Clinical trials: Chronic Kidney Disease (CKD)
Type 1 Diabetes Mellitus, Chronic Kidney Disease (CKD) With Diabetes Mellitus (DM)
Mitigating DKA in Type 1 Diabetes for Safe Use of SGLT Inhibitors Using Dual Continuous Ketone and Glucose Monitoring.
The goal of this clinical trial is to develop and evaluate a novel diabetes ketoacidosis risk mitigation strategy to support the safe use of sodium-glucose cotransporter-2 inhibitors (SGLT2i) therapy in participants with type 1…
- Conditions
- Type 1 Diabetes Mellitus, Chronic Kidney Disease (CKD) With Diabetes Mellitus (DM), Chronic Kidney Disease, Diabetic Ketoacidosis
- Trial name
- SCOUT-CKD (NCT07325201)
- Testing
- Sotagliflozin initiation
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- HealthPartners Institute
Renal Insufficiency,Chronic, Dietary Intake Patterns
Strategies for Proactive Health in People With Kidney Function Decline
This prospective cohort study aims to investigate how kidney function decline affects multiple body systems and how personalized nutrition can help maintain health and slow disease progression.
- Conditions
- Renal Insufficiency,Chronic, Dietary Intake Patterns, Malnutrition, Frailty
- Trial name
- NCT07245186
- Where
- China
- Volunteers
- 1,800 people
- Sponsor
- Huashan Hospital
Chronic Kidney Disease (CKD), Secondary Hyperparathyroidism
A Study of PLS240 in Pediatric Participants With Secondary Hyperparathyroidism and Chronic Kidney Disease on Hemodialysis
Approximately 56 participants who are 1 month old to 17 years old will be enrolled in this study. The total duration for this study will be 38 weeks (or up to 42 weeks when participants require a washout period due to prior…
- Trial name
- NCT07890584
- Testing
- PLS240, Standard of Care
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Pathalys Pharma
Type 2 Diabetes, Chronic Kidney Disease (CKD) Stages G2 to G3b
A Study to Learn More About How Well Finerenone Works in Real-world in People With Type 2 Diabetes and Chronic Kidney Disease in Primary Care (IMSS= Instituto Mexicano Del Seguro Social)
The main purpose of this study is to learn how treatment with finerenone affects the urinary albumin-to-creatinine ratio (uACR), a marker of kidney health, over time in adults with type 2 diabetes and chronic kidney disease who…
- Trial name
- FINE-IMSS-MX (NCT07841015)
- Testing
- Finerenone
- Where
- Mexico
- Volunteers
- 800 people
- Sponsor
- Bayer
Atherosclerotic Cardiovascular Disease (ASCVD), Chronic Kidney Disease (CKD)
The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)
The main purpose of this study is to determine if retatrutide can significantly lower the incidence of serious heart-related complications or prevent the worsening of kidney function.
- Trial name
- NCT06383390
- Testing
- Retatrutide
- Where
- 742 sites in United States, Argentina and 25 more
- Volunteers
- 10,000 people
- Sponsor
- Eli Lilly and Company
CKD - Chronic Kidney Disease
The Use of Risk Prediction to Identify Patients at Risk for Chronic Kidney Disease: Patient and Provider Interventions for Patients at High Risk for Chronic Kidney Disease
This prospective, cluster-randomized trial is structured as a pragmatic study, embedding the outreach intervention within routine clinical workflows. The intervention reflects real-world provider-patient communication methods.
- Trial name
- RISK (NCT07857200)
- Testing
- Letter Intervention, Letter + Phone Call Intervention:, Augmented usual care
- Where
- United States
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Obesity, Chronic Kidney Disease
Patient-centred Intervention With Virtual Support for Obesity and Kidney Transplant Access
Obesity has a serious impact on people's health and quality of life. For those with advanced kidney disease (i.e. approaching the need for dialysis), obesity is especially problematic - obesity can not only lead to worsening…
- Conditions
- Obesity, Chronic Kidney Disease, Chronic Renal Disease, CKD
- Trial name
- PIVOT (NCT07858331)
- Testing
- Semaglutide, Virtual Weight Management Coaching
- Where
- 2 sites in Canada
- Volunteers
- 880 people
- Sponsor
- Kristin Clemens
Chronic Kidney Disease (CKD), Hemodialysis Complication
ESA Hyporesponsiveness in Hemodialysis Patients
This prospective cohort study aims to evaluate the development, persistence, and recovery of erythropoiesis-stimulating agent (ESA) hyporesponsiveness among patients receiving maintenance hemodialysis.
- Conditions
- Chronic Kidney Disease (CKD), Hemodialysis Complication, Anemia
- Trial name
- NCT07855458
- Volunteers
- 200 people
- Sponsor
- Assiut University
Chronic Kidney Disease(CKD), Type 2 DM
Implementation pRogram to Improve Screening and Management for CKD in Diabetes (Program 1) (IRIS-CKD)
IRIS-CKD is an implementation study to improve guideline-recommended screening of chronic kidney disease (CKD) in individuals with type 2 diabetes (T2D) in the United States.
- Conditions
- Chronic Kidney Disease(CKD), Type 2 DM, Type 2 Diabetes Mellitus (T2DM)
- Trial name
- IRIS-CKD (NCT06906627)
- Testing
- (IRIS-CKD Screening Program): Home Kit, (IRIS-CKD Screening Program): Standard Lab Order
- Where
- 7 sites in United States
- Volunteers
- 500 people
- Sponsor
- Duke University
Chronic Kidney Disease(CKD), Type 2 DM
Implementation pRogram to Improve Screening and Management for CKD in Diabetes (IRIS-CKD) (Program 2)
IRIS-CKD is a two-program implementation study to improve guideline-recommended screening and treatment of chronic kidney disease (CKD) in individuals with type 2 diabetes (T2D) in the United States.
- Conditions
- Chronic Kidney Disease(CKD), Type 2 DM, Type 2 Diabetes Mellitus (T2DM)
- Trial name
- IRIS-CKD (NCT06906640)
- Testing
- (IRIS-CKD Management Program): Education, (IRIS-CKD Management Program): GDMT
- Where
- 7 sites in United States
- Volunteers
- 212 people
- Sponsor
- Duke University
CKD - Chronic Kidney Disease, Renal Function
Walnuts for Cardiorenal Protection in Adults With Chronic Kidney Disease
To date, no rigorous randomized controlled trials have demonstrated a protective effect of daily moderate walnut consumption on kidney function or chronic kidney disease (CKD) progression in individuals with CKD.
- Conditions
- CKD - Chronic Kidney Disease, Renal Function, Cardiovascular Biomarkers
- Trial name
- NutReCard (NCT07851454)
- Testing
- Daily Walnut Consumption
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Institut Investigacio Sanitaria Pere Virgili
Obesity, Type 2 Diabetes (T2D)
A Retrospective Real-World Cohort Study
The primary objectives are to determine the prevalence and overlap of major cardiometabolic diseases, identify multimorbidity clusters, and characterize demographic, clinical, laboratory, and treatment patterns across the cohort…
- Conditions
- Obesity, Type 2 Diabetes (T2D), Prediabetes, Cardiovascular Disease (CVD)
- Trial name
- SCALA-TK-CM (NCT07781371)
- Testing
- No treatment given
- Where
- Denmark
- Volunteers
- 100,000 people
- Sponsor
- Novo Nordisk A/S
Chronic Kidney Disease (CKD)
An Observational Extension Study for Adult Patients Treated in Study R5459-RT-1944 Who Receive a Kidney Transplant
The main purpose of this study is to continue to see how vonsetamig works in the body and to monitor the outcomes after kidney transplant for participants previously treated in the R5459-RT-1944 study (NCT05092347).
- Trial name
- NCT05106387
- Testing
- Noninterventional
- Where
- 9 sites in United States
- Volunteers
- 20 people
- Sponsor
- Regeneron Pharmaceuticals
Chronic Kidney Disease Mineral and Bone Disorder, Chronic Kidney Disease (CKD)
The CPH-MBD Cohort
Persons with chronic kidney disease (CKD) have a 3-fold increased risk of bone fracture and a 10-fold increased risk of cardiovascular disease than the general population.
- Conditions
- Chronic Kidney Disease Mineral and Bone Disorder, Chronic Kidney Disease (CKD), Bone Markers
- Trial name
- NCT07193056
- Where
- Denmark
- Volunteers
- 1,000 people
- Sponsor
- Herlev Hospital
CKD (Chronic Kidney Disease) Stage 5D
ASPIrin in Reducing Events in Dialysis ( ASPIRED )
People with kidney failure requiring dialysis have a much higher risk of developing cardiovascular (CV) disease compared with the general population.
- Trial name
- NCT04381143
- Testing
- Aspirin 100 mg Oral Tablet
- Where
- 127 sites in China
- Volunteers
- 9,082 people
- Sponsor
- Guangdong Provincial People's Hospital
Chronic Kidney Disease (CKD)
Domperidone and the Risk of Serious Adverse Events
This study will assess whether initiating domperidone at doses ≥30 mg/day compared to <30 mg/day in patients with advanced chronic kidney disease (CKD) (estimated glomerular filtration rate [eGFR] <45 mL/min/1.73 m² but not…
- Trial name
- NCT07098078
- Testing
- Domperidone (drug)
- Where
- Canada
- Volunteers
- 15,000 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Chronic Kidney Disease (CKD)
Lorazepam and the Risk of Serious Adverse Events
This is a population-based cohort study assessing whether initiating a new outpatient prescription of a higher dose of lorazepam (>1-4 mg/day) compared to a lower dose (0.5-1 mg/day) in older adults with low kidney function (an…
- Trial name
- NCT07179978
- Testing
- Lorazepam
- Where
- Canada
- Volunteers
- 12,308 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Chronic Kidney Disease (CKD)
Tamsulosin and the Risk of Serious Adverse Events
This is a population-based cohort study assessing whether initiating a higher dose of tamsulosin (0.8 mg/day) compared to a lower dose (0.4 mg/day) in older adults with advanced chronic kidney disease (CKD) (an estimated…
- Trial name
- NCT07274228
- Testing
- Tamsulosin
- Where
- Canada
- Volunteers
- 14,000 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Chronic Kidney Disease (CKD), Elderly
Escitalopram and the Risk of Serious Adverse Events
The goal of this population-based cohort study is to assess the safety of initiating a new outpatient prescription of 10mg/day of Escitalopram (higher dose) compared to 5 mg/day (lower dose) in adults over the age of 65 with low…
- Conditions
- Chronic Kidney Disease (CKD), Elderly, Outpatient
- Trial name
- NCT07274241
- Testing
- Escitalopram
- Where
- Canada
- Volunteers
- 12,145 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Older Adults (65 Years and Older), Chronic Kidney Disease (CKD)
Pramipexole and the Risk of Serious Adverse Events
This is a population-based cohort study assessing whether initiation of a higher dose of pramipexole (0.25 or 0.375 mg/day), compared with a lower dose (0.125 mg/day), in older adults with advanced chronic kidney disease (CKD)…
- Trial name
- NCT07382960
- Testing
- Pramipexole
- Where
- Canada
- Volunteers
- 1,100 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's