L) after exposure to Control night
Time frame: One night
Determined from NMR analysis of blood plasma
Dimethylsulfone concentration (mmol/L) after exposure to low vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Dimethylsulfone concentration (mmol/L) after exposure to intermediate vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Dimethylsulfone concentration (mmol/L) after exposure to high vibration night
Time frame: One night
Determined from NMR analysis of blood plasma
Response to an oral glucose bolus, calculated as area under curve for glucose, in the morning after the control night
Time frame: One night
Area under the curve (AUC) calculated using the trapezoidal rule, from glucose samples collected 10, 20, 30, 60, 90 and 120 minutes after the glucose bolus.
Response to an oral glucose bolus, calculated as area under curve for glucose, in the morning after the low vibration night
Time frame: One night
Area under the curve (AUC) calculated using the trapezoidal rule, from glucose samples collected 10, 20, 30, 60, 90 and 120 minutes after the glucose bolus.
Response to an oral glucose bolus, calculated as area under curve for glucose, in the morning after the intermediate vibration night
Time frame: One night
Area under the curve (AUC) calculated using the trapezoidal rule, from glucose samples collected 10, 20, 30, 60, 90 and 120 minutes after the glucose bolus.
Response to an oral glucose bolus, calculated as area under curve for glucose, in the morning after the high vibration night
Time frame: One night
Area under the curve (AUC) calculated using the trapezoidal rule, from glucose samples collected 10, 20, 30, 60, 90 and 120 minutes after the glucose bolus.
Response to an oral glucose load calculated as area under curve for insulin, in the morning after the low vibration night
Time frame: One night
Area under the curve (AUC) calculated using the trapezoidal rule, from insulin samples collected 10, 20, 30, 60, 90 and 120 minutes after the glucose bolus
Response to an oral glucose load calculated as area under curve for insulin, in the morning after the intermediate vibration night
Time frame: One night
Area under the curve (AUC) calculated using the trapezoidal rule, from insulin samples collected 10, 20, 30, 60, 90 and 120 minutes after the glucose bolus
Response to an oral glucose load calculated as area under curve for insulin, in the morning after the high vibration night
Time frame: One night
Area under the curve (AUC) calculated using the trapezoidal rule, from insulin samples collected 10, 20, 30, 60, 90 and 120 minutes after the glucose bolus
Early response to an oral glucose load calculated as area under curve for insulin, in the morning after the control night
Time frame: One night
Area under the curve (AUC) calculated using the trapezoidal rule, from insulin samples collected 10, 20 and 30 minutes after the glucose bolus
Early response to an oral glucose load calculated as area under curve for insulin, in the morning after the low vibration night
Time frame: One night
Area under the curve (AUC) calculated using the trapezoidal rule, from insulin samples collected 10, 20 and 30 minutes after the glucose bolus
Early response to an oral glucose load calculated as area under curve for insulin, in the morning after the intermediate vibration night
Time frame: One night
Area under the curve (AUC) calculated using the trapezoidal rule, from insulin samples collected 10, 20 and 30 minutes after the glucose bolus
Early response to an oral glucose load calculated as area under curve for insulin, in the morning after the high vibration night
Time frame: One night
Area under the curve (AUC) calculated using the trapezoidal rule, from insulin samples collected 10, 20 and 30 minutes after the glucose bolus
Glucose tolerance in the morning after exposure to low vibration, assessed as glucose concentration 120 minutes after a glucose bolus
Time frame: One night
Glucose concentrations determined from plasma samples with the Hexokinase/G-6-PDH method
Glucose tolerance in the morning after exposure to intermediate vibration, assessed as glucose concentration 120 minutes after a glucose bolus
Time frame: One night
Glucose concentrations determined from plasma samples with the Hexokinase/G-6-PDH method
Glucose tolerance in the morning after exposure to high vibration, assessed as glucose concentration 120 minutes after a glucose bolus
Time frame: One night
Glucose concentrations determined from plasma samples with the Hexokinase/G-6-PDH method
Glucose tolerance in the morning after Control night, assessed as glucose concentration 120 minutes after a glucose bolus
Time frame: One night
Glucose concentrations determined from plasma samples with the Hexokinase/G-6-PDH method
Stumvoll Insulin sensitivity Index in the morning after control
Time frame: One night
.226 - 0.0032 × BMI - 0.0000645 × I120 - 0.00375 × G90, where I120 and G90 represent insulin concentration 120 minutes after the glucose bolus, and glucose concentration 90 minutes after the glucose bolus, respectively.
Stumvoll Insulin sensitivity Index in the morning after exposure to low vibration
Time frame: One night
.226 - 0.0032 × BMI - 0.0000645 × I120 - 0.00375 × G90, where I120 and G90 represent insulin concentration 120 minutes after the glucose bolus, and glucose concentration 90 minutes after the glucose bolus, respectively.
Stumvoll Insulin sensitivity Index in the morning after exposure to intermediate vibration
Time frame: One night
.226 - 0.0032 × BMI - 0.0000645 × I120 - 0.00375 × G90, where I120 and G90 represent insulin concentration 120 minutes after the glucose bolus, and glucose concentration 90 minutes after the glucose bolus, respectively.
Stumvoll Insulin sensitivity Index in the morning after exposure to high vibration
Time frame: One night
.226 - 0.0032 × BMI - 0.0000645 × I120 - 0.00375 × G90, where I120 and G90 represent insulin concentration 120 minutes after the glucose bolus, and glucose concentration 90 minutes after the glucose bolus, respectively.
Matsuda insulin sensitivity index in the morning after control exposure
Time frame: One night
Calculated as 10,000/square root of [fasting glucose × fasting insulin] × [mean glucose × mean insulin during oral glucose tolerance test])
Matsuda insulin sensitivity index in the morning after exposure to low vibration
Time frame: One night
Calculated as 10,000/square root of [fasting glucose × fasting insulin] × [mean glucose × mean insulin during oral glucose tolerance test])
Matsuda insulin sensitivity index in the morning after exposure to intermediate vibration
Time frame: One night
Calculated as 10,000/square root of [fasting glucose × fasting insulin] × [mean glucose × mean insulin during oral glucose tolerance test])
Matsuda insulin sensitivity index in the morning after exposure to high vibration
Time frame: One night
Calculated as 10,000/square root of [fasting glucose × fasting insulin] × [mean glucose × mean insulin during oral glucose tolerance test])

34 secondary outcomes

Evening subjective sleepiness, assessed using the Karolinska Sleepiness Scale after exposure to control
Time frame: One night
Evening subjective sleepiness, assessed using the Karolinska Sleepiness Scale after exposure to low vibration
Time frame: One night
Evening subjective sleepiness, assessed using the Karolinska Sleepiness Scale after exposure to intermediate vibration
Time frame: One night
Evening subjective sleepiness, assessed using the Karolinska Sleepiness Scale after exposure to high vibration
Time frame: One night
Morning subjective sleepiness, assessed using the Karolinska Sleepiness Scale after exposure to control
Time frame: One night
Morning subjective sleepiness, assessed using the Karolinska Sleepiness Scale after exposure to low vibration
Time frame: One night
Morning subjective sleepiness, assessed using the Karolinska Sleepiness Scale after exposure to intermediate vibration
Time frame: One night
Morning subjective sleepiness, assessed using the Karolinska Sleepiness Scale after exposure to high vibration
Time frame: One night
Self-reported sleep disturbance by vibration after control exposure
Time frame: One night
Self-reported sleep disturbance by vibration after exposure to low vibration
Time frame: One night
Self-reported sleep disturbance by vibration after exposure to intermediate vibration
Time frame: One night
Self-reported sleep disturbance by vibration after exposure to high vibration
Time frame: One night
Morning positive affect, assessed using the Positive and Negative Affect Schedule (PANAS) after control exposure
Time frame: One night.
Morning positive affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to low vibration
Time frame: One night.
Morning positive affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to intermediate vibration
Time frame: One night.
Morning positive affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to high vibration
Time frame: One night.
Morning negative affect, assessed using the Positive and Negative Affect Schedule (PANAS) after control exposure
Time frame: One night.
Morning negative affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to low vibration
Time frame: One night.
Morning negative affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to intermediate vibration
Time frame: One night.
Morning negative affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to high vibration
Time frame: One night.
Evening negative affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to control
Time frame: One night.
Evening negative affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to low vibration
Time frame: One night.
Evening negative affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to intermediate vibration
Time frame: One night.
Evening negative affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to high vibration
Time frame: One night.
Evening positive affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to control
Time frame: One night.
Evening positive affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to low vibration
Time frame: One night.
Evening positive affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to intermediate vibration
Time frame: One night.
Evening positive affect, assessed using the Positive and Negative Affect Schedule (PANAS) after exposure to high vibration
Time frame: One night.
Event-related cardiovascular activation in response to control
Time frame: One night
Event-related cardiovascular activation in response to low vibration
Time frame: One night
Event-related cardiovascular activation in response to intermediate vibration
Time frame: One night
Event-related cardiovascular activation in response to high vibration
Time frame: One night
Evening neurobehavioural speed
Time frame: One night
Evening neurobehavioural accuracy
Time frame: One night

Results and safety

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

Research links

Official record on ClinicalTrials.govLast updated by the sponsor 13 Mar 2025.

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Referral and contact

AzTrials does not enrol participants or take referrals. Contact the study team or a site listed below; they decide who can take part. This study is not recruiting at the moment.

Michael G Smith, PhD principal investigator

Göteborg University

1 site in 1 country: see every site and its status.

Questions about this trial

What is this clinical trial studying?

The full registered description is in the About this study section and the official record.

Who may be eligible to take part?

The sponsor lists 1 inclusion and 11 exclusion criteria. Eligibility is decided by the study team after screening, so read the full criteria and contact a listed site.

Is this clinical trial currently recruiting?

The record says: finished, as of the sponsor's last update on 13 Mar 2025. Status can change between updates, so confirm with the study contact before making plans.

Where is the study taking place?

The record lists 1 site in Sweden. Whether a site is taking part right now should be confirmed with that site. See every site.

What are the possible benefits and risks?

They depend on the study and the treatment, and no study can promise a benefit. The study team explains the known risks during informed consent, before anyone joins; the record itself does not list them.

Are results available for this study?

The study is completed, but results are not available in the source record. That does not mean the treatment did or did not work.

How can a doctor refer a patient or contact the research team?

The record lists no contact. The official record names the sponsor, who can be asked directly. AzTrials does not enrol participants or take referrals.

What does the primary outcome measure?

Fasting insulin resistance in the morning immediately after the Control night (time frame: One night). The study lists 237 primary outcomes in all. It is what the study was designed to measure, not a finding.

Where can I read the original study information?

On the ClinicalTrials.gov record for NCT06260254.

Does a listing mean the treatment is approved or proven to work?

No. A listing means the study is registered. It does not show that the treatment is safe, works, or is approved by a regulator.

How often is this information updated?

AzTrials copies changed records from ClinicalTrials.gov every night and reloads the whole registry every week. The sponsor last updated this record on 13 Mar 2025.